scholarly journals Tinjauan Pustaka: Kajian in Vivo dari Obat Luka Kulit Berbahan Acalypha Indica, Aloe Vera, dan Centella Asiatica

2021 ◽  
Vol 27 (1) ◽  
pp. 73-80
Author(s):  
Yanto Hindrawan ◽  
Rina Priastini Susilowati ◽  
Monica Puspa Sari
Keyword(s):  
Wound Healing ◽  
Aloe Vera ◽  
Centella Asiatica ◽  
Google Scholar ◽  
Acalypha Indica

Luka merupakan gangguan pada sel dan jaringan anatomi yang dapat disebabkan oleh beberapa hal baik disengaja maupun tidak disengaja. Luka terutama pada kulit jika tidak diobati dengan baik maka dapat menimbulkan infeksi. Hal ini disebabkan oleh proses penyembuhan luka yang kompleks dan dinamis. Proses ini memerlukan bantuan berupa obat yang terbuat dari bahan sintesis ataupun alami. Tinjauan pustaka ini ditulis dengan tujuan untuk mengevaluasi kemanjuran tiga tanaman obat yang sering digunakan untuk mengobati luka, yaitu  Acalypha indica, Aloe vera , dan Centella asiatica.  Penelusuran dan penapisan pustaka di lakukan dengan Proquest, Pubmed dan Google Scholar dengan kata kunci wound healing AND Acalypha indica OR Centella asiatica OR wound healing OR Aloe vera.  Sebanyak 25 makalah dipilih untuk penulisan tinjauan pustaka ini.  Acalypha indica, Aloe vera , dan Centella asiatica merupakan tanaman obat yang efektif untuk mengobati luka luar. Hal in telah dibuktikan dalam berbagai studi in vivo  bahwa  ekstrak tanaman herbal ini memiliki efektivitas yang baik untuk menyembuhkan luka dibandingkan obat medis. Penggunaa tanaman herbal untuk pengobatan juga dianggap lebih murah, aman, mudah didapat dan diolah. Acalypha indica, Aloe vera dan Centella asiatica merupakan tanaman obat yang efektif untuk mengobati luka luar.

scholarly journals Review: Interaksi Antara Obat Konvensional dan Herbal untuk Diabetes Mellitus

2021 ◽  
Vol 8 (1) ◽  
pp. 56-70
Author(s):  
Izzah Al Mukminah ◽  
Raden Bayu Indradi
Keyword(s):  
Diabetes Mellitus ◽  
Aloe Vera ◽  
Google Scholar ◽  
Diabetes Melitus

Pendahuluan: Prevalensi Diabetes Melitus (DM) di Indonesia tinggi dan bahkan mengalami fluktuasi dari 422 juta jiwa menjadi 463 juta jiwa dalam 5 tahun. Pada tatalaksana penyakit DM, salah satunya ialah terapi farmakologi menggunakan Obat Antihiperglikemik (OAH). Saat ini selain OAH, masyarakat juga menggunakan herbal untuk mengatasi DM. Senyawa aktif herbal yang telah terbukti berkontribusi dalam pengobatan beragam dan multikomponen, namun tidak semua komponen tersebut diketahui memberikan efek terapeutik pada DM. Maka, tujuan dari tinjauan pustaka ini untuk mengetahui interaksi yang terjadi antara obat konvensional dan herbal untuk DM. Metode: Pencarian literatur dilakukan pada bulan Mei 2020. Situs yang digunakan adalah Google Scholar, Elsevier dan NCBI.  Kata kunci yang digunakan untuk menemukan sumber jurnal ialah “interaksi obat DM dan herbal”, “interaction of diabetic drugs and herbs”, “herbal untuk diabetes”, dan “herbs for diabetes”. Jurnal yang digunakan sebagai sumber berjumlah 15 jurnal dengan fokus penelitian secara in vivo  dan klinis. Hasil: Multikomponen pada herbal tersebut jika digunakan bersamaan dengan OAH berpotensi untuk menimbulkan interaksi, beberapa studi melaporkan bahwa OAH dan herbal untuk antidiabetes memiliki interaksi sinergis atau antagonis. Berdasarkan pustaka beberapa penelitian interaksi obat dan herbal bisa terjadi, seperti Metformin, Glibenklamid dan Pioglitazon dengan Aloe vera berinteraksi sinergis. Kesimpulan: Potensi interaksi antagonis dan sinergis muncul pada beberapa hasil penelitian interaksi herbal dengan OAH.

scholarly journals Surgery and Medicinal Plants: A review of important indigenous medicinal plants of Iran for burn wound healing

2019 ◽  
Vol 6 (2) ◽  
pp. 264-269
Author(s):  
Masoud Sharifian ◽  
Afshin Hasanvand ◽  
Gholam Basati ◽  
Saber Abbaszadeh
Keyword(s):  
Wound Healing ◽  
Medicinal Plants ◽  
Herbal Remedy ◽  
Medical Science ◽  
Aloe Vera ◽  
Centella Asiatica ◽  
Recovery Process ◽  
Herbal Remedies ◽  
Burn Wound ◽  
Burn Wounds

Surgical Science is one of the branches of medical science that deals with surgical and medicinal interventions, which can cure surgical wounds, cuts, burns and so on. The accelerated recovery process has always been a concern for surgeons and physicians. Standard local antibiotic drugs such as silver nitrate, mafenide acetate, sulfadiazine silver and AgNO3 are also used to treat wounds which are associated with some complications. Considering the fact that no effective herbal remedy has been introduced for wound healing, the purpose of this review is to investigate and identify indigenous Iranian herbs used for wound healing after surgery, especially burn wounds. In this systematic review paper, published articles in the period 1952 to 2017 with keywords of surgery, wound healing, burns, herbs, etc. from databases such as SID, MEDLIB, ProQuest, Magiran, Europe PubMed Central and Google Scholar. Abstract and title of all articles were studied and non-relevant articles were deleted and remaining articles were used for review. Based on the results of the study, Malva sylvestris, Camellia sinensis, Aloe vera, Cydonia oblonga, Scrophularia striata, Centella asiatica, Arnebia euchroma, Calendula officinalis and Hypericum perforatum are the most important herbal remedies for burn restoration. The following is an explanation of the most important herbal remedies for native burn wounds in Iran.

Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo

Phytomedicine ◽  
2017 ◽  
Vol 28 ◽  
pp. 19-26 ◽  
Author(s):  
Hussain Mustatab Wahedi ◽  
Minsun Jeong ◽  
Jae Kyoung Chae ◽  
Seon Gil Do ◽  
Hyeokjun Yoon ◽  
...  
Keyword(s):  
Wound Healing ◽  
Signaling Pathways ◽  
Aloe Vera ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Smad Signaling

scholarly journals In vivo study of Centella asiatica (L.) Urban as a drug gel for diabetes wounds

MEDISAINS ◽  
2021 ◽  
Vol 19 (3) ◽  
pp. 77
Author(s):  
Rohmayanti Rohmayanti ◽  
Widarika Santi Hapsari
Keyword(s):  
Wound Healing ◽  
Centella Asiatica ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Wound ◽  
Tropical Plant ◽  
Diabetic Wound Healing ◽  
Diabetic Wounds ◽  
Concentration Levels

Background: Centella asiatica L. Urban is a tropical plant whose spread is quite broad as Indonesia. One of the ingredients of Centella asiatica L. Urban is asiaticoside which has excellent wound healing abilities. However, research on diabetic wound healing with Centella asiatica L. Urban extract formulation in the form of a gel has not been found. Therefore, it is necessary to look at the healing activity of diabetic wounds using Centella asiatica L. Urban extract in the form of a gel.Objective: This experimental study aims to explore the effect of gel extract derived from the Centella asiatica L. Urban on the length of time for wound healing.Methods: The subjects in this study were eight weeks old Balb-C mice conditioned to hyperglycemia and were divided into five groups. The Centella asiatica L. Urban extract is provided in three concentration levels, with 3%, 5%, and 7%. As a form of negative control, used gel without Centella asiatica L. Urban extract and positive control without gel, only hydrocolloid dressing.Results: Centella asiatica L. Urban at concentrations of 3% (with the value of Sig. > 0.05), 5%, and 7% showed the ability to heal wounds.Conclusions: Centella asiatica L. Urban gel extract with a concentration of 3% had a significant effect on wound healing compared to other preparations.

Preparation of Centella Extracts Loaded Aloe Vera Transdermal Patches for Wound Healing Purpose

2014 ◽  
Vol 1060 ◽  
pp. 54-57
Author(s):  
Panupong Puttarak ◽  
Wiwat Pichayakorn ◽  
Kanchana Sripoka ◽  
Khwanrudee Chaimud ◽  
Pharkphoom Panichayupakaranant
Keyword(s):  
Wound Healing ◽  
Aloe Vera ◽  
Centella Asiatica ◽  
Peel Strength ◽  
Asiatic Acid ◽  
Active Ingredients ◽  
Pentacyclic Triterpenoids ◽  
Physiochemical Properties ◽  
Transdermal Patches ◽  
Aloe Vera Gel

Transdermal patch is a drug delivery system using a polymer for controlling the drug release. In this study, polysaccharides from aloe vera gel were used as polymer in transdermal patches because they are compatible, biodegradable, and safe to apply on skin without any side effect. Pentacyclic triterpenoids rich (asiatic acid, madecassic acid, asiaticoside and madecassoside) Centella asiatica extracts were added as active ingredients. Both polymer and active ingredients show pharmacological effects as wound healing. It was found that the optimized formulation contained polysaccharides from aloe vera gel blended with 20% glycerine and 15% sodium alginate calculated based on aloe vera mass could produce the good films. These films could be controlled with respect to physical properties thickness (0.509±0.015 mm), tensile strength (1.391±0.131 MPa), elongation at break (116.2±13.15%), peel strength (0.116±0.044 N), the highest swelling times (20 minutes), and the percentage of degradation at 30 minutes (51.57±5.96%). About 0.34 % centella extracts (57% pentacyclic triterpenoids) could be found in these films. After stability studies at 4, 25 and 45 °C for 10 weeks, films stored at 45 °C were loss of flexibility and brittleness that could not be further evaluated. While films stored at 4 and 25 °C were good physiochemical properties and stable as same as films base.

scholarly journals EFEKTIFITAS EKSTRAK TANAMAN JARAK PAGAR (JATROPHA CURCAS L.) TERHADAP PENYEMBUHAN LUKA : LITERATUR REVIEW

2020 ◽  
Vol 6 (2) ◽  
pp. 184-191
Author(s):  
Suhirman Suhirman ◽  
Takdir Tahir ◽  
Saldy Yusuf
Keyword(s):  
Wound Healing ◽  
Jatropha Curcas ◽  
Google Scholar ◽  
Jatropha Curcas L ◽  
Mesh Terms

Latar belakang : Kandungan ekstrak tumbuhan telah digunakan sudah sejak lama sebagai salah satu metode alternatif/komplementer terutama dalam penyembuhan luka, hanya saja belum terinci sehingga perlu pengujian baik secara in vitro maupun in vivo. Tujuan : Untuk mengetahui sejauhmana efektifitas tanaman Jatropha Curcas L. terhadap penyembuhan luka dengan pendekatan dari beberapa penelitian yang telah ada sebelumnya. Metode : Metode  dari tinjauan literature ini menggunakan pedoman Prisma  dengan penelusuran artikel ilmiah menggunakan data based Pubmed, Google Scholar dan Science Direct.  Melakukan pencarian pada Pubmed dengan kata kunci Extract Jatropha Curcas L. [MeSH Terms] AND wound healing [MeSH Terms], google Scholar dengan kata kunci Extract Jatropha Curcas L AND wound healing, sedangkan Science Direct dengan kata kunci Ekstrak Jatropha Curcas L. AND wound healing  Hasil : Dari beberapa artikel penelitian yang telah diulas menunjukkan bahwa efektifitas dari ekstrak tanaman jarak pagar (Jatropha Curcas L.) memiliki pengaruh terhadap penyembuhan luka pada hewan coba tikus Wistar.    

scholarly journals Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1554 ◽  
Author(s):  
Chang Liu ◽  
Yan Cui ◽  
Fuwei Pi ◽  
Yuliang Cheng ◽  
Yahui Guo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Biological Activities ◽  
Structural Characteristics ◽  
Research Work ◽  
Aloe Vera ◽  
Research Progress ◽  
Future Research ◽  
Clinical Experiments

: Aloe vera is a medicinal plant species of the genus Aloe with a long history of usage around the world. Acemannan, considered one of the main bioactive polysaccharides of Aloe vera, possesses immunoregulation, anti-cancer, anti-oxidation, wound healing and bone proliferation promotion, neuroprotection, and intestinal health promotion activities, among others. In this review, recent advancements in the extraction, purification, structural characteristics and biological activities of acemannan from Aloe vera were summarized. Among these advancements, the structural characteristics of purified polysaccharides were reviewed in detail. Meanwhile, the biological activities of acemannan from Aloe vera determined by in vivo, in vitro and clinical experiments are summarized, and possible mechanisms of these bioactivities were discussed. Moreover, the latest research progress on the use of acemannan in dentistry and wound healing was also summarized in details. The structure-activity relationships of acemannan and its medical applications were discussed. Finally, new perspectives for future research work on acemannan were proposed. In conclusion, this review summarizes the extraction, purification, structural characteristics, biological activities and pharmacological applications of acemannan, and provides information for the industrial production and possible applications in dentistry and wound healing in the future.

scholarly journals Identification of Major Active Ingredients Responsible for Burn Wound Healing ofCentella asiaticaHerbs

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Fang Wu ◽  
Difei Bian ◽  
Yufeng Xia ◽  
Zhunan Gong ◽  
Qian Tan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Burn Injury ◽  
Centella Asiatica ◽  
Asiatic Acid ◽  
Burn Wound ◽  
Active Constituent ◽  
Healthy Human ◽  
Burn Wound Healing

Centella asiaticaherbs have been prescribed as a traditional medicine for wound healing in China and Southeast Asia for a long time. They contain many kinds of triterpenoid compounds, mainly including glycosides (asiaticoside and madecassoside) and corresponding aglycones (asiatic acid and madecassic acid). To identify which is the major active constituent, a comprehensive and comparative study of these compounds was performed.In vitro, primary human skin fibroblasts, originating from healthy human foreskin samples, were treated with various concentrations of asiaticoside, madecassoside, asiatic acid, and madecassic acid, respectively. Cell proliferation, collagen synthesis, MMP-1/TIMP-1 balance, and TGF-β/Smad signaling pathway were investigated.In vivo, mice were orally administered with the four compounds mentioned above for two weeks after burn injury. The speed and quality of wound healing, as well as TGF-β1levels in skin tissues, were examined. Interestingly, in contrast to prevalent postulations, asiaticoside and madecassoside themselves, rather than their corresponding metabolites asiatic acid and madecassic acid, are recognized as the main active constituents ofC. asiaticaherbs responsible for burn wound healing. Furthermore, madecassoside is more effective than asiaticoside (P=0.0446for procollagen type III synthesisin vitro,P=0.0057for wound healing speed, andP=0.0491for wound healing patternin vivo, correspondingly).

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