scholarly journals Future Trends of Diabetes: Changing Basic Concepts Towards More Rational Attitudes

2019 ◽  
Vol 1 (1) ◽  
pp. 5-6
Author(s):  
Alkhatib J
Keyword(s):  
Metabolic Syndrome ◽  
Diabetic Complications ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Future Trends ◽  
Insulin Deficiency ◽  
Basic Concepts ◽  
Points Of View ◽  
Type 2 Diabetic

In this editorial, I would like to go through some philosophical aspects in conceptual formulations. Diabetes has been defined as part of metabolic syndrome. Diabetes is associated with insulin deficiency either in concentration or function. This is the classical and traditional picture associated with diabetes type 2. Diabetic complications are also associated with these concepts involving the metabolic points of view.

scholarly journals Role of standard test meal in initiation of insulin therapy in type 2 diabetes

2009 ◽  
Vol 137 (9-10) ◽  
pp. 490-496
Author(s):  
Branka Koprivica ◽  
Teodora Beljic-Zivkovic ◽  
Tatjana Ille
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Insulin Secretion ◽  
Glycaemic Control ◽  
Combination Therapy ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Standard Meal ◽  
Target Values

Introduction Secondary monotherapy failure in diabetes mellitus type 2 occurs early in the course of disease. Choosing the optimal combination therapy depends on the primary pathogenic mechanism. Evaluation of the residual beta cell function is of primary importance in deciding whether insulin should be included in the combination therapy. Objective To investigate the influence of standard meal test and homeostasis model assessment (HOMA-B) index, as markers of residual insulin secretion, on the efficacy of two different therapeutic strategies in secondary sulphonylurea (SU) failure. Methods In the group of thirty subjects with diabetes type 2, metabolic syndrome and secondary SU failure, metformin (MET) was added for the following six months. In the group of 30 subjects with diabetes type 2, secondary SU failure, with no metabolic syndrome, insulin (INS) was added for the same period. During the six-month follow-up period, fasting, postprandial, mean daily blood glucose and glycosylated haemoglobin (HbA1C) were evaluated. Fasting and meal stimulated C-peptide (CP) and insulin levels were measured at the beginning; absolute and relative increase of CP (delta CP, delta CP%), and HOMA-B were calculated. Correlation between CP secretion and HOMA-B at the beginning and glycaemic control after six months of therapy were evaluated by using Pearson correlation coefficient. Results Glycaemic control after six months was significantly improved in both therapeutic combinations (p<0.01). However, target values were not met in either group. Stimulated CP levels correlated best with all the parameters of glycaemic control in the group SU+MET (r -0.479 to -0.791; p<0.01), and in the group SU+INS (r 0.382 to 0.635; p<0.01). HOMA-B correlated only with HbA1C in the SU+MET group (r=-0.382; p<0.05). Conclusion Clinical diagnosis of metabolic syndrome and evaluation of residual insulin secretion are necessary in choosing the best combination therapy in secondary SU failure in subjects with type 2 diabetes. Stimulated standard meal CP level is a clinically useful marker of residual insulin secretion.

scholarly journals Assessment of the lipidic and glucose metabolism of the atom industrial workers

2011 ◽  
Vol 3 (1) ◽  
pp. 9-15
Author(s):  
Oksana A. Belykh ◽  
Olga Y. Larina
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Glucose Metabolism ◽  
Diabetes Type 2 ◽  
Cardiovascular Complications ◽  
Diabetes Type ◽  
Metabolic Abnormalities ◽  
Industrial Workers ◽  
Complex Treatment

We studied lipid and glucose metabolism in 152 patients with Metabolic syndrome. Research has shown hyperglycemia, dyslipidemia and hypertension, which initiated an increase of obesity degree and were accompanied by cardiovascular complications and Diabetes type 2. The complex treatment, including normalization of body weight and drug therapy of metformin and sibutramine in a period of three months resulted in normalization of metabolic abnormalities.

scholarly journals СУЧАСНІ ПІДХОДИ ДО ФАРМАКОЛОГІЧНОЇ КОРЕКЦІЇ МЕТАБОЛІЧНИХ ЗРУШЕНЬ ПРИ ЦУКРОВОМУ ДІАБЕТІ ТИПУ 2

2019 ◽  
Vol 77 (3) ◽  
pp. 71-80
Author(s):  
Kh. I. Kurylo ◽  
A. S. Volska ◽  
I. M. Klishch ◽  
B. V. Zablotskyi
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Metabolic Changes ◽  
Hypoglycemic Action

Diabetes mellitus is caused by one of the largest medical and social problems in Ukraine, because it causes a high risk of invasive disease. According to the WHO data, the number of patients is rising and people of varying age groups become ill, which causes an increase in the incidence of 3 to 4 pauses and the overall life expectancy of 20-30%. Pathogenesis of diabetes mellitus and enclosure, require the extraction of drugs for prophylaxis and treatment with late pharmacological effects. One of these is a herbal remedy. Analysis and systematization of the literature on metabolitotropic effects and substantiation of the use of new goat's-rue, blueberry and taurine phytocompositions for the correction of metabolic changes in diabetes type 2 were carried out. The methods of information search, analysis of literature on the medicinal plants with hypoglycemic action were used. The literary resources on pharmacological correction of metabolic changes in diabetes type 2 deal with natural herbs and amino acids that possess hypoglycemic action and can be used with therapeutic and prophylactic measure in patients with type 2 diabetes. In type 2 diabetes mellitus significant anticytolytic, detoxifying and antioxidant properties of phytocompositions were confirmed. It is known that in hyperglycemia and insulin resistance that occur at type 2 diabetes mellitus end products of glycosylation and glucose autooxidation are formed, which is accompanied by the activation of lipid peroxidation and the formation of a large number of free radicals. It is known that one of the basic mechanisms for the development of insulin resistance, diabetes mellitus and specific diabetic angiopathies is oxidative stress. One of the major pathogenetic factors in the development and course of type 2 diabetes mellitus is metabolic syndrome. It has been established that correction using both investigated phytocompositions and reference phytopreparation with different efficiency prevented the development of metabolic changes in metabolic syndrome. Biologically active components of medicinal plants, may show hypoglycemic effect which will influence the activity of the enzymes, glucose transcription and the function of the peptide to the incyline, the processes which play an important role in the pathogenesis of diabetes.

scholarly journals Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome

2013 ◽  
Vol 31 (2) ◽  
pp. 223-238 ◽  
Author(s):  
Patricio López-Jaramillo ◽  
Ramiro A. Sánchez ◽  
Margarita Diaz ◽  
Leonardo Cobos ◽  
Alfonso Bryce ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Latin American ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Patients With Diabetes

scholarly journals C-Peptide: A New Mediator of Atherosclerosis in Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Dusica Vasic ◽  
Daniel Walcher
Keyword(s):  
Risk Factors ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Cleavage Product ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Type 2 Diabetic

Diabetes type 2 and insulin resistance are the risk factors for cardiovascular disease. It is already known that atherosclerosis is an inflammatory disease, and a lot of different factors are involved in its onset. C-peptide is a cleavage product of proinsulin, an active substance with a number of effects within different complications of diabetes. In this paper we discuss the role of C-peptide and its effects in the development of atherosclerosis in type 2 diabetic patients.

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