STUDY OF MICROALBUMINURIA IN PATIENTS WITH NORMOGLYCEMIC HYPERTENSION

2021 ◽  
pp. 68-70
Author(s):  
Ketan Prajapati ◽  
Sanket Makwana ◽  
M. J. Sonagara
Keyword(s):  
Body Mass Index ◽  
Essential Hypertension ◽  
Body Mass ◽  
Independent Predictor ◽  
Blood Pressure Measurement ◽  
Cardiovascular Morbidity ◽  
Morbidity And Mortality ◽  
Hypertensive Patients ◽  
Arterial Blood ◽  
Cardiovascular Morbidity And Mortality

INTRODUCTION:Hypertension is one of the most important risk factors for cardiovascular disease. The incidence of microalbuminuria is more common among hypertensive patients, even in nondiabetic patients. Microalbuminuria is an independent predictor of cardiovascular morbidity and mortality in patients with essential hypertension. Therefore, current guidelines recommend routine screening of microalbuminuria in hypertensive patients to ensure appropriate interventions are initiated early in the disease process before progression to chronic kidney disease and/or renal failure. AIMS & OBJECTIVES:This study is done to estimate the prevalence of microalbuminuria in patients with normoglycemic hypertension and to identify other variables associated with it. MATERIAL & METHODS:In this study, we randomly selected 100 patients with essential hypertension based on inclusion and exclusion criteria. CBC, renal function test, 24-hour urine albumin excretion (UAE), Body mass index (BMI), and arterial blood pressure measurement were done among all selected patients. Data entry was done in Microsoft Ofce Excel and analysis was done using the software package Epi Info (Version 7.1.5) from CDC, Atlanta, U.S.A. OBSERVATIONS & RESULTS: The study was conducted among 100 hypertensive patients out of which 74 were male and 24 were female. Out of 100 patients, microalbuminuria was present in 44 patients. Mean arterial pressure was found high among patients with microalbuminuria than patients without microalbuminuria. The presence of microalbumin in urine was found to increase with the increasing severity of hypertension. Mean body mass index and serum creatinine were found higher in the microalbuminuric group than the normoalbuminuric group. CONCLUSION:The incidence of microalbuminuria is more common among hypertensive patients, even in nondiabetic patients. The presence of microalbuminuria is an independent predictor of cardiovascular morbidity and mortality in patients with essential hypertension. Screening for microalbuminuria is a relatively simple process, should facilitate early vascular disease detection.

Abstract P128: The Epigenomic Signature of Life's Simple 7

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Niranjan Gowda ◽  
Marguerite R Irvin ◽  
Bertha A Hidalgo ◽  
Hemant K Tiwari ◽  
Devin M Absher ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Dna Methylation ◽  
Body Mass ◽  
Mixed Models ◽  
Fixed Effects ◽  
Random Effect ◽  
Cardiovascular Morbidity ◽  
Morbidity And Mortality ◽  
Chronological Age ◽  
Cardiovascular Morbidity And Mortality

Introduction: Life’s Simple 7 (LS7) comprises seven health factors and behaviors promoted by the American Heart Association to reduce cardiovascular morbidity and mortality. Despite compelling evidence of inverse association between LS7 adherence and a variety of adverse health outcomes, the epigenetic sequelae of healthy lifestyle have not been comprehensively characterized and may offer valuable insights into the underlying biological mechanisms. Hypothesis: We hypothesized that LS7 adherence is associated with an epigenetic signature that is consistent with the deceleration of the aging process. Methods: Using data from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN, n=853), we have estimated cross-sectional associations between epigenome-wide DNA methylation at 487,432 cytosine-phosphate-guanine (CpG) sites in CD4+ T-cells and the number of achieved LS7 goals as measured by study staff (blood pressure, body mass index, total cholesterol, and fasting glucose) or reported by the participant (diet, smoking, physical activity). The associations were tested using linear mixed models adjusted for age, sex, study site, technical artifacts (fixed effects), and family relatedness (random effect). Additionally, we tested associations between LS7 compliance and age acceleration, estimated from DNA methylation data and chronological age using two complementary validated algorithms (1: Horvath and 2: Hannum). These linear mixed models adjusted for chronological age, sex, study site, CD4+ T-cell subtype estimates (fixed effects), and family relatedness (random effect). Epigenome-wide association results were considered statistically significant if they fell under the Bonferroni corrected threshold (alpha=0.05/487,432= 1.03x10 -7 ). Results: Methylation of an intronic CpG site in CPT1A , cg00574958, was positively associated with the number of achieved LS7 goals at the epigenome-wide significance level (beta= 0.008, SE= 0.001, P= 4.7x10 -8 ). CPT1A encodes a key enzyme in the beta-oxidation process and has previously been linked to fasting triglycerides, body mass index, and adiponectin levels. Age acceleration was associated with LS7 adherence under the Hannum algorithm (beta=-0.01, SE= 0.006, P= 0.02) but not the Horvath algorithm (beta=-0.005, SE= 0.004, P= 0.18). Conclusions: Achievement of LS7 goals was significantly associated with methylation variation in CPT1A , a critical lipid metabolism gene, and was associated with age deceleration in the Hannum but not the Horvath models. Following independent replication, future studies should consider interrogating CPT1A methylation in relation to cardiovascular morbidity and mortality in a prospective setting.

scholarly journals CORRELATION BETWEEN BODY MASS INDEX AND MICROALBUMINURIA IN ESSENTIAL HYPERTENSIVE ADULTS

2020 ◽  
pp. 54-56
Author(s):  
IRENGBAM SUSUPRIYA DEVI ◽  
GLADYS RAI ◽  
V. P. S PUNIA ◽  
MANOJ KUMAR NANDKEOLIAR
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Early Morning ◽  
Mean Value ◽  
Control Group ◽  
Inclusion Criteria ◽  
Hypertensive Patients ◽  
Positive Correlation ◽  
Arterial Blood ◽  
The Mean

Objective: This study aimed to find the correlation between body mass index (BMI) and microalbuminuria (MA) in essential hypertensive adults. Methods: This study included 35 essential hypertensive patients in the 18–65 years of age group, who satisfied the inclusion criteria. Arterial blood pressure was measured by a sphygmomanometer and the first voided early morning urine sample was collected for the estimation of microalbumin. Results: The mean age of the population studied was 49±11.08 in essential hypertensive patients and 46.89±11.10 in the control group. The mean value of BMI in the hypertensive group was found to be 27.59±5.45. In the present study, the mean value of microalbumin in essential hypertensive patients was 20.95±16.96. A significant positive correlation between BMI and MA was observed in the study with p<0.001. Conclusion: Our study shows a positive correlation between BMI and MA. Therefore, this study will help in the early detection of renal injury and prevents its progression to renal failure by lifestyle and diet modifications.

scholarly journals Electrocardiographic Strain Pattern and Prediction of Cardiovascular Morbidity and Mortality in Hypertensive Patients

Hypertension ◽  
2004 ◽  
Vol 44 (1) ◽  
pp. 48-54 ◽  
Author(s):  
Peter M. Okin ◽  
Richard B. Devereux ◽  
Markku S. Nieminen ◽  
Sverker Jern ◽  
Lasse Oikarinen ◽  
...  
Keyword(s):  
Cardiovascular Morbidity ◽  
Morbidity And Mortality ◽  
Hypertensive Patients ◽  
Strain Pattern ◽  
Cardiovascular Morbidity And Mortality

scholarly journals Comparison Between Valsartan and Amlodipine Regarding Cardiovascular Morbidity and Mortality in Hypertensive Patients With Glucose Intolerance

Hypertension ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 580-586 ◽  
Author(s):  
Takashi Muramatsu ◽  
Kunihiro Matsushita ◽  
Kentaro Yamashita ◽  
Takahisa Kondo ◽  
Kengo Maeda ◽  
...  
Keyword(s):  
Glucose Intolerance ◽  
Cardiovascular Morbidity ◽  
Morbidity And Mortality ◽  
Hypertensive Patients ◽  
Cardiovascular Morbidity And Mortality

Cardiovascular Morbidity and Mortality and Left Ventricular Geometric Patterns in Hypertensive Patients Treated in Primary Care

2009 ◽  
Vol 62 (3) ◽  
pp. 246-254
Author(s):  
Francisco J. Tovillas-Morán ◽  
Edurne Zabaleta-del-Olmo ◽  
Antoni Dalfó-Baqué ◽  
Miguel Vilaplana-Cosculluela ◽  
Josep M. Galcerán ◽  
...  
Keyword(s):  
Primary Care ◽  
Left Ventricular ◽  
Cardiovascular Morbidity ◽  
Morbidity And Mortality ◽  
Hypertensive Patients ◽  
Geometric Patterns ◽  
Cardiovascular Morbidity And Mortality

scholarly journals Prevalence of Hyperuricemia and its Association with Sociodemography among Hypertensive Patients at Birat Medical College Teaching Hospital

2021 ◽  
Vol 6 (1) ◽  
pp. 1388-1391
Author(s):  
Ram Kumar Mehta ◽  
Ram L Mallick ◽  
Surya Parajuli ◽  
Rajneesh Jha
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Teaching Hospital ◽  
Serum Uric Acid Level ◽  
College Teaching ◽  
Cardiovascular Morbidity ◽  
Morbidity And Mortality ◽  
Hypertensive Patients ◽  
Medical College ◽  
Cardiovascular Morbidity And Mortality

Introduction: Hypertension is the most common cardiovascular diseases. In only 5-10 % of hypertensive patients, underlying cause can be identified (secondary hypertension). Serum uric acid is thought to play a pathogenic role in development of hypertension and is also a commonly associated condition in patients with hypertension. Management of hyperuricemia will ultimately help in reducing cardiovascular morbidity and mortality. Objectives: To determine the prevalence of hyperuricemia among hypertensive patients atiending Birat Medical College Teaching Hospital and also to find association between hyperuricemia and socio-demographic variables. Methodology: This was a descriptive hospital based cross-sectional study conducted in 168 hypertensive patients at Birat Medical College Teaching Hospital, Nepal for a period of 6 months from 1 September 2020 to 28th February 2021. Sociodemographic variables were recorded and serum uric acid level was obtained based on the pre-structured questionnaires. Data were analyzed by Statistical Package for the Social Sciences version 20 (SPSS 20). Result: Prevalence of hyperuricemia was 42 (25%) among hypertensive patients with more prevalent in male 33 (30.8%) than female 9 (14.8%). Hyperuricemia was more prevalent in patients having higher BMI and patients aged more than 60 years i.e. 38 (34.5%) and 25 (41.7%) respectively. It was more prevalent among patients with hypertension for more than 15 years 10 (41.7%) and non-vegetarian 33 (25.8%). Hyperuricemia was significantly associated with those aged more than 60 years (p=0.002) and BMI >25 kg/m2 (p=0.002). Conclusion: Hyperuricemia was common associated condition among hypertensive patients. Hyperuricemia is mainly associated with male gender, non-vegetarian and patients with longer duration of hypertension. Similarly, it was strongly associated with older age and patients having higher BMI. Monitoring of serum uric acid and management of hyperuricemia might be helpful in management of hypertension and thus decreasing cardiovascular morbidity and mortality. 

Sign in / Sign up

Export Citation Format

Share Document