scholarly journals Analysis of Treatment Results of the Thoracic Part of Oesophageal Cancer

2019 ◽  
Vol 7 (1) ◽  
pp. 82-87 ◽  
Author(s):  
Bekzhan Alipbayevich Orazbayev ◽  
Kani Musulmanbekov ◽  
Akat Bukenov
Keyword(s):  
Overall Survival ◽  
Treatment Results ◽  
Cumulative Survival ◽  
Patients With Cancer ◽  
Results Of Treatment ◽  
Regional Metastases ◽  
Thoracic Part ◽  
Radical Type ◽  
Methods Of Treatment ◽  
Thoracic Oesophagus

AIM: This study aims to evaluate the methods of treatment of the thoracic part of oesophagal cancer and to predict the results of treatment depending on the factors of the prognosis. MATERIALS AND METHODS: The results of treatment of 366 patients with cancer of the thoracic part of the oesophagus for 10 years (2007-2016) by the department of thoracic oncology of the Karaganda oncological dispensary were studied. RESULTS: The overall five-year survival rate, regardless of the method of treatment, was only 8.72% (28 of 321), and in the 6-10 year period 8.41% (27 of 321) lived, p < 0.05. Analysis of the overall survival of patients with cancer of the thoracic part of oesophagus showed that the method of treatment does not have a significant effect on life expectancy. A multivariate analysis of 19 grades that affect the prognosis of the disease was carried out. CONCLUSION: Radical type of treatment of the middle and lower thoracic oesophagus is surgical, in which the median of cumulative survival is 19 months. Traditional radiotherapy should be used in a limited way, as it is palliative, with a median survival of no more than 9 months. The leading factor in the prognosis for thoracic part of oesophagal cancer is the presence of regional metastases, on which the choice of method of treatment depends.

scholarly journals Tracheal cancer – treatment results, prognostic factors and incidence of other neoplasms

2016 ◽  
Vol 50 (4) ◽  
pp. 409-417 ◽  
Author(s):  
Aleksandra Napieralska ◽  
Leszek Miszczyk ◽  
Sławomir Blamek
Keyword(s):  
Overall Survival ◽  
Prognostic Factors ◽  
Statistical Tests ◽  
Performance Status ◽  
Univariate Analysis ◽  
Treatment Results ◽  
Invasive Treatment ◽  
Results Of Treatment ◽  
Additional Surgery ◽  
Tracheal Neoplasms

AbstractBackgroundTracheal cancers (TC) are rare and treatment results that are reported are typically not satisfactory. The purpose of this research was assessment of the results of treatment of TC patients, identification of potential additional surgery candidates, evaluation of prognostic factors, and assessment of the occurrence of other malignancies.Patients and methodsThe Regional Cancer Database and the Hospital Database were searched for patients with tracheal neoplasms. Fifty-eight of 418 patients identified initially, met the inclusion criteria (primary TC with confirmed histology and complete treatment records). Standard statistical tests were used.ResultsSquamous cell carcinoma (SCC; 63.8%) and adenoid cystic carcinoma (ACC; 15.5%) were the most commonly diagnosed histological types of TC. Radiotherapy was delivered in 48 cases, surgery or endoscopic resection in 20, and chemotherapy in 14. TC was diagnosed as a second cancer in 10 patients, in 1 patient it occurred prior to the lung cancer, and in 1 was diagnosed simultaneously. During the median follow-up of 12.7 months, 85.5% of the patients died because of the disease. Local recurrence occurred in 17% cases. In univariate analysis, patients with ACC had statistically better five-year overall survival (77.8%) than those diagnosed with SCC (8.4%, p = 0.0001). Radiotherapy, performance status and haemoptysis were factors significantly influencing overall survival (OS) in the multivariate analysis. Among patients who were not treated surgically, 15–26% were found to constitute additional surgery candidates, depending on the selection criteria.ConclusionsThe diagnostic workup should be focused on the identification of TC patients suitable for invasive treatment and radiotherapy. Respiratory system cancer survivors can be considered a risk group for tracheal cancer. Radiotherapy constitutes an important part of the treatment of patients with TC.

scholarly journals Gender specificity in the interpretation of treatment results for patients with colorectal cancer in the Republic of Tatarstan

2020 ◽  
Vol 5 (2) ◽  
pp. 124-129
Author(s):  
Bulat I. Gataullin ◽  
Rustem Sh. Khasanov ◽  
Anatolii A. Savelev ◽  
Ilgiz G. Gataullin
Keyword(s):  
Colorectal Cancer ◽  
Distant Metastases ◽  
Long Term Results ◽  
Treatment Results ◽  
Kras Gene ◽  
Results Of Treatment ◽  
Age Related ◽  
Mutational Status ◽  
Regional Metastases ◽  
Poorly Differentiated

Objective - to identify the gender-specific features of modeling the prognosis of treatment outcomes for patients with colorectal cancer (CRC). Materials and methods. The study included 654 patients with colorectal cancer (CRC) who were treated from 2013 to 2015, of which 434 were men, 220 were women. The average age of the patients was 64.1±10.2 years. All patients underwent genetic analysis for the presence of a mutation in the KRAS gene from the primary tumor. Results. The gender approach to assessing the long-term results of treatment of patients with CRC showed that in men with colorectal cancer, the most favorable treatment results were observed in patients with tumors in stage T 1-2 N0 M0, regardless of the differentiation of the tumor and its mutational status. In men, poorly differentiated tumors with any T, with the presence of regional metastases and a mutation of the KRAS gene, even in the absence of distant metastases, should be considered prognostically unfavorable: not a single patient lived for 5 years. In women, based on the decision tree analysis, the most favorable treatment results were observed in patients with tumors in the stage T 1-2-3 N0 M0 under the age of 70 years (five-year survival rate of 90%), with tumors T 1-2 N0 M0 - over the age of 70 years (five-year survival of 81.8%), regardless of the differentiation of the tumor and its mutational status. Tumors of any differentiation of the T3-4 N0 stage with the presence of distant metastases (5% of patients lived for 5 years) and poorly differentiated T4N0M0 tumors (five-year survival of 8%) are prognostically unfavorable for women. Conclusion. The study of gender and age-related features of the development and course of CRC is relevant for oncologists to select effective diagnostic, therapeutic and rehabilitation measures.

THE EFFECTS OF ELECTROACUPUNCTURE COMBINED WITH ACUPRESSURE POINTS, MASSAGE TREATMENT AND “DOC HOAT TANG KY SINH” REMEDY ON TREATING SCIATICA DUE TO LUMBAR SPONDYLOSIS

2020 ◽  
pp. 105-111
Author(s):  
Giang Huynh Huong ◽  
Tan Nguyen Thi ◽  
Hung Nguyen Van
Keyword(s):  
Traditional Medicine ◽  
Modern Medicine ◽  
Common Disease ◽  
Working Ability ◽  
Treatment Results ◽  
Lumbar Spondylosis ◽  
Before And After ◽  
Massage Treatment ◽  
Long Time ◽  
Methods Of Treatment

Background: Sciatica due to lumbar spondylosis is a common disease syndrome, include pathological signs from lumbar spine and sciatic nerve. It occurs for a long time and affects to working ability and daily life. Currently there are many methods of treatment with modern medicine and traditional medicine. Electroacupuncture combined with acupressure point, massage treatment and “Doc hoat tang ky sinh” remedy is a highly effective method on treating sciatica due to lumbar spondylosis. Objectives: To evaluate the effectives of electroacupuncture combined with acupressure point, massage treatment and “Doc hoat tang ky sinh” remedy on treating sciatica due to lumbar spondylosis. Materials and Method: A total of 43 patients was diagnosed sciatica caused by lumbar spondylosis who treated at Thua Thien Hue Traditional Medicine Hospital. The study was designed by method of prospective study, assessed the results before and after the treatment. Results: Very good: 34.9%; good: 34.9%; average 7%. There was not any unexpected effects observed in this trial. Conclusion: Electroacupuncture combined with acupressure point, massage treatment and “Doc hoat tang ky sinh” remedy is a effective method on treating sciatica caused by lumbar spondylosis. Key words: sciatica, lumbar spondylosis, acupuncture, electroacupuncture, acupressure point, massage treatment

scholarly journals EARLY VASOACTIVE THERAPY AT BLEEDINGS FROM VARICOSE EXPANDED VEINS OF THE ESOPHAGUS AND THE STOMACH — THE PROSPECT OF IMPROVEMENT OF TREATMENT RESULTS

2019 ◽  
Vol 20 (1) ◽  
pp. 66-68
Author(s):  
V. G. Verbitskiy ◽  
A. V. Fedorov
Keyword(s):  
Emergency Medical Service ◽  
Intravenous Administration ◽  
Medical Service ◽  
Synthetic Analog ◽  
Treatment Results ◽  
Bleeding Point ◽  
Results Of Treatment ◽  
Emergency Medical

In 2015–2016 the research on use of a terlipressin at a pre-hospital stage of emergency medical service in BU RSSMP of Chuvashia was conducted. At bleeding presumably from VRV PZh at a pre-hospital stage entered i.v. bolyusno a synthetic analog of a vasopressin Terlipressin in a dose of 1–2 mg to 310 patients, at the same time results of treatment of 236 cases at which bleeding from VRV PZh was confirmed further in republic hospitals are analysed. Results of early intravenous administration of drug Terlipressin allow to judge expediency and efficiency of its use at a pre-hospital stage, before endoscopic specification of a bleeding point.

scholarly journals Questions of complex treatment of extensive small pelvis phlegmons in patients with diabetes mellitus

2019 ◽  
Vol 41 part 3 (2) ◽  
pp. 21-24
Author(s):  
N. N. Veligotskiy ◽  
A. S. Trushin ◽  
A. I. Seroshtanov ◽  
A. A. Sheptukha ◽  
I. Ye. Bugakov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Complex Treatment ◽  
Ozone Therapy ◽  
Treatment Results ◽  
Results Of Treatment ◽  
Patients With Diabetes

The complex treatment results of 127 patients with extensive purulent processes in diabetes mellitus that were treated in our clinic with ozone therapy and ultrasonic cavitations at 2001–2018 are presents. The problems of the course of the disease and the aggravating influence of the accompanying pathology on it are noted. The options improving the results of treatment considered.Keywords: phlegmon, small pelvis, diabetes mellitus, multiple organ failure, ozone therapy, cavitations.

scholarly journals COMPARATIVE ANALYSIS OF INTERNATIONAL STANDARDS AND OUR EXPERIENCE IN TREATMENT OF PATIENTS WITH CHRONIC HEMORRHOID A BASE FOR EVIDENTIAL MEDICINE

2020 ◽  
pp. 90-93
Author(s):  
V. V. Bojko ◽  
V. V. Makarov ◽  
V. V. Tsodikov ◽  
L. G. Tarasenko
Keyword(s):  
Clinical Experience ◽  
High Efficiency ◽  
International Standards ◽  
Clinical Protocols ◽  
Clinical Protocol ◽  
Surgical Decision ◽  
Results Of Treatment ◽  
Methods Of Treatment ◽  
Single Approach

Summary. Aim. Decrease the amount of postoperative complications and improve quality of life for patients by a chronic hemorrhoid (CH). Materials and methods. Both international and national foreign clinical protocols are analysed. The obtained data are confronted with our clinical experience. Results and their discussion. Materials and methods. In the looks of foreign colleagues to tactics of treatment of patients with CH are analysed. The obtained data are confronted from positions of the best medical practice of providing of medicaid to the patients with a CH. Results and their discussion. In spite of insignificant differences in the volume of operative treatment of patients of CH, international practice adheres to single approach on tactics of surgical decision of this problem. Among the radical methods of treatment recommend next methodologies as an operation of choice: hemorrhoidectomy Milligan - Morgan, Ferguson and Parks, that in all researches were marked as high-efficiency. Clinical experience of our clinic, that Milligan–Morgan hemorrhoidectomy is the operation of choice for patients with 3-4 degrees of fall of knots, and applications of modern methodologies allows to bring down lacks of this operation and to attain the level of complications less than 1 %. Conclusions. The necessity of development of compatible clinical protocol of medicare to the patients takes place with CH. Introduction of single home standards of providing of medicare to the patients with CH will allow to bring down the risk of development of complications and improve the results of treatment. The got results of own researches on providing of medicare to the patients with CH are comparable with the results of foreign colleagues.

scholarly journals Overall survival of patients with non-small cell lung cancer after surgery treatment

2018 ◽  
Vol 75 (12) ◽  
pp. 1157-1164
Author(s):  
Olivera Loncarevic ◽  
Slobodan Acimovic ◽  
Jelena Vukovic ◽  
Marko Stojisavljevic ◽  
Nebojsa Maric ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Small Cell ◽  
The Other ◽  
Small Cell Lung ◽  
Cumulative Survival ◽  
Recurrence Group

Background/Aim. Lung cancer is one of the most common malignant tumors. About 80% of all lung cancers are non-small cell lung cancer (NSCLC). According to histopathological characteristics, the most common types of NSCLC are squamous cell carcinoma and adenocarcinoma. The aim of this study was to evaluate the overall survival rate in the NSCLC patients initially received surgery according to its histopathological type and T ? primary tumor, N ?regional lymph nodes, M ? distant metastasis (TNM) stages which were treated with surgical treatment, and after that, according to the TNM stage, chemotherapy protocols and/or radiation therapy. Methods. This retrospective case series study included all patients with NSCLC admitted to the Military Medical Academy in Belgrade in the period 2010?2015. A total number of selected patients was 85 (27 females and 58 males). Results. Out of 41 patients with squamous cell carcinoma, 19.5% deceased. On the other hand, in the group of patients with adenocarcinoma, 43.2% out of 44 patients deceased. The average cumulative survival was statistically significantly lower in the adenocarcinoma patients in comparison to the patients with squamous cell carcinoma (1,605.2 vs.1,304.8 days; p = 0.005). On the other hand, the average cumulative survival was statistically significantly lower in our patients in the recurrence group with adenocarcinoma in comparison to the recurrence group with squamous cell carcinoma (1,212.8 vs. 1,835.5 days; p = 0.032). Conclusion. Adenocarcinoma is more aggressive cancer in comparing to squamous cell carcinoma with lower overall survival in comparing to squamous cell carcinoma. Additional studies are needed to identify risk factors for recurrence after surgery, and to additionally explain role of tumor markers and molecular biological techniques in the progression of this kind of cancer.

scholarly journals Pathogenic mutations and overall survival in 3,084 patients with cancer: the Hellenic Cooperative Oncology Group Precision Medicine Initiative

Oncotarget ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 1-14
Author(s):  
Elena Fountzilas ◽  
Vassiliki Kotoula ◽  
Georgia-Angeliki Koliou ◽  
Eleni Giannoulatou ◽  
Helen Gogas ◽  
...  
Keyword(s):  
Overall Survival ◽  
Precision Medicine ◽  
Oncology Group ◽  
Patients With Cancer ◽  
Pathogenic Mutations ◽  
Precision Medicine Initiative

Outcome of Childhood Acute Promyelocytic Leukemia With All-Trans-Retinoic Acid and Chemotherapy

2004 ◽  
Vol 22 (8) ◽  
pp. 1404-1412 ◽  
Author(s):  
S. de Botton ◽  
V. Coiteux ◽  
S. Chevret ◽  
C. Rayon ◽  
E. Vilmer ◽  
...  
Keyword(s):  
Overall Survival ◽  
Retinoic Acid ◽  
Acute Promyelocytic Leukemia ◽  
Survival Rates ◽  
Age Groups ◽  
Pseudotumor Cerebri ◽  
Promyelocytic Leukemia ◽  
Results Of Treatment ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

Purpose To determine the results of treatment combining all-trans-retinoic acid (ATRA) and chemotherapy (CT) in childhood acute promyelocytic leukemia (APL). Patients and Methods Children (< 18 years) with newly diagnosed APL were included in the APL93 trial, treated by ATRA followed or combined with daunorubicin-cytarabine, and then randomly assigned between no maintenance, intermittent ATRA, continuous CT, or both. Results Of the 576 patients included in APL93 trial, 31 (5%) were children, including 22 girls (71%) and nine boys (29%). Thirty of the children (97%) obtained complete remission (CR). ATRA syndrome occurred in four children (13%), who all achieved CR, and headaches occurred in 12 children (39%), with signs of pseudotumor cerebri in five children (16%). Seven patients (23%) relapsed. None of the eight patients who received both ATRA and CT for maintenance relapsed. All relapsing patients achieved a second CR. Twenty-two patients remained in first CR after 43+ to 96+ months, six remained in second CR after 17+ to 66+ months, and three patients had died. The 5-year event-free survival (EFS), relapse, and overall survival rates were 71%, 27%, and 90%, respectively. No difference between adults and children included in the APL93 trial was seen for CR rate, 5-year relapse rate, EFS, and overall survival, but significantly better survival was seen in children after adjustment on WBC counts (P = .02) and incidence of microgranular M3 variant (P = .04). Conclusion ATRA combined with CT for induction and also probably for maintenance provides as favorable results in children with APL as in adults and currently constitutes the reference first-line treatment in both age groups.

Prognostic significance of the TNM system criteria, levels of serum insulin-like growth factors and their transport proteins, VEGF and MMP-7 in colorectal cancer

2021 ◽  
Vol 66 (8) ◽  
pp. 459-464
Author(s):  
A. A. Nikolaev ◽  
I. V. Babkina ◽  
Elena Sergeevna Gershtein ◽  
A. A. Alferov ◽  
V. V. Delektorskaya ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Serum Insulin ◽  
Prognostic Significance ◽  
Colon Adenocarcinoma ◽  
Serum Levels ◽  
Long Term Results ◽  
Tnm System ◽  
Results Of Treatment ◽  
Kaplan Meier

The analysis of long-term results of treatment of 88 primary patients with colon adenocarcinoma at various stages of tumor process is presented, taking into account the TNM system criteria, and serum IGF-1, IGF-2, IGFBP-1, IGFBP-2, IGFBP-3, VEGF, and MMP-7 levels. The overall survival rate assessed by Kaplan-Meier method and Cox multivariate regression model was used as the criterion of prognosis. It was established that IGF-1, IGFBP-2 and VEGF serum levels along with the stage of colorectal cancer might be considered as statistically significant independent predictors of overall survival in patients.

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