Preparation and Characterisation of Carvacrol Encapsulated in Gellan Gum Hydrogel

2017 ◽  
Vol 4 (1) ◽  
pp. 9-14
Author(s):  
Adila Mohamad Jaafar ◽  
Norafida Hasnu ◽  
Nur Aisyah Nasuha Mohd Azam
Keyword(s):  
Gellan Gum

Co-polymerized Gellan Gum: A Carrier for Controlled Drug Delivery

2016 ◽  
Vol 5 (3) ◽  
pp. 151-162
Author(s):  
Ranjeet Pareek ◽  
Shakuntla Verma ◽  
Viney Lather ◽  
Deepti Pandita
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Gellan Gum

Gellan gum biosynthesis in Sphingomonas paucimobilis ATCC 31461: Genes, enzymes and exopolysaccharide production engineering

2002 ◽  
Vol 29 (4) ◽  
pp. 170-176
Author(s):  
I Sá-Correia ◽  
A M Fialho ◽  
P Videira ◽  
L M Moreira ◽  
A R Marques ◽  
...  
Keyword(s):  
Gellan Gum ◽  
Sphingomonas Paucimobilis ◽  
Production Engineering ◽  
Exopolysaccharide Production

scholarly journals Anti-Inflammatory Properties of Injectable Betamethasone-Loaded Tyramine-Modified Gellan Gum/Silk Fibroin Hydrogels

Biomolecules ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1456
Author(s):  
Isabel Matos Oliveira ◽  
Cristiana Gonçalves ◽  
Myeong Eun Shin ◽  
Sumi Lee ◽  
Rui Luis Reis ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mechanical Properties ◽  
Silk Fibroin ◽  
Therapeutic Efficacy ◽  
Composite Structures ◽  
Gelation Time ◽  
Polymeric Materials ◽  
Gellan Gum ◽  
Traditional Use

Rheumatoid arthritis is a rheumatic disease for which a healing treatment does not presently exist. Silk fibroin has been extensively studied for use in drug delivery systems due to its uniqueness, versatility and strong clinical track record in medicine. However, in general, natural polymeric materials are not mechanically stable enough, and have high rates of biodegradation. Thus, synthetic materials such as gellan gum can be used to produce composite structures with biological signals to promote tissue-specific interactions while providing the desired mechanical properties. In this work, we aimed to produce hydrogels of tyramine-modified gellan gum with silk fibroin (Ty–GG/SF) via horseradish peroxidase (HRP), with encapsulated betamethasone, to improve the biocompatibility and mechanical properties, and further increase therapeutic efficacy to treat rheumatoid arthritis (RA). The Ty–GG/SF hydrogels presented a β-sheet secondary structure, with gelation time around 2–5 min, good resistance to enzymatic degradation, a suitable injectability profile, viscoelastic capacity with a significant solid component and a betamethasone-controlled release profile over time. In vitro studies showed that Ty–GG/SF hydrogels did not produce a deleterious effect on cellular metabolic activity, morphology or proliferation. Furthermore, Ty–GG/SF hydrogels with encapsulated betamethasone revealed greater therapeutic efficacy than the drug applied alone. Therefore, this strategy can provide an improvement in therapeutic efficacy when compared to the traditional use of drugs for the treatment of rheumatoid arthritis.

scholarly journals Preparation and characterization of gellan gum-chitosan polyelectrolyte complex films with the incorporation of thyme essential oil nanoemulsion

2021 ◽  
Vol 114 ◽  
pp. 106570
Author(s):  
Xinhui Zhang ◽  
Donghong Liu ◽  
Tony Z. Jin ◽  
Weijun Chen ◽  
Qiao He ◽  
...  
Keyword(s):  
Essential Oil ◽  
Polyelectrolyte Complex ◽  
Gellan Gum ◽  
Thyme Essential Oil

scholarly journals Effects of gellan gum and inulin on mixed‐gel properties and molecular structure of gelatin

2021 ◽  
Author(s):  
Juanjuan Wang ◽  
Xue Zhao ◽  
Changyu Zhou ◽  
Chong Wang ◽  
Yanyan Zheng ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Gellan Gum ◽  
Gel Properties

scholarly journals Chemical modification strategies for viscosity-dependent processing of gellan gum

2021 ◽  
pp. 118335
Author(s):  
Christine Gering ◽  
Anum Rasheed ◽  
Janne T. Koivisto ◽  
Jenny Párraga ◽  
Sampo Tuukkanen ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Gellan Gum
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