scholarly journals Protective Effect of Vitamin E on Nicotine Induced Reproductive Toxicity in Male Rats

2015 ◽  
Vol 23 (1) ◽  
pp. 7 ◽  
Author(s):  
WA Oyeyemi ◽  
ST Shittu ◽  
TA Kolawole ◽  
P Ubanecheand ◽  
AO Akinola
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Reproductive Toxicity ◽  
Male Rats

Chemoprotection of ethylene glycol monoethyl ether-induced reproductive toxicity in male rats by kolaviron, isolated biflavonoid from Garcinia kola seed

2011 ◽  
Vol 31 (5) ◽  
pp. 506-517 ◽  
Author(s):  
IA Adedara ◽  
EO Farombi
Keyword(s):  
Vitamin E ◽  
Ethylene Glycol ◽  
Protective Effect ◽  
Reproductive Toxicity ◽  
Male Rats ◽  
Antioxidant Systems ◽  
Sod Activity ◽  
Garcinia Kola ◽  
Monoethyl Ether ◽  
Glycol Monoethyl Ether

The present study investigated the protective effect of kolaviron, a biflavonoid from the seed of Garcinia kola, on ethylene glycol monoethyl ether (EGEE)–induced reproductive toxicity in male rats. The protective effect of kolaviron was validated using vitamin E, a standard antioxidant. EGEE was administered at a dose of 200 mg/kg. Other groups of rats were simultaneously treated with kolaviron (100 and 200 mg/kg) and vitamin E (50 mg/kg) for 14 days. EGEE treatment resulted in significant decrease in glutathione (GSH) level, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities but markedly increased the glutathione-S-transferase (GST) and lactate dehydrogenase (LDH) activities in the testes. In the spermatozoa, administration of EGEE caused significant decrease in the activities of CAT, GPx, GST and LDH as well as in the level of GSH but significantly increased SOD activity with concomitant increase in hydrogen peroxide and malondialdehyde levels in both testes and spermatozoa. EGEE-exposed rats showed marked testicular degeneration with concomitant decrease in spermatozoa quantity and quality. Overall, EGEE causes reproductive dysfunction in rats by altering antioxidant systems in the testes and spermatozoa. Kolaviron or vitamin E exhibited protective effects against EGEE-induced male reproductive toxicity by enhancement of antioxidant status and improvement in spermatozoa quantity and quality.

scholarly journals Colibri® insecticide induces male reproductive toxicity: alleviating effects of Lannea acida (Anacardiaceae) in rats

2019 ◽  
Vol 29 (1) ◽  
Author(s):  
Aimé Césaire Momo Tetsatsi ◽  
Pepin Alango Nkeng-Effouet ◽  
Désiré Munyali Alumeti ◽  
Georges Roméo Fozin Bonsou ◽  
Albert Kamanyi ◽  
...  
Keyword(s):  
Vitamin E ◽  
Preventive Measures ◽  
Clomiphene Citrate ◽  
Reproductive Toxicity ◽  
Male Rats ◽  
Sexual Hormones ◽  
Organ Weights ◽  
Stress Markers ◽  
Testis Histology ◽  
Neonicotinoid Insecticide

Abstract Background Imidacloprid, a neonicotinoid insecticide, has been associated to severe reproductive toxicity in mammals. Although some preventive measures have been reported, curative strategies are yet to be explored. The present study was designed to investigate the alleviating effects of Lannea acida on the reproductive toxicity of colibri®, a commercial formulation of imidacloprid, in adult male rats. Materials and methods Seventy rats were orally administered with colibri® (22.5 mg/kg, 10 mL/kg) for 14 days and treated for other 14 or 28 days with either aqueous or methanol extracts of L. acida (170 or 340 mg/kg). Control animals were similarly treated with clomiphene citrate or vitamin E. Sexual organ weights, spermatozoa characteristics, sexual hormones, stress markers and testis histology were evaluated at the end of each treatment period. Results Colibri® exposition induced reproductive toxicity marked by a decrease in sex organ weights, spermatozoa count, motility and viability. Colibri® also decreased testosterone, luteinizing hormone, follicle stimulating hormone concentrations and increased testicular oxidative stress. Spermatozoa morphology and testis histology were also severely altered. Similar to clomiphene citrate and vitamin E, treatment with L. acida extracts significantly (p ≤ 0.05–0.001) reversed the above-mentioned damages, especially after 28 days of treatment with aqueous (340 mg/kg) and methanol (170 mg/kg) extracts. Conclusion Present results indicate that L. acida exerts curative effects against colibri®-induced male reproductive toxicity. These results justify the use of this plant as fertility enhancer and suggest that it could be an alternative in the management of pesticide-derived male infertility.

scholarly journals Effects of Vitamin E Supplementation in Male Rats with Crude Oil-Induced Reproductive Toxicity

2017 ◽  
Vol 9 (3) ◽  
pp. 332-337
Author(s):  
Izuchukwu S. OCHIOGU ◽  
Udensi M. IGWEBUIKE ◽  
Edmund C. MBEGBU ◽  
Ikenna O. EZEH ◽  
Paschal F. NNAMANI
Keyword(s):  
Vitamin E ◽  
Crude Oil ◽  
Dose Group ◽  
Low Dose ◽  
Reproductive Toxicity ◽  
Male Rats ◽  
High Dose ◽  
Serum Total Protein ◽  
The Mean ◽  
Vitamin E Supplementation

Crude oil intoxication is a major threat among people and animals living around the crude oil producing regions of the world, hence the search for ameliorating agents. Forty-four male Wistar rats assigned into three groups were used to investigate the effects of vitamin E supplementation on crude oil-induced reprotoxicity (reproductive toxicity) in male rats. Group A represented the unexposed control, whereas groups B and C were exposed orally to 0.15 and 0.3 ml of crude oil respectively every other day for 56 days. Both the low dose and high dose oral administration of crude oil caused a significant reduction in the serum testosterone level (STL) and cauda epididymal sperm reserve (CESR) of the exposed rats when compared to the control. Crude oil withdrawal and vitamin E supplementation significantly improved the cauda epididymal sperm reserve (CESR) in all the subgroups. The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities of the control and low dose group were significantly lower than those of the high dose group. The high dose crude oil administration significantly decreased the mean serum total protein (STP) and sodium ions (Na+) concentration. The mean serum total cholesterol (STC) value of the low dose group was significantly higher than those of the control and high dose group. However, crude oil withdrawal and vitamin E supplementation did not significantly alter the mean serum total protein (STP) and mean serum total cholesterol (STC) values in all the subgroups. Vitamin E supplementation following low dose crude oil withdrawal enhanced the mean serum Chloride ions (Cl-)concentration. The present findings revealed that Nigerian Qua Iboe Brent crude oil induced serious reprotoxic effects in male rats which vitamin E administration within 28 days did not completely reverse. 

scholarly journals Vitamin B17 Ameliorates Methotrexate-Induced Reproductive Toxicity, Oxidative Stress, and Testicular Injury in Male Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Shatha G. Felemban ◽  
Maha A. Aldubayan ◽  
Ahmad H. Alhowail ◽  
Ibtesam S. Almami
Keyword(s):  
Protective Effect ◽  
Antioxidant Properties ◽  
Reproductive Toxicity ◽  
Male Rats ◽  
Nuclear Antigen ◽  
Plasma Testosterone ◽  
Control Group ◽  
Albino Rats ◽  
Testicular Toxicity ◽  
Testicular Weight

Methotrexate (MTX; 4-amino-10-methylfolic acid) is a folic acid reductase inhibitor used to treat autoimmune diseases and certain types of cancer. Testicular toxicity resulting from MTX is a significant side effect that may cause subsequent infertility. The present study was conducted to examine the ameliorating effects of vitamin B17 (VitB17) against testicular toxicity induced by MTX in male rats. A total of 50 male albino rats were equally divided into five groups [control group; vitamin B17 group (VitB17) administered VitB17 only; methotrexate group administered MTX only; cotreated group, (VitB17+MTX) and posttreated group (MTX+VitB17)]. In methotrexate group (MTX), a significant decrease was observed in body weight and the testicular weight, as well as the levels of plasma testosterone, luteinizing hormone and follicle-stimulating hormone compared with control. The sperm count, viability, morphology index, total motility, and progressive motility also decreased in MTX rats compared with control. Furthermore, the levels of reduced glutathione, catalase, and superoxide dismutase, as well as proliferating cell nuclear antigen protein expression, in the testicular tissue decreased in MTX compared with control. In addition, MTX caused a significant increase in DNA and tissue damage compared with control. However, VitB17 ameliorated these effects, indicating that it has a preventative and curative effect against MTX-induced reproductive toxicity in male rats. The protective effect of VitB17 may be associated to its antioxidant properties as it possibly acts as a free-radical scavenger and lipid peroxidation inhibitor, as well as its protective effect on the levels of GSH, SOD, and CAT.

scholarly journals Protective Effect of Vitamin E Against Lead-induced Memory and Learning Impairment in Male Rats

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Iraj Salehi ◽  
Maryam Sahab Soleimani ◽  
Mahsa Poorhamze ◽  
Fahimeh Ghasemi Moravej ◽  
Alireza Komaki ◽  
...  
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Male Rats ◽  
Memory And Learning ◽  
Learning Impairment

scholarly journals Protective effect of propolis against aluminum chloride-induced reproductive toxicity in male rats

2021 ◽  
Vol 9 (2) ◽  
pp. 083-088
Author(s):  
Essam Eldin Abdelhady Salama ◽  
Ahmed Fathalla El Fouhil ◽  
Khaleel Ibrahim Alyahya ◽  
Sameerah Yasain Shaheen ◽  
Sanaa Ahmed Alshaarawy ◽  
...  
Keyword(s):  
Protective Effect ◽  
Aluminum Chloride ◽  
Testosterone Level ◽  
Reproductive Toxicity ◽  
Ethanol Extract ◽  
Treated Group ◽  
Male Rats ◽  
Serum Testosterone Level ◽  
Plasma Testosterone ◽  
Daily Ingestion

The aim of the present study was to investigate the toxic effects of aluminum chloride (AlCl3) on the reproductive organs, as well as, the protective effect of propolis against AlCl3-induced reproductive toxicity in male rats. Eighty adult male fertile Sprague Dawley albino rats were randomly divided into four groups of 20 each. Group 1: served as control group and received only distilled water. Group 2: received a daily ingestion of 80 mg/kg of AlCl3. Group 3: received a daily ingestion of 200 mg/kg of an ethanol extract of propolis. Group 4: received a daily ingestion of 80 mg/kg of AlCl3 in addition to 200 mg/kg of an ethanol extract of propolis. The duration of experiment was six weeks. At the end of the experiment, the testes, seminal vesicles, prostate glands and epididymides were dissected out, and weighed. Sperm characteristics were evaluated and plasma testosterone level was estimated. There were no significant changes between the control and the propolis-treated group. AlCl3-treated group showed a highly significant decrease in the index weights of testes and prostate glands, a highly significant lower sperm count, motility and viability, a highly significant increase in the number of abnormal sperms, as well as, a highly significant decrease in serum testosterone level (p < 0.001), compared to control. Rats of AlCl3+propolis-treated group showed a highly significant improvement in all previous alterations. In conclusion, propolis appeared to ameliorate AlCl3-induced reproductive toxicity in male rats.

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