THE INFLUENCE OF TREATMENT WITH INACTIVE VITAMIN ON INTRARENAL BLOOD FLOW IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2020 ◽  
pp. 360-366
Author(s):  
Е. В. Болотова ◽  
В. В. Трембач ◽  
А. В. Дудникова
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Blood Flow ◽  
Pulmonary Disease ◽  
Resistance Index ◽  
Main Group ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Ckd Stage

Целью работы стала оценка динамики ультразвуковых параметров почечного кровотока у больных ХОБЛ, имеющих начальные стадии хронической болезни почек (ХБП), на фоне лечения препаратами неактивного витамина D . В исследование включены 264 пациента с ХОБЛ II-IV степени тяжести в сочетании с ХБП I-II стадии: 135 пациентов основной группы и 129 - контрольной. Каждая группа была разделена на четыре подгруппы по величине объема форсированного выдоха (ОФВ) и уровню витамина D . В основной группе был назначен препарат нативного витамина D по схеме, обеспечивающей поддержание уровня >34,3 нг/мл в течение года, в контрольной - согласно рекомендациям Российской ассоциации эндокринологов. Всем пациентам на этапе включения в исследование и после его окончания проводили УЗИ почек с расчетом индекса резистентности Пурсилота ( RI ), исследование уровня альбуминурии. У 16 (24,1%) пациентов основной группы выявлено уменьшение тяжести альбуминурии с А3 до А2, ау 58 (42,9%) - повышение СКФ. Статистически значимое снижение значения индекса резистентности почечных артерий зафиксировано у пациентов основной группы со среднетяжелым течением ХОБЛ ( GOLD 2) и дефицитом витамина D ( р <0,05). Поддержание уровня витамина D более 34,3 нг/мл в течение 12 мес у пациентов с ХОБЛ в сочетании с ХБП I-II стадии ассоциировано с уменьшением тяжести альбуминурии, повышением СКФ, статистически значимым снижение индекса резистентности почечных артерий у пациентов основной группы со среднетяжелым течением ХОБЛ ( GOLD 2) и дефицитом витамина D . The aim of the work was to assess the dynamics of ultrasound parameters of renal blood flow in patients with chronic obstructive pulmonary disease (COPD)and initial stages of chronic kidney disease (CKD) during treatment with inactive vitamin D . The study included 264 patients with COPD of 2-4 degrees of severity in combination with CKD of 1-2 stages: 135 patients of the main group and 129 patients of the control group. Each group was divided into 4 subgroups according to the value of FEVand vitamin D level. In the main group, the native vitamin D was prescribed according to the scheme providing maintenance of vitamin D level >34,3 ng/ml during the year, in the control group - according to the recommendations of the Russian Association of Endocrinologists. An ultrasound of the kidneys with the calculation of the resistance index ( RI ) and albuminuria level were carried out in all patients at inclusion into the study and after its completion. A decrease in the severity of albuminuria from A3 to A2 was revealed in 24,1 % (16), and an increase in GFR - in 42,9 % (58) patients of all patients in the main group. A statistically significant decrease in the renal artery resistance index was recorded in the group of patients with moderate COPD ( GOLD 2) and vitamin D deficiency in the main group ( p <0,05). The maintaining of vitamin D levels more than 34,3 ng/ ml over 12 months in patients with COPD in combination with CKD stage 1-2 was associated with a decrease in the severity of albuminuria, with an increase in GFR, and statistically significant decrease of resistance index in renal arteries of patients with moderate clinical course of COPD ( GOLD 2) and lack of vitamin D .

scholarly journals Administration of vitamin D to ameliorate dyspnea of chronic obstructive pulmonary disease patients: a randomized controlled trial

2019 ◽  
Vol 5 (2) ◽  
pp. e22-e22
Author(s):  
Samad Ghodrati ◽  
Arian Ezzatpanah ◽  
Masoud Asadi-Khiavi ◽  
Shohreh Alian Samakkah ◽  
Abdolreza Esmaeilzadeh ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Pulmonary Disease ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Randomized Controlled

Introduction: As one of the most common causes of human morbidity and mortality, chronic obstructive pulmonary disease (COPD) affects millions around the world. Some evidences have already considered about association between serum levels of vitamin D and COPD. Objectives: This study was aimed to evaluate the effects of vitamin D supplementation on COPD improvement. Patients and Methods: This study was designed as a randomized controlled trial. Forty COPD patients with vitamin D deficiency were enrolled into two groups; cases group who administered vitamin D and control group who received placebo. The severity of dyspnea and spirometric indices were analyzed in both groups. Values were presented as mean and standard deviation (SD) and differences were considered significant at the level of P<0.05. Results: Spirometric indices did not show significant differences before and after vitamin D administration (P>0.05). Dyspnea severity was significantly improved after receiving vitamin D supplementation in comparison with placebo consumption (P=0.03). Conclusion: Spirometric indices were not affected during vitamin D supplementation therapy but it showed a significantly positive effect on the curing of dyspnea. Therefore, adjuvant therapy of COPD using vitamin D supplementation is recommended to better handling of dyspnea in COPD cases.

Clinical efficacy of hepatoprotector in the complex therapy of non-alcoholic steatohepatitis against the background of obesity for comorbidity with chronic obstructive pulmonary disease

2021 ◽  
Author(s):  
O. S. Khukhlina ◽  
O. Ye. Hryniuk
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Liver Steatosis ◽  
Subjective Assessment ◽  
Main Group ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Alcoholic Steatohepatitis ◽  
Complex Therapy

Objective — to establish the Antral efficacy in terms its effects on the intensity of clinical and biochemical syndromes of non‑alcoholic steatohepatitis (NASH) against the background of obesity at comorbidity with chronic obstructive pulmonary disease (COPD). Materials and methods. The examinations involved 65 NASH patients with I degree obesity and COPD 2 — 3 D. The patients were divided into two groups: 32 patients control groups received NASH therapy (Essentiale forte N (Sanofi Avensis/Nutterman and Cie GmbH) 300 mg, 2 caps., 3 times per day) for 30 days and basic COPD therapy. The second, main group consisted of 33 NASH patients with I degree obesity and COPD 2 — 3 D, who along with the basic therapy for COPD received hepatoprotector Antral (Farmak, Ukraine) 200 mg, 3 times daily for 30 days. The mean age of the patients was 56.3 ± 3.21 years. The comparison group consisted of 30 apparently healthy people (AHP). The values of 30 practically healthy individuals were used as reference. Results. According to the scale of subjective assessment of the intensity of asthenia after treatment in patients of the main group, the effectiveness of its elimination was 3.9 times higher than that of patients in the control group (relative risk 3.87; 95 % CI [1.16 — 12.91], p < 0.05). The manifestations of dyspepsia disappeared faster in the patients of the main group. The use of antral 3.7 times more influenced the manifestations of cholestasis (p < 0.05). Body mass index (BMI) > 32 kg/m2 after treatment, which included a hypocaloric diet and Antral, remained in 13 patients in the main group (39.4 %) versus 29 patients in control group (90.6 %) (p < 0.05). During one month after the treatment, markers of cytolysis remained in 9 patients in control group (28.1 %), and in 1 patient of the main group (3.0 %) (OR 9.28; 95 % CI [1.11 — 77, 52], p < 0.05). The increased activity of cholestasis markers after treatment remained only in 5 patients in the main group (15.2 %) in comparison with 22 (68.8 %) controls. In the dynamics of treatment of patients in the main group, significant increase in the protein‑synthesizing function of the liver was revealed (albumin levels increased by 30.56 % (p < 0.05) relative to the indicator in the control group). Conclusions. The use of Antral in the complex therapy of NASH of patients with the concomitant obesity and COPD was more effective than standard therapy in terms of removal of clinical NASH syndromes: asthenic‑vegetative, dyspepsia, abdominal discomfort, cholestasis, hepatomegaly, degree of liver steatosis; biochemical syndromes: cytolysis, cholestasis, mesenchymal inflammation, hepatocellular failure.  

scholarly journals Is There Relation Between 25(OH) Vitamin D and Chronic Obstructive Pulmonary Disease?

2017 ◽  
Vol 5 (2) ◽  
pp. 87-91
Author(s):  
Farshid Divani ◽  
Alireza zahedi ◽  
Maryam Vasheghani ◽  
Ebrahim Nadi ◽  
Jalal Poorolajal ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Serum Level ◽  
Vitamin D Deficiency ◽  
Pulmonary Disease ◽  
Control Group ◽  
Chronic Obstructive ◽  
Case Group ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

Background: Vitamin D level can affect pulmonary function in patient who have chronic obstructive pulmonary disease (COPD). Objectives: There are few studies that assess this subject, so we investigate the relation of Vitamin D and COPD. Materials and Methods: A case-control study was conducted among the patients referred to the pulmonology clinic of Shahid Beheshti hospital of Hamadan, in which 68 of patients were assigned into the case group with COPD and 68 patients into the control group. Both groups were evaluated for respiratory differences as clinical or laboratory and the blood level of vitamin D was measured. Results: Of 136 evaluated participants with the mean age of 58.83 years old, 68 patients were studied as case group consisting of 2 females and 66 males. The results suggested that the serum level of vitamin D in COPD patients and control group patients were 22.22 ± 15.83 ng/mL and 27.47 ± 21.43 ng/mL, respectively. It was also found that there was a positive correlation between lung function and serum level of vitamin D in COPD. The greater the severity of COPD (forced expiratory volume in the first second [FEV1] lower level) was, the more the vitamin D deficiency was seen. It was also clarified that there was an indirect correlation between the serum level of vitamin D in COPD patients and body mass index (BMI). Conclusions: Prevalence of vitamin D deficiency in COPD patients was more than that in control group patients. Due to the growing prevalence of vitamin D deficiency in such patients, any use of vitamin D maybe suggested.

scholarly journals Assessment of effectiveness of training of respiratory musculature in patients with chronic obstructive pulmonary disease and obesity

2019 ◽  
Vol 27 (3) ◽  
pp. 367-374
Author(s):  
Evgeniy S. Ovsyannikov ◽  
Andrey V. Budnevsky ◽  
Yanina S. Shkatova
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Main Group ◽  
Control Group ◽  
Chronic Obstructive ◽  
Clinical Group ◽  
Forced Expiration ◽  
Obstructive Pulmonary Disease

Aim. To assess the influence of training of respiratory musculature on the expressiveness of symptoms, tolerance to physical loads, spirometric parameters and quality of life of patients with chronic obstructive pulmonary disease (COPD) and obesity. Materials and Methods. The study included 52 patients with COPD (clinical group D) and obesity, of them 42 men and 10 women with the mean age 65.4±6.8 years and body mass index 33.6±2.9 kg/m2. The patients were divided to 2 groups: the main group with training of respiratory musculature (TRM) within 12 months using a respiratory exerciser, and the control group with simulation of TRM using the same exerciser, but with minimal load. Results. In 12 months the patients of the main group showed a reliable reduction of dyspnea on mMRC scale (Modified Medical Research Council), improvement of health related quality of life on St. George’s Respiratory Questionnaire (SGRQ), increase in forced expiration volume in 1 second and in forced vital capacity of lungs, increase in the covered distance in 6-minute walk test, reduction of the average duration of hospitalization for exacerbation of COPD. Conclusion. Taking into account the obtained data, TRM can be considered as an effective component of the lung rehabilitation program in patients with COPD.

scholarly journals Clinical and functional features of the nasal cavity, paranasal sinuses and pharynx in patients with chronic obstructive pulmonary disease in remission

2014 ◽  
Vol 95 (3) ◽  
pp. 352-356
Author(s):  
E A Gilifanov ◽  
V A Nevzorova ◽  
S A Artyushkin ◽  
D G Pavlush ◽  
L B Ardeeva
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Nasal Cavity ◽  
Pulmonary Disease ◽  
Paranasal Sinuses ◽  
Functional Condition ◽  
Main Group ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Functional Features

Aim. To assess functional condition of the nasal cavity, paranasal sinuses, pharynx in patients with remission of chronic obstructive pulmonary disease. Methods. Patients were distributed to 2 groups. The main group included 49 patients with stages II and III of chronic obstructive pulmonary disease in remission, control group included 50 healthy non-smoking volunteers without any known respiratory diseases. Patients underwent general examination, completed by rigid endoscopic examination, examination of ciliary clearance, anterior active rhinomanometry, olfactometry, nasal cavity and paranasal sinuses computed tomography. Pharynx examination included nasal cavity posterior endoscopy, mesopharyngoscopy, lower part of the parynx was examined by rigid endoscope with viewing angle of 70°. Results. Ciliary clearance was 26.7±3.06 minutes in patients of the main group, compared to 16.4±1.11 minutes in patients of the control group. Smell acuity was 1.86±0.11 units in patients of the main group, compared to 2.3±0.15 units in patients of the control group. Signs of nasal and pharyngeal diseases, including signs of chronic inflammation of nasal mucosa and chronic catarrhal pharyngitis was found in 30 patients. Conclusion. Patients with chronic obstructive pulmonary disease had higher prevalence of chronic rhinitis and pharyngitis, worse smell acuity and impaired ciliary clearance compared to healthy controls.

Pathogenetic rationale for the use of intermittent normobaric hypoxytherapy in the rehabilitation of patients with chronic obstructive pulmonary disease

2021 ◽  
Author(s):  
N. P. Masik ◽  
S. V. Nechiporuk
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Respiratory Function ◽  
Clinical Symptoms ◽  
Main Group ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
And Control ◽  
Adaptive Reactions

Objective — to determine affects of the intermittent normobaric hypoxytherapy on the dynamics of general non‑specific adaptive reactions in the complex rehabilitation of patients with chronic obstructive pulmonary disease (COPD). Materials and methods. The treatment and examinations involved 450 patients with COPD, including GOLD 2 in 55.56 % (250 people) and GOLD 3 in 44.44 % (200 patients). The mean age was (52.65 ± 14.80) years, proportion of female and male subjects was equal. All patients received basic drug therapy according to the Order of MoH of Ukraine. The disease duration was 10 to 30 years, the remission stage was established in all patients. Patients were randomized into two groups: main (400 people) and control (50 people) with the same COPD severity distribution. Patients of the main group received additional 30 minutes sessions of interval normobaric hypoxytherapy for 20 days. The examination were performed for the dynamics of clinical symptoms, respiratory function, nonspecific resistance of an organism. Results. Most patients had symptoms of the disease against the background of basic COPD medication even on the remission stage. Unfavorable and intense adaptive reactions were determined in 71.33 % of COPD patients, and eustress reactions only in 16.89 %. Sanogenetic types of adaptive reactions were found in 28.45 % of subjects, maladaptive types — in 21.78 % of persons, pathogenetic — in 63.33 % of patients. At GOLD 2, tense reactions were diagnosed in 69.6 % of subjects, and in GOLD 3 in 73.0 %. As the severity of the disease increased, there was an increase in the development of intense training and activation responses. Upon completion of the course of hypoxytherapy, the exercise tolerance increased, and shortness of breath appeared only after severe physical activity in 90.25 % of patients in the main group, whereas in the control group similar changes were observed only in 20.0 % of patients. The respiratory function indicators in patients of the main group increased on average by 17.52 %, while in the control group — by 3.3 %. In the main group, favorable adaptation reactions prevailed in 88.25 % of patients, while in the control group this indicator was 32.0 %. The percentage of adverse reactions in the main group decreased significantly and was 11.75 % after treatment, the proportion of stress reactions — 46.25 %. In GOLD 2, the proportion of pathogenetic reactions decreased to 17.33 % and 56.00 % of the main and control groups, and in GOLD 3 — in 20.44 % and 44.0 %, respectively (p < 0.05). Conclusions. The use of a course of normobaric hypoxytherapy promoted the reduction of the main clinical COPD symptoms, increase of the frequency of favorable adaptive reactions up to 88.25 %, it raised clinical effectiveness of the treatment, which allowed to avoid disease exacerbations during the year in 80.95 % of patients.  

Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 29 (2) ◽  
pp. 864-872
Author(s):  
Fernanda Borowsky da Rosa ◽  
Adriane Schmidt Pasqualoto ◽  
Catriona M. Steele ◽  
Renata Mancopes
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Oral Cavity ◽  
Pulmonary Disease ◽  
Thermal Sensation ◽  
Sensory Function ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Age Related ◽  
Copd Patients

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Objective This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years ( SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years ( SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical evaluation of oral and oropharyngeal sensation by a speech-language pathologist. The sensory evaluation explored the detection of tactile and temperature stimuli delivered by cotton swab to six locations in the oral cavity and two in the oropharynx as well as identification of the taste of stimuli administered in 5-ml boluses to the mouth. Analyses explored the frequencies of accurate responses regarding stimulus location, temperature and taste between groups, and between age groups (“≤ 65 years” and “> 65 years”) within the COPD cohort. Results We found significantly higher frequencies of reported use of inhaled medications ( p < .001) and xerostomia ( p = .003) in the COPD cohort. Oral cavity thermal sensation ( p = .009) was reduced in the COPD participants, and a significant age-related decline in gustatory sensation was found in the COPD group ( p = .018). Conclusion This study found that most of the measures of oral and oropharyngeal sensation remained intact in the COPD group. Oral thermal sensation was impaired in individuals with COPD, and reduced gustatory sensation was observed in the older COPD participants. Possible links between these results and the use of inhaled medication by individuals with COPD are discussed.

scholarly journals Chronic Obstructive Pulmonary Disease Is Associated with Low Levels of Vitamin D

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e38934 ◽  
Author(s):  
Louise Jeanette Pauline Persson ◽  
Marianne Aanerud ◽  
Pieter Sicco Hiemstra ◽  
Jon Andrew Hardie ◽  
Per Sigvald Bakke ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Low Levels

The Effect of Aminophylline on Cerebral Blood Flow in Patients with Chronic Obstructive Pulmonary Disease

CHEST Journal ◽  
1987 ◽  
Vol 91 (6) ◽  
pp. 874-877 ◽  
Author(s):  
David L. Bowton ◽  
Peter T. Alford ◽  
Byron D. McLees ◽  
Donald S. Prough ◽  
David A. Stump
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease
Sign in / Sign up

Export Citation Format

Share Document