scholarly journals CONDYLOMA LATA IN A 21-YEAR-OLD MALE TREATED WITH DOXYCYCLINE: A CASE REPORT

2014 ◽  
Vol 6 (2) ◽  
Author(s):  
Hendra Minarto
Keyword(s):  
Human Immunodeficiency Virus ◽  
Risk Factor ◽  
Case Report ◽  
Hiv Transmission ◽  
Treponema Pallidum ◽  
Initial Therapy ◽  
Secondary Syphilis ◽  
Immunodeficiency Virus ◽  
The World

Abstrak: Kondiloma lata merupakan salah satu manifestasi sifilis sekunder yang disebabkan oleh Treponema pallidum. Manifestasi klinis kondiloma lata berupa papul-papul berwarna putih atau keabuan pada daerah tubuh yang hangat dan lembab. Sifilis memerlukan perhatian serius karena penyakit ini merupakan salah satu faktor risiko transmisi human immunodeficiency virus (HIV) di seluruh dunia. Kami melaporkan satu kasus kondiloma lata pada seorang laki-laki berusia 21 tahun di daerah penis, skrotum, perineal, dan perianal sejak 2 bulan lalu, yang diterapi dengan doksisiklin 2 x 100 mg selama 30 hari. Pada pemeriksaan serologik awal didapatkan hasil reaktif untuk tes VDRL (1/256), tes RPR (1/512) dan tes TPHA (1/5120). Perbaikan signifikan terlihat setelah 30 hari terapi doksisiklin dimana semua lesi menghilang. Pemeriksaan serologik 3 bulan setelah awal terapi menunjukkan penurunan titer sebanyak empat kali lipat untuk tes VDRL (1/64), tes RPR (1/128), dan enam kali lipat untuk tes TPHA (1/640). Simpulan: Telah dilaporkan kasus kondiloma lata dengan diagnosis ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan serologik. Terapi doksisiklin selama 30 hari memberikan hasil yang memuaskan. Pemeriksaan serologik harus dilakukan pada bulan ke-6 dan 12 untuk monitoring keberhasilan terapi. Kata kunci: kondiloma lata, sifilis sekunder, Treponema pallidum, doksisiklin   Abstract: Condyloma lata is one manifestation of secondary syphilis caused by Treponema pallidum. It is described clinically as multiple whitish or gray papules found in warm and moist areas. Syphilis requires serious attention since it still remains a risk factor of human immunodeficiency virus (HIV) transmission all around the world. We reported a case of a 21-year-old male suffered from condyloma lata on his penile, scrotal, perineal, and perianal regions for 2 months and treated with 30 days course of 100 mg doxycyline two times daily. Early serologic examinations revealed reactive values of VDRL test (1/256), RPR test (1/512), and TPHA test (1:5120). Significant improvement was observed after 30 days course of doxycyline therapy where all lesions have resolved. Further serologic examinations as follow up showed a fourfold titre decrease of VDRL test (1/64), RPR test (1/128) and sixfold titre decrease of TPHA test (1/640) 3 months after the initial therapy. Conclusion: The diagnosis of condyloma lata in this case was established based on anamnesis, physical examination, and serologic findings. Treatment with doxycycline gave satisfactory result. Serologic examination as follow up needs to be performed at 6 and 12-months after the initial treatment to monitor the success of therapy. Keywords: condyloma lata, secondary syphilis, Treponema pallidum, doxycycline.

scholarly journals Outcomes of prevention of HIV mother-to-child transmission in Cipto Mangunkusumo Hospital

2012 ◽  
Vol 52 (5) ◽  
pp. 294
Author(s):  
Dina Muktiarti ◽  
Nia Kurniati ◽  
Arwin Akib ◽  
Zakiudin Munasir
Keyword(s):  
Human Immunodeficiency Virus ◽  
Risk Factor ◽  
Hiv Transmission ◽  
Pmtct Program ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Immunodeficiency Virus ◽  
Mother To Child ◽  
Prevention Of Hiv

Background Human immunodeficiency virus (HIV) infectionis increasing worldwide. One foute of HIV transmission is frommother to child, during pregnancy, delivery or breastfeeding.Prevention of mother􀁂to􀁂child transmission may be an effectivestrategy to reduce the cases of new HIV infections.Objectives To investigate the incidence of HIV infection ininfants born to mothers with HIV and who received prophylactictherapy at birth, as well as to note the outcomes of HIVinfectedchildren in this program.Methods This retrospective study was carried out over a 9􀁂yearperiod, from January 20 03 to December 2011. The participantswere HIVexposed infants who attended the HIV clinic, at theDepartment of Child Health, Cipto Mangunkusumo Hospital,Jakarta. Infants were treated according to the prevention ofmother􀁂to􀁂child transmission (PMTCT) protocol at CMH.Parents' and infants' data was recorded. The end point of thisstudy was recording of HIVinfection status in the infants.Results There were 238 infants included in this study. HIVinfection was confirmed in 6 (2.5%) infants, while 170 (71.4%)subjects were uninfected, and 62 (26.1%) subjects were lostto follow􀁂up. No subjects who underwent complete PMTCTmanagement were infected. Most subjects were male, full􀁂tenn,and delivered by caesarean section in our hospital. The mostfrequently observed parental risk factor was intravenous druguse. Maternal antiretroviral therapy (ART) was given duringpregnancy in most cases. Morbidities in all subjects were low.Conclusion The PMTCT program at CMH was effective forreducing the number ofHIVinfected infants from mothers withHIY. [Paediatrlndanes. 2012;52:294-9]. 

scholarly journals Secondary Syphilis in Human Immunodeficiency Virus (HIV)-Infected Men Who Have Sex with Men (MSM): A Case Report

2020 ◽  
Vol 32 (1) ◽  
pp. 75
Author(s):  
Ade Fernandes ◽  
Evy Ervianti
Keyword(s):  
Human Immunodeficiency Virus ◽  
Treatment Success ◽  
Venereal Disease ◽  
Treponema Pallidum ◽  
Clinical Manifestations ◽  
Secondary Syphilis ◽  
Response To Treatment ◽  
Immunodeficiency Virus ◽  
Tertiary Stage ◽  
Sex With Men

Background: Recently, the incidence of syphilis among men who have sex with men (MSM) has increased rapidly, especially among Human Immunodeficiency Virus (HIV)-infected MSM. Coinfection with these two organisms alter the symptoms and signs, progression of the disease, and the risk of progressing to the tertiary stage. Purpose: To report a case of secondary syphilis in HIV-infected MSM.  Case: A 24-year-old male complaint of multiple redness macule for 1-month duration on his chest, back, groin, palm, and soles. The rash was neither painful nor pruritic. He also complains of hair loss resulting "moth eaten" alopecia. One month before, he had a painless ulcer on his genital, which resolved without treatment. His HIV infection was diagnosed two years earlier. He had been sexually active with multiple homosexual partners without using a condom since 2010. The Venereal Disease Research Laboratory test (VDRL) titer was 1/32, and Treponema pallidum haemagglutination assay (TPHA) was 1/20480. Initial treatment was a single dose of 2.4 million units of benzathine penicillin. Serologic examination was reevaluated on month 1, 3, 6, and 9 after therapy and declined in the third month. Discussion: For HIV-infected persons, the clinical manifestations of syphilis in most of the cases remain the same. However, the lesions are more aggressive, and coexistence of primary and secondary syphilis is more frequent. Serologic tests are accurate and reliable for the diagnosis and for following a patient’s response to treatment. Penicillin is effective but physical and serological follow up is needed. Conclusion: HIV-infected MSM have higher risk of syphilis. Staging is needed to determine the treatment. Serologic examination should be repeated and long enough to monitor the treatment success.

scholarly journals Human immunodeficiency virus and tuberculosis in Argentina: prevalence, genotypes and risk factors

2008 ◽  
Vol 57 (2) ◽  
pp. 190-197 ◽  
Author(s):  
Maria A. Pando ◽  
Cristina De Salvo ◽  
Christian T. Bautista ◽  
Lindsay Eyzaguirre ◽  
Gladys Carrion ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Highly Active Antiretroviral Therapy ◽  
Hiv Transmission ◽  
Treponema Pallidum ◽  
Risk Groups ◽  
Highly Active ◽  
Subtype B ◽  
Human T Cell ◽  
Immunodeficiency Virus ◽  
Hiv 1

The objective of this study was to determine the prevalence and genetic variability of human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted infections (STIs) among 205 patients with clinical diagnosis of tuberculosis (TB) in Buenos Aires in 2001. Infections with hepatitis B virus (HBV), HIV-1, hepatitis C virus (HCV), Treponema pallidum and human T-cell lymphotropic virus types I/II were diagnosed in 37/187 (19.8 %), 35/205 (17.1 %), 22/187 (11.8 %), 13/187 (7.0 %) and 4/181 (2.2 %) patients, respectively. Almost one in three participants (33.1 %) presented at least one infection in addition to TB. Multiresistance to TB drugs (isoniazid plus rifampicin) was detected in the isolates recovered from three patients. Injecting drug use was detected as the main risk factor for HIV, HBV and HCV infections. Of ten patients who died, eight were infected with HIV. HIV genetic characterization showed the presence of two different subtypes. Env subtype F was found in 13/24 samples (54.2 %) and subtype B in 11/24 samples (45.8 %) by heteroduplex mobility assay. Sequencing of the protease/RT region was performed in ten samples: three were characterized as subtype B and seven as B/F recombinants by bootscanning analysis. Phylogenetic analysis of four full-length sequences showed that three were the circulating recombinant form CRF12_BF. The results of this study suggest an urgent need to detect HIV infection in high-risk groups to prevent future HIV transmission as well as morbidity and mortality associated with TB by providing highly active antiretroviral therapy (HAART) and/or TB treatment. Collaboration between TB and HIV programmes seems to be the best approach to decrease the incidence of these diseases, especially in high-prevalence HIV settings.

scholarly journals Syphilis? An Unusual Cause of Surgical Emergency in a Human Immunodeficiency Virus-Infected Man

2015 ◽  
Vol 2 (3) ◽  
Author(s):  
Rachel A. Bender Ignacio ◽  
Lisa L. Koch ◽  
Shireesha Dhanireddy ◽  
B. Charmie Godornes ◽  
Sheila A. Lukehart ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Polymerase Chain Reaction ◽  
Treponema Pallidum ◽  
Secondary Syphilis ◽  
Anorectal Surgery ◽  
Chain Reaction ◽  
Surgical Emergency ◽  
Immunodeficiency Virus ◽  
Polymerase Chain ◽  
Anorectal Pathology

Abstract We report on a human immunodeficiency virus-infected man undergoing urgent anorectal surgery, with multi-centimeter fungating masses discovered inside the anus. Initial pathology was inconclusive. After the patient developed a disseminated rash postoperatively determined to be secondary syphilis, the anorectal pathology was reviewed and Treponema pallidum DNA was amplified by polymerase chain reaction from the mass.

Oral Manifestation of Secondary Syphilis in a Patient With The Human Immunodeficiency Virus: Case Report

2014 ◽  
Vol 117 (2) ◽  
pp. e179-e180
Author(s):  
MARCELO ANDERSON BARBOSA NASCIMENTO ◽  
TIAGO JOÃO DA SILVA FILHO ◽  
THÂMARA MANOELA MARINHO BEZERRA ◽  
THAIS ALINE OLIVEIRA MACIEL ◽  
ÉRICKA JANINE DANTAS DA SILVEIRA ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Case Report ◽  
Secondary Syphilis ◽  
Oral Manifestation ◽  
Immunodeficiency Virus

scholarly journals The Great Impostor: Transaminitis Masking the Coinfection of Syphilis and Human Immunodeficiency Virus

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Sunit Tolia ◽  
Hassan Kassem ◽  
Ana Capatina-Rata
Keyword(s):  
Human Immunodeficiency Virus ◽  
Primary Care Physicians ◽  
Treponema Pallidum ◽  
Disease Process ◽  
The United States ◽  
Secondary Syphilis ◽  
Cutaneous Manifestations ◽  
Hiv Coinfection ◽  
Immunodeficiency Virus ◽  
Alkaline Phosphate

Introduction. The incidence of syphilis continues to rise in the United States over the past 15 years. This disease process is classified into stages and may present with a coinfection of Human Immunodeficiency Virus (HIV).Case Report. We present a case of a 32-year-old African American male who presented with cutaneous manifestations of secondary syphilis and transaminitis. A workup revealed that the transaminitis was secondary to underlying syphilitic hepatitis in the presence of HIV coinfection. The patient had a reactive rapid plasma reagin (RPR) of 1 : 64 TU and reactiveTreponema pallidumparticle agglutination assay (TPPA). Lab findings showed alkaline phosphate (ALP) of 648 unit/L, aspartate aminotransferase (AST) of 251 unit/L, and alanine aminotransferase (ALT) of 409 unit/L.Conclusion. Syphilitic hepatitis is a recognized entity in the medical literature. It is a manifestation of secondary syphilis and it is more commonly seen in coinfected patients with both syphilis and HIV. Therefore, primary care physicians should keep infectious etiologies (e.g., syphilis and HIV) in the differential diagnosis of patients who present with unexplained liver dysfunction in a cholestatic pattern.

scholarly journals Continuum of Care UNAIDS Fast-Track Targets Evaluation of Patients Living with Human Immunodeficiency Virus Infection

Healthcare ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1249
Author(s):  
Cristian Jianu ◽  
Corina Itu-Mureşan ◽  
Adriana Violeta Topan ◽  
Irina Filipescu ◽  
Mihaela Elena Jianu ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Fast Track ◽  
Hiv Transmission ◽  
Strand Transfer ◽  
Nations Programme ◽  
United Nations Programme ◽  
Immunodeficiency Virus ◽  
Integrase Strand Transfer Inhibitors ◽  
Living With Hiv

The current study evaluated the progress of continuum healthcare for patients living with human immunodeficiency virus (HIV) infection from Cluj County in two moments, 2016 and 2020, and compared the results to the Fast-Track targets (FTTs) proposed by the Joint United Nations Programme (UNAIDS) on HIV/AIDS. By the end of 2020, 368 out of 385 confirmed HIV-positive patients from Cluj County were under surveillance in our center, representing almost 95% of the patients living with HIV and knowing their diagnosis, compared to 87.9% in 2016. Nearly 97% of those in active follow-up from Cluj County were under antiretroviral therapy (ART) in 2020, compared to 89% in 2016. The number of virally suppressed patients from those under ART was almost 94% in 2020, compared to 82.7% in 2016, and the increase is observed regardless of the ART regime. A shift towards integrase strand transfer inhibitors, with a higher efficacy, fewer adverse effects, and fewer drug interactions, is observed, which could contribute to the decrease in HIV transmission.

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