Effects of Milk Thistle, Artichoke and Olive Extracts in Comparison with Atorvastatin and Gemfibrozil on Liver Function in Broiler Chicken

Numerous complementary feeds to support liver function are commercially available for small animals. Aiming to furnish a scientific support for clinicians/nutritionists that necessitate a complementary feed to support liver function in dogs and cats, with the present paper, we analyzed scientific evidences supporting the use, for this purpose, of ingredients/additives such as artichoke (Cynara scolymus), curcumin, dandelion (Taraxacum officinale), milk thistle (Silybum marianum), phosphatidylcholine, and S-adenosylmethionine. Although sustained by significant results, our review found only few scientific papers, and albeit we believe that they represent a significant aid in handling hepatopathies, in the authors’ opinion, this topic probably deserves, and would benefit of, further studies.

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Impact of Milk Thistle (Silybum marianum [L.] Gaertn.) Seeds in Broiler Chicken Diets on Rearing Results, Carcass Composition, and Meat Quality

Animals ◽

10.3390/ani11061550 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1550

Author(s):

Alina Janocha ◽

Anna Milczarek ◽

Daria Pietrusiak

Keyword(s):

Meat Quality ◽

Broiler Chickens ◽

Broiler Chicken ◽

Carcass Composition ◽

Milk Thistle ◽

Feed Conversion ◽

Silybum Marianum ◽

Leg Muscles ◽

Study Results ◽

The Impact

The studies aimed to evaluate the impact of milk thistle seeds in broiler chicken feed rations on rearing results, carcass composition and meat quality. The experiment involved 120 broiler chickens randomly allocated to three equinumerous groups (C, MT02, MT23). Each group was divided into five subgroups of eight chickens each. Over the first 21 days of life the birds were fed starter rations, and over the following 21 days received grower rations. Chicken starter/grower diets in groups MT02 and MT23 were supplemented with ground seeds of milk thistle in the amount of 0/2% (MT02) and 2/3% (MT23). It was demonstrated that Silybum marianum added to feed rations over the whole rearing period (group MT23) increased above 3% the birds’ body weight on rearing day 42. (p < 0.05) and decreased about 7% the feed conversion ratio (p < 0.05) in comparison to group C. No effect of feeding on the carcass composition was observed, including on muscularity and fattening grade, although diets containing milk thistle reduced (by 15% and 19% in group MT02 and MT23, respectively) the content of crude fat in chicken leg muscles (p < 0.05). The highest (p < 0.05) content of polyunsaturated fatty acids (PUFA) was determined in the breast (38.06%) and leg (37.63%) muscles of chicken receiving feed rations containing Silybum marianum throughout the rearing period. No effect of nutrition on the evaluated physical properties of muscles was observed, except on the decrease in lightness color (L*) and increase in values a* and C as well as a decrease of water holding capacity of the breast muscles. It was found that Silybum marianum in chicken diets had a positive effect on the evaluated meat flavor characteristics of the muscles. To sum up, based on the study results, including ground seeds of milk thistle in broiler chickens nutrition can be recommended in the amount of 2/3% in starter/grower diets, respectively.

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Evaluation of optimum inclusion levels of biostrong® 510 15% as a replacement for antibiotic growth promoters in broiler chicken production under field conditions in Nigeria

Nigerian Journal of Animal Production ◽

10.51791/njap.v46i3.860 ◽

2020 ◽

Vol 46 (3) ◽

pp. 82-100

Author(s):

O. Moses ◽

P. A Onimisi ◽

J. O Jegede ◽

M. Afolayan

Keyword(s):

Liver Function ◽

Broiler Chicken ◽

Pathogenic Bacteria ◽

Density Lipoprotein ◽

Quality Parameters ◽

Control Treatment ◽

Control Group ◽

Growth Promoters ◽

Liver Health ◽

Antibiotic Growth Promoters

An experiment was conducted to evaluate the efficacy of Biostrong® 510 15% (BSG) inbroiler chickens diet. It was included at 0 g, 75 g, 100 g and 125 g/100 Kg diet, for T1-T4respectively while T5 had Oxytetracycline. Data was collected on growth performanceindices, haematological parameters, liver function indices, kidney function, blood mineralprofile, immune response, antioxidant capacity, villi morphometrics, lipid profile, ileum andceacum microbial contents, carcass quality parameters, and tibia bone quality indices. Alldata collected were subjected to analysis of variance and significant differences amongtreatment means were compared using the Tukey test of significance. Growth erformance showed that broilers fed diet containing 100g BSG had optimum performance among other levels. Haematological and liver function indices were not significantly (P>0.05) different. Birds fed BSG showed decreased cholesterol, triglycerides and high-density lipoprotein compared to the control treatment. Birds fed levels of BSG and AGP had significantly higher bone weight, bone density, bone dry matter and bone ash as compared to birds on the control group. All carcass evaluation parameters were significantly (P<0.05) different among treatments except for dressed weight, breast and kidney. Levels of BSG in the diet significantly lowered the cost of production than AGPs of finisher broilers improved liver health, bone strength, villi characteristics, increased beneficial bacteria population and also prevent the colonization of the gut by pathogenic bacteria thus improving the health of the birds. Biostrong® 510 15%, can therefore effectively replace antibiotic growth promoters in broiler chicken production.

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Acetaminophen: Macula densa hypersecretory activity by induced hepatotoxicity

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010012895x ◽

1987 ◽

Vol 45 ◽

pp. 934-935

Author(s):

S.S. Poolsawat ◽

C.A. Huerta ◽

S.TY. Lae ◽

G.A. Miranda

Keyword(s):

Cell Proliferation ◽

Liver Function ◽

Chronic Inflammation ◽

Foam Cell ◽

Term Effect ◽

Short Term ◽

Drug Induced ◽

Experimental Induction ◽

Tissue Alterations ◽

Toxic Responses

Introduction. Experimental induction of altered histology by chemical toxins is of particular importance if its outcome resembles histopathological phenomena. Hepatotoxic drugs and chemicals are agents that can be converted by the liver into various metabolites which consequently evoke toxic responses. Very often, these drugs are intentionally administered to resolve an illness unrelated to liver function. Because of hepatic detoxification, the resulting metabolites are suggested to be integrated into the macromolecular processes of liver function and cause an array of cellular and tissue alterations, such as increased cytoplasmic lysis, centrilobular and localized necroses, chronic inflammation and “foam cell” proliferation of the hepatic sinusoids (1-4).Most experimentally drug-induced toxicity studies have concentrated primarily on the hepatic response, frequently overlooking other physiological phenomena which are directly related to liver function. Categorically, many studies have been short-term effect investigations which seldom have followed up the complications to other tissues and organs when the liver has failed to function normally.

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