scholarly journals COGNITIVE FUNCTIONS AND STRUCTURE OF DISORDERS IN PATIENTS WITH HYPERTENSION

2020 ◽  
Vol 1 ◽  
Author(s):  
Viktoriia Krotova
Keyword(s):  
Cognitive Impairment ◽  
Arterial Hypertension ◽  
Verbal Memory ◽  
Neuropsychological Tests ◽  
Cognitive Activity ◽  
Cognitive Disorders ◽  
Main Group ◽  
Medical Rehabilitation ◽  
Brain Functions ◽  
Delayed Reproduction

Age and heredity, cardiovascular disease, especially arterial hypertension is an important risk factor for cognitive impairment. The aim of the study is to determine the features of the development and structure of cognitive impairment in patients with controlled stage II arterial hypertension using a battery of neuropsychological tests. The main group of the study consisted of 157 patients with hypertension and CI, mean age of the group was 52.3±0.68 years. After research using a battery of neuropsychological tests, data were obtained on the presence of cognitive disorders in 32.22 % of cases. According to the MoCA test in patients with hypertension there was a decrease in scores on all subscales compared to healthy, but the largest deviations (over 20% of the maximum score) were observed in the ability to serial subtraction (35.0 %), delayed reproduction (27,0 %), abstraction (by 24.0 %), in visual-constructive / executive skills (by 21.0 %). All patients with hypertension with detected CI were violations of the concentration of the excitatory process in the visual and motor analyzers. Thus, only 2 patients (1.3 %) performed tasks without errors in 5 sectors (normal), up to 4 sectors coped with counting 28 (17.8 %) patients, up to 3 sectors - 65 (41.4 %), up to 2 sector - 56 (35.7%), another 6 (3.8%) patients aged 55 to 65 years could not complete the task without errors - by method F.E. Rybakov.The level of attention and speed of sensor motor reactions was carried out according to the method of "Schulte Tables". Patients were characterized by rapid fatigue, uneven performance of the task, refusal to perform further due to fatigue and inability to concentrate. The average time of the task in patients of the main group throughout the study exceeded the data of patients in the comparison group by 1.3-1.6 times), and almost healthy individuals - 1.4-1.7 times.Patients with hypertension have disorders at different levels of higher brain functions and correspond to all areas of human cognitive activity, but the most affected are neurodynamic processes (the ability to concentrate, the speed of psychomotor reactions) and verbal memory, which affect efficiency and success in work, and this is important for medical rehabilitation and maintaining the mental health of patients.

scholarly journals Place of arterial hypertension in brain lesion development - from minor cognitive disorders to dementia

2014 ◽  
Vol 11 (1) ◽  
pp. 45-51
Author(s):  
V N Shishkova
Keyword(s):  
Cognitive Impairment ◽  
Arterial Hypertension ◽  
Primary Care Physicians ◽  
Family Doctor ◽  
Brain Lesion ◽  
Cognitive Disorders ◽  
Epidemiological Studies ◽  
Adequate Treatment ◽  
Leading Position ◽  
Somatic Diseases

He problem of cognitive impairment in patients with somatic diseases today occupies a leading position, as it represents one of the most widespread manifestations of organic brain damage. The role of arterial hypertension(AH) in the formation of cognitive impairment (CI) has been shown in large epidemiological studies. CI detected in 73% of patients of both middle and senior age with hypertension duration of more than 5 years. Early detection of potentially treatable cognitive disorders is one of the most important tasks of the modern practitioner, cardiologist, endocrinologist, family doctor, as the patients in the early stages of CI constitute the majority of people seeking help. In today's world, primary care physicians' actions are often crucial in the prediction of dementia, since the detection of early forms of non-dementia CI and timely and adequate treatment of cardiovascular disease, especially hypertension, is often enough for the severity of the CI patients was significantly decreased, and dementia never came.

When to expect cognitive disorders in hypertension

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
T Khomazyuk ◽  
V.U Krotova
Keyword(s):  
Blood Pressure ◽  
Cognitive Impairment ◽  
Arterial Hypertension ◽  
Systolic Blood Pressure ◽  
Blood Pressure Variability ◽  
Cognitive Disorders ◽  
Monitoring Data ◽  
Moderate Degree ◽  
Daily Monitoring ◽  
Systolic Blood Pressure Variability

Abstract   In large-scale clinical studies, age, arterial hypertension (AH), multi-focal atherosclerosis, and cognitive disorders (CD) are interrelated, affecting the level of disability, quality of life, and social adaptation of patients with cardiovascular diseases. Aim of the study To determine the prognostic criteria for cognitive disorders in patients with hypertension. Methods To achieve the aim of the study, the examinations were performed in 182 outpatients with AH II stage, 34–68 years, in 164 of them were CD according to neuropsychological tests of MMSE and MoCA, mostly of mild and moderate degree. The relationship between clinical data, cognitive function characteristics and daily monitoring data of hypertension were evaluated. The data obtained were analyzed using medical methods statistics. Results Among factors such as age (>60 years), gender (male / female), disease duration (>10 years), waist circumference, overweight or obesity, hypercholesterolemia, no influence on the development of CD was detected (p>0.05)). Risk factors for the development of CD in hypertension were an burdensome history of CD in closest relatives (2.79 (95% CI 1.15–6.77) relative to practically healthy individuals and 2.41 (1.01–5.88)), high vegetative index (rs +0,15; p<0,05). The correlation between CD and high rates of blood pressure variability according to daily monitoring of blood pressure in patients with hypertension, even under conditions of blood pressure control, is confirmed by the results of correlation and one-factor logit analysis. Thus, elevated levels of systolic blood pressure variability in the day and at night increased the chances of developing CD in patients with hypertension by 2.11 times, (rs = +0.57 and rs = +0.61; p<0.001). It was found that the likelihood of developing cognitive impairment exceeds 50% (high risk) if the level of systolic blood pressure variability is above 12 mm Hg in the day (area under ROC curve AUC = 0.891; 95% CI 0.883–0.940. (AUC = 0.891; 95% CI 0.883–0.940; ST = 82.5% and SP = 92.9%) and at night over 10 mm Hg (AUC = 0.922; 95% CI 0.861–0.963; ST = 82.5% and SP = 85.7%) according to daily blood pressure monitoring. Conclusion The prognosis for the development of cognitive impairment in arterial hypertension is influenced by: evidence of family CD history, autonomic nervous system index and variability of day and night blood pressure characteristics, according to ambulatory daily monitoring data. Funding Acknowledgement Type of funding source: None

Abstract P084: When To Expect And Why To Analyze Cognitive Disorders In Arterial Hypertension

Hypertension ◽  
2020 ◽  
Vol 76 (Suppl_1) ◽  
Author(s):  
Viktoriia Krotova ◽  
Tatyana Khomazyuk
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cognitive Impairment ◽  
High Risk ◽  
Arterial Hypertension ◽  
Social Activity ◽  
Life Quality ◽  
Cognitive Disorders ◽  
Daily Monitoring ◽  
Close Relatives

To study the relationship between quality of life (LQ) and cognitive impairment, as well as to identify risk factors for their development in patients with arterial hypertension (AH). Examined 509 outpatients with controlled AH stage II with SCORE risk of CVD <5 %. Non-dementia cognitive impairment were found 24,32±0,11 points on МCA scale in 164 (32.2 %). Patients also demonstrated a significant (p <0.001) decrease in the LQ indicators on all SF-36 scales compared to healthy ones by an average of 24.5-66.0 points. According to the results of correlation analysisthe most significant was the direct relationship between cognitive impairment on МCA scale and assessment of physical health (rs=+0,65; p<0,001), mental health (rs=+0,60; p<0,001), life activity limitations (rs=+0,33; p<0,001) and social activity (rs=+0,35; p<0,001), indicating an association between deterioration in LQ components and cognitive impairment.It turned out that the risk factors for developing cognitive impairment with AH were a history of cognitive impairment in close relatives (2.79 (95 % CI 1.15-6.77) compared with healthy people and 2.41 (95 % CI 1.01-5.88) - AH patients without cognitive impairment), a high vegetative index (rs +0.15; p <0.05) according to daily monitoring of BP and elevated levels of systolic BP variability in day and at night, that increased the chances of developing cognitive impairment in AH patients by 2.11 times, (rs = + 0.57 and rs = + 0.61; p<0.001). It was found that the likelihood of developing cognitive impairment exceeds 50 % (high risk) if the level of systolic BP variability is above 12 mm Hg in day (area under ROC curve AUC = 0.891; 95 % CI 0.883-0.940. (AUC = 0.891; 95 % CI 0.883-0.940; ST = 82.5 % and SP = 92.9 %) and at night – over 10 mm Hg (AUC = 0.922; 95 % CI 0.861-0.963; ST = 82.5 % and SP = 85.7 %) according to daily BP monitoring. In patients with AH for more than 10 years with dissatisfaction of life quality, even with controlled blood pressure, the presence of cognitive impairment needs to be clarified in immediate families, and pay attention to the high autonomic index and variability of systolic blood pressure monitored day and night, due to the high risk of development and progression of cognitive impairment, which worsens the prognosis of cardiovascular events.

scholarly journals Early detection of cognitive impairment in patients with hypertension and evaluation of treatment effectiveness according to EEG data

2020 ◽  
Vol 11 (2) ◽  
pp. 81-93
Author(s):  
M. V. Nikolaenko ◽  
E. A. Kizhevatova ◽  
N. V. Drobotya
Keyword(s):  
Cognitive Impairment ◽  
Arterial Hypertension ◽  
Combined Therapy ◽  
Cognitive Disorders ◽  
Quantitative Eeg ◽  
Dynamic Monitoring ◽  
Total Power ◽  
Eeg Analysis ◽  
Total Strength ◽  
Quantitative Eeg Analysis

Objective: to establish the relationship between the presence of cognitive disorders in patients with arterial hypertension and changes in EEG, to assess the dynamics of these changes against the background of various modes of cerebroprotective therapy.Materials and methods: the study involved 92 people with arterial hypertension, whose average age was 63 ± 8.2 years. The research was carried out on the device “Encephalan-EEGR-19/26”. To assess cognitive functions, patients were tested using the MoСA test. Patients with cognitive impairment were divided into three groups of dynamic monitoring with diff erent modes of cerebroprotective therapy.Results: non-specifi c patterns in the slow-wave range were registered in patients with cognitive impairment during visual EEG analysis. In the quantitative analysis of the EEG revealed changes in the frequency and amplitude of the alpha rhythm, the power variation on the basic rhythms, the reduction of the total strength of the rhythms, the increase in relative power of slow rhythms in the frontal leads to the total power of the rhythms. After the treatment, most patients showed an increase in scores on the “Montreal scale”, a decrease in anxiety and depression on the” Hospital scale”, and an increase in the SF-36 index. Quantitative EEG analysis revealed positive dynamics comparable to the clinic and test data. The most favorable EEG dynamics was registered in groups of patients receiving neuroprotective and combined therapy.Conclusions: the results obtained indicate the diagnostic value of quantitative EEG analysis and the feasibility of adding drugs that improve the metabolism and blood supply to the brain to standard antihypertensive therapy.

scholarly journals Disorders of cognitive activity in patients with multiple sclerosis and hepatocerebral degeneration and its prevention

2020 ◽  
Vol 24 (4) ◽  
pp. 589-594
Author(s):  
I. Voloshyn-Gaponov ◽  
I. Lantukh ◽  
P. Gaponov
Keyword(s):  
Multiple Sclerosis ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Functions ◽  
Verbal Memory ◽  
Cognitive Activity ◽  
Cognitive Disorders ◽  
Biological Aging ◽  
Treatment And Prevention ◽  
The Brain

Annotation. Currently, there is an increase in dementias of various origins, which is largely due to the tendency of the aging population of the globe, with adverse environmental factors. Dementia also occurs at a young, working-aged, which makes them not only a medical but also a social problem. The incidence of Alzheimer's disease (AD) is so high that the WHO has declared the 21st century the century of the AD epidemic. The task of the work is to conduct a comprehensive clinical and laboratory examination of patients with multiple sclerosis (MS) and patients with Wilson's disease (WD) to study the problem of neurodegenerative diseases. The Mini-Mental Status Exam (MMSE) scale was used to screen for cognitive function and to study the level of intellectual performance of patients. To determine verbal memory, the method was used: “memorization of 10 words”, and to study the personality and emotional sphere, the method of Derogatis SCl-90-P was used. The sample of patients with MS was 111 people, and psycho diagnostic examination of patients with WD was performed in 33 patients. Various cognitive disorders are characteristic of MS patients. The level of general intellectual productivity is in the range from normative indicators to very pronounced systemic disorders of cognitive functions. With the age of patients and the duration of the disease, the severity of these disorders increases. A comprehensive clinical and laboratory study showed that the pathogenesis and stages of development of the dementia process in patients with WD and MS coincide with those in patients with Alzheimer’s disease and depends on three groups of factors: genetic predisposition, natural (biological) aging, and endogenous and exogenous pathogenic factors. on the brain. The study concluded that in patients with WD and MS in the pathogenetic process are always involved structures that ensure the functioning of cognitive functions of the brain, which leads to the development of their defects. For the treatment and prevention of these patients, a comprehensive, pathogenetically grounded, and personalized therapy should be prescribed.

Differentiated approach to treatment of cognitive disorders associated with SARS-CoV-2 (COVID-19), taking into account comorbidity factor

2021 ◽  
pp. 18-24
Author(s):  
M. V. Putilina ◽  
N. V. Teplova ◽  
O. S. Gerasimova
Keyword(s):  
Diabetes Mellitus ◽  
Cognitive Impairment ◽  
Arterial Hypertension ◽  
Clinical Picture ◽  
Clinical Guidelines ◽  
Cognitive Disorders ◽  
Pleiotropic Effects ◽  
Comorbid Conditions ◽  
The Difference

The prevalence of cognitive impairment in COVID-19 ranges from 59 to 65 per cent. Such variability may be associated with age and comorbidity. Arterial hypertension, diabetes mellitus, atherosclerosis are the most common comorbid conditions in patients with COVID-19. The cohort of patients with hypertension and diabetes is aged 50 and over, which suggests that age is the most important reason for the difference in the clinical picture of cognitive impairment. To date, there are no clinical guidelines for the management of patients with cognitive impairment and COVID-19, which leads to the use of various drugs, often symptomatic, increasing the risk of polypharmacy. A differentiated approach to therapy should be based on the rule of using drugs with pleiotropic effects and proven effcacy, such as Duzofarm and Nimopin.

scholarly journals NCOG-68. COMPARING COGNITIVE PROFILES OF PERSONS WITH BRAIN AND NON-BRAIN METASTATIC CANCER

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii144-ii144
Author(s):  
Gabrielle Willhelm ◽  
Victor Del Bene ◽  
Stephen Aita ◽  
Meredith Gammon ◽  
Adam Gerstenecker ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Executive Functioning ◽  
Processing Speed ◽  
Verbal Memory ◽  
Neuropsychological Tests ◽  
Metastatic Cancer ◽  
Verbal Learning ◽  
Cognitive Profiles ◽  
Neuropsychological Battery ◽  
Elevated Rate

Abstract OBJECTIVE Cognitive impairment in primary cancer and brain metastatic (BM) cancer has been well-documented. However, to date, there are no neuropsychological studies comparing the cognitive profiles of people with BM and non-brain metastatic cancer (NBM). The present study addressed this gap in the literature by comparing the cognitive profiles of participants with BM and NBM. METHOD The study sample consisted of 61 BM, 40 NBM, and 37 healthy control (HC) participants. All participants completed the same neuropsychological battery, including tests of processing speed, attention, working memory, expressive language, auditory-verbal memory, and executive functioning. RESULTS Both clinical groups showed reduced processing speed, verbal learning/memory, and executive functions. BM participants performed below HC participants across all neuropsychological tests, while NBM participants performed below control participants on tests of processing speed and executive functioning. The clinical groups differed in semantic verbal fluency (NBM &gt; BM). Fifty-seven percent of BM participants had ≥ 3 impaired scores (i.e., ≤ 5th percentile), and 25% of NBM participants had the same level of cognitive impairment. CONCLUSION Over half of BM participants were cognitively impaired on at least three neuropsychological tests, and 25% of NBM participants also demonstrated this same level of cognitive impairment. In the BM group, the elevated rate of cognitive dysfunction is likely due to the greater neurologic disease burden posed by brain metastases, while in the NBM group, the cognitive deficits are possibly due to systemic illness and treatment effects.

scholarly journals Cognitive functioning in adolescents with migraine

2016 ◽  
Vol 10 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Melissa Andréia Costa-Silva ◽  
Ana Carolina de Almeida Prado ◽  
Leonardo Cruz de Souza ◽  
Rodrigo Santiago Gomez ◽  
Antônio Lúcio Teixeira
Keyword(s):  
Cognitive Impairment ◽  
Executive Function ◽  
Cognitive Deficits ◽  
Verbal Memory ◽  
Neuropsychological Tests ◽  
Cognitive Changes ◽  
History Of ◽  
Processing Information ◽  
Short And Long Term

Although migraine is highly prevalent in children and teenagers, it often goes undetected in these patients, resulting in underdiagnosis and inadequate treatment. Several studies have investigated cognitive changes in adults with migraine. However, there are few studies focusing on children and adolescents. Objective : To investigate cognitive performance of adolescents with migraine. Methods : Twenty-eight adolescents diagnosed with migraine and twenty-six individuals without a history of headache were recruited for the study. All participants were evaluated using standardized neuropsychological tests. Results : Adolescents with migraine had worse performance on tests evaluating short- and long-term verbal memory, attention, executive function, and speed of processing information than controls. Conclusion : Cognitive dysfunction is common in adolescents with migraine. Since the cognitive deficits found in adolescents with migraine are similar to those reported in adults with migraine, cognitive impairment seems to persist throughout life.

scholarly journals THRESHOLD FRACTION ANISOTROPY LEVEL AND VASCULAR DEMENTIA PREDICTION FOR SUBJECTS WITH DIAGNOSED ENCEPHALOPATHY

2019 ◽  
pp. 59-65 ◽  
Author(s):  
I. M. Levashkina ◽  
S. V. Serebryakova ◽  
O. V. Tikhomirova ◽  
E. V. Kitaigorodskaya
Keyword(s):  
Cognitive Impairment ◽  
Vascular Dementia ◽  
Neuropsychological Tests ◽  
Measurement Method ◽  
Quantitative Measurement ◽  
Diffusion Tensor ◽  
Cognitive Disorders ◽  
Internal Capsule ◽  
Diffusion Tensor Mri ◽  
Dementia Risk

As a consequence of the cerebral tracts’ damages, encephalopathy comes with cognitive disorders. Diffusion-tensor MRI is a cerebral tracts’ integrity quantitative measurement method. The main purpose of the study was to develop criteria of cerebral tracts integrity using DT-MRI to predict vascular dementia, to find threshold CFA level in liable tracts to measure dementia risk. DT-MR results were compared with neuropsychological tests of subjects with diagnosed encephalopathy. Identified statistically significant (р<0,005) FA decrease in three regions for those subjects with cognitive impairment: front sections of corona radiata, inferior longitudinal fasciculi and anterior horn of internal capsule. Threshold FA level calculated for these 3 region of interests, they can be predictors of the risk of cognitive disorders for subjects with diagnosed encephalopathy.

scholarly journals 338 - Risk factors for moderate cognitive impairment and dementia in the Kazakh and Kyrgyz populations (preliminary results)

2020 ◽  
Vol 32 (S1) ◽  
pp. 97-98
Author(s):  
Saule T. Turuspekova ◽  
B. Demesinova ◽  
Z. Rayimzhanov ◽  
R. Nurzhanova ◽  
L. Bespalova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Thyroid Gland ◽  
Angina Pectoris ◽  
Arterial Hypertension ◽  
Cognitive Disorders ◽  
Relative Number ◽  
Intermediate Stage ◽  
Cardiac Ischemia ◽  
Moderate Cognitive Impairment

The current demographic situation in Kazakhstan and Kyrgyzstan is associated with pronounced processes of population aging. Today, about two million elderly people live in Kazakhstan, which makes up more than 10% of the population, which crosses a seven percent threshold for determining the “aging” country in the world.For Kyrgyzstan, an increase in the proportion of the elderly is a new phenomenon. At the beginning of 2016, there were 965,385 people over 50 in Kyrgyzstan, which is 16% of the total population, of whom 60 and over are 7.06%. According to the average version of the forecast, the relative number of people 60 years and older will almost triple by 2050. (M. B. Denisenko, 2011, Report of a statistical study, 2017) The aging of the population is the most significant social problem of the XXI st century and is associated with the development of cognitive impairment and dementia. Moderate cognitive impairment, according to several authors are an intermediate stage between normal aging and dementia (Brodaty H., 2013, Peterson, 2009).The cause of cognitive disorders in old age can be a number of diseases, including neurodegenerative. According to projections, it is expected that neurodegenerative diseases will surpass cancer as the leading cause of death by 2040 (Walter U., 2013). The Global prevalence pattern of dementia depends on several factors, from life expectancy to the health status, last but not least from the particular environment.Purpose of the study. To study the prevalence of cognitive impairment and the main risk factors for their occurrence among people over 60 in the Kazakh and Kyrgyz populations.Materials and methods.The screening was attended by 300 respondents (150 Kazakhs and 150 Kyrgyz) aged 60 to 90 years (average age 65.6). The material was collected using the Questionnaire for the Champ Clinic and the MOCA test (cut-off point <26) based on the city polyclinics of Almaty and Bishkek.Results:moderate cognitive impairment was detected - 39.9%, mild cognitive impairment - 33.4%, normal cognitive function - 26.7% in Kazakhs. In the Kyrgyz population, a moderate cognitive impairment was identified - 48.3%; pronounced cognitive impairment - 15.4%, dementia - 8.2%. Expected risk factors for cognitive impairment: 1) in Kazakhs, arterial hypertension - 86.89%, cardiac ischemia, angina pectoris - 70.21%, pathology of the thyroid gland and pancreas (diabetes, hyperthyroidism and hypothyroidism) - 29.50%, atherosclerotic vascular diseases - 29.9%, brain injury - 18.22%, education level - 4.24%, depression - 0.6%, respectively. 2) in Kyrgyz: arterial hypertension - 49%, cardiac ischemia, angina pectoris - 13%, pathology of the thyroid gland and pancreas (diabetes, hyperthyroidism and hypothyroidism) - 21%, low level of education - 11%, Bad habits of smoking and alcohol - 25 %, 20%, respectively.Conclusions:The transformation of the demographic burden can have important implications for the social security system.We have an urgent need to continue screening the population to identify the main risk factors for moderate cognitive impairment in individuals in the Kazakh and Kyrgyz populations.

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