scholarly journals Gender specificity in the interpretation of treatment results for patients with colorectal cancer in the Republic of Tatarstan

2020 ◽  
Vol 5 (2) ◽  
pp. 124-129
Author(s):  
Bulat I. Gataullin ◽  
Rustem Sh. Khasanov ◽  
Anatolii A. Savelev ◽  
Ilgiz G. Gataullin
Keyword(s):  
Colorectal Cancer ◽  
Distant Metastases ◽  
Long Term Results ◽  
Treatment Results ◽  
Kras Gene ◽  
Results Of Treatment ◽  
Age Related ◽  
Mutational Status ◽  
Regional Metastases ◽  
Poorly Differentiated

Objective - to identify the gender-specific features of modeling the prognosis of treatment outcomes for patients with colorectal cancer (CRC). Materials and methods. The study included 654 patients with colorectal cancer (CRC) who were treated from 2013 to 2015, of which 434 were men, 220 were women. The average age of the patients was 64.1±10.2 years. All patients underwent genetic analysis for the presence of a mutation in the KRAS gene from the primary tumor. Results. The gender approach to assessing the long-term results of treatment of patients with CRC showed that in men with colorectal cancer, the most favorable treatment results were observed in patients with tumors in stage T 1-2 N0 M0, regardless of the differentiation of the tumor and its mutational status. In men, poorly differentiated tumors with any T, with the presence of regional metastases and a mutation of the KRAS gene, even in the absence of distant metastases, should be considered prognostically unfavorable: not a single patient lived for 5 years. In women, based on the decision tree analysis, the most favorable treatment results were observed in patients with tumors in the stage T 1-2-3 N0 M0 under the age of 70 years (five-year survival rate of 90%), with tumors T 1-2 N0 M0 - over the age of 70 years (five-year survival of 81.8%), regardless of the differentiation of the tumor and its mutational status. Tumors of any differentiation of the T3-4 N0 stage with the presence of distant metastases (5% of patients lived for 5 years) and poorly differentiated T4N0M0 tumors (five-year survival of 8%) are prognostically unfavorable for women. Conclusion. The study of gender and age-related features of the development and course of CRC is relevant for oncologists to select effective diagnostic, therapeutic and rehabilitation measures.

scholarly journals GENDER SPECIFICITY OF COLORECTAL CANCER IN THE REPUBLIC OF TATARSTAN

2021 ◽  
Vol 20 (1) ◽  
pp. 16-23
Author(s):  
B. I. Gataullin ◽  
R. Sh. Khasanov ◽  
A. A. Savelyev ◽  
I. G. Gataullin
Keyword(s):  
Colorectal Cancer ◽  
Survival Rate ◽  
Decision Tree ◽  
Distant Metastases ◽  
Low Grade ◽  
Treatment Results ◽  
Ras Gene ◽  
Mutational Status ◽  
The Republic ◽  
Stage T1

The purpose of the study: to develop an expert system based on the construction of a «decision tree» for predicting the 5-year survival rate of patients with colorectal cancer.Material and Methods. T he study included 654 patients with colorectal cancer (CRC) who were treated from 2013 to 2015, including 434 men and 220 women. The average age of patients was 64,1 ± 10,2 years. All patients underwent genetic analysis for the presence of a mutation in the K-ras gene from the primary tumor.Results. For the Republic of Tatarstan, there are regional features of mutation of the K-ras gene: the frequency of mutations in tumors in men was less frequent (20.3 %) than in women (37.7 %), in patients of Slavic nationality, mutations were slightly more frequent – 39 % than in Tatars – 21 %. The gender approach to assessing long-term treatment results showed that in men with colorectal cancer, the most favorable treatment results were observed in patients with tumors in stage T1–2N0M0, regardless of the differentiation of the tumor and its mutational status. Low-grade tumors with any T should be considered prognostically unfavorable in men, with the presence of regional metastases and mutation of the K-ras gene, even in the absence of distant metastases: no patient lived 5 years. Based on the construction of a «decision tree», the most favorable treatment results were observed in female patients with tumors in stage T1–2–3N0M0 at the age of 70 years (5-year survival rate of 90 %), with tumors T1–2N0M0 at the age of 70 years (5-year survival rate of 81.8 %), regardless of the tumor differentiation and its mutational status. Tumors of any differentiation are prognostically unfavorable for women of the T3–4N0 stage with the presence of distant metastases (6 % of patients lived 5 years) and lowdifferentiated stage T4N0M0 tumors (5-year survival rate of 8 %).Conclusion. G ender- and age-associated features of the development and course of CRC are relevant for oncologists to choose effective diagnostic and therapeutic measures.

Prognostic significance of the TNM system criteria, levels of serum insulin-like growth factors and their transport proteins, VEGF and MMP-7 in colorectal cancer

2021 ◽  
Vol 66 (8) ◽  
pp. 459-464
Author(s):  
A. A. Nikolaev ◽  
I. V. Babkina ◽  
Elena Sergeevna Gershtein ◽  
A. A. Alferov ◽  
V. V. Delektorskaya ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Serum Insulin ◽  
Prognostic Significance ◽  
Colon Adenocarcinoma ◽  
Serum Levels ◽  
Long Term Results ◽  
Tnm System ◽  
Results Of Treatment ◽  
Kaplan Meier

The analysis of long-term results of treatment of 88 primary patients with colon adenocarcinoma at various stages of tumor process is presented, taking into account the TNM system criteria, and serum IGF-1, IGF-2, IGFBP-1, IGFBP-2, IGFBP-3, VEGF, and MMP-7 levels. The overall survival rate assessed by Kaplan-Meier method and Cox multivariate regression model was used as the criterion of prognosis. It was established that IGF-1, IGFBP-2 and VEGF serum levels along with the stage of colorectal cancer might be considered as statistically significant independent predictors of overall survival in patients.

scholarly journals Combined treatment of patients with liver colorectal cancer metastases

2021 ◽  
Vol 26 (2) ◽  
pp. 120-128
Author(s):  
D. N. Kostromitsky ◽  
A. Y. Dobrodeev ◽  
S. G. Afanasyev ◽  
A. S. Tarasova
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Metastatic Colorectal Cancer ◽  
Anticancer Agents ◽  
Combined Treatment ◽  
Malignant Neoplasm ◽  
Standard Of Care ◽  
Distant Metastases ◽  
Colorectal Cancer Liver Metastases ◽  
Results Of Treatment

The literature review is devoted to the analysis of the main methods of treatment of patients with colorectal cancer liver metastases. The analysis of the clinical trials results over the past 10 years has been carried out. Colorectal cancer is the common malignant neoplasm. About 20% of patients have distant metastases in the diagnosing. Liver is the most frequent targeted organ, liver metastases are detected in 14,5% of patients with colorectal cancer. Despite the encouraging results of treatment of certain groups of patients with metastatic colorectal cancer, the treatment tactics for most patients is limited to palliative chemotherapy. In recent years, the survival of patients with metastatic colorectal cancer has significantly improved due to the success of systemic therapy. The median overall survival has reached for 2 years due to combination chemotherapy based on fluoropyrimidines, oxaliplatin, irinotecan in combination with monoclonal antibodies (bevacizumab, cetuximab and panitumumab). The optimal combination and sequence of using these anticancer agents in the treatment of metastatic colorectal cancer has not yet been determined. Surgery is the standard of care for this category of patients. At the same time, until nowdays there are no clear and generally accepted criteria for choosing the optimal volume of surgical intervention, prescribing first-line chemotherapy and using other methods of antitumor treatment.

ENDOMETRIAL CANCER IN PATIENTS OLDER THAN 70 YEARS: CLINICAL AND MORPHOLOGICAL CHARACTERISTICS AND LONGTERM RESULTS

2019 ◽  
Vol 65 (3) ◽  
pp. 414-421
Author(s):  
Yuliya Gavrish ◽  
Anna Artemeva ◽  
Yu. Trifanov ◽  
A. Nyuganen ◽  
Anna Sidoruk ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Age Groups ◽  
Morphological Characteristics ◽  
Comparative Assessment ◽  
Long Term Results ◽  
Results Of Treatment ◽  
Age Related ◽  
Group 2 ◽  
Two Age Groups

On the basis of the Department of Oncogynecology together with the pathoanatomical department of the N.N. Petrov Research Institute of Oncology conducted a comparative assessment of age-related features of endometrial cancer. The study included 309 patients, which were divided into two groups: group 1 - from 50 to 69 years (n = 150), group 2 - 70 years and older (n = 159). The article presents a comparative assessment of treatment, morphological characteristics of the tumor and the prevalence of the tumor process in two age groups, as well as the long-term results of treatment.

scholarly journals The Results of Cytoreductive Operations in Patients with Colorectal Cancer with Simultaneous Liver Polymetastases

2018 ◽  
Vol 3 (2) ◽  
pp. 54-59
Author(s):  
SV V Kozlov ◽  
OI I Kaganov ◽  
AE E Orlov ◽  
AM M Kozlov
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Liver Metastases ◽  
Cytoreductive Surgery ◽  
Stage Iv ◽  
Long Term Results ◽  
Control Group ◽  
Results Of Treatment ◽  
Cytoreductive Treatment

Aim - to improve the long-term results of cytoreductive treatment of patients with simultaneous multiple bilobar liver metastases of colorectal cancer by the use of RFTA. Materials and methods. The study presents the results of treatment of 168 patients diagnosed with colorectal cancer of stage IV with simultaneous bilobar metastases in the liver. In the main group, cytoreductive tumor removal was accompanied by radiofrequency thermal ablation (RFTA) of metastatic formations. In the control group only the primary tumor was removed. Results. The use of RFTA during cytoreductive surgery does not worsen the immediate results of surgical treatment, in comparison with patients, where the effect on liver metastases has not been performed, but allows to increase medians of uneventful and overall survival from 9 and 22 months to 17 and 29 months, respectively. Conclusions. The use of RFTA for simultaneous multiple bilobar metastases in the liver during cytoreductive surgery makes it possible to achieve 22.7% of the three-year uneventfulness and 4.3% of the five-year overall survival.

scholarly journals KRAS gene mutation in patients with primary colorectal cancer

Acta Medica ◽  
2019 ◽  
Vol 50 (1) ◽  
pp. 20-25
Author(s):  
Minh Thuc Vu Thi ◽  
Van Thieu Le ◽  
Quang Huy Huynh ◽  
Minh Duc Nguyen
Keyword(s):  
Colorectal Cancer ◽  
Gene Mutation ◽  
Kras Mutation ◽  
Pcr Amplification ◽  
Colorectal Cancers ◽  
Kras Gene ◽  
Kras Mutations ◽  
Exon 2 ◽  
Mutational Status ◽  
Keywords Colorectal Cancer

Objective: KRAS mutation occurs in 30% to 50% of colorectal cancers. The aim of our study was to determine the frequency of KRAS mutations among patients with colorectal cancer; and the relationship with clinicopathologic features. Materials and Methods: 79 colorectal cancer cases at a hospital in Hai Phong of Vietnam were collected, including 45 colon cancer and 34 rectal cancer during January 2010 and July 2012. PCR amplification and DNA sequencing were used to detect mutations in exon 2 of KRAS gene. The study was based on informed consent and approval by the Ethics Committee of Viet Tiep Hospital. Results: KRAS mutation was found in 40.4% (225/557) colorectal cancer. All mutation locations were in codon 12. There was significant association (p < 0.05) between KRAS mutations, tumor size and tumor stage. No significant association was observed between KRAS mutations and gender, tumor location, tumor grade or histologic presence of mucin (p>0.05). Conclusion: Determining the KRAS mutational status of tumor samples has become an essential tool for managing patients with colorectal cancers Keywords: colorectal cancer, KRAS gene mutation, clinicopathology.

Aggressiveness of care and overall survival in young metastatic colorectal cancer patients.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 3563-3563 ◽  
Author(s):  
Madeleine Fish ◽  
Katie Kanter ◽  
Gianluca Mauri ◽  
Nora Horick ◽  
Jill N Allen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Massachusetts General Hospital ◽  
Performance Status ◽  
Clinicopathological Features ◽  
Rank Test ◽  
Braf Mutations ◽  
Younger Patients ◽  
Age Related ◽  
Mutational Status

3563 Background: Colorectal cancer (CRC) incidence in patients younger than 50 years of age is steadily rising by 2% annually. Early-onset CRC usually presents with more aggressive features; however, data on prognosis are widely conflicting. Clinicians may hold an age-related bias in treating younger patients, but this proclivity and its effects have not been quantified. Methods: Patients with a history of metastatic CRC who consented to a departmental chart review protocol were collected between 2014 and 2018 at Massachusetts General Hospital. The cohort was divided into two groups based on age at initial diagnosis: < 50 and ≥50. Data were gathered on treatments and clinicopathological features. A log-rank test compared survival from the diagnosis of metastatic disease between age groups. The distributions of clinicopathological features were compared using Wilcoxon rank sum tests. Results: 464 metastatic CRC patients were identified. 155 patients (33%) were < 50 (median age 43, 49% female) and 309 patients (67%) were ≥50 (median age 61, 45% female). Sex did not significantly differ between the two groups (p = 0.45). Patients < 50 received more lines of therapy after metastatic diagnosis than patients ≥50 (mean 2.7 v. 2.2; p = 0.002). Younger patients also received more resections of distant metastases (mean 0.62 v. 0.48; p = 0.01). A higher rate of enrollment in clinical trials for patients < 50 approached significance (p = 0.06). Even so, patients < 50 did not see a significant survival benefit over older patients (2/5-year survival from metastatic diagnosis 77%/47% v. 73%/38%, p = 0.23). Patients < 50 had a lower proportion of right-sided tumors (p = 0.0002) and BRAF mutations (p = 0.0009). There was no difference in MSI status (p = 0.28), RAS mutational status (p = 0.40), mucinous features (p = 0.53), or signet ring features (p = 0.26). Conclusions: Overall survival in patients < 50 is similar to patients ≥50, despite patients < 50 receiving more aggressive therapy. Further study is warranted to better understand these differences. Potential areas of interest include performance status, age-related treatment bias, and biological factors.

scholarly journals Analysis of Treatment Results of the Thoracic Part of Oesophageal Cancer

2019 ◽  
Vol 7 (1) ◽  
pp. 82-87 ◽  
Author(s):  
Bekzhan Alipbayevich Orazbayev ◽  
Kani Musulmanbekov ◽  
Akat Bukenov
Keyword(s):  
Overall Survival ◽  
Treatment Results ◽  
Cumulative Survival ◽  
Patients With Cancer ◽  
Results Of Treatment ◽  
Regional Metastases ◽  
Thoracic Part ◽  
Radical Type ◽  
Methods Of Treatment ◽  
Thoracic Oesophagus

AIM: This study aims to evaluate the methods of treatment of the thoracic part of oesophagal cancer and to predict the results of treatment depending on the factors of the prognosis. MATERIALS AND METHODS: The results of treatment of 366 patients with cancer of the thoracic part of the oesophagus for 10 years (2007-2016) by the department of thoracic oncology of the Karaganda oncological dispensary were studied. RESULTS: The overall five-year survival rate, regardless of the method of treatment, was only 8.72% (28 of 321), and in the 6-10 year period 8.41% (27 of 321) lived, p < 0.05. Analysis of the overall survival of patients with cancer of the thoracic part of oesophagus showed that the method of treatment does not have a significant effect on life expectancy. A multivariate analysis of 19 grades that affect the prognosis of the disease was carried out. CONCLUSION: Radical type of treatment of the middle and lower thoracic oesophagus is surgical, in which the median of cumulative survival is 19 months. Traditional radiotherapy should be used in a limited way, as it is palliative, with a median survival of no more than 9 months. The leading factor in the prognosis for thoracic part of oesophagal cancer is the presence of regional metastases, on which the choice of method of treatment depends.

scholarly journals Factors Affecting the Results of Treatment of Plantar Fasciitis and Their Prognostic Value

2020 ◽  
pp. 24-30
Author(s):  
O.A. Turchyn ◽  
A.P. Liabakh ◽  
O.O. Kostrub
Keyword(s):  
Conservative Treatment ◽  
Plantar Fasciitis ◽  
Prognostic Value ◽  
Statistical Correlation ◽  
Long Term Results ◽  
Treatment Results ◽  
Factors Affecting ◽  
Results Of Treatment ◽  
Positive Treatment ◽  
Low Probability

Summary. Objective: to determine the prognostic value of the factors influencing the outcome of treatment of plantar fasciitis, to develop a system for predicting the results of treatment of plantar fasciitis. Materials and Methods. Analysis of long-term results of conservative treatment of 145 patients with plantar fasciitis. Clinical, instrumental and statistical (correlation-regression analysis) research methods were used. The factors that influenced the end result of treatment were identified. Results. The statistically significant influence of age, gender, disease duration up to 6 months, BMI up to 25, the presence of “functional” equinus, pronated foot and history of treatment on the prevalence of positive treatment results were determined. The estimation of the informative nature of the presented factors for the probability of achieving positive results of treatment, the calculation of the prognostic coefficients and their sum were determined. A high prognostic evaluation of a successful treatment outcome should be expected with a total prognosis of +5 to +25; a total estimate of prognostic coefficients from -15 to +5 determines the average probability of positive treatment results; the sum of the prognostic coefficients from -34 to -15 determines the low probability of achieving positive treatment results. Conclusions. The result of treatment of plantar fasciitis depends on age, sex, duration of the disease up to 6 months, BMI, "functional" equinus, pronated foot, and medical history. The system for predicting treatment outcomes involves the possibility of obtaining high, medium and low probability of a positive result when applying conservative treatment.

COLORECTAL CANCER AND FEATURES OF ITS METASTASIS

2017 ◽  
Vol 63 (3) ◽  
pp. 450-455
Author(s):  
Oleg Vlasov ◽  
Sergey Tkachev ◽  
Vasiliy Prorokov
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Lymph Nodes ◽  
Abdominal Cavity ◽  
Combined Treatment ◽  
Distant Metastases ◽  
Tumor Localization ◽  
Preoperative Radiation ◽  
Tumor Dissemination ◽  
Regional Metastases

The article analyzes the frequency of regional metastasis detection in patients with operative colorectal cancer as well as the frequency and patterns of the appearance of distant metastases depending on the presence or absence of regional metastases, tumor localization and the method of treatment. It was found that the frequency of distant metastases in colorectal cancer depended mainly on the presence or absence of metastases in the regional lymph nodes. Some influence on the decrease in the frequency of distant metastasis was exacerbated by the preoperative radiation exposure by radiomodifiers and on the increase - the interval between the end of the radiation treatment phase and the moment of surgery. In rectal cancer the localization of distant metastases depended on the level of tumor localization. In colon cancer the major part (81.6%) of distant metastases was located in the liver, the rest 18.4% -extrahepatic and was represented by peritoneum dissemination, metastases in the ovary and retroperitoneal lymph nodes. Among colon cancer patients after the combined treatment there were no cases of tumor dissemination through the abdominal cavity and the appearance of lymphogenous metastases.

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