DERMATOLOGICAL SIDE EFFECTS OF COVID-19 VACCINATION

SummaryHydroxyurea (HU) is usually a well tolerated antineoplastic agent and is commonly used in the treatment of chronic myeloproliferative diseases. Dermatological side effects are frequently seen in patients receiving longterm HU therapy. Cutaneous ulcers have been reported occasionally.We report on four patients with cutaneous ulcers whilst on long-term hydroxyurea therapy for myeloproliferative diseases. In all patients we were able to reduce the dose, or stop HU altogether and their ulcers markedly improved. Our observations suggest that cutaneous ulcers should be considered as possible side effect of long-term HU therapy and healing of the ulcers can be achieved not only by cessation of the HU treatment, but also by reducing the dose of hydroxyurea for a limited time.

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Dermatological Side Effects of Anti-tumor Necrosis Factor Alpha Therapy

Journal of Rheumatic Diseases ◽

10.4078/jrd.2014.21.1.9 ◽

2014 ◽

Vol 21 (1) ◽

pp. 9 ◽

Cited By ~ 1

Author(s):

Seong Hun Moon ◽

Joo Yeon Ko

Keyword(s):

Side Effects ◽

Tumor Necrosis Factor ◽

Tumor Necrosis Factor Alpha ◽

Tumor Necrosis ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Dermatological Side Effects ◽

Alpha Therapy ◽

Necrosis Factor

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DRUG INDUCED DERMATOLOGICAL REACTION OF THE 100 MOST COMMONLY PRESCRIBED MEDICATIONS IN UK HOSPITALS

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2019v11i5.35703 ◽

2019 ◽

pp. 54-57

Author(s):

MOHAMMED AL-ABADIE ◽

FARIS OUMEISH ◽

MOHAMMED AL-RUBAYE ◽

DINA AL-ABADIE ◽

PATRICK ANTHONY BALL ◽

...

Keyword(s):

United Kingdom ◽

Side Effects ◽

Stevens Johnson Syndrome ◽

Drug Induced ◽

The United Kingdom ◽

Johnson Syndrome ◽

Medication Side ◽

Drug Adverse Reaction ◽

Skin Conditions ◽

Dermatological Side Effects

Objective: It is commonly reported that medicines have side effects related to dermatological practice. However, it is extremely difficult to establish how commonly, or rarely skin-related medication side effects occur. Common dermatological side effects include rash, pruritus, and photosensitivity. Objective: To demonstrate the dermatological side-effects of the most commonly prescribed medications in the United Kingdom. Methods: This paper discusses dermatological side-effects of the commonly prescribed medications, including uncommon or rare manifestations such as angioedema and Stevens - Johnson syndrome (SJS). The list used for the most frequently prescribed drugs in the United Kingdom was created by nurses. This list was compared to the British National Formulary to demonstrate the reported frequency of occurrence of dermatological side-effects or complications. Conclusion: The top 100 prescribed medication cause a number of dermatological side effects that need to be considered when they are prescribed to patients who have pre-existing skin conditions. Additionally, when confronted with a common dermatological problem in any patient, clinicians should always consider the possibility of a drug adverse reaction.

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Dermatological side effects of immunotherapy drugs and targeted cancer therapies: Importance of dermatology and oncology collaboration

Journal of Oncology Pharmacy Practice ◽

10.1177/1078155220970621 ◽

2020 ◽

pp. 107815522097062

Author(s):

Uğur Çelik ◽

Ertuğrul H Aydemir ◽

Burhan Engin ◽

Muazzez Ç Oba ◽

Mesut Yılmaz ◽

...

Keyword(s):

Side Effects ◽

Outpatient Clinic ◽

Targeted Therapies ◽

Side Effect ◽

Common Side Effect ◽

Cancer Therapies ◽

Anti Cancer ◽

Targeted Cancer Therapies ◽

Dermatological Side Effects ◽

Skin Side Effects

Introduction Novel anti-cancer drugs such as targeted cancer therapies and immune check-point inhibitors (ICIs) have adverse events, especially concerning the skin. The aim of this study is to report an overview of the commonly consulted dermatological side effects of ICIs and targeted cancer therapies in clinical practice, along with their management. Methods In this single-center study, we evaluated consecutive oncological patients who were referred from the oncology outpatient clinic to the dermatology outpatient clinic due to skin side effects of ICIs and targeted therapies. All patients were examined and treated at the same day of referral by experienced dermatologists. Patient characteristics, clinical findings, diagnostic workups and treatments were retrieved from outpatient records. Results Sixty three patients were enrolled. Most common diagnoses were lung carcinoma, melanoma and colon carcinoma. Fifty patients (79%) were using targeted therapies while 13 (21%) were using ICIs. Xerosis was the most common side effect (44%), followed by acneiform rash, paronychia, eczema and pruritus. Majority of the side effects were grade 2 and 3. Psoriasis was a common side effect of ICIs. One patient had a newly developed dysplastic nevus on vemurafenib treatment. Oncological treatment was not withheld in any of the patients. Conclusions This study revealed the most commonly consulted skin side effects of novel anti-cancer drugs and their management in daily practice. We underlie the importance of collaborative work of oncology and dermatology professionals as early management of cutaneous side effects of targeted therapies and ICIs improves patient outcomes.

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Assessment and Management of the Dermatological Side Effects of Direct-Acting Antiviral Agent Groups Used in the Treatment of Hepatitis C: A Prospective Study

Medical Bulletin of Haseki ◽

10.4274/haseki.galenos.2021.6704 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Senay Agirgol ◽

Muharrem Agirgol

Keyword(s):

Hepatitis C ◽

Side Effects ◽

Prospective Study ◽

Antiviral Agent ◽

Direct Acting Antiviral ◽

Direct Acting ◽

Dermatological Side Effects ◽

A Prospective Study

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Cytarabine ears – A side effect of cytarabine therapy

Journal of Oncology Pharmacy Practice ◽

10.1177/1078155219848800 ◽

2019 ◽

Vol 26 (2) ◽

pp. 471-473

Author(s):

Divya Doval ◽

Sanjeev Kumar Sharma ◽

Meet Kumar ◽

Vipin Khandelwal ◽

Dharma Choudhary

Keyword(s):

Side Effects ◽

Hematological Malignancies ◽

Bone Marrow Suppression ◽

Delayed Hypersensitivity ◽

Hypersensitivity Reactions ◽

Acute Leukemias ◽

Corneal Toxicity ◽

Dermatological Side Effects ◽

Dose Dependent ◽

Leukemias And Lymphomas

Cytarabine, a pyramidine analog, is used for treating various hematological malignancies such as acute leukemias and lymphomas. Side effects of cytarabine are dose dependent and include bone marrow suppression, fever, cerebellar toxicity, cardiomyopathy, hepato-renal insufficiency, necrotizing enterocolitis, pancreatitis, acute respiratory distress, corneal toxicity and dermatological side effects. The dermatological side effects can be immediate or due to delayed hypersensitivity reactions. They have been attributed largely to release of cytokines. We present three such cases of delayed hypersensitivity to cytarabine affecting the ears bilaterally.

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