STUDY OF CLINICALAND HAEMATOLOGICAL PROFILE OF ANEMIA IN GERIATRIC PATIENTS AT A TERTIARY LEVEL CENTRE IN HARYANA

2021 ◽  
pp. 17-19
Author(s):  
Priya Dalal ◽  
Atindra Narayan ◽  
Auditi Narayan ◽  
D.K. Sharma
Keyword(s):  
Chronic Disease ◽  
Elderly Patients ◽  
Social Services ◽  
Negative Impact ◽  
Health Resources ◽  
The Elderly ◽  
Differential Count ◽  
Anemia Of Chronic Disease ◽  
Haematological Profile ◽  
Rbc Indices

Background: The demographic transition with ageing of population is a global phenomenon and in recent years there has been an increasing international awareness of health issues relating to aging population. Anemia represents an emerging global health problem producing a negative impact in the quality of life among the elderly and requiring greater allocation of health resources. Aims: To identify elderly patients with anemia and study the etiology, clinical parameters, laboratory parameters in these patients. Methods: A total of 100 patients were enrolled in this study. The entire medical history were obtained from each of the cases including previous medical reports and imaging studies. Complete blood counts , RBC indices,total WBC count, differential count, platelet count, haematocrit, ESR, peripheral smears ,reticulocyte count, ferritin, iron and TIBC were recorded for each patient. The data was compiled and analyzed using Statistical Package for social services (SPSS vs 20). Results: Among the etiologies, iron deciency anemia was seen in 43% of patients, anemia of chronic disease in 32%, anemia of chronic kidney disease and unexplained anemia in 11 % patients. Among clinical features the commonest symptom was easy fatiguability and commonest sign was pallor. Peripheral smear study showed that normocytic normochromic anemia was commonest type. Conclusion: This study showed that the commonest cause for anemia among elderly patients is iron deciency anemia followed by anemia due to chronic disease. Geriatric anemia is a disease that often goes unreported hence every effort should be made to identify the disease and evaluate the cause.

scholarly journals The Elderly Spiritual Description with Chronic Disease in Elderly and Children Social Services Centres of Binjai and Medan

2020 ◽  
Vol 2 (2) ◽  
pp. 53-58
Author(s):  
Adelina Sembiring ◽  
Martaulina Sinaga ◽  
Lisbeth Gurning
Keyword(s):  
Chronic Disease ◽  
Chronic Diseases ◽  
Social Services ◽  
Health Workers ◽  
Descriptive Analysis ◽  
The Elderly ◽  
Health Condition ◽  
Spiritual Needs ◽  
Service Unit ◽  
Natural Beauty

At this time many elderly suffer from chronic diseases so that their spiritual needs need attention. This study aims to determine the spiritual description of the elderly who suffer from chronic diseases in the Social Service Unit for the Elderly Children under five in Binjai and Medan areas. The research design used was descriptive with a sample size of 64 people with purposive sampling method. The instrument used was a questionnaire prepared using a Likert scale. This research was conducted on 28 November to 19 December 2014. The characteristics of the respondents and the spiritual description of the elderly who suffer from chronic diseases are described by descriptive analysis to determine the frequency and percentage. The results showed, the characteristics of male respondents were 51.6%, aged 60-70 years 57.8%, Islam 95.3%, not going to school 59.4% Spiritual description of the elderly who suffer from chronic disease is quite good (56 people, 87.5%), the elderly who say good (8 people, 12.5%). To be able to undergo a declining health condition due to diseases suffered by the elderly, it is hoped that all parties, both families, health workers understand the spiritual needs of the elderly so that the elderly can accept their conditions, socialize with those around them, enjoy the natural beauty of their surroundings, and believe that God will give strength in living his condition.

Ciprofloxacin in Elderly Patients with Underlying Chronic Diseases

1988 ◽  
Vol 16 (5) ◽  
pp. 386-393 ◽  
Author(s):  
W. Bianchi ◽  
F. Maggiolo ◽  
H. Ohnmeiss
Keyword(s):  
Chronic Disease ◽  
Side Effects ◽  
Elderly Patients ◽  
Chronic Diseases ◽  
Age Groups ◽  
The Elderly ◽  
Clinical Failure ◽  
Clinical Resolution ◽  
High Incidence ◽  
Resistance To Infection

Age is not as important in predisposing to infections as are the associated problems peculiar to certain age groups. Factors such as the advanced age of the patients combined with the presence of chronic disease reduce their resistance to infection. This study comprises 212 elderly patients (aged 65–98 years) who were treated with 500–1000 mg/day ciprofloxacin for 1–18 days. Despite the high incidence of associated chronic diseases, microbiology showed that infections were eradicated in 88.5%. Clinical resolution occurred in 75.5% of patients and clinical failure occurred in 6.1%. Treatment was well tolerated, with clinical side-effects reported in only seven patients. Ciprofloxacin may be considered an effective and safe antimicrobial agent for the treatment of infections in the elderly.

scholarly journals Emphasizing the Nurse Practitioner Role in Addressing Unique Challenges Associated with Benzodiazepine use among the Elderly

2021 ◽  
Vol 1 (1) ◽  
pp. 37-46
Author(s):  
Jennifer Lynn Fournier ◽  
Robyn Gorham
Keyword(s):  
Elderly Patients ◽  
Nurse Practitioners ◽  
Nurse Practitioner ◽  
Patient Population ◽  
Negative Impact ◽  
The Elderly ◽  
Monitoring Therapy ◽  
Benzodiazepine Use ◽  
The Continuum

Aim: The aim of this paper is to discuss the use of benzodiazepine medications among the elderly, and the role of a nurse practitioner within this patient population.  Background: Benzodiazepines are well known to have a negative impact on the mobility of elderly patients and to contribute to increased falls. These medications also have an impact on elderly patients’ ability to perform activities of daily living and to drive. Nurse practitioners offer holistic care to elderly patients. This includes prescribing medications, monitoring therapy, deprescribing medications and identifying opportunities for safe alternatives to treat a variety of conditions. Methods: This paper presents a narrative review focused on the effect of benzodiazepine medications on the elderly patient population, with an emphasis on the use of benzodiazepines in insomnia.  Conclusions: Findings of this review confirm the known risks associated with the use of benzodiazepines in the elderly and that these medications should be carefully considered in ongoing management.  The conclusions of this review support the use of nurse practitioners in the enhancement of the healthcare of the elderly through the continuum of assessment, monitoring, deprescribing of benzodiazepine medications when appropriate, as well as opportunities to implement alternative treatments.

Competing Influences of Genetic and Leukaemia-Specific Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the NCRN AML14 and 15 Trials.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 835-835
Author(s):  
Claire H. Seedhouse ◽  
Martin Grundy ◽  
Paul White ◽  
Yun Li ◽  
Janet Fisher ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Protein Expression ◽  
Cell Biology ◽  
Genetic Factors ◽  
Negative Impact ◽  
Rflp Analysis ◽  
The Elderly ◽  
P Glycoprotein ◽  
Specific Factors ◽  
And Function

Abstract Background. P-glycoprotein (pgp), expressed on acute myeloid leukaemia (AML) blasts, is associated with failure to respond to chemotherapy in AML. This study aimed to determine whether expression and function of pgp may be linked to polymorphisms of the encoding gene (MDR1, also known as ABCB1) and whether leukaemia-specific changes in cell biology may override genetic factors in predicting pgp expression. G1199A, G2677T and C3435T polymorphisms in MDR1 (RFLP analysis) as well as pgp protein expression (using MRK-16) and function (modulation of R123 accumulation by PSC 833) were studied in leukaemic blast samples from 817 patients with AML entered into the NCRN AML14 and AML15 clinical trials. Age, low white blood cell count (WBC), high bcl2, secondary AML and MDS and adverse cytogenetics all correlated with high pgp expression. However, ABCB1 3435TT homozygosity had a negative impact on pgp. Overall, pgp expression was high in 41% of the cohort, but in elderly patients high pgp expression was found in 54% with the 3435C allele versus 32% in the 3435TT group (P=0.009). This is similar to the frequency of pgp in younger patients (34%) and indicates that the 3435TT polymorphism affects pgp expression in elderly patients by preventing the upregulation of pgp protein normally seen in this group. No association was found between genetic factors and pgp function. In a subset of 341 patients, pgp protein levels were analysed on a quantitative scale in relation to C3435T and G2677T gene polymorphisms. The lowest protein expression occurred in the variant TT group for both polymorphisms. Differences were even more marked in the elderly subset (using Mann-Whitney test, P = 0.003 and 0.002 respectively). Linkage disequilibrium occurs between positions 2677 and 3435, and there was a highly significant association between the haplotype and pgp protein expression (P=0.001). ABCB1 mRNA was also measured in 81 patients and was found to be high in patients with the G1199A allele (median expression 0.36 ABCB1/b2M ratio v 0.06 in the GG group, P=0.04), suggesting that the 1199A polymorphism affects ABCB1. However no further correlations were found between the 1199A polymorphism and pgp protein or function. The association between pgp and a low white WBC, (P<0.001) was further examined by cell cycle analysis in 40 patients confirming that pgp is associated with a low proportion of cycling cells - median % cycling cells: pgp negative/low 4.0%, pgp intermediate/high 1.0% (P=0.02). Conclusions. We conclude that there is an extended MDR phenotype of indolent, pgp positive, bcl2-high cells in AML, particularly in the elderly, and that pgp is affected by an interaction between genetic factors and acquired, leukaemia-specific factors.

scholarly journals Anemia of Aging: A Model of Erythropoiesis in Cancer Patients

1998 ◽  
Vol 5 (2_suppl) ◽  
pp. 17-21 ◽  
Author(s):  
Lodovico Balducci ◽  
Cheryl L. Hardy
Keyword(s):  
Chronic Disease ◽  
Cancer Patients ◽  
The Elderly ◽  
Comorbid Conditions ◽  
Older Patient ◽  
Anemia Of Chronic Disease

Anemia produces deleterious effects in the older patient with cancer and corresponds with an increasing prevalence of comorbid conditions. Erythropoietin can improve anemia of chronic disease, the most common form of anemia in the elderly.

scholarly journals Frailty in Acute and Chronic Coronary Syndrome Patients Entering Cardiac Rehabilitation

2021 ◽  
Vol 10 (8) ◽  
pp. 1696
Author(s):  
Francesco Giallauria ◽  
Anna Di Lorenzo ◽  
Elio Venturini ◽  
Mario Pacileo ◽  
Antonello D’Andrea ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Cardiac Rehabilitation ◽  
Frail Elderly ◽  
Negative Impact ◽  
Standard Of Care ◽  
The Elderly ◽  
Cognitive Status ◽  
Thrombotic Risk ◽  
Coronary Syndrome ◽  
Negative Effect

Worldwide population ageing is partly due to advanced standard of care, leading to increased incidence and prevalence of geriatric syndromes such as frailty and disability. Hence, the age at the onset of acute coronary syndromes (ACS) keeps growing as well. Moreover, ageing is a risk factor for both frailty and cardiovascular disease (CVD). Frailty and CVD in the elderly share pathophysiological mechanisms and associated conditions, such as malnutrition, sarcopenia, anemia, polypharmacy and both increased bleeding/thrombotic risk, leading to a negative impact on outcomes. In geriatric populations ACS is associated with an increased frailty degree that has a negative effect on re-hospitalization and mortality outcomes. Frail elderly patients are increasingly referred to cardiac rehabilitation (CR) programs after ACS; however, plans of care must be tailored on individual’s clinical complexity in terms of functional capacity, nutritional status and comorbidities, cognitive status, socio-economic support. Completing rehabilitative intervention with a reduced frailty degree, disability prevention, improvement in functional state and quality of life and reduction of re-hospitalization are the goals of CR program. Tools for detecting frailty and guidelines for management of frail elderly patients post-ACS are still debated. This review focused on the need of an early identification of frail patients in elderly with ACS and at elaborating personalized plans of care and secondary prevention in CR setting.

scholarly journals Serum prohepcidin and other iron metabolism parameters in elderly patients with anemia of chronic disease and with iron deficiency anemia

2013 ◽  
Vol 123 (3) ◽  
pp. 105-111
Author(s):  
Justyna Przybyszewska ◽  
Ewa Żekanowska ◽  
Kornelia Kędziora‑Kornatowska ◽  
Joanna Boinska ◽  
Roman Cichon ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Elderly Patients ◽  
Iron Deficiency Anemia ◽  
Iron Metabolism ◽  
Deficiency Anemia ◽  
Anemia Of Chronic Disease

scholarly journals Analysis of Clinical Parameters, Drug Consumption and Use of Health Resources in a Southern European Population with Alcohol Abuse Disorder During COVID-19 Pandemic

2021 ◽  
Author(s):  
Ana Lear-Claveras ◽  
Beatriz González-Álvarez ◽  
Sabela Couso-Varela ◽  
Ana Clavería ◽  
Bárbara Oliván-Blázquez
Keyword(s):  
Blood Pressure ◽  
Alcohol Abuse ◽  
Social Services ◽  
Negative Impact ◽  
Health Resources ◽  
European Population ◽  
T Test ◽  
Addictive Disorders ◽  
Specialized Care ◽  
The Impact

The disruption in healthcare attention to people with alcohol dependence, along with psychological decompensation consequence of lockdown derived from COVID-19 pandemic, could have a negative impact on people who suffers from alcohol abuse disorder. Retrospective observational study of 9,966 men aged ˃16 years registered as having diagnosis of alcohol abuse disorder in the electronic medical records (EMR) of the Aragon Regional Health Service (Spain). Of those who were not infected during the study period (9,576), clinical (Glutamate-oxaloacetate -GOT-, Glutamate pyruvate -GPT-, creatinine, glomerular filtration, systolic blood pressure -SBP-, diastolic blood pressure -DBP-, total cholesterol, LDL, HDL, triglycerides, and body mass index -BMI-), pharmacological (dose per inhabitant per day -DHD- of drugs used in addictive disorders, benzodiazepines and antidepressants) and health resource use variables (primary and specialized care) were considered. Student´s T-test for matched samples was performed. After carrying out the Levene´s test, the Student´s T-test was used to analyze the changes in clinical variables between alcohol abuse disorder patients with and without COVID-19. Only creatinine and LDL show a significant but clinically irrelevant changes just after and 6 months after the end of strict lockdown. The total number of DHDs for all drugs included in the study (except for Benzodiazepines), decreased. In the same way, the use of health services by these patients also decreased. The impact of COVID-19 among this group of patients has been moderate. The reorganization of health and social services after the declaration of the state of alarm in our country, made possible the maintenance of care for this vulnerable patients.

scholarly journals Telemonitoring is Acceptable Amongst Community Dwelling Older Australians with Chronic Conditions: A Literature Review

2020 ◽  
Vol 1 (1) ◽  
pp. 13-18
Author(s):  
Yuana Dwi Agustin
Keyword(s):  
Chronic Disease ◽  
Literature Review ◽  
Elderly Patients ◽  
Chronic Conditions ◽  
Journal Article ◽  
The Elderly ◽  
Community Dwelling ◽  
Health Conditions ◽  
The World ◽  
Computerized System

Introduction: Chronic disease is a serious health problem and the leading cause of death in the world. In 2008, chronic disease caused the death of 36 million people worldwide, or the equivalent of 36% of the world's deaths. Chronic conditions accounted for about 9 out of every 10 deaths in Australia in 2015. Method: This study used pretest and posttest methods for telemonitoring intervention in the elderly with chronic conditions. The method of using telemonitoring was explained by the researcher before the research was carried out, this is evident by 20 respondents out of 21 respondents who stated that the explanation of computer use was easy to understand, and more than half of the respondents stated that the computerized system in telemonitoring was easy to use. Result: The results of the research in this journal article explain that more than half of the research respondents would recommend using telemonitoring every day to their family and friends. This proves that the use of telemonitoring can be accepted by the elderly in Australia. Conclusion: chronic disease conditions experienced by the elderly can be prevented by using telemonitoring which can help evaluate the health conditions of the elderly without having home visits, because nurses will know the condition of the elderly/patients who are at home every day.

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