scholarly journals Novel coronavirus 2019-nCoV: Could this virus become a possible global pandemic

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Vengadesh Letchumanan ◽  
Nurul-Syakima Ab Mutalib ◽  
Bey-Hing Goh ◽  
Learn-Han Lee
Keyword(s):  
Supportive Care ◽  
Close Contact ◽  
International Community ◽  
Antiviral Drugs ◽  
Specific Drug ◽  
Infected Person ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus ◽  
Death Cases

In December 2019, the emerging of a new coronavirus-induced pneumonia created a distress among people in China and the international community. This virus was identified as novel coronavirus 2019-nCoV. At the time this Review went to press, the virus has spread to across 27 countries, infecting 17,488 people and caused 362 deaths. The transmission of 2019-nCoV to individuals of different countries is predominantly through close contact with an infected person. Based on the available data, there is a rising trend of infected and death cases. At this point, there is no specific drug or vaccine to treat infected patients besides supportive care. Nevertheless, researchers and doctors around the world have reported the success of using existing antiviral drugs to treat patients.

Nanotechnology-Based Approaches and Investigational Therapeutics against COVID-19

2021 ◽  
Vol 27 ◽  
Author(s):  
Md. Mominur Rahman ◽  
Muniruddin Ahmed ◽  
Mohammad Touhidul Islam ◽  
Md. Robin Khan ◽  
Sharifa Sultana ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Social Isolation ◽  
Healthcare Professionals ◽  
Pivotal Role ◽  
Specific Drug ◽  
Work From Home ◽  
Global Pandemic ◽  
Preventive Actions ◽  
The World ◽  
Novel Coronavirus

: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus which is currently responsible for the global pandemic since December 2019. This class of coronavirus has affected 217 countries around the world. Most of the countries have taken some non-remedial preventive actions like country lockdown, work from home, travel bans, and the most significant one is social isolation. Pharmacists, doctors, nurses, technologists, and all other healthcare professionals are playing a pivotal role during this pandemic. Unluckily, there is no specific drug that can treat patients who are confirmed with COVID-19, though favipiravir and remdesivir have appeared as favorable antiviral drugs. Some vaccines have already developed, and vaccination has started worldwide. Different nanotechnologies are in the developing stage in many countries for preventing SARS-COV-2 and treating COVID-19 conditions. In this article, we review the COVID-19 pandemic situation as well as the nanotechnology-based approaches and investigational therapeutics against COVID-19.

scholarly journals Update on the SARS-CoV-2 (COVID-19) Outbreak: A Global Pandemic Challenge

2020 ◽  
Author(s):  
Abhishek Kumar Soni
Keyword(s):  
World Health ◽  
Global Public Health ◽  
Global Challenge ◽  
Global Pandemic ◽  
Therapeutic Algorithms ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization ◽  
And Control ◽  
Death Cases

The 2019 novel coronavirus (previously 2019-nCoV) or coronavirus infectious disease 2019 (COVID-19) outbreak has been summarized as on March 29, 2020. COVID-19 is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SERS-CoV-2). The disease was first seen during an outbreak in Wuhan, China and continuous spreading from human to human around the sphere. The disease is uncontrolled and increasing the death toll through. The world is facing a global challenge to protect human lives caused by coronavirus outbreak. The number of infected patients is increasing day by day due to COVID-19 as a pandemic. The world health organization (WHO) has declared global public health emergency on January 30, 2020. The disease has been spread around 201 countries with total confirmed cases 634835 and death cases 29891 as on March 29, 2020. The goal of this review to summaries and update the clinical/medical features and suggestions for diagnosis of the COVID-19 as a pandemic. The discussion of the various therapeutic algorithms, risk, prevention and control based on the latest reports has been provided.

scholarly journals A comprehensive review on COVID-19: What we know and how to treat against the novel coronavirus

2021 ◽  
Vol 292 ◽  
pp. 03091
Author(s):  
Jiacheng Wang ◽  
Xianhao Xu ◽  
Zihan Xu
Keyword(s):  
Vaccine Development ◽  
Therapeutic Strategies ◽  
Antiviral Drugs ◽  
Extensive Study ◽  
Passive Immunity ◽  
The Novel ◽  
Comprehensive Review ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

COVID-19 emerged in Wuhan, China, at the end of 2019 and then soon evolved into a global pandemic. The novel coronavirus inducing this pandemic is under extensive study held by researchers all over the world. We give out a comprehensive review of what we have known about this novel coronavirus, including the pathogenesis. Passive immunity, different strategies, and targets for vaccine development and antiviral drugs are introduced as therapeutic strategies. At last, many other properties of SARS-Cov-2 are discussed.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

scholarly journals Progression and Trends in Virus from Influenza A to COVID-19: An Overview of Recent Studies

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1145
Author(s):  
Hakimeh Baghaei Daemi ◽  
Muhammad Fakhar-e-Alam Kulyar ◽  
Xinlin He ◽  
Chengfei Li ◽  
Morteza Karimpour ◽  
...  
Keyword(s):  
Influenza A ◽  
H1n1 Virus ◽  
World Health ◽  
H1n1 Pandemic ◽  
Global Pandemic ◽  
First Case ◽  
Influenza A H1n1 ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

Influenza is a highly known contagious viral infection that has been responsible for the death of many people in history with pandemics. These pandemics have been occurring every 10 to 30 years in the last century. The most recent global pandemic prior to COVID-19 was the 2009 influenza A (H1N1) pandemic. A decade ago, the H1N1 virus caused 12,500 deaths in just 19 months globally. Now, again, the world has been challenged with another pandemic. Since December 2019, the first case of a novel coronavirus (COVID-19) infection was detected in Wuhan. This infection has risen rapidly throughout the world; even the World Health Organization (WHO) announced COVID-19 as a worldwide emergency to ensure human health and public safety. This review article aims to discuss important issues relating to COVID-19, including clinical, epidemiological, and pathological features of COVID-19 and recent progress in diagnosis and treatment approaches for the COVID-19 infection. We also highlight key similarities and differences between COVID-19 and influenza A to ensure the theoretical and practical details of COVID-19.

scholarly journals Wellness Constraints Among International University Students Transitioning Through Covid 19

2021 ◽  
Vol 58 (3) ◽  
pp. 3444-3456
Author(s):  
Mr J Dorasamy, Et. al.
Keyword(s):  
World Health Organization ◽  
Social Economic ◽  
World Health ◽  
Social Emotional ◽  
Global Pandemic ◽  
Rapid Spread ◽  
The World ◽  
International University ◽  
Novel Coronavirus ◽  
Health Organization

The World Health Organization (Who) In March 2020 Declared Covid 19 A Pandemic, Due To The  Global And Rapid Spread Of A Novel Coronavirus (Who, 2020). The Covid 19 Pandemic Being Highly Infectious And Unpredictable, Has  Disrupted  Social, Economic, Environmental And Political Spheres Of Life. Globally, People Have Ventured Into A “Lockdown World”, Increasing Uncertainty About Their Future Amidst The Covid 19 Pandemic. As A Result Of The Pandemic, Social Alteration Has Taken The Form Of Social Distancing, Self-Isolation And Self-Quarantine.  Many Were Unprepared For The Shift From The “Normal”, Propelling  Undue  Stress Under The New Normal Way Of Doing Things During The Current Global Pandemic Crisis. This Has Been Accompanied By Social, Emotional And Mental Effects, As The Ongoing And Fluid Nature Of The Pandemic Has Created Uncertainty For Many People. The Covid 19 Pandemic, As A Multidimensional Stressor Affecting Wellbeing, Has Affected Individuals, Families, Educational, Occupational, And Broader Societal Systems.  

Impact of COVID-19 pandemic on pilgrim city: A case of Haridwar, Uttarakhand, India

2021 ◽  
pp. 91-96
Author(s):  
Shreya Giri
Keyword(s):  
Geographic Location ◽  
State Level ◽  
Family Welfare ◽  
Global Pandemic ◽  
The World ◽  
Recent Outbreak ◽  
River Ganga ◽  
The Government ◽  
Novel Coronavirus ◽  
Pilgrimage Tourism

India has one of the largest pilgrim traffic in the world as it has large number of sacred and holy sites of different religions. Besides tourism has been a rising industry in India during last few decades thus providing excellent opportunities for pilgrimage tourism until the outbreak of Novel Coronavirus hit the Pilgrim industry. The Covid-19 global pandemic has led to fatal situation and is inextricably affecting the economy of the nation. One such case is of Haridwar “The Gateway to the abode of Gods” in the Uttarakhand state of India. Every year lakhs of devotees visit Haridwar to take bath in the holy river Ganga in order to attain virtue. Haridwar is a famous religious city for the Hindus and it is also attractive to other domestic and foreign tourists because of its marvellous geographic location and physio-cultural tourist resources. The Ministry of Health and Family Welfare has raised awareness about the recent outbreak and the Government is taking several measures and formulating various concord at both central and state level to prevent the adversities of COVID-19. In this paper, an attempt has been made to highlight how the pandemic has left the pilgrimage industry gasping. The paper also suggests certain measures to cope up the Covid-19 outbreak thus consequently moving the economy of the region.

Novel Coronavirus (COVID-19) Outbreak: Hope and Search for Effective Therapeutic Agent

2020 ◽  
Vol 17 (8) ◽  
pp. 940-942
Author(s):  
Saurabh Kumar
Keyword(s):  
Drug Therapy ◽  
Respiratory Diseases ◽  
Therapeutic Agent ◽  
Effective Therapy ◽  
High Rate ◽  
Major Threat ◽  
Common Drug ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

Background: Novel Coronavirus (COVID-19), respiratory diseases and a major threat to mankind is spreading at an unstoppable rate affecting almost every part of the world with Europe being the most affected continent. Originated from China in December 2019 with sequence homology similar to SARS having a high rate of mutation has created a global pandemic with no effective therapy available. Objective: This editorial summarizes the list of potential antiviral drugs or other effective therapy that is in the clinical trial. Methods: The literature search is based on recent publications (year, 2020) available on PubMed and drug/therapy registered on the ClinicalTrial.gov portal. Results: Hydroxychloroquine, tocilizumab, lopinavir/ritonavir, remdesivir, and convalescent plasma are some of the most common drug/therapy that has come as a hope against COVID-19. Conclusion: In view of the current COVID-19 situation, more rigorous efforts are needed. Drugs with better outcomes need more exploration.

scholarly journals National Institute for the Infectious Diseases “L. Spallanzani” IRCCS. Recommendations for COVID-19 Clinical Management

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Emanuele Nicastri ◽  
Nicola Petrosillo ◽  
Tommaso Ascoli Bartoli ◽  
Luciana Lepore ◽  
Annalisa Mondi ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
World Health ◽  
Expert Opinions ◽  
Respiratory Involvement ◽  
Health Authorities ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Affected Country

On January 9th, 2020, the “World Health Organization” (WHO) declared the identification, by Chinese Health authorities, of a novel coronavirus, further classified as SARS-CoV-2 responsible of a diseases (COVID-19) ranging from asymptomatic cases to severe respiratory involvement. On March 9th, 2020, WHO declared COVID-19 a global pandemic. Italy is the second most affected country by COVID-19 infection after China. The “L. Spallanzani” National Institute for the Infectious Diseases, IRCCS has been the first Italian hospital to admit and manage patients affected by COVID-19. Hereby, we show our recommendations for the management of COVID-19 patients, based on very limited clinical evidences; these recomendations should be considered as expert opinions, which may be modified according to newly produced literature data. *for the INMI COVID-19 Treatment Group – ICOTREG Abdeddaim A, Agrati C, Albarello F, Antinori A, Ascoli Bartoli T, Baldini F, Bellagamba R, Bevilacqua N, Bibas M, Biava G, Boumis E, Busso D, Camici M, Capobianchi MR, Capone A, Caravella I, Cataldo A, Cerilli S, Chinello G, Cicalini S, Corpolongo A, Cristofaro M, D’Abramo A, Dantimi C, De Angelis G, De Palo MG, D’Offizi G, De Zottis F, Di Lorenzo R, Di Stefano F, Fusetti M, Galati V, Gagliardini R, Garotto G, Gebremeskel Tekle Saba, Giancola ML, Giansante F, Girardi E, Goletti D, Granata G, Greci MC, Grilli E, Grisetti S, Gualano G, Iacomi F, Iannicelli G, Ippolito G, Lepore L, Libertone R, Lionetti R, Liuzzi G, Loiacono L, Macchione M,  Marchioni L, Mariano A, Marini MC, Maritti M, Mastrobattista A, Mazzotta V, Mencarini P, Migliorisi-Ramazzini P, Mondi A, Montalbano M, Mosti S, Murachelli S, Musso M, Nicastri E, Noto P, Oliva A, Palazzolo C, Palmieri F, Pareo C, Petrone A, Pianura E, Pinnetti C, Pontarelli A, Puro V, Rianda A, Rosati S, Sampaolesi A, Santagata C, Scarcia D’Aprano S, Scarabello A, Schininà V, Scorzolini L, Stazi GV, Taibi C, Taglietti F, Tonnarini R, Topino S, Vergori A, Vincenzi L, Visco-Comandini U, Vittozzi P, Zaccarelli M, Zaccaro G.

scholarly journals How to Face COVID-19 in Ophthalmology Practice

2020 ◽  
Vol 9 (3) ◽  
pp. 164-171 ◽  
Author(s):  
Xiaoting Pei ◽  
Xinwei Jiao ◽  
Dingli Lu ◽  
Di Qi ◽  
Shenzhen Huang ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Severe Acute Respiratory Syndrome ◽  
Search Strategy ◽  
International Community ◽  
The Novel ◽  
The World ◽  
Novel Coronavirus

Background: The novel coronavirus pneumonia has attracted considerable attention from the international community. With the spread of outbreaks around the world, the WHO characterized COVID-19 as a pandemic. Methods: Relevant studies in PubMed were searched from January 1, 2020 to April 12, 2020, using the following search strategy: (“novel coronavirus pneumonia” OR “severe acute respiratory syndrome coronavirus 2” OR “coronavirus disease 2019” OR “COVID-19” OR “novel coronavirus pneumonia”) AND (“ophthalmology” OR “ophthalmologist” OR “eye” OR “conjunctiva” OR “conjunctivitis” OR “corneal” OR “keratitis”). Results: SARS-CoV-2 can spread through aerosol and is detected in tears of patients with COVID-19 infection. Notably, some infected patients had conjunctivitis, and conjunctivitis was the first symptom in some patients later diagnosed to have COVID-19 infection. This would increase the risk for ophthalmologists through inpatient consultations or regular clinical practice. When dealing with seemingly regular ophthalmic patients, the vigilance of ophthalmologists and associated staff tends to be reduced. Conclusion: Ophthalmologists must continuously update their knowledge regarding COVID-19 and take effective measures to prevent COVID-19 transmission.

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