scholarly journals A Comparison of Tramadol and Pethidine Analgesia on the Duration of Labour

2021 ◽  
Vol 10 (1) ◽  
pp. 1-6
Author(s):  
Rozhan Yassin Khalil ◽  
Gashbin Kamal Faraj
Keyword(s):  
Side Effects ◽  
Pregnant Women ◽  
Drug Administration ◽  
Analgesic Effect ◽  
Uterine Contraction ◽  
Analgesic Efficacy ◽  
Labor Pain ◽  
Analog Scale ◽  
Labor Duration ◽  
Active Labor

Background: A standard obstetric analgesic should have a good analgesic effect without reducing the intensity of uterine contraction. The present study aimed to evaluate and compare the efficacy of intramuscular tramadol and pethidine on labor pain and duration. Material and Methods: A total of 170 multigravida women in active labor were randomly assigned to two identical groups, so that 85 pregnant women received pethidine (50mg/2ml) and 85 pregnant women received tramadol (100mg/2ml) intramuscularly. Results: The labor duration in the tramadol group was shorter than in the pethidine group. In 1st stage of labor, 64.7% of the participants in the tramadol group received the drug for 120±30 minutes, while 67.1% in the pethidine group received the drug for 180±30 minutes. In the 2nd stage, 44.7% of the participants in the tramadol group received the drug for 15±5 minutes, while 51.8% in the pethidine group received the drug for 25±5 minutes. The Visual Analog Scale (VAS) was used before, and 1 and 3 hours after drug administration. The pethidine group obtained a lower VAS mean score compared to those in the tramadol group at 1 hour after drug administration (4 vs 6; P≤.001). Moreover, there was a significant higher level of vomiting and dizziness among women in the pethidine group (29.4% vs 1.2%; P≤.001). Conclusion: Tramadol appears to lead to a shorter labor duration and cause lower maternal side-effects, although its analgesic efficacy was not as much as pethidine.

Effect of Focusing on Maryam’s Flower During the First Stage of the Labor on the Labor Pain, Labor Duration, and Levels of Comfort and Satisfaction

2020 ◽  
pp. 105477382098491
Author(s):  
Hülya Türkmen ◽  
Serap Çetinkaya ◽  
Hafize Kiliç ◽  
Emine Apay ◽  
Devrim Karamüftüoğlu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Intervention Group ◽  
Comfort Level ◽  
Labor Pain ◽  
Cervical Dilatation ◽  
Control Group ◽  
Flower Opening ◽  
Labor Duration ◽  
Significant Difference ◽  
Physical Comfort

This randomized controlled experimental study was conducted with an intervention group ( n = 61) and a control group ( n = 63) consisting of primipara pregnant women. The pregnant women in the intervention group were asked to focus their attention on Maryam’s flower opening its leaf buds and imagine the labor’s progress during the course of their labor. The VAS was administered to each group at specific times (at 4–5 cm, 6–7 cm, 8–9 cm cervical dilatation) to determine their level of labor pain. A statistically significant difference was found between the groups’ mean pain scores at 4–5 cm, 6–7 cm, and 8–9 cm cervical dilatation ( p < .05). The labor duration of the pregnant women in the intervention group was significantly shorter than that of the pregnant women in the control group ( p = .017). The physical comfort level of the intervention group was significantly higher than that of the control group at 8–9 cm cervical dilatation ( p = .039).

Baricity, Needle Direction, and Intrathecal Sufentanil Labor Analgesia

1997 ◽  
Vol 86 (3) ◽  
pp. 592-598 ◽  
Author(s):  
Fazeela Ferouz ◽  
Mark C. Norris ◽  
Valerie A. Arkoosh ◽  
Barbara L. Leighton ◽  
Louis M. Boxer ◽  
...  
Keyword(s):  
Side Effects ◽  
Pain Relief ◽  
Normal Saline ◽  
Analgesic Efficacy ◽  
Study Drug ◽  
Labor Analgesia ◽  
Labor Pain ◽  
Double Blind Study ◽  
Drug Injection ◽  
Double Blind

Background Intrathecal sufentanil relieves labor pain but centrally mediated side effects are common. Preventing rostral spread of intrathecal sufentanil should limit these side effects. Both direction of the lateral opening of a pencil-point needle and drug baricity modify the spread of intrathecal local anesthetics. This randomized, prospective, double-blind study examines the effects of these variables on intrathecal sufentanil labor analgesia. Methods Forty laboring, full-term parturients, whose cervixes were dilated less than 5 cm and who requested analgesia for labor were enrolled. Combined spinal epidural analgesia was induced in patients in the sitting position. They were allocated to receive 10 micrograms intrathecal sufentanil diluted with either normal saline or dextrose with the aperture of the pencil-point needle directed cephalad or caudad during drug injection. Thus there were four groups of ten patients: dextrose up, dextrose down, saline up, and saline down. Sufentanil was diluted with normal saline to a concentration of 10 micrograms/ml. The study drug was made by mixing 1 ml sufentanil solution with either 1 ml 10% dextrose or 1 ml normal saline. Visual analog scores for pain, pruritus, nausea, and pain relief were recorded before and 5, 10, 15, and 30 min after drug injection. Results Baricity, but not needle orientation, influenced pain relief and pruritus. Sufentanil in dextrose produced less itching but also less analgesia. Nine of 20 women in the dextrose groups compared with 1 of 20 in the saline groups requested additional analgesia by 30 min. Conclusions Little or no labor analgesia developed for patients receiving sufentanil with dextrose. A supraspinal action may contribute to intrathecal sufentanil's analgesic efficacy.

A Clinical Study on Physiological Response in Electroacupuncture Analgesia and Meperidine Analgesia for Colonoscopy

1997 ◽  
Vol 25 (01) ◽  
pp. 13-20 ◽  
Author(s):  
Hwang-Huei Wang ◽  
Yung-Hsien Chan ◽  
Ding-Ming Liu ◽  
Yu-Jen Ho
Keyword(s):  
Clinical Study ◽  
Side Effects ◽  
Pain Relief ◽  
Serum Concentration ◽  
Analgesic Effect ◽  
Physiological Response ◽  
Analgesic Efficacy ◽  
Colonoscopic Examination ◽  
Significant Difference ◽  
Curve Change

Fifty-nine patients underwent consecutive colonoscopic examination with premedication of electroacupuncture analgesia (EA) were compared with conventional meperidine analgesia (MA) in pain relief and changes of neurotransmitters in serum. The results showed that analgesic efficacy of both groups were the same but with less side effects in the EA group (P < 0.01) especially in regard to dizziness. Serum concentration of β-endorphin in both groups has a similar curve change at 4 different phases during colonoscopy. Serum concentration of epinephrine, norepinephrine, dopamine and cortisol showed no significant difference between these two groups. The analgesic effect of EA and MA during colonoscopic examination may be closely related to β-endorphin production in serum.

scholarly journals Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials

2020 ◽  
Vol 2;23 (4;2) ◽  
pp. 175-201
Author(s):  
Chi Wai Cheung
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Randomized Controlled Trials ◽  
Safety Profile ◽  
Clinical Studies ◽  
Analgesic Efficacy ◽  
Labor Pain ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Randomized Controlled

Background: Meperidine, a synthetic opioid, has a rapid onset and short duration of action. Mounting evidence has challenged meperidine’s analgesic benefits, and concerns have been raised about its safety profile. Despite recommendations to restrict the prescription of meperidine, the drug remains frequently used. Objectives: The aim of this study was to evaluate the evidence regarding the efficacy and safety of meperidine for acute postoperative and labor pain. Study Design: This was a narrative review of the analgesic efficacy and side effects of meperidine compared to other analgesic drugs for acute postoperative and labor pain in adults. Setting: Randomized controlled trials that compared the analgesic efficacy and side effect profile of meperidine versus another analgesic drug in adult patients were evaluated. Methods: A systemized search of randomized controlled trials studying meperidine for acute postoperative or labor pain in the adult patient population from PubMed, Medline, and EMBASE was performed. Included studies reported on different routes of meperidine administration including intramuscular, intravenous, and patient-controlled analgesia in various surgical procedures such as abdominal surgery, Cesarean section, gynecological surgery, orthopedic surgery, cardiothoracic surgery, as well as for labor analgesia. Meperidine’s analgesic efficacy and safety profile were compared to other opioids (morphine, tramadol, fentanyl, buprenorphine, nalbuphine, and pentazocine), nonsteroidal anti-inflammatory drugs (ketorolac, diclofenac, and indomethacin), dipyrone, ketamine, and bupivacaine. Results: A total of 62 randomized controlled trials published between 1972 and 2018 were reviewed. Meperidine had a similar or inferior analgesic efficacy compared to other analgesics for acute postoperative or labor pain. Meperidine was associated with more sedation and respiratory depression. Limitations: The sample sizes of many clinical studies were small, and therefore probably insufficiently powered to detect differences in uncommon side effects, such as central nervous system toxicity. In addition, some of the included clinical studies were old. Conclusion: Considering the availability of other effective analgesics with potentially fewer side effects, the use of meperidine for acute postoperative or labor pain should not be recommended. Key words: Acute postoperative pain, adverse effects, labor analgesia, meperidine, pethidine

THE EFFECT OF 10 % LIDOCAINE SPRAYED TO NASAL PACKS ON PAIN AFTER ELECTIVE SEPTOPLASTY.

2020 ◽  
Vol 7 (8) ◽  
pp. 14-17
Keyword(s):  
Side Effects ◽  
Postoperative Period ◽  
Analgesic Effect ◽  
Nasal Packing ◽  
Control Group ◽  
Analog Scale ◽  
Analgesic Requirement ◽  
Significant Difference ◽  
Male Patients ◽  
Rescue Drug

Aim To study analgesic effect of lidocaine10 % sprayed to 10 cm х 10 cm gauze swabs with neomycin and bacitracin ointment nasal packing using visual analog scale (VAS) in postoperative period for patients underwent septoplasty operation. Materials and methods 100 patients aged between 17 and 50 years and divided into two equal groups. Group L lidocaine 10% was sprayed to gauze swabs with neomycin and bacitracin ointment nasal packing and group S control group 0.9% NaCl applied to same nasal packing. Postoperatively, VAS scale, side effects and analgesic requirements were recorded. Results There were no differences between the number of female and male patients. Postoperative pain was less in group L than group S, there was a statistically significant difference between L group and S group (p <0.05). The patient in the S group needs more rescue drug. L group had significantly better pain score versus S group at all intervals (2, 6, 12, 18, and 24) postoperative period. Conclusion Lidocaine 10% sprayed to 10 cm х 10 cm gauze swabs with neomycin and bacitracin ointment nasal pack provide better analgesic effect and reduced needs to analgesic requirement after septoplasty surgery.

scholarly journals Labour Analgesia When Epidural Is Not a Choice: Tramadol versus Pentazocine

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Jyothi Shetty ◽  
Ashwini Vishalakshi ◽  
Deeksha Pandey
Keyword(s):  
Side Effects ◽  
Pain Relief ◽  
Epidural Analgesia ◽  
Labor Pain ◽  
Resource Poor Setting ◽  
Analog Scale ◽  
The World ◽  
Resource Poor ◽  
The Given ◽  
First Stage Of Labor

Background. Parenteral opioids, thus, are still popular for pain relief in labor in many countries throughout the world. Aim. To evaluate and compare the efficacy of intramuscular tramadol and pentazocine in the first stage of labor. Method. Sixty-five patients were divided into pentazocine group and tramadol group. Subjects received either 30 mg pentazocine or 1 mg/kg tramadol intramuscularly. Pain was assessed using visual analog scale (VAS) before the administration of the drug, at 1 h, 2 h, 4 h, and at full dilatation. Maternal and neonatal side effects were determined. Results. Analgesic effect of the two drugs was not significantly different. Neither of these analgesics was effective towards the end of the first stage. However, in the tramadol group, the majority of women (55%) rated pain as severe, whereas in the pentazocine group, the majority of women (60%) rated pain as moderately severe. There were not many side effects with either of the drug in the given dosage. Mean injection to delivery interval was significantly shorter in the tramadol group as compared to the pentazocine group. Conclusion. Pentazocine or tramadol can be given for labor pain relief as an alternative to epidural analgesia in resource poor setting.

scholarly journals Música e parto: uma terapia para o alívio da dor

2021 ◽  
Vol 11 (34) ◽  
pp. 277-286
Author(s):  
Stefani Bernardino Lorencetto ◽  
Stephany Correia Lemes ◽  
Camila Breviglieri Bertella ◽  
Bianca Massari Tuci ◽  
Janize Silva Maia
Keyword(s):  
Pain Management ◽  
Side Effects ◽  
Literature Review ◽  
Music Therapy ◽  
Pregnant Women ◽  
Labor Pain ◽  
Exclusion Criteria ◽  
Safe Method ◽  
Non Invasive ◽  
Fear And Anxiety

A dor proveniente do trabalho de parto no Brasil é sinônimo de sofrimento, comumente associada ao medo entre as gestantes. Descrever os benefícios proporcionados pela musicoterapia para alívio da dor do parto. Realizou-se uma revisão integrativa da literatura nas bases de dados PUBMED, BVS, BDENF, nos idiomas português e inglês, publicados no período de 2000 a 2020. Foram encontrados 3.590 artigos, mas após a análise dos resultados, e por meio dos critérios de exclusão, foram selecionados 27 artigos. As principais evidências observadas foram que a musicoterapia pode proporcionar à parturiente diminuição do medo, da ansiedade, relaxamento, distração da dor, dentre outros benefícios. A musicoterapia é um método não farmacológico, não invasivo, simples, de baixo custo, eficiente, seguro e que não possui efeitos colaterais e pode ser utilizado para o alívio da dor do parto.Descritores: Dor do Parto, Musicoterapia, Trabalho de Parto, Manejo da Dor. Music and childbirth: a therapy for pain reliefAbstract: In Brazil, the pain from labor means suffering, which is often linked to fear among pregnant women. To describe the benefits provided by music therapy with regards to labor pain. An integrative literature review of pieces from the PUBMED, BVS and BDENF databases published between 2000 and 2020 was carried out in Portuguese and English. Were found 3.590 articles, but only 27 articles were selected after applying the exclusion criteria and analyzing articles results. The main evidence noted were the decrease in fear and anxiety as well as relaxation and distraction from pain experienced by pregnant women through the use of music therapy, amongst others benefits. Music therapy is a non-pharmacological, non-invasive, simple, affordable, efficient and safe method without side effects which can be used to relieve labor pain.Descriptors: Labor Pain, Music Therapy, Childbirth, Pain Management. Música y el parto: una terapia para el alivio del dolorResumen: El dolor proveniente del trabajo de parto en Brasil es sinónimo de sufrimiento, comúnmente asociada al miedo entre las gestantes. Describir los beneficios proporcionados por la musicoterapia para alivio del dolor del parto. Se realizó una revisión integradora de la literatura en las bases de datos PUBMED, BVS, BDENF, en los idiomas portugués e inglés, publicados entre 2000 y 2020. Fueron encontrados 3590 artículos. Después de analizar los resultados fueron escogidos 27 artículos por criterio de exclusión. Las principales evidencias observadas fueron que la musicoterapia puede proporcionar a la parturiente diminución del miedo, de la ansiedad, relajamiento, distracción del dolor, entre otros beneficios. La musicoterapia es un método no farmacológico, no evasivo, simple, de bajo costo, eficiente, seguro y que no tiene efectos colaterales y puede ser utilizado para alivio del dolor del parto.Descriptores: Dolor del Parto, Musicoterapia, Trabajo del Parto, Manejo del Dolor.

scholarly journals Pain Relief in labour: A randomized controlled trial comparing pentazocine with Tramadol

1970 ◽  
Vol 3 (1) ◽  
pp. 14-18 ◽  
Author(s):  
O Kuti ◽  
AF Faponle ◽  
AB Adeyemi ◽  
AT Owolabi
Keyword(s):  
Side Effects ◽  
Pain Relief ◽  
Drug Administration ◽  
Controlled Trial ◽  
Analgesic Efficacy ◽  
Labour Pain ◽  
Double Blind ◽  
Active Labour ◽  
Good Pain Relief ◽  
Randomised Controlled

Aim: To assess and compare the analgesic efficacy and side effects of Pentazocine and Tramadol. Method: This double blind randomised controlled trial was carried out at the labour ward of Wesley Guild Hospital Ilesa Nigeria. One hundred normal pregnant women in active labour at term were randomly assigned to receive either intramuscular Pentazocine 30mg or intramuscular tramadol 100mg, at request for analgesia. Analgesic efficacy was assessed by verbal scales of pain intensity and relief; maternal and neonatal side effects were determined. Results: At 60 minutes after drug administration 47.7% and 30.9% of women, in the pentazocine and tramadol group respectively, experienced moderate to good pain relief. Significantly more women in the pentazocine group (34.1%) than in the tramadol group(14.3%) rated their pain as mild (P < 0.05) sixty minutes after drug administration. Mean time to first subsequent request for analgesia was greater in the pentazocine group (181 minutes vs 113 minutes; P < 0.05). There was no significant differences between the drugs in maternal side effects, labour and neonatal outcomes. Conclusion: Pentazocine provides better pain relief than tramadol in labor. Key words: Labour pain, pentazocine, tramadol doi:10.3126/njog.v3i1.1433NJOG 2008 May-June; 3(1): 14 - 18

scholarly journals Evaluating the Effect of Dexmedetomidine Intravenous Infusion on Labor Pain Management in Primipar Term Pregnant Women

2020 ◽  
Author(s):  
Abasali Delavari ◽  
Arezoo Esmailzadeh ◽  
Mahdi Dehgan ◽  
Marzieh Lak
Keyword(s):  
Heart Rate ◽  
Pregnant Women ◽  
Drug Administration ◽  
Fetal Heart Rate ◽  
Fetal Heart ◽  
Intervention Group ◽  
Labor Pain ◽  
Control Group ◽  
Significant Difference ◽  
The Mean

Abstract Background: The pain of labor is very severe. Most women prefer painless labor to routine labor if they are aware of the methods of analgesia. The aim of this study was to evaluate the effect of Dexmedetomidine intravenous infusion on labor pain management in primipar term pregnant women. Methods: In this Non-randomized clinical trial with control group, all primipar term pregnant women were enrolled in the study. In the intervention group, after the active phase of labor, Dexmedetomidine was given according to the protocol and continued until phase two of labor. The control group received no intervention to reduce pain. Patients in both groups were evaluated for, fetal heart rate, Apgar scores, vital signs, pain intensity and sedation score. Results: There were no significant difference in primary fetal heart rate, primary maternal hemodynamics, and mean Apgar scores of 1 and 5 minutes, between the two groups (p>0.05). There was no significant difference in the mean of fetal heart rate in different stages between two groups. Intra-group analysis in the intervention group showed that mean systolic and diastolic blood pressure were significantly decreased after drug administration but were in normal range. The active phase of labor in the intervention group was significantly shorter than the control group (p = 0.002). The mean VAS score after Dexmedetomidine administration decreased significantly from 9.25 at baseline to 4.61 after drug administration, 3.88 during labor and 1.88 after placental expulsion. The mean RSS score after Dexmedetomidine administration increased significantly from 1 at baseline to 2.05 after drug administration, 2.22 during labor and 2.05 after placental expulsion. Conclusion: Based on results, it seems that administration of Dexmedetomidine to manage labor pain with careful monitoring of mother and fetus is recommended. Due to limited studies, further larger and multicenter studies are needed to be performed.Trial registration: This study was registered on Iranian registry of clinical trials, identification number IRCT20161022030421N5, registered on February 2, 2019, https://irct.ir/trial/40134.

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