COVID-19 and Digestive System Involvement: Can We Learn from the Past

Background and aim. The year 2020 will remain in the medical history as the year of COVID-19 pandemic. Although COVID-19 is considered mainly a respiratory disease, it is well known now that SARS-CoV-2 can affect major organs including the digestive system. This is a comprehensive review on gastrointestinal involvement in the SARS-CoV-2 infection, also the digestive damage due to COVID-19. Methods. A literature search was undertaken in main databases of medical publications following the search items digestive or gastrointestinal or gastric or enteral and SARS-CoV-2 or COVID-19. Data on gastrointestinal symptoms and alterations in this viral condition were collected and presented. Only observational studies were included. Results. In this review we discuss the recent information on the relationship between COVID-19 and the digestive system. The putative underlying pathogenic mechanisms of COVID-19 as well as the clinical findings in relation to gastrointestinal changes are presented. Conclusions. SARS-CoV-2 virus can affect any part of the digestive system. Patients with chronic diseases are at greatest risk of adverse out-comes. There is a considerable risk for drug-drug interactions in patients who require a large treatment schedule.

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COVID-19 Digestive System Involvement and Clinical Outcomes in a Large Academic Hospital in Milan, Italy

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2020.05.011 ◽

2020 ◽

Vol 18 (10) ◽

pp. 2366-2368.e3 ◽

Cited By ~ 7

Author(s):

Alessio Aghemo ◽

Daniele Piovani ◽

Tommaso Lorenzo Parigi ◽

Enrico Brunetta ◽

Nicola Pugliese ◽

...

Keyword(s):

Clinical Outcomes ◽

Digestive System ◽

Academic Hospital ◽

System Involvement

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Digestive system involvement of novel coronavirus infection: Prevention and control infection from a gastroenterology perspective

Journal of Digestive Diseases ◽

10.1111/1751-2980.12862 ◽

2020 ◽

Vol 21 (4) ◽

pp. 199-204 ◽

Cited By ~ 24

Author(s):

Lian Yong Li ◽

Wei Wu ◽

Sheng Chen ◽

Jian Wen Gu ◽

Xin Lou Li ◽

...

Keyword(s):

Prevention And Control ◽

Digestive System ◽

Infection Prevention ◽

Infection Prevention And Control ◽

System Involvement ◽

Coronavirus Infection ◽

Control Infection ◽

Novel Coronavirus ◽

And Control

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Obesity-associated digestive cancers: A review of mechanisms and interventions

Tumor Biology ◽

10.1177/1010428317695020 ◽

2017 ◽

Vol 39 (3) ◽

pp. 101042831769502 ◽

Cited By ~ 16

Author(s):

Jiachen Zheng ◽

Ming Zhao ◽

Jiahui Li ◽

Guoying Lou ◽

Yanyan Yuan ◽

...

Keyword(s):

Digestive System ◽

Survival Rates ◽

Gene Mutations ◽

Colorectal Cancers ◽

Growth Factor Signaling ◽

Related Gene ◽

The Past ◽

Digestive Cancers ◽

Liver And Pancreas ◽

Prevalence Of Obesity

The prevalence of obesity has steadily increased over the past few decades. Previous studies suggest that obesity is an oncogenic factor and that over 20% of all cancers are obesity-related. Among such cancers, digestive system malignancies (including esophageal adenocarcinomas, colorectal cancers, and cancers of the gastric cardia, liver, and pancreas) are reported most frequently. While the 5-year survival rates of cancers of the breast and prostate are 90%, that rate is only 45% for digestive cancers. In this review, the mechanisms of obesity-associated digestive cancers are discussed, with an emphasis on obesity-related gene mutations, insulin and insulin-like growth factor signaling pathways, chronic inflammation, and altered adipokine levels. Evidence that these factors often function interdependently rather than independently in carcinogenesis is presented. Recommended interventions that may reduce the burden of obesity-associated digestive cancers, such as participation in physical activity, diet modulation, and calorie restriction, are also described.

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Noninfectious Causes of Fever in 128 Patients with Systemic Lupus Erythematosus

Iranian Journal of Public Health ◽

10.18502/ijph.v48i1.783 ◽

2019 ◽

Author(s):

Feng GUO ◽

Jianmei CHEN ◽

Yu XIE ◽

Xueping ZHOU

Keyword(s):

Systemic Lupus Erythematosus ◽

Lymph Nodes ◽

Lupus Erythematosus ◽

Digestive System ◽

Multivariate Logistic Regression Analysis ◽

Complement C3 ◽

Systemic Lupus ◽

System Involvement ◽

Dsdna Antibody ◽

Spleen And Lymph Nodes

Background: This study aimed to explore the clinical characteristics of noninfectious fever in patients with systemic lupus erythematosus (SLE) and the underlying causes through multivariate analysis. Methods: Clinical data of 128 patients with SLE who were admitted to Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, P.R. China from January 2015 to December 2017 were retrospectively analyzed. Results: The following factors were closely associated with fever: patient age, treatment history, SLEDAI score, enlarged liver, spleen and lymph nodes, low hemoglobin, leukopenia, CRP, complement C3, albumin, anti-dsDNA antibody, glucocorticoids, and cyclophosphamide. Multivariate logistic regression analysis showed that factors, such as enlarged liver, spleen and lymph nodes, digestive system involvement, low hemoglobin, leukopenia, CRP, decreased albumin, anti-dsDNA antibody, glucocorticoids and cyclophosphamide, were closely associated with noninfectious fever in SLE. Conclusion: Noninfectious fever is a common clinical manifestation of SLE. Factors, such as enlarged liver, spleen and lymph nodes, digestive system involvement, low hemoglobin, leukopenia, CRP, decreased albumin, anti-dsDNA antibody, glucocorticoids, and cyclophosphamide, were independent risk factors for noninfectious fever in SLE.

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Understanding human gut diseases at single-cell resolution

Human Molecular Genetics ◽

10.1093/hmg/ddaa130 ◽

2020 ◽

Vol 29 (R1) ◽

pp. R51-R58 ◽

Cited By ~ 1

Author(s):

Emilia Bigaeva ◽

Werna T C Uniken Venema ◽

Rinse K Weersma ◽

Eleonora A M Festen

Keyword(s):

Single Cell ◽

Digestive System ◽

Cell Types ◽

Specific Cell ◽

Human Gut ◽

The Past ◽

Distinct Cell ◽

Transcriptional Variation ◽

Single Cell Rna Sequencing ◽

Inflammatory Bowel

Abstract Our understanding of gut functioning and pathophysiology has grown considerably in the past decades, and advancing technologies enable us to deepen this understanding. Single-cell RNA sequencing (scRNA-seq) has opened a new realm of cellular diversity and transcriptional variation in the human gut at a high, single-cell resolution. ScRNA-seq has pushed the science of the digestive system forward by characterizing the function of distinct cell types within complex intestinal cellular environments, by illuminating the heterogeneity within specific cell populations and by identifying novel cell types in the human gut that could contribute to a variety of intestinal diseases. In this review, we highlight recent discoveries made with scRNA-seq that significantly advance our understanding of the human gut both in health and across the spectrum of gut diseases, including inflammatory bowel disease, colorectal carcinoma and celiac disease.

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