scholarly journals Effect of Ajwa date seed powder on visceral fat depots and inflammatory response in high fat fed Sprague Dawley female rats.

2021 ◽  
Vol 10 (4) ◽  
pp. 200-205
Author(s):  
Farhana Yasmin Bhatti ◽  
Fariha Ahmad Khan ◽  
Abdul Mudabbir Rehan ◽  
Zoobia Irum ◽  
Sadia Chiragh
Keyword(s):  
Body Weight ◽  
Visceral Fat ◽  
High Fat Diet ◽  
Female Rats ◽  
P Value ◽  
Sprague Dawley ◽  
High Fat ◽  
Fat Depots ◽  
Date Seed ◽  
Perinephric Fat

ABSTRACT Background: Central obesity a worldwide metabolic and cosmetic problem poses significant health risk. Ajwa date seed has antioxidant property and its high fiber content may prevent fat absorption and reduce fat deposition. Objective: To evaluate the effect of Ajwa date seed powder on visceral fat depots and inflammatory response in high fat fed Sprague Dawley female rats. Methodology: Thirty-six healthy rats of four weeks age were divided into three groups and followed for 12 weeks. Group A (normal control) received regular diet. Group B (HFD control) received high fat diet, while group C (HFD+Ajwa group) received high fat diet along with 2% Ajwa date seed powder. Body weight was measured weekly. Blood sample was drawn for the estimation of serum IL-6 and leptin levels by ELISA method at 12th week. After which rats were euthanized; perinephric fat was removed and weighed in grams. Results: HFD+Ajwa group gained less body weight as compared to HFD control group (p value = 0.012). There was a remarkable reduction in perinephric fat weight (p value ≤ 0.001) and level of IL-6 in HFD+Ajwa group (p value ≤ 0.001) as compared to HFD control. There was no significant difference in serum leptin level of the rats of all groups (p value = 0.567). Conclusion: Ajwa date seed can prevent visceral adiposity and gain in body weight. Moreover, it has anti-inflammatory effect; but no significant effect on satiety hormone. Key Words: Obesity, Visceral fat, P. dactylifera L (Ajwa date) seed, IL-6, Leptin.

Effects of chronic testosterone administration on the degree of preference for a high-fat diet and body weight in gonadal-intact and ovariectomized female rats

2018 ◽  
Vol 349 ◽  
pp. 102-108 ◽  
Author(s):  
Takeshi Iwasa ◽  
Toshiya Matsuzaki ◽  
Kiyohito Yano ◽  
Mayila Yiliyasi ◽  
Akira Kuwahara ◽  
...  
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Female Rats ◽  
High Fat ◽  
Testosterone Administration

scholarly journals Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity

2019 ◽  
Vol 8 (3) ◽  
pp. 203-216 ◽  
Author(s):  
Anna C Simcocks ◽  
Kayte A Jenkin ◽  
Lannie O’Keefe ◽  
Chrishan S Samuel ◽  
Michael L Mathai ◽  
...  
Keyword(s):  
Body Weight ◽  
G Protein ◽  
High Fat Diet ◽  
Chow Diet ◽  
Sprague Dawley ◽  
High Fat ◽  
G Protein Coupled Receptor ◽  
Diet Induced Obesity ◽  
Sprague Dawley Rats ◽  
G Protein Coupled

Atypical cannabinoid compounds O-1602 and O-1918 are ligands for the putative cannabinoid receptors G protein-coupled receptor 55 and G protein-coupled receptor 18. The role of O-1602 and O-1918 in attenuating obesity and obesity-related pathologies is unknown. Therefore, we aimed to determine the role that either compound had on body weight and body composition, renal and hepatic function in diet-induced obesity. Male Sprague–Dawley rats were fed a high-fat diet (40% digestible energy from lipids) or a standard chow diet for 10 weeks. In a separate cohort, male Sprague–Dawley rats were fed a high-fat diet for 9 weeks and then injected daily with 5 mg/kg O-1602, 1 mg/kg O-1918 or vehicle (0.9% saline/0.75% Tween 80) for a further 6 weeks. Our data demonstrated that high-fat feeding upregulates whole kidney G protein receptor 55 expression. In diet-induced obesity, we also demonstrated O-1602 reduces body weight, body fat and improves albuminuria. Despite this, treatment with O-1602 resulted in gross morphological changes in the liver and kidney. Treatment with O-1918 improved albuminuria, but did not alter body weight or fat composition. In addition, treatment with O-1918 also upregulated circulation of pro-inflammatory cytokines including IL-1α, IL-2, IL-17α, IL-18 and RANTES as well as plasma AST. Thus O-1602 and O-1918 appear not to be suitable treatments for obesity and related comorbidities, due to their effects on organ morphology and pro-inflammatory signaling in obesity.

scholarly journals SUN-239 Effects of High-Fat Diet-Induced Obesity on Pulsatile LH Secretion and Hypothalamic KISS1 Expression in Female Rats

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Shiori Minabe ◽  
Kinuyo Iwata ◽  
Youki Watanabe ◽  
Hitoshi Ozawa
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Pulse Frequency ◽  
Female Rats ◽  
Standard Diet ◽  
High Fat ◽  
Estrous Cycles ◽  
Menstrual Dysfunction ◽  
Estrous Cyclicity ◽  
Lh Secretion

Abstract Female obesity is associated with menstrual dysfunction leading to anovulation and infertility. It has recently been reported obesity-induced infertility is involved in the dysfunction of a kisspeptin neuron, a key player in reproduction via direct stimulation of gonadotropin releasing hormone (GnRH) and subsequent gonadotropin release in mammalian species. Previous studies reported that obesity due to high-fat diet (HFD) for 8 months induced a disruption in estrous cyclicity, caused by a decrease in Kiss1 (coding kisspeptin) expression in the hypothalamic arcuate nucleus (ARC) in female rodents. Here we showed the effects of shorter-term (4 months) HFD on pulsatile LH secretion and hypothalamic Kiss1 expression to show pathogenic mechanism underlying obesity-induced infertility. Female Wistar-Imamichi strain rats (7 weeks old) fed on either a standard diet (10% calories from fat) or a high-fat diet (45% calories from fat) for 4 months. Estrous cyclicity and body weight were monitored regularly. All animals were implanted with a jugular catheter and collected blood samples to analyze pulsatile LH secretion, after a week of the ovariectomy with low-dose replacement estradiol to negate influence of changes in ovarian steroid levels and mimic diestrous levels of plasma estrogen. On the next day of the blood sampling, rats were perfused with 0.05 M PBS followed by 4% paraformaldehyde and their brains were collected for in situ hybridization of Kiss1 and Gnrh1. The HFD-fed rats showed progressive increases in body weight, along with hyperphagia and adipose tissue accumulation, compared with control animals. Fifty-eight percent of the HFD-fed rats exhibited irregular estrous cycles, whereas remaining HFD-fed rats showed regular cycles. Two out of 7 rats showing HFD-induced irregular estrous cycles exhibited profound suppression of the LH pulse frequency and the number of Kiss1-expressing cells in the ARC, whereas remaining HFD-fed rats showed normal LH pulses and ARC Kiss1 expressions. The number of Kiss1-expressing cells in the ARC had close positive correlation with LH pulse frequency (R2=0.6872, P<0.001) in both groups. Additionally, the number of Kiss1- or Gnrh1-expressing cells in the anteroventral periventricular nucleus or the preoptic area, were comparable between groups. Taken together, our finding reveals the possibility that irregular menstruation was also induced by changes in the kisspeptin-GnRH independent pathway during the incipient stage of obese infertility.

scholarly journals Erchen Decoction Mitigates Lipid Metabolism Disorder by the Regulation of PPARγ and LPL Gene in a High-Fat Diet C57BL/6 Mice Model

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Mengting Zhang ◽  
Yanfei Shao ◽  
Bizhen Gao ◽  
Jicheng Chen ◽  
Ping Zhang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Weight ◽  
Lipid Metabolism ◽  
Visceral Fat ◽  
Protein Level ◽  
High Fat Diet ◽  
Blood Lipid ◽  
Abdominal Circumference ◽  
High Fat ◽  
Gene And Protein Expression

Erchen decoction (ECD) is a common treatment prescribed in traditional Chinese medicine (TCM) clinics, which has remarkable efficacy in the treatment of obesity, fatty liver, hyperlipidemia, diabetes, and other diseases caused by phlegm. In this study, we investigated the effect that ECD had on the lipid metabolism induced by high-fat diet in C57BL/6 mice. Body weight, body length, and abdominal circumference were detected. Blood lipid content was measured via biochemical assay kit. The gene and protein expression of PPARγ and LPL in visceral fat and skeletal muscle of mice was measured by real-time PCR and western blot. The research discovered that the phlegm-resolving effect that ECD had on high-fat diet mice was mainly manifested as reduced body weight, Lee’s index, abdominal circumference, and level of TG and TC. Meanwhile, we observed significantly increased PPARγ mRNA and protein level in visceral fat and PPARγ and LPL protein level in skeletal muscle in the ECD group. Contrarily, a decrease in PPARγ mRNA level in skeletal muscle in the ECD group was observed. Therefore, we speculate that ECD regulates the lipid metabolic disorder by decreasing the blood lipid level. Moreover, the potential molecular mechanism of ECD is to promote the expression of PPARγ in visceral fat and skeletal muscle and the expression of LPL in skeletal muscle.

scholarly journals The Effects of Duodenojejunal Omega Switch in Combination with High-Fat Diet and Control Diet on Incretins, Body Weight, and Glucose Tolerance in Sprague-Dawley Rats

2017 ◽  
Vol 28 (3) ◽  
pp. 748-759 ◽  
Author(s):  
Dominika Stygar ◽  
Tomasz Sawczyn ◽  
Bronisława Skrzep-Poloczek ◽  
Aleksander J. Owczarek ◽  
Natalia Matysiak ◽  
...  
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
High Fat Diet ◽  
Control Diet ◽  
Sprague Dawley ◽  
High Fat ◽  
Sprague Dawley Rats ◽  
And Control

scholarly journals Specified Kiwifruit Extract Blocks Increase of Body Weight and Visceral Fat in High-fat-diet-fed Mice by Inhibiting Intestinal Lipase

2019 ◽  
Vol 25 (2) ◽  
pp. 295-302
Author(s):  
Satomi Iwata ◽  
Takako Kato ◽  
Akari Yokoyama ◽  
Junko Hirota ◽  
Takuo Ogihara
Keyword(s):  
Body Weight ◽  
Visceral Fat ◽  
High Fat Diet ◽  
High Fat

scholarly journals Supplement of bamboo extract lowers serum monocyte chemoattractant protein-1 concentration in mice fed a diet containing a high level of saturated fat

2011 ◽  
Vol 106 (12) ◽  
pp. 1810-1813 ◽  
Author(s):  
Jason K. Higa ◽  
Wanyu Liu ◽  
Marla J. Berry ◽  
Jun Panee
Keyword(s):  
Body Weight ◽  
Visceral Fat ◽  
High Fat Diet ◽  
Water Extract ◽  
Control Group ◽  
Standard Diet ◽  
High Fat ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine up-regulated in obese subjects, contributing to the development of type 2 diabetes. The present study investigated the inhibitory effect of an ethanol–water extract from bamboo (BEX,Phyllostachys edulis) on the blood concentration of MCP-1. C57BL/6J mice were fed a standard diet or a high-fat diet with or without the BEX supplement (11 g dry mass/17 000 kJ) for 6 months. A total of ten mice were used in each group. Body weight and food consumption were measured weekly. After euthanisation, the weight of visceral fat and circulating MCP-1 concentration were measured. In comparison with the standard control group, the high-fat control group had increased body weight, abdominal fat storage and serum MCP-1 concentration by 60 % (P < 0·001), 266 % (P < 0·001) and 180 % (P < 0·01), respectively. In comparison with the high-fat control group, the high-fat BEX group showed a 3 % decrease in body weight (P < 0·01), 24 % decrease in mesenteric fat depot (P < 0·01) and 49 % decrease in serum MCP-1 concentration (P < 0·05). The present study suggests that the BEX supplement in the high-fat diet ameliorates elevated MCP-1 concentrations in the blood, and whether this is related to modulated endocrine properties of the visceral fat is to be studied.

The effects of ovariectomy and lifelong high-fat diet consumption on body weight, appetite, and lifespan in female rats

2018 ◽  
Vol 97 ◽  
pp. 25-30 ◽  
Author(s):  
Takeshi Iwasa ◽  
Toshiya Matsuzaki ◽  
Kiyohito Yano ◽  
Minoru Irahara
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Female Rats ◽  
High Fat

scholarly journals Effect of Citrus Limon Essential Oil on Lipid Profile and Obesity in Wistar Rats

2021 ◽  
pp. 1-5
Author(s):  
Souhaila Benchaoui ◽  
Meriem Gueracheha ◽  
Asma Boutebsou
Keyword(s):  
Body Weight ◽  
Essential Oil ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Intraperitoneal Administration ◽  
Female Rats ◽  
Abdominal Circumference ◽  
Citrus Limon ◽  
Standard Diet ◽  
High Fat

Obesity causes many pathologies; no therapeutic axis has provided an effective solution to this problem. The use of herbal medicine with healthy food and physical activity is recommended, and essential oils are the best known of these natural substances. The objective of this study is to evaluate the effect of Citrus limon essential oil on body weight and lipid profile. The plant material is the lemon; the extraction method is hydrodistillation. The experiment lasted 20 days and involved 15 female rats (2 to 3 months old) weighing between 160g and 230g. The rats were divided into 3 groups: the first receiving a standard diet, the second receiving a high-fat diet, and the third receiving a high-fat diet and treated with essential oil. The extraction yield is 1.69%. The physicochemical characteristics comply with AFNOR. This study shows that a high-lipid diet induces obesity characterized by hyperlipidemia. Intraperitoneal administration of the essential oil caused a decrease in body weight, abdominal circumference, plasma total cholesterol, and triglycerides and an increase in HDL-cholesterol. Considering this study, we found that lemon essential oil has beneficial effects on metabolic alterations. Its inclusion in the diet may help improve the metabolic profile and reduce the incidence of obesity and its long-term complications.

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