Schiff Base: An Overview of its Medicinal Chemistry Potential for New Drug Molecules

Schiff base denotes a reaction product of a primary amine and a carbonyl compound. Schiff bases possess a wide variety of biological activity specially antibacterial and antifungal properties. Metal complexes of Schiff base have been studied for their biological activities. This review articles provide a summary of medicinal chemistry features of Schiff base and various reports published on biological activities of Schiff base and its metal complexes.

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A review on biological activities of Schiff base ligand and their metal complexes

International Journal of ChemTech Research ◽

10.20902/ijctr.2019.130126 ◽

2020 ◽

Vol 13 (1) ◽

pp. 217-221

Author(s):

P.M. Jadhav

Keyword(s):

Schiff Base ◽

Metal Complexes ◽

Schiff Bases ◽

Carbonyl Compounds ◽

Biological Activities ◽

Condensation Reaction ◽

Cytotoxic Activities ◽

Wide Range ◽

Enzymatic Agents ◽

Dye Industry

Schiff bases and their metal complexes are wide range of biological applications and are synthesized from the condensation reaction of amino compounds with carbonyl compounds. Schiff base and their metal complexes have a wide variety of applications in food and dye industry, agrochemical, polymer, catalysis, analytical chemistry, antifertility, antiinflammatory activity, antiradical activity, and biological system as enzymatic agents. Several have reviewed them of their antimicrobial, antibacterial, antifungal, antitumor, and cytotoxic activities. This review summarized the most promising biological activities of Schiff bases and their metal complexes

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A review on versatile applications of novel Schiff bases and their metal complexes

Letters in Applied NanoBioScience ◽

10.33263/lianbs84.675681 ◽

2019 ◽

Vol 8 (4) ◽

pp. 675-681

Keyword(s):

Schiff Base ◽

Metal Complexes ◽

Schiff Bases ◽

Carbonyl Compounds ◽

Biological Activities ◽

Schiff Base Complexes ◽

Amino Compound ◽

Azomethine Group ◽

Catalytic Activities ◽

Schiff Base Metal Complexes

Metal complexes synthesized from Schiff bases and furthermore Schiff bases are versatile in nature. Such types of compounds were prepared from the condensation of an amino compound with carbonyl compounds (aldehyde or ketone) during which the carbonyl group is replaced by an imine or azomethine group. Schiff bases and their derivatives are widely employed in industries, polymers, dyes and medicative and pharmaceutical fields and additionally exhibit biological activities like antibacterial, antifungal, anti-inflammatory, antimalarial, antiviral, and antipyretic properties. Many Schiff base metal complexes exhibit glorious catalytic activities in numerous mechanisms. Their several applications in homogenous and heterogeneous catalysis were according troughout last decade. Several Schiff base complexes were helpful for their application as catalysts in reactions involving at high temperatures because of the high thermal and moisture stabilities. This text totally based on literature review with examples of the most promising applied Schiff bases and their complexes in several areas, summarizing the applications of Schiff bases and their numerous derivatives and complexes.

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Performance of Schiff Bases Metal Complexes and their Ligand in Biological Activity: A Review

Al-Nahrain Journal of Science ◽

10.22401/anjs.24.1.01 ◽

2021 ◽

Vol 24 (1) ◽

pp. 1-10

Author(s):

Farah M. Ibrahim ◽

◽

Saifaldeen M. Abdalhadi ◽

Keyword(s):

Biological Activity ◽

Schiff Base ◽

Metal Complexes ◽

Schiff Bases ◽

Base Metal ◽

Broad Class ◽

Condensation Process ◽

Human System ◽

Wide Range ◽

Schiff Base Metal Complexes

Schiff bases are a broad class synthesized compound, which is prepared for the condensation process between the primary amine group and an aldehyde or ketone group. Schiff base metal complexes play an important role in many applications such as biological activity, catalytic activity, and optical property. The wide range application of Schiff base metal complexes came from the versatility of Schiff base reactions with many different transition metals. This flexibility of the reactions was given these complexes, many different properties and uses in a biological human system such as antibacterial, antifungal, anticancer, antimalarial, and others. This review gives many examples of Schiff bases, metal complexes, and there ligands with biological applications in the human system.

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APPLICATION OF METAL COMPLEXES OF SCHIFF BASES AS AN ANTIMICROBIAL DRUG: A REVIEW OF RECENT WORKS

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2017.v9i3.19966 ◽

2017 ◽

Vol 9 (3) ◽

pp. 27 ◽

Cited By ~ 3

Author(s):

Kumble Divya ◽

Geetha M. Pinto ◽

Asha F Pinto

Keyword(s):

Schiff Base ◽

Transition Metal ◽

Metal Complexes ◽

Schiff Bases ◽

Transition Metal Complexes ◽

Biological Activities ◽

Wide Spectrum ◽

Antimicrobial Activities ◽

Primary Amines ◽

Unusual Structure

Schiff bases are versatile ligands which are synthesized from the condensation of primary amines with carbonyl groups. Synthesis of Schiff base transition metal complexes by using Schiff base as ligands appears to be fascinating in view of the possibility of obtaining coordination compounds of unusual structure and stability. These transition metal complexes have received exceptional consideration because of their active part in metalloenzymes and as biomimetic model compounds due to their closeness to natural proteins and enzymes. These compounds are very important in pharmaceutical fields because of their wide spectrum of biological activities. Most of them show biological activities including antibacterial, antifungal, antidiabetic, antitumor, antiproliferative, anticancer, herbicidal, and anti-inflammatory activities. The biological activity of the transition metal complexes derived from the Schiff base ligands has been widely studied. This review summarizes the importance, Scope and antimicrobial activities of Schiff base metal complexes.

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The Importance of 2-AminoThiazole Schiff Bases as Antimicrobial and Anticancer Agents

Al-Mustansiriyah Journal of Science ◽

10.23851/mjs.v31i3.865 ◽

2020 ◽

Vol 31 (3) ◽

pp. 46

Author(s):

Shayma L. Abdulhadi ◽

Maadh Q. Abdulkadir ◽

May M. Al-Mudhafar

Keyword(s):

Biological Activity ◽

Schiff Base ◽

Metal Complexes ◽

Anticancer Activity ◽

Schiff Bases ◽

Anticancer Agents ◽

Pharmaceutical Chemistry ◽

Schiff Base Derivatives ◽

Derivatives Of ◽

Diverse Biological Activity

The pharmacophore 2-aminothiazole has an interesting role in pharmaceutical chemistry as this led to the synthesis of many types of compounds with diverse biological activity. Schiff base derivatives at the same time contribute to drug evolution importantly. In this review, the Schiff base derivatives of 2-aminothiazole formed and some of their metal complexes are being focused on, and the antimicrobial and anticancer activity of them is being illustrated.

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Synthesis and Biological Activity of Hydrazones and Derivatives: A Review

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557519666191014142448 ◽

2020 ◽

Vol 20 (5) ◽

pp. 342-368 ◽

Cited By ~ 5

Author(s):

Juliana de Oliveira Carneiro Brum ◽

Tanos Celmar Costa França ◽

Steven R. LaPlante ◽

José Daniel Figueroa Villar

Keyword(s):

Biological Activity ◽

Medicinal Chemistry ◽

Biological Activities ◽

New Drugs ◽

New Drug ◽

Cancer Inflammation

Hydrazones and their derivatives are very important compounds in medicinal chemistry due to their reported biological activity for the treatment of several diseases, like Alzheimer’s, cancer, inflammation, and leishmaniasis. However, most of the investigations on hydrazones available in literature today are directed to the synthesis of these molecules with little discussion available on their biological activities. With the purpose of bringing lights into this issue, we performed a revision of the literature and wrote this review based on some of the most current research reports of hydrazones and derivatives, making it clear that the synthesis of these molecules can lead to new drug prototypes. Our goal is to encourage more studies focused on the synthesis and evaluation of new hydrazones, as a contribution to the development of potential new drugs for the treatment of various diseases.

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