scholarly journals THE EFFECTIVENESS OF IMMUNOVAC VP-4 FOR IMMUNOLOGICAL PARAMETERS IN FREQUENTLY AND LONG-TERM ILL CHILDREN

2019 ◽  
Vol 1 (1) ◽  
pp. 104-110 ◽  
Author(s):  
E. P. Foshina ◽  
T. A. Serova ◽  
I. B. Bisheva ◽  
O. V. Slatinova
Keyword(s):  
Respiratory Tract ◽  
Upper Respiratory Tract ◽  
Immunological Parameters ◽  
Local Synthesis ◽  
Specific Antibodies ◽  
Mucous Membranes ◽  
Nasal Secretions ◽  
Upper Respiratory ◽  
High Level

Aim.To study the level of specific antibodies of different isotypes to the antigens of Staphylococcus aureus and Klebsiella рneumoniae in the serum, saliva and nazal secret and the concentration of IgA,sIgA,IgG in saliva from frequently and long-term ill children in nasal-oral administration of Immunovac VP-4.Materials and methods.Specific antibodies to S. aureus and K.pneumoniae, contained in saliva, nasal, and serum were determined by the method of enzyme immunoassay. Concentrations of immunoglobulins of classes G, A and sА in saliva were determined by radial immunodiffusion using a commercial kit produced by the NPC «Medical immunology».Results. The high level of specific antibodies contained in the serum and nasal secretions, the level of antibodies in saliva is negligible. The serum is dominated by IgG-isotype antibodies, saliva and nasal secret — antibodies of IgA-isotope. After the introduction of Immunovac VP-4 there was a statistically significant increase in the level of specific antibacterial antibodies in serum, saliva and nasal secret, and increasing levels of IgG and sIgA in saliva.Conclusion. Obtained data demonstratet that the nasal-oral scheme of administration of Immunovac VP-4 frequently and long-term ill children allowed to increase the level of specific antibodies in serum, saliva and nasal secret to bacterial antigens that are part of the vaccine and to normalize the local synthesis of IgG and sIgA, which play a major role in the protection of the respiratory tract and mucous membranes of the upper respiratory tract.

Effect of sulfur baths on the upper respiratory tract and hearing organ

1927 ◽  
Vol 23 (8) ◽  
pp. 856-856
Author(s):  
N. Bobrovsky
Keyword(s):  
Respiratory Tract ◽  
Upper Respiratory Tract ◽  
Upper Airways ◽  
Hearing Organ ◽  
Upper Respiratory

The question of the effect of H2S on the mucosa of the upper respiratory tract and the hearing organ is currently not yet sufficiently developed. Observations of Dr. Mogilnitsky on patients with sulfur baths suggest that H2S acts directly on the mucosa of the upper airways, causing its hyperaemia, increased secretion and reduction of atrophic phenomena; long-term action of H2S, on the contrary, increases atrophic phenomena.

scholarly journals THE STATE OF SKIN AND MUCOSAL MICROBIOTES IN WORKERS AS AN ADAPTATION CRITERION TO OCCUPATIONAL FACTORS (BASED ON THE OIL EXTRACTION INDUSTRY)

2019 ◽  
Vol 98 (9) ◽  
pp. 1015-1020
Author(s):  
G. G. Gimranova ◽  
Lyaylya M. Masyagutova ◽  
L. G. Gizatullina
Keyword(s):  
Respiratory Tract ◽  
Working Conditions ◽  
Oil Production ◽  
Oil Extraction ◽  
Upper Respiratory Tract ◽  
Occupational Factors ◽  
Mucous Membranes ◽  
Number Of Microorganisms ◽  
Deep Layers ◽  
Upper Respiratory

Introduction. The working conditions of workers in oil-producing industries do not exclude the negative impact of a harmful biological factor of the working environment. The combined effect of harmful and dangerous factors (noise, vibration, a complex of chemicals of varying intensity), adverse climatic and geographical conditions in the process of oil production lead to violations of the structural and functional state of the body and increase the risk of disease caused by opportunistic microorganisms. Material and methods. To study the effect of working conditions of workers engaged in oil extraction on the qualitative and quantitative composition of the microorganism, an investigation of skin microbiota and microbiocenosis of the upper respiratory tract mucosa was carried out. Using the method of skin prints from the inner surface of the forearm on a plate with blood agar allowed, along with the total number of microorganisms, to determine the presence of hemolytic forms on the surface and in deep layers of the skin of oil workers. Estimate the influence of working conditions on the microbiocenosis of the upper respiratory tract and mucosal anti-infective resistance of the mucous membrane analyzed the species composition of the microbiota of the nasal mucosa and pharynx in workers, directly and indirectly engaged in oil production. Results. Studies show in workers directly involved in oil extraction, the number of microorganisms of the skin is significantly higher than that of healthy people in average by 2.0-3.6 times on the surface and 1.7-3.7 times in the deep layers. For machinists, these differences achieve 2.5-4.0 and 1.2-4.0 times, respectively, and for engineering and technical workers, 1.4-2.3 on the skin surface and 1.2-2.5 in the deep layers. For drillers, drillers’ assistants, operators, the presence of conditionally pathogenic microorganisms of 3-5 or more components on the nasal and pharyngeal polymicrobial associations is typical, and for engineers, engineers and technicians from 2-4, less often 5 components. Conclusion. The impact of occupational factors affecting workers in the process of oil extraction, contributes to the development of microbiocenosis lesions of the skin and mucous membranes. On the surface of the skin and mucous membranes of the upper respiratory tract there are a wide variety and specific structure of the microflora, specific to each of the studied groups in the workers examined.

scholarly journals Assessment of Postvaccine Immunity against Streptococcus pneumoniae in Patients with Asplenia, including an Analysis of Its Impact on Bacterial Flora of the Upper Respiratory Tract and Incidence of Infections

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Alina Olender ◽  
Katarzyna Małkińska ◽  
Jacek Roliński ◽  
Ewelina Grywalska ◽  
Elżbieta Pels ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Bacterial Flora ◽  
Carrier State ◽  
Control Group ◽  
Pathogenic Microorganisms ◽  
Upper Respiratory Tract ◽  
Specific Antibodies ◽  
Positive Effects ◽  
Upper Respiratory ◽  
Potentially Pathogenic Microorganisms

S. pneumoniae is a microorganism that may cause a serious threat in postsplenectomy patients due to a potentially invasive course of infection. In order to assess a protective activity after vaccination with the 23-valent vaccine, we made an analysis of the level of antibodies in patients with asplenia compared to a control group of healthy donors. Additionally, colonization by potentially pathogenic microorganisms of the upper respiratory tract was analyzed to determine the carrier state by strains with vaccine serotype. No such strains were found in the research, yet three non-vaccine-serotype strains were found. Colonization of the upper respiratory tract by potentially pathogenic microorganisms may be connected with increased susceptibility observed and incidence of infections in patients with asplenia. However, colonization by S. pneumoniae may not have an effect on the level of specific antibodies with the 23-valent vaccine against S. pneumoniae (PPV23) in postsplenectomy patients and healthy people. The response to vaccination against S. pneumoniae showed a lower level of specific antibodies in patients with splenectomy performed more than 2 years before the test than in patients with a recently removed spleen, i.e., from 1 month to 2 years before the test. Vaccination against pneumococci also has positive effects on incidence of other etiology infections, which is of high significance in the prophylaxis of infectious diseases in this group of patients.

scholarly journals Case Report: Infection With SARS-CoV-2 in the Presence of High Levels of Vaccine-Induced Neutralizing Antibody Responses

2021 ◽  
Vol 8 ◽  
Author(s):  
Bianca Schulte ◽  
Benjamin Marx ◽  
Marek Korencak ◽  
Dorian Emmert ◽  
Souhaib Aldabbagh ◽  
...  
Keyword(s):  
Case Report ◽  
Respiratory Tract ◽  
Neutralizing Antibody ◽  
Antibody Responses ◽  
Upper Respiratory Tract ◽  
Protective Measures ◽  
Specific Antibodies ◽  
Household Members ◽  
Upper Respiratory

We present a case of SARS-CoV-2 B.1. 525 infection in a healthcare worker despite the presence of highly neutralizing, multivariant-specific antibodies 7 weeks after full vaccination with the mRNA vaccine BNT162b2. We show that the virus replicated to high levels in the upper respiratory tract over the course of several days in the presence of strong antibody responses. The virus was readily propagatable in vitro, demonstrating the potential to transmit to others, bolstered by the fact that several household members were equally infected. This highlights the importance of protective measures even in vaccinated individuals.

scholarly journals INFLUENCE OF LACTOBACILLUS SPP. ON COLONIZATION AND ANTI-INFECTIOUS RESISTANCE OF THE MUCOUS MEMBRANES OF THE UPPER RESPIRATORY TRACT

2017 ◽  
Author(s):  
S. V. Kalinichenko ◽  
O. O. Korotkykh ◽  
S. I. Pokhil ◽  
M. G. Bakumenko
Keyword(s):  
Staphylococcus Aureus ◽  
Respiratory Tract ◽  
Immunoglobulin A ◽  
Secretory Immunoglobulin A ◽  
Upper Respiratory Tract ◽  
Colonization Resistance ◽  
Mucous Membranes ◽  
Upper Respiratory ◽  
Lactobacillus Spp ◽  
Secretory Immunoglobulin

Background. Lactobacilli are very important for the formation of colonization resistance and have pronounced antagonistic effect against a wide range of microorganisms. That is why the lactobacilli have extensive use as a component of classic probiotic agents that are widely used to prevent and treat dysbiotic conditions of digestive and genital systems of people.Objective. The aim of the research was to study the effect of lactobacilli on anti-infectious resistance of mucous membranes of upper respiratory tract.Methods. The colonization degree (lg CFU / g) of nasal mucosal membranes by Lactobacillus spp. and S. aureus was determined in all carriers before the experiment. Also, the level of lysozyme and secretory immunoglobulin A (sIgA) in nasal secretions cavities was identified.Results. It was established a clear dysfunction of anti-infectious resistance in carriers of Staphylococcus aureus - a decrease of colonization resistance and local immunity of mucous membranes of upper respiratory tract. As for the anti-infectious resistance of nasal mucosal of S. aureus carriers, the level of lysozyme and secretory immunoglobulin A gradually increased after the application of probiotic strain L. rhamnosus GG, and in 21 days it reached rates of healthy individuals.Conclusions. It was found out that probiotics for nasal passages sanitation in Staphylococcus aureus carriers lead to gradual eradication of the pathogen (S. aureus) with restoration of colonization and anti-infectious resistance, mucous membranes and upper respiratory tract.

scholarly journals THE USING OF NEW PRESERVING SOLUTION FOR THE STORAGE AND THE DEMONSTRATION OF ANATOMICAL PREPARATIONS

2019 ◽  
Vol 27 (4) ◽  
pp. 61-64
Author(s):  
V. N. Nikolenko ◽  
A. L. Urakov ◽  
L. I. Rastegaeva ◽  
E. A. Kozyreva ◽  
L. A. Gridin ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Russian Patent ◽  
Upper Respiratory Tract ◽  
Museum Exhibits ◽  
Long Term Storage ◽  
Shape Structure ◽  
Mucous Membranes ◽  
Upper Respiratory ◽  
Term Storage

For storage and open demonstration of moist anatomical educational preparations and museum exhibits proposed to use a new preservative, which is an aqueous solution of 0.014-0.019% 3-iodine-2-propinilbutilcarbonate. The solution has high antiseptic activity and does not have a local irritant effect on the skin, mucous membranes of the upper respiratory tract and oral cavity, as well as on the conjunctiva of the eyes. The proposed preservative is non-toxic and environmentally safety. Long-term storage and use of anatomical preparations in the proposed preservative does not cause any damaging changes, violations of their shape, structure and color. The method is patented by the Russian Patent Agency.

scholarly journals Congenital Neutropenia in Children: Evaluation of Infectious Complications, Treatment Results and Long-Term Outcome

2021 ◽  
Author(s):  
Işık Odaman Al ◽  
Yeşim Oymak ◽  
Tuba Hİlkay Karapınar ◽  
Melek Erdem ◽  
Salih Gözmen ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Infectious Complications ◽  
Upper Respiratory Tract ◽  
Congenital Neutropenia ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Upper Respiratory

Objective: Infections are an important cause of morbidity and mortality for patients with congenital neutropenia. In the present study, we report on the incidence, type, localization of documented infections, as well as the clinical features and long-term outcome in patients with congenital neutropenia in our clinic. Method: We performed a retrospective chart review of children with neutropenia seen at our hospital from 2000-2018. The data of 15 patients with congenital neutropenia were included in this study. Clinical and laboratory data were analyzed retrospectively using patients’ files and an electronic data system. Results: The median age at diagnosis was 34 months (range, four months- 150 months) and the median follow-up time was 48 months (range, 13-179 months). The leading causes of hospital admission before the establishment of the diagnosis were upper respiratory tract infection in six, pneumonia in four, gingival stomatitis in three and soft tissue infection in two patients. We reached the documented 74 hospitalization episodes and the most common reasons for hospitalization were pneumonia (35%), fever (21%), stomatitis (16%), cutaneous and deep soft tissue infections (12%). Conclusion: The management of infectious complications in children with congenital neutropenia is crucial. Early diagnosis is essential to prevent infections and permanent organ damage. Congenital neutropenia should be suspected in patients with a history of frequent upper respiratory tract infection, and necessary investigations should be performed accordingly. However, it should be kept in mind that the clinical findings of the patients may vary despite having the same mutation.

Occupational upper respiratory tract and ear diseases in cement industry workers

1927 ◽  
Vol 23 (9) ◽  
pp. 973-973
Author(s):  
N. Bobrovsky
Keyword(s):  
Respiratory Tract ◽  
Cement Industry ◽  
Upper Respiratory Tract ◽  
Cement Dust ◽  
Ear Diseases ◽  
Contradictory Information ◽  
Mucous Membranes ◽  
Upper Respiratory

The scarce and contradictory information about the effect of cement dust on the mucous membranes of the upper respiratory tract is considerably supplemented by Dr. Potapov's report on the results of a special team surveying the workers of the Volsk cement plants.

Sign in / Sign up

Export Citation Format

Share Document