Study of the skin-resorptive effect of a skin antiseptic based on polyvinylpyrollidone-iodineОценка эффективности профилактических дезинфекционных мероприятий на основе комплексного анализа микробиома мест содержания служебных собак

2021 ◽  
pp. 7-11
Author(s):  
Marina Vasilevna Bidevkina ◽  
◽  
Tatyana Nikolaevna Potapova ◽  
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Age Group ◽  
Rat Pups ◽  
White Rats ◽  
Immature Rats ◽  
Different Ages ◽  
Old Rats ◽  
Stimulating Hormone

The skin-resorptive effect of a skin antiseptic based on polyvinylpyrollidone-iodine on immature rats of different ages was studied.The skin-resorptive effect of the drug in doses of 5.0 and 0.5 g/kg was revealed on 2–6 week-old rats. The animals showed changes in thyroxine and thyroid-stimulating hormone, as well as general toxic indicators. Absorption of the drug through the skin at a dose of 0.5 g/kg on 4–8 week old rat pups has not been established. The rationale for the use of a skin antiseptic for the hygienic treatment of hands containing PVP-iodine in the age group of children from 8 years old is given. Keywords: toxicity, skin-resorptive effect, immature white rats, skin antiseptic, iodine, thyroxine, thyroid-stimulating hormone.

Peculiarities of the ultrastructure of neurons of the neocortex of 5-day-day rats under conditions of prenatal alcoholization

2021 ◽  
Vol 23 (1) ◽  
pp. 35-38
Author(s):  
L. I. Bon ◽  
◽  
S. M. Zimatkin ◽  
Keyword(s):  
Oxidative Stress ◽  
Pyramidal Neurons ◽  
Direct Action ◽  
Ultrastructural Changes ◽  
Initial Weight ◽  
Rat Pups ◽  
White Rats ◽  
Old Rats ◽  
Antenatal Alcoholization

The aim of this work was to study the ultrastructure of the internal pyramidal neurons of the neocortex of 5-day-old rat pups after antenatal alcoholization. The studies were carried out on female outbred white rats with an initial weight of 230 ± 20 g and their offspring. Prenatal alcoholization causes deep and varied ultrastructural changes in pyramidal neurons in the neocortex of 5-day-old rats. Moreover, these violations of direct action not only as a consequence of the damaging effect of alcohol, its metabolite acetehyde or the oxidative stress they cause on the membranes and organelles of neurons during embryogenesis, but also as a violation of the normal "program" of development" of neurons in the cortex.

scholarly journals Behavioral activity of rats in experimental hyperotherosis, and its correction with iodine-containing preparations

2019 ◽  
Vol 1 (1) ◽  
pp. 58-61
Author(s):  
N. A. Balakirev ◽  
A. A. Deltsov ◽  
V. I. Maksimov ◽  
S. A. Kozlov ◽  
I. N. Staroverova
Keyword(s):  
Trace Elements ◽  
Intramuscular Injection ◽  
Thyroid Stimulating Hormone ◽  
Behavioral Activity ◽  
Average Content ◽  
Healthy Group ◽  
White Rats ◽  
Iron Preparation ◽  
Stimulating Hormone

Investigated the behavioral activity of rats in experimental hypothyroidism and its correction with iodine-containing drugs. It has been established that with the introduction of mercazole thyreostatics for 8 weeks in white rats, experimental hypothyroidism develops. In which there was a decrease in the content of thyroxine (T4) to 5.25 ng / ml, an increase in the content of thyroid stimulating hormone (TSH) to 8.75 ng / ml, while in animals from the control (healthy) group, these indicators were: average T4 content 43.70 ng / ml; the average content of TSH is 1.73 ng / ml. Next, animals with iodine-containing preparations (Sedimin-Fe+, Sedimin-Se+) were administered to patients with experimental hypothyroidism as an intramuscular injection, 2 times with an interval of 10 days, and a bio-iron preparation with trace elements orally for 20 days. . So in the experimental groups that were injected drugs Sedimin-Fe+ and Sedimin-Se+ T4 value recovered to 52.7 ± 3.48 and 54.8 ± 4.17 ng / ml, respectively. In the group of the bio-iron with micronutrients receiving the feed, the T4 value reached 56.2 ± 4.13 ng / ml, while in sick animals this indicator was 5.25 ± 0.55 ng / ml. The value of TSH, after treatment with iodine-containing preparations, also returned to normal and after application of the drug Sedimin-Fe + 0.37 ± 0.14, Sedimin-Se + 0.51 ± 0.18 and Bio-iron with trace elements 0.47 ± 0.15 ng / ml, while in sick animals this indicator was 8.75 ± 0.55 ng / ml.

scholarly journals Influence of Allopurinol on Evoked Cortical Afterdischarges During Early Ontogenesis

2012 ◽  
pp. S111-S117
Author(s):  
K. JANDOVÁ ◽  
V. RILJAK ◽  
J. POKORNÝ ◽  
D. MAREŠOVÁ
Keyword(s):  
Hypobaric Hypoxia ◽  
Simulated Altitude ◽  
Intermittent Hypobaric Hypoxia ◽  
Rat Pups ◽  
Immature Rats ◽  
Old Rats ◽  
Freely Moving ◽  
Pre Treatment ◽  
Experimental Group

The aim of our study was to test the hypothesis, whether repeated allopurinol pre-treatment (in dose of 135 mg/kg s.c.) can influence changes of brain excitability caused by long-term hypoxia exposition in young immature rats. Rat pups were exposed together with their mother in to an intermittent hypobaric hypoxia (simulated altitude of 7 000 m) since the day of birth till the 11th day (youngest experimental group) or 17th day for 8 hours a day. Allopurinol was administered daily immediately before each hypoxia exposition. The duration of evoked afterdischarges (ADs) and the shape of evoked graphoelements were evaluated in 12, 18, 25 and 35-day-old freely moving male pups. Hypobaric hypoxia prolonged the duration of ADs in 12, 18 and 25-day-old rats. The ADs were prolonged in 35-day-old rats only after the first stimulation. Allopurinol shorted the duration of ADs only in 12-day-old pups. In older experimental group the effect of allopurinol treatment was less pronounced.

scholarly journals Lipid Profile in Thyroid Autoimmunity - A Study among Reproductive Age Group Females of Central Kerala

2021 ◽  
Vol 10 (37) ◽  
pp. 3231-3236
Author(s):  
Sindhu Panakkaparambil Surendranath ◽  
Anil Palakkaparambil ◽  
Suchithra Erath Thadathil ◽  
Shibu Thadathil Sreedharan
Keyword(s):  
Lipid Profile ◽  
Thyroid Autoimmunity ◽  
Thyroid Stimulating Hormone ◽  
Reproductive Age ◽  
Age Group ◽  
Positive Group ◽  
Detailed Medical History ◽  
Reproductive Age Group ◽  
Biochemical Abnormalities ◽  
Stimulating Hormone

BACKGROUND One of the most common causes of thyroid dysfunction among women is autoimmunity, especially in fertile age group. Thyroid hormone disorders are associated with a number of biochemical abnormalities including dyslipidaemia, metabolic dysfunctions, spontaneous miscarriage, and preterm delivery. Dyslipidaemia is one of the most common metabolic abnormalities present in patients with thyroid disease. The purpose of this study was to find the association between anti-thyroid peroxidase antibody (anti-TPO) and dyslipidaemia in reproductive age group females from Central Kerala. METHODS A total of 200 asymptomatic women, all in reproductive age group, from a tertiary hospital in Kerala participated in this study. Demographic data and detailed medical history of the participants were collected. Anti-TPO and thyroid stimulating hormone (TSH) were measured using chemiluminescence immunoassay system. Serum lipid profile was estimated using fully automated random-access clinical chemistry analyser EM - 360. Continuous variables were compared between the groups using Mann–Whitney U-test. P value lesser than 0.05 was considered as statistically significant. RESULTS The mean age of the subjects was 32.92 ± 11.82 years. A total of 47 participants (23.5 %) were anti-TPO positive. Abnormality in lipid profile was present in 72.34 % (N = 34) of the anti-TPO positive participants. In the anti-TPO positive group, 51.06 % of the participants had hypercholesterolemia. In the anti-TPO positive group, anti-TPO levels show a statistically significant correlation with total cholesterol and triglyceride levels (P = 0.07 and P < 0.01). A total of 9 % (N = 18) had thyroid stimulating hormone (TSH) values greater than normal range (0.34- 4.25 µIU/mL) suggesting presence of hypothyroidism. TSH values were also significantly associated with lipid profile in the anti-TPO positive group. Both thyroid autoimmunity and dyslipidaemia can affect fertility, pregnancy and other reproductive outcomes. CONCLUSIONS Women should be screened for autoimmune antibodies and associated biochemical abnormalities to estimate and reduce the risk of cardiovascular morbidity, negative pregnancy outcomes and infertility. KEY WORDS Thyroid Autoimmunity, Anti-TPO Antibody, Dyslipidaemia

CLINICAL EVALUATION OF THE THYROID STIMULATING HORMONE ACTIVITY IN EXOPHTHALMOS

1961 ◽  
Vol 38 (4) ◽  
pp. 577-584 ◽  
Author(s):  
Sven Erik Björkman ◽  
Torsten Denneberg ◽  
Inge Hedenskog
Keyword(s):  
Clinical Evaluation ◽  
Thyroid Stimulating Hormone ◽  
Significant Rise ◽  
Hormone Activity ◽  
Control Subjects ◽  
Long Duration ◽  
Stimulating Factor ◽  
Stimulating Hormone

ABSTRACT A method for demonstrating the presence of a thyroid stimulating factor in the blood of patients with progressive exophthalmos after thyroidectomy or after treatment with radioiodine is described. The method consists of transfusing freshly drawn blood from the patients to euthyroid recipients and subsequently following the PBI level of the recipients at regular intervals. Six exophthalmic patients tested in this manner were found to have such a factor in their circulating blood. After transfusion of their blood a significant rise in the PBI level of the recipients could be demonstrated. Two other patients, one with exophthalmos of long duration did not show this response nor did it occur after transfusion of blood from two control subjects. In one case the action of this factor was compared with that of animal thyrotrophin and found to be of the same magnitude.

Follicle-stimulating hormone-dependent estrogen secretion by rat Sertoli cells in vitro: Modulation by calcium

1991 ◽  
Vol 125 (3) ◽  
pp. 280-285 ◽  
Author(s):  
J. Alan Talbot ◽  
Ann Lambert ◽  
Robert Mitchell ◽  
Marek Grabinski ◽  
David C. Anderson ◽  
...  
Keyword(s):  
Sertoli Cells ◽  
Culture Medium ◽  
Follicle Stimulating Hormone ◽  
Dibutyryl Camp ◽  
Immature Rat ◽  
Estradiol Secretion ◽  
Old Rats ◽  
Stimulating Hormone

Abstract We have investigated the role of Ca2+ in the control of FSH-induced estradiol secretion by Sertoli cells isolated from 8-10 days old rats. Exogenous Ca2+ (4-8 mmol/1) inhibited FSH-stimulated E2 secretion such that, with 8 mmol/l Ca2+ and FSH (8 IU/l) E2 secretion decreased from 2091±322 to 1480±84 pmol/l (p<0.002), whilst chelation of Ca2+ in the culture medium with EGTA (3 mmol/l) increased E2 secretion from 360±45 to 1242±133 pmol/l) in the absence of FSH. Further, EGTA (3 mmol/l) markedly potentiated FSH (8 IU/l), forskolin (1 μmol/l) and dibutyryl cAMP (1 mmol/l)-stimulated E2 secretion. Addition of the Ca2+ ionophores, ionomycin (2-5 μmol/l) and A23187 (2 μmol/l), inhibited FSH (8 IU/l)-stimulated E2 secretion by >80%. The effect of ionomycin was totally reversible, whereas that of A23187 was irreversible. Ionomycin (5 μmol/l) had no effect on EGTA-induced E2 secretion in the absence of FSH, but reduced EGTA-provoked E2 secretion by 59% in the presence of FSH (8 IU/l). Similarly, forskolin- and dibutyryl cAMP-provoked E2 production was inhibited 46-50% by ionomycin (5 μmol/l). We conclude that FSH-induced E2 secretion from immature rat Sertoli cells is modulated by intra- and extracellular Ca2+.

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