Synthesis and Characterization of Gellan Gum-Pyridoxine Nanoparticle for Treatment of Localized Peripheral Neuropathy

Biopolymer has full application as a drug carrier and scaffold in tissue engineering because of its biodegradability and non-toxicity. The present study is focused on novel biopolymer gellan gum as a drug delivery agent. The objective of the study is to synthesize the gellan gum nanoparticle by solvent evaporation emulsification method and characterize it using SEM, DLS, FTIR, and XRD. As pyridoxine is effectively used to treat diabetic peripheral neuropathy, it has been encapsulated with gellan gum and characterized. The antioxidant assay was performed using ABTS reagent, and the activity increases with increasing concentration of nanoparticle. Also, it has significant antimicrobial activity against gram-positive bacteria. Apart from this, the drug release kinetics of the gellan gum- pyridoxine nanoparticle was studied.

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Synthesis and Characterization of Erythromycin Loaded PLGA and PCL Microspheres: Antimicrobial Application

10.21203/rs.3.rs-1097114/v1 ◽

2021 ◽

Author(s):

Lamia Bennabi ◽

Ilham Abedelemalek ◽

Abedelkader Ammari ◽

Khaldia Sediri ◽

Fatima Bennabi ◽

...

Keyword(s):

Electron Microscopy ◽

Glycolic Acid ◽

Release Kinetics ◽

Synthesis And Characterization ◽

X Ray Diffraction ◽

X Ray ◽

Complementary Effect ◽

Kinetics Of ◽

Scanning Electron

Abstract We presents in this work the preparation of several formulations, based on biocompatible biodegradable polymers: polycaprolactone (PCL) and poly(lactic-co-glycolic) acid (PLGA) loaded with Erythromycin (ERYT) antibiotic. These biocompatible materials were used to prepare microspheres with and without immobilized ERYT via simple evaporation method by simple emulsion. The particle size was determined by scanning electron microscopy and the absence of the interaction with ERYT was confirmed via X-ray diffraction and infrared spectroscopy. The release kinetics of ERYT were studied and then, ERYT loaded PCL and PLGA blends microspheres were used for the inhibition of gram-positive S. aureus strain. The microbial activity was carried-out by Agar diffusion disc method. The results show that PCL/PLGA blend and PCL alone inhibited the strain by ERYT present in kinetic aliquots with the complementary effect of the polymers. A numerical model was proposed for modeling the kinetics reported in our study.

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Synthesis and characterization of fluorescent chitosan–ZnSe/ZnS nanoparticles for potential drug carriers

RSC Advances ◽

10.1039/c5ra02933c ◽

2015 ◽

Vol 5 (49) ◽

pp. 38810-38817 ◽

Cited By ~ 6

Author(s):

Yeping Li ◽

Jingbo Xu ◽

Yun Xu ◽

Liying Huang ◽

Junli Wang ◽

...

Keyword(s):

Quantum Dots ◽

Drug Carrier ◽

Drug Carriers ◽

Cancer Drug ◽

Synthesis And Characterization ◽

Potential Drug ◽

Zns Nanoparticles ◽

New Approach ◽

Anti Cancer

The objective of the study is to describe a new approach of combining quantum dots into chitosan as an anti-cancer drug carrier.

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Synthesis and characterization of photo-curable bis-quaternary ammonium dimethacrylate with antimicrobial activity for dental restoration materials

European Polymer Journal ◽

10.1016/j.eurpolymj.2015.11.011 ◽

2016 ◽

Vol 74 ◽

pp. 81-90 ◽

Cited By ~ 41

Author(s):

Pooyan Makvandi ◽

Mousa Ghaemy ◽

Mojtaba Mohseni

Keyword(s):

Antimicrobial Activity ◽

Quaternary Ammonium ◽

Dental Restoration ◽

Synthesis And Characterization

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Synthesis and characterization of porous CaCO3 microspheres templated by yeast cells and the application as pH value-sensitive anticancer drug carrier

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2020.111545 ◽

2021 ◽

Vol 199 ◽

pp. 111545

Author(s):

Yan Wei ◽

Ruize Sun ◽

Hui Su ◽

Hao Xu ◽

Lichuang Zhang ◽

...

Keyword(s):

Anticancer Drug ◽

Ph Value ◽

Drug Carrier ◽

Yeast Cells ◽

Synthesis And Characterization

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Synthesis and Characterization of Nanoporous Monetite Which Can Be Applicable for Drug Carrier

Journal of Nanomaterials ◽

10.1155/2012/931492 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 11

Author(s):

Esmael Salimi ◽

Jafar Javadpour

Keyword(s):

Surface Area ◽

Cetyltrimethylammonium Bromide ◽

Drug Carrier ◽

Synthesis And Characterization ◽

X Ray ◽

Plate Shape ◽

Desorption Isotherms ◽

Adsorption Desorption

Wormhole-like mesostructured monetite was successfully synthesized using cetyltrimethylammonium bromide (C19H42BrN, CTAB), as a porosity agent. X-ray techniques and FTIR reveal that the crystalline grains consist of highly crystalline pure monetite phase. Monetite rods with diameter around 20–40 nm and length in the range of 50–200 nm were confirmed by FESEM and TEM. Based on N2adsorption-desorption isotherms investigation, surface area increased up to 31.5 m2/g due to the removal of surfactant after calcinations at 400°C. The results indicate that CTAB can not only affect monetite crystallization but also change particles morphology from plate shape to rod-like.

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DESIGN, SYNTHESIS, AND CHARACTERIZATION OF THE SOME NOVEL 2‐AMINO-PYRIDINE‐3‐ CARBONITRILE AND 2‐AMINO-4H-PYRAN‐3‐CARBONITRILE DERIVATIVES AGAINST ANTIMICROBIAL ACTIVITY AND ANTIOXIDANT ACTIVITY

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i12.39745 ◽

2020 ◽

pp. 125-134

Author(s):

SURENDRA BABU LAGU ◽

RAJENDRA PRASAD YEJELLA

Keyword(s):

Antimicrobial Activity ◽

Antioxidant Activity ◽

Antimicrobial Activities ◽

Docking Studies ◽

Synthesis And Characterization ◽

Zone Of Inhibition ◽

Design Synthesis ◽

Instrumental Methods ◽

Objective Investigation

Objective: Investigation, the series of newer 2‐amino-pyridine‐3‐carbonitrile and 2‐amino-4H-pyran‐3‐carbonitrile derivative were synthesized and evaluated antimicrobial activities and antioxidant activity. Methods: Novel synthesized chalcones were further condensation to give 2-amino-3-cyanopyridine and 2-amino-3-cyanopyrans in the presence of malononitrile, pyridine, and ammonia acetate. The product is characterized by conventional and instrumental methods. Pyridine and 4-H-Pyran and their analogs occupy prime position due to their diverse applications. Results: The compounds A3C and B3C exhibited marked zone of inhibition with 30.02±0.02 mm and 29.06±0.01 mm, respectively. Docking studies suggested possible interactions with dihydrofolic reductase 4 with 9.15 and −9.67 kcal/mol, respectively. The IC50 30.28±0.01 exhibited A3C by 2,2-diphenylpicrylhydrazyl methods which is better among the series. The 2-amino-3-cyanopyridine derivatives were found good activity than 2-amino-3-cyanopyrane derivative. Among all synthesized compounds few having potent activity and some are near to the standard. Conclusion: Antimicrobial activity and antioxidant of the newly synthesized pyrans and pyridines derivatives will definitely inspire future researchers for the preparation of new analogs.

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