scholarly journals Multiple Sclerosis Detection via 6-layer Stochastic Pooling Convolutional Neural Network and Multiple-way Data Augmentation

STEMedicine ◽  
2021 ◽  
Vol 2 (8) ◽  
pp. e101
Author(s):  
Jian Wang ◽  
Dimas Lima

Multiple sclerosis is one of most widespread autoimmune neuroinflammatory diseases which mainly damages body function such as movement, sensation, and vision. Despite of conventional clinical presentation, brain magnetic resonance imaging of white matter lesions is often applied to diagnose multiple sclerosis at the early stage. In this article, we proposed a 6-layer stochastic pooling convolutional neural network with multiple-way data augmentation for multiple sclerosis detection in brain MRI images. Our approach does not demand hand-crafted features unlike those traditional machine learning methods. Via application of stochastic pooling and multiple-way data augmentation, our 6-layer CNN achieved equivalent performance against those deep learning methods which consist of so many layers and parameters that ordinarily bring difficulty to training. The results showed that this 6-layer CNN obtained a sensitivity of 95.98±0.46%, a specificity of 95.67±0.92%, and an accuracy of 95.82±0.58%. According to comparison experiments, our results are better than state-of-the-art approaches. Further, we also conducted ablation experiments to examine the contribution of stochastic pooling and multiple-way data augmentation to the original CNN model. The contrast experiments revealed that our scheme of stochastic pooling and multiple-way data augmentation enhanced the original 6-layer CNN model compared to those using maximum pooling or average pooling and inadequate data augmentation.

2017 ◽  
Vol 42 (1) ◽  
Author(s):  
Shui-Hua Wang ◽  
Yi-Ding Lv ◽  
Yuxiu Sui ◽  
Shuai Liu ◽  
Su-Jing Wang ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Shahab U. Ansari ◽  
Kamran Javed ◽  
Saeed Mian Qaisar ◽  
Rashad Jillani ◽  
Usman Haider

Multiple sclerosis (MS) is a chronic and autoimmune disease that forms lesions in the central nervous system. Quantitative analysis of these lesions has proved to be very useful in clinical trials for therapies and assessing disease prognosis. However, the efficacy of these quantitative analyses greatly depends on how accurately the MS lesions have been identified and segmented in brain MRI. This is usually carried out by radiologists who label 3D MR images slice by slice using commonly available segmentation tools. However, such manual practices are time consuming and error prone. To circumvent this problem, several automatic segmentation techniques have been investigated in recent years. In this paper, we propose a new framework for automatic brain lesion segmentation that employs a novel convolutional neural network (CNN) architecture. In order to segment lesions of different sizes, we have to pick a specific filter or size 3 × 3 or 5 × 5. Sometimes, it is hard to decide which filter will work better to get the best results. Google Net has solved this problem by introducing an inception module. An inception module uses 3 × 3 , 5 × 5 , 1 × 1 and max pooling filters in parallel fashion. Results show that incorporating inception modules in a CNN has improved the performance of the network in the segmentation of MS lesions. We compared the results of the proposed CNN architecture for two loss functions: binary cross entropy (BCE) and structural similarity index measure (SSIM) using the publicly available ISBI-2015 challenge dataset. A score of 93.81 which is higher than the human rater with BCE loss function is achieved.


2021 ◽  
Author(s):  
Mosleh Hmoud Al-Adhaileh

Abstract Alzheimer's disease (AD) is a high-risk and atrophic neurological illness that slowly and gradually destroys brain cells (i.e. neurons). As the most common type of amentia, AD affects 60–65% of all people with amentia and poses major health dangers to middle-aged and elderly people. For classification of AD in the early stage, classification systems and computer-aided diagnostic techniques have been developed. Previously, machine learning approaches were applied to develop diagnostic systems by extracting features from neural images. Currently, deep learning approaches have been used in many real-time medical imaging applications. In this study, two deep neural network techniques, AlexNet and Restnet50, were applied for the classification and recognition of AD. The data used in this study to evaluate and test the proposed model included those from brain magnetic resonance imaging (MRI) images collected from the Kaggle website. A convolutional neural network (CNN) algorithm was applied to classify AD efficiently. CNNs were pre-trained using AlexNet and Restnet50 transfer learning models. The results of this experimentation showed that the proposed method is superior to the existing systems in terms of detection accuracy. The AlexNet model achieved outstanding performance based on five evaluation metrics (accuracy, F1 score, precision, sensitivity and specificity) for the brain MRI datasets. AlexNet displayed an accuracy of 94.53%, specificity of 98.21%, F1 score of 94.12% and sensitivity of 100%, outperforming Restnet50. The proposed method can help improve CAD methods for AD in medical investigations.


2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Shui-Hua Wang ◽  
Kaihong Wu ◽  
Tianshu Chu ◽  
Steven L. Fernandes ◽  
Qinghua Zhou ◽  
...  

Aim. This study proposes a new artificial intelligence model based on cardiovascular computed tomography for more efficient and precise recognition of Tetralogy of Fallot (TOF). Methods. Our model is a structurally optimized stochastic pooling convolutional neural network (SOSPCNN), which combines stochastic pooling, structural optimization, and convolutional neural network. In addition, multiple-way data augmentation is used to overcome overfitting. Grad-CAM is employed to provide explainability to the proposed SOSPCNN model. Meanwhile, both desktop and web apps are developed based on this SOSPCNN model. Results. The results on ten runs of 10-fold crossvalidation show that our SOSPCNN model yields a sensitivity of 92.25 ± 2.19 , a specificity of 92.75 ± 2.49 , a precision of 92.79 ± 2.29 , an accuracy of 92.50 ± 1.18 , an F1 score of 92.48 ± 1.17 , an MCC of 85.06 ± 2.38 , an FMI of 92.50 ± 1.17 , and an AUC of 0.9587. Conclusion. The SOSPCNN method performed better than three state-of-the-art TOF recognition approaches.


Sensors ◽  
2021 ◽  
Vol 22 (1) ◽  
pp. 167
Author(s):  
Almudena López-Dorado ◽  
Miguel Ortiz ◽  
María Satue ◽  
María J. Rodrigo ◽  
Rafael Barea ◽  
...  

Background: The aim of this paper is to implement a system to facilitate the diagnosis of multiple sclerosis (MS) in its initial stages. It does so using a convolutional neural network (CNN) to classify images captured with swept-source optical coherence tomography (SS-OCT). Methods: SS-OCT images from 48 control subjects and 48 recently diagnosed MS patients have been used. These images show the thicknesses (45 × 60 points) of the following structures: complete retina, retinal nerve fiber layer, two ganglion cell layers (GCL+, GCL++) and choroid. The Cohen distance is used to identify the structures and the regions within them with greatest discriminant capacity. The original database of OCT images is augmented by a deep convolutional generative adversarial network to expand the CNN’s training set. Results: The retinal structures with greatest discriminant capacity are the GCL++ (44.99% of image points), complete retina (26.71%) and GCL+ (22.93%). Thresholding these images and using them as inputs to a CNN comprising two convolution modules and one classification module obtains sensitivity = specificity = 1.0. Conclusions: Feature pre-selection and the use of a convolutional neural network may be a promising, nonharmful, low-cost, easy-to-perform and effective means of assisting the early diagnosis of MS based on SS-OCT thickness data.


Electronics ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 81
Author(s):  
Jianbin Xiong ◽  
Dezheng Yu ◽  
Shuangyin Liu ◽  
Lei Shu ◽  
Xiaochan Wang ◽  
...  

Plant phenotypic image recognition (PPIR) is an important branch of smart agriculture. In recent years, deep learning has achieved significant breakthroughs in image recognition. Consequently, PPIR technology that is based on deep learning is becoming increasingly popular. First, this paper introduces the development and application of PPIR technology, followed by its classification and analysis. Second, it presents the theory of four types of deep learning methods and their applications in PPIR. These methods include the convolutional neural network, deep belief network, recurrent neural network, and stacked autoencoder, and they are applied to identify plant species, diagnose plant diseases, etc. Finally, the difficulties and challenges of deep learning in PPIR are discussed.


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