Development of new water toxicity analysis instrument

The aims of this study are to measure the level of service quality and how to improve the quality of service execution in re-measurement tera and tera of UTTP in Commerce On duty Co-Operation, Industrial and Commerce Of Sub-Province of Pacitan. This research’s object is traditional market of Minulyo Pacitan as mains market in Sub-Province of Pacitan with 100 perpetrator people of sample as user/owner of UTTP (ukur,timbang, takar, dan perlengkapannya) with method intake of sampel by Convenience Sampling. The technique of collecting data uses questionnaires and direct interview. This research use qualitative analysis instrument test of validity and reliability to know valid or not and reliabel or not about the questions of questionnaire. Then, this research was done with Servqual method as instrument to do measurement of service quality. The measurement of service quality in Servqual method pursuant to five service dimension that is tangibles, responsiveness, realibility, assurance, and empathy. This research will be measured of gap 5 that is difference among performance and its expectation. Ad for yielded gap from a enumeration of Servqual 5 gap, -146 progressively lower him mount the quality of given service activities. Therefore, its needs the existence of priority repair of service quality, in this case is service of remeasurement tera and tera of UTTP at biggest difference or gap that is at variable of Responsiveness ( Energy Listen carefully) and attribute that has smallest difference that is – 0.44 at dimension question of variable of Tangibles ( Evidence Physical). Keyword: Quality Of Service, Method of Service Quality.

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Quantification of small-scale heterogeneity in aquatic aminopeptidase activity

Aquatic Microbial Ecology ◽

10.3354/ame01930 ◽

2020 ◽

Vol 84 ◽

pp. 127-140

Author(s):

BM Gaas ◽

JW Ammerman

Keyword(s):

Chlorophyll Fluorescence ◽

Leucine Aminopeptidase ◽

Hudson River ◽

Aminopeptidase Activity ◽

Small Scale ◽

Analysis Instrument ◽

Sequential Samples ◽

Degree Of Confidence ◽

The Mean ◽

Hydrolysis Of

Leucine aminopeptidase (LAP) is one of the enzymes involved in the hydrolysis of peptides, and is sometimes used to indicate potential nitrogen limitation in microbes. Small-scale variability has the potential to confound interpretation of underlying patterns in LAP activity in time or space. An automated flow-injection analysis instrument was used to address the small-scale variability of LAP activity within contiguous regions of the Hudson River plume (New Jersey, USA). LAP activity had a coefficient of variation (CV) of ca. 0.5 with occasional values above 1.0. The mean CVs for other biological parameters—chlorophyll fluorescence and nitrate concentration—were similar, and were much lower for salinity. LAP activity changed by an average of 35 nmol l-1 h-1 at different salinities, and variations in LAP activity were higher crossing region boundaries than within a region. Differences in LAP activity were ±100 nmol l-1 h-1 between sequential samples spaced <10 m apart. Variogram analysis indicated an inherent spatial variability of 52 nmol l-1 h-1 throughout the study area. Large changes in LAP activity were often associated with small changes in salinity and chlorophyll fluorescence, and were sensitive to the sampling frequency. This study concludes that LAP measurements in a sample could realistically be expected to range from zero to twice the average, and changes between areas or times should be at least 2-fold to have some degree of confidence that apparent patterns (or lack thereof) in activity are real.

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A study on the toxicity analysis and biodegradation of bisphenol A with the help of bacterial and fungal species

International Journal of Chemical and Environmental Sciences ◽

10.15864/ijcaes.1106 ◽

2019 ◽

Vol 1 (1) ◽

Keyword(s):

Bisphenol A ◽

Fungal Species ◽

Toxicity Analysis

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An Analysis Instrument for Gameplay Information Flows Supporting Sustainability Complex Problem-Solving

Proceedings of the 12th European Conference on Game Based Learning ◽

10.34190/gbl.19.171 ◽

2019 ◽

Cited By ~ 1

Keyword(s):

Problem Solving ◽

Complex Problem ◽

Information Flows ◽

Complex Problem Solving ◽

Analysis Instrument

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A Novel Approach for the Identification of Pharmacophores Through Differential Toxicity Analysis of Estrogen Receptor Positive and Negative Cell Lines

10.21236/ada538258 ◽

2009 ◽

Author(s):

Albert R. Cunningham

Keyword(s):

Estrogen Receptor ◽

Cell Lines ◽

Negative Cell ◽

Novel Approach ◽

Differential Toxicity ◽

Estrogen Receptor Positive ◽

Toxicity Analysis

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Design of potential IKK-β inhibitors using molecular docking and molecular dynamics techniques for their anti-cancer potential

Current Computer - Aided Drug Design ◽

10.2174/1573409916666200102121505 ◽

2020 ◽

Vol 16 ◽

Author(s):

Salam Pradeep Singh ◽

Iftikar Hussain ◽

Bolin Kumar Konwar ◽

Ramesh Chandra Deka ◽

Chingakham Brajakishor Singh

Keyword(s):

Molecular Dynamics ◽

Molecular Docking ◽

Md Simulation ◽

Inflammatory Diseases ◽

Binding Free Energy ◽

Anti Cancer ◽

Dietary Phytochemicals ◽

Toxicity Analysis ◽

The Stability ◽

Stable Trajectory

Aim and Objective: To evaluate a set of seventy phytochemicals for their potential ability to bind the inhibitor of nuclear factor kappaB kinase beta (IKK-β) which is a prime target for cancer and inflammatory diseases. Materials and Methods: Seventy phytochemicals were screened against IKK-β enzyme using DFT-based molecular docking technique and the top docking hits were carried forward for molecular dynamics (MD) simulation protocols. The adme-toxicity analysis was also carried out for the top docking hits. Results: Sesamin, matairesinol and resveratrol were found to be the top docking hits with a total score of -413 kJ/mol, -398.11 kJ/mol and 266.73 kJ/mol respectively. Glu100 and Gly102 were found to be the most common interacting residues. The result from MD simulation observed a stable trajectory with a binding free energy of -107.62 kJ/mol for matairesinol, -120.37 kJ/mol for sesamin and -40.56 kJ/mol for resveratrol. The DFT calculation revealed the stability of the compounds. The ADME-Toxicity prediction observed that these compounds fall within the permissible area of Boiled-Egg and it does not violate any rule for pharmacological criteria, drug-likeness etc. Conclusion: The study interprets that dietary phytochemicals are potent inhibitors of IKK-β enzyme with favourable binding affinity and less toxic effects. In fact, there is a gradual rise in the use of plant-derived molecules because of its lesser side effects compared to chemotherapy. The study has also provided an insight by which the phytochemicals inhibited the IKK-β enzyme. The investigation would also provide in understanding the inhibitory mode of certain dietary phytochemicals in treating cancer.

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