The Efficacy of Bisphosphonate to Increase the Skull Density Ratio of MRI-guided Focused Ultrasound Candidates with Brain Disorders

2019 ◽  
Vol 10 (2) ◽  
Author(s):  
Hisashi Ito ◽  
Jordi Rumia ◽  
Shigeru Fukutake ◽  
Kazuaki Yamamoto ◽  
Toshio Yamaguchi ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Density Ratio ◽  
Brain Disorders ◽  
Mri Guided

Significance of mri Guided Focused Ultrasound Thalamotomy for Parkinson Disease: a Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Pooja ◽  
SK Pahuja ◽  
Karan Veer
Keyword(s):  
Focused Ultrasound ◽  
Online Resources ◽  
Research Review ◽  
Brain Disorders ◽  
Invasive Procedures ◽  
Internal Globus Pallidus ◽  
Non Invasive ◽  
Safe Technique ◽  
Ventral Intermediate Nucleus ◽  
Mri Guided

Background: Magnetic-Resonance guided Focused Ultrasound (FUS) thalamotomy is a new and less invasive surgical technique for treating Parkinson’s disease (PD). During therapy the required part of cerebral (as STN, Internal Globus Pallidus, and Ventral Intermediate Nucleus) is ablated with less possibility of infection and brain hemorrhage as normally happen in invasive procedures. Introduction: New advancement in the technique enable it for transcranial transportation of US. Now a days, US coupling with MRI confirms the accurate energy transferring and monitoring. So, MRI guided FUS lesioning is discovered for various psychiatrics and brain disorders. Methods: A technical overview of non-invasive MRI-FUS thalamotomy to treat various tremors is described here. Research, review articles, and book chapters are extracted from online resources using related search strings from year 1994-2020. Results: MRgFUS is concluded a non-invasive, satisfactory and safe technique to reduce the tremor. Table 1 shows the significance of it.

scholarly journals AAPM Task Group 241: A Medical Physicist’s Guide to MRI‐guided Focused Ultrasound Body Systems

2021 ◽  
Author(s):  
Allison Payne ◽  
Rajiv Chopra ◽  
Nicholas Ellens ◽  
Lili Chen ◽  
Pejman Ghanouni ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Task Group ◽  
Mri Guided

Invited. On the feasibility of MRI-guided focused ultrasound for local induction of gene expression

1998 ◽  
Vol 8 (1) ◽  
pp. 101-104 ◽  
Author(s):  
David P. Madio ◽  
Peter van Gelderen ◽  
Daryl DesPres ◽  
Alan W. Olson ◽  
Jacco A. de Zwart ◽  
...  
Keyword(s):  
Gene Expression ◽  
Focused Ultrasound ◽  
Mri Guided

scholarly journals MRI-guided focused ultrasound ablation of lumbar medial branch nerve: Feasibility and safety study in a swine model

2016 ◽  
Vol 32 (7) ◽  
pp. 786-794 ◽  
Author(s):  
Elena A. Kaye ◽  
Sebastien Monette ◽  
Govindarajan Srimathveeravalli ◽  
Majid Maybody ◽  
Stephen B. Solomon ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Swine Model ◽  
Medial Branch ◽  
Safety Study ◽  
Ultrasound Ablation ◽  
Mri Guided ◽  
Focused Ultrasound Ablation

Predictors of thermal increase in magnetic resonance–guided focused ultrasound treatment for essential tremor: histogram analysis of skull density ratio values for 1024 elements

2021 ◽  
pp. 1-6
Author(s):  
Ken Iijima ◽  
Hajime Yokota ◽  
Toshio Yamaguchi ◽  
Masayuki Nakano ◽  
Takahiro Ouchi ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Operating Characteristic ◽  
Focused Ultrasound ◽  
Characteristic Curve ◽  
Density Ratio ◽  
Predictive Ability ◽  
Curve Analysis ◽  
Regression Analyses ◽  
Multivariate Logistic Regression ◽  
Operating Characteristic Curve

OBJECTIVE Sufficient thermal increase capable of generating thermocoagulation is indispensable for an effective clinical outcome in patients undergoing magnetic resonance–guided focused ultrasound (MRgFUS). The skull density ratio (SDR) is one of the most dominant predictors of thermal increase prior to treatment. However, users currently rely only on the average SDR value (SDRmean) as a screening criterion, although some patients with low SDRmean values can achieve sufficient thermal increase. The present study aimed to examine the numerical distribution of SDR values across 1024 elements to identify more precise predictors of thermal increase during MRgFUS. METHODS The authors retrospectively analyzed the correlations between the skull parameters and the maximum temperature achieved during unilateral ventral intermediate nucleus thalamotomy with MRgFUS in a cohort of 55 patients. In addition, the numerical distribution of SDR values was quantified across 1024 elements by using the skewness, kurtosis, entropy, and uniformity of the SDR histogram. Next, the authors evaluated the correlation between the aforementioned indices and a peak temperature > 55°C by using univariate and multivariate logistic regression analyses. Receiver operating characteristic curve analysis was performed to compare the predictive ability of the indices. The diagnostic performance of significant factors was also assessed. RESULTS The SDR skewness (SDRskewness) was identified as a significant predictor of thermal increase in the univariate and multivariate logistic regression analyses (p < 0.001, p = 0.013). Moreover, the receiver operating characteristic curve analysis indicated that the SDRskewness exhibited a better predictive ability than the SDRmean, with area under the curve values of 0.847 and 0.784, respectively. CONCLUSIONS The SDRskewness is a more accurate predictor of thermal increase than the conventional SDRmean. The authors suggest setting the SDRskewness cutoff value to 0.68. SDRskewness may allow for the inclusion of treatable patients with essential tremor who would have been screened out based on the SDRmean exclusion criterion.

scholarly journals A dual-mode hemispherical sparse array for 3D passive acoustic mapping and skull localization within a clinical MRI guided focused ultrasound device

2018 ◽  
Vol 63 (6) ◽  
pp. 065008 ◽  
Author(s):  
Calum Crake ◽  
Spencer T Brinker ◽  
Christian M Coviello ◽  
Margaret S Livingstone ◽  
Nathan J McDannold
Keyword(s):  
Focused Ultrasound ◽  
Dual Mode ◽  
Sparse Array ◽  
Ultrasound Device ◽  
Mri Guided ◽  
Passive Acoustic ◽  
Acoustic Mapping ◽  
Clinical Mri

scholarly journals The Distribution of Skull Score and Skull Density Ratio in Tremor Patients for MR-Guided Focused Ultrasound Thalamotomy

2021 ◽  
Vol 15 ◽  
Author(s):  
Kevin Wen-Kai Tsai ◽  
Jui-Cheng Chen ◽  
Hui-Chin Lai ◽  
Wei-Chieh Chang ◽  
Takaomi Taira ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Cortical Bone ◽  
Focused Ultrasound ◽  
Density Ratio ◽  
Ct Images ◽  
Image Feature ◽  
Cumulative Distribution ◽  
Invasive Surgical Approach ◽  
Highly Correlated ◽  
The Brain

ObjectiveMagnetic resonance-guided focused ultrasound (MRgFUS) is a minimum-invasive surgical approach to non-incisionally cause the thermos-coagulation inside the human brain. The skull score (SS) has already been approved as one of the most dominant factors related to a successful MRgFUS treatment. In this study, we first reveal the SS distribution of the tremor patients, and correlate the SS with the image feature from customized skull density ratio (cSDR). This correlation might give a direction to future clinical studies for improving the SS.MethodsTwo hundred and forty-six patients received a computed tomography (CT) scan of the brain, and a bone-enhanced filter was applied and reconstructed to a high spatial resolution CT images. The SS of all patients would be estimated by the MRgFUS system after importing the reconstructed CT images into the MRgFUS system. The histogram and the cumulative distribution of the SS from all the patients were calculated to show the percentage of the patients whose SS lower than 0.3 and 0.4. The same CT images of all patients were utilized to calculated the cSDR by first segmented the trabecular bone and the cortical bone from the CT images and divided the average trabecular bone intensity (aTBI) by the average cortical bone intensity (aCBI). The Pearson’s correlations between the SS and the cSDR, aTBI, and the aCBI were calculated, respectively.ResultsThere were 19.19 and 50% of the patient who had the SS lower than the empirical threshold 0.3 and 0.4, respectively. The Pearson’s correlation between the SS and the cSDR, aCBI, and the aTBI were R = 0.8145, 0.5723, and 0.8842.ConclusionHalf of the patients were eligible for the MRgFUS thalamotomy based on the SS, and nearly 20% of patients were empirically difficult to achieve a therapeutic temperature during MRgFUS. The SS and our cSDR are highly correlated, and the SS had a higher correlation with aTBI than with aCBI. This is the first report to explicitly reveal the SS population and indicate a potential way to increase the chance to achieve a therapeutic temperature for those who originally have low SS.

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