Ibandronat in the Therapy of Osteoporosis in Turner Syndrome

2018 ◽  
Vol 69 (7) ◽  
pp. 1692-1694
Author(s):  
Dana Maria Albulescu ◽  
Adelina Smaranda Preda ◽  
Adrian Camen ◽  
Nina Ionovici
Keyword(s):  
Turner Syndrome ◽  
Chromosomal Abnormalities ◽  
Bone Involvement ◽  
Hormone Deficiency ◽  
Bone Pathology ◽  
Sexual Hormone ◽  
T Score ◽  
Cardio Vascular ◽  
Turn Over

Turner syndrome represents a condition that associates diverse pathology with somatic, metabolic (diabetes), cardio-vascular, digestive, respiratory and bone involvement along with chromosomal abnormalities. In our study we have analyzed the bone pathology that occurs in Turner syndrome and the response in the therapy with ibandronat. The decrease in value of the bone turn-over biomarkers and the decrease of the T score after the administration of ibandronate p.o. in a monthly dosage demonstrates the efficiency of this bisphosphonate in the treatment of the osteoporosis secondary to sexual hormone deficiency in Turner syndrome.

scholarly journals Fertility Preservation in Girls with Turner Syndrome: Prognostic Signs of the Presence of Ovarian Follicles

2009 ◽  
Vol 94 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Borgström Birgit ◽  
Hreinsson Julius ◽  
Rasmussen Carsten ◽  
Sheikhi Maryam ◽  
Fried Gabriel ◽  
...  
Keyword(s):  
Turner Syndrome ◽  
Fertility Preservation ◽  
Chromosomal Abnormalities ◽  
Ovarian Tissue ◽  
Ovarian Follicle ◽  
University Hospital ◽  
Serum Concentrations ◽  
Pubertal Stage ◽  
Group 12 ◽  
Tissue Piece

Abstract Context: Many girls with Turner syndrome have follicles in their ovaries at adolescence. Objective: Our objective was to study which girls might benefit from ovarian tissue freezing for fertility preservation. Design: Clinical and laboratory parameters and ovarian follicle counts were analyzed among girls referred by 25 pediatric endocrinologists. Subjects and Setting: Fifty-seven girls with Turner syndrome, aged 8–19.8 yr, were studied at a university hospital. Interventions: Ovarian tissue was biopsied laparoscopically, studied for the presence of follicles, and cryopreserved. Blood samples were drawn for hormone measurements. Main Outcome Measures: Presence of follicles in the biopsied tissue related to age, signs of spontaneous puberty, karyotype, and serum concentrations of gonadotropins and anti-Müllerian hormone were assessed. Results: Ovarian biopsy was feasible in 47 of the 57 girls. In 15 of the 57 girls (26%), there were follicles in the tissue piece analyzed histologically. Six of seven girls (86%) with mosaicism, six of 22 (27%) with structural chromosomal abnormalities, and three of 28 with karyotype 45X (10.7%) had follicles. Eight of the 13 girls (62%) with spontaneous menarche had follicles, and 11 of the 19 girls (58%) who had signs of spontaneous puberty had follicles. The age group 12–16 yr had the highest proportion of girls with follicles. Normal FSH and anti-Müllerian hormone concentrations for age and pubertal stage were more frequent in girls with follicles. Conclusions: Signs of spontaneous puberty, mosaicism, and normal hormone concentrations were positive and statistically significant but not exclusive prognostic factors as regards finding follicles.

scholarly journals Chromosomal abnormalities and atrial fibrillation and ischemic stroke incidence: a nationwide population-based study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jun Hwan Cho ◽  
Eue-Keun Choi ◽  
In-Ki Moon ◽  
Jin- Hyung Jung ◽  
Kyung-Do Han ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Down Syndrome ◽  
Ischemic Stroke ◽  
Turner Syndrome ◽  
Chromosomal Abnormalities ◽  
Klinefelter Syndrome ◽  
Control Group ◽  
Stroke Incidence ◽  
Cox Regression Analysis ◽  
Increased Risk

Abstract There is a paucity of information as to whether chromosomal abnormalities, including Down Syndrome, Turner Syndrome, and Klinefelter Syndrome, have an association with atrial fibrillation (AF) and ischemic stroke development. Data from 3660 patients with Down Syndrome, 2408 with Turner Syndrome, and 851 with Klinefelter Syndrome without a history of AF and ischemic stroke were collected from the Korean National Health Insurance Service (2007–2014). These patients were followed-up for new-onset AF and ischemic stroke. Age- and sex-matched control subjects (at a ratio of 1:10) were selected and compared with the patients with chromosomal abnormalities. Down Syndrome patients showed a higher incidence of AF and ischemic stroke than controls. Turner Syndrome and Klinefelter Syndrome patients showed a higher incidence of AF than did the control group, but not of stroke. Multivariate Cox regression analysis revealed that three chromosomal abnormalities were independent risk factors for AF, and Down Syndrome was independently associated with the risk of stroke. In conclusion, Down Syndrome, Turner Syndrome, and Klinefelter Syndrome showed an increased risk of AF. Down Syndrome patients only showed an increased risk of stroke. Therefore, AF surveillance and active stroke prevention would be beneficial in patients with these chromosomal abnormalities.

Opposite effects of growth hormone and estrogens on the pregnancy zone protein serum levels in children and adolescents

1993 ◽  
Vol 128 (4) ◽  
pp. 334-338 ◽  
Author(s):  
K Devriendt ◽  
G Massa ◽  
F de Zegher ◽  
M Vanderschueren-Lodeweyckx ◽  
JJ Cassiman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Turner Syndrome ◽  
Recombinant Human Growth Hormone ◽  
Serum Levels ◽  
Hormone Deficiency ◽  
Normal Range ◽  
Protein Levels ◽  
Pregnancy Zone Protein ◽  
Protein Serum

Serum levels of pregnancy zone protein were measured in children with growth hormone deficiency and in girls with Turner syndrome, before and during treatment with recombinant human growth hormone and in healthy controls. The pregnancy zone protein serum levels in growth hormone deficiency patients before treatment were significantly higher than in controls (median value 2420 μg/l vs 434 μg/l; p≤0.001). In Turner syndrome patients they were within the normal range. The administration of rhGH to both growth hormone deficiency and Turner syndrome patients resulted in a significant decrease in the serum pregnancy zone protein levels by approximately 50%. The addition of 50 ng·kg−1·d −1 ethinylestradiol to the growth hormone treatment in Turner syndrome patients led to an increase in pregnancy zone protein concentrations in four out of five patients. Elevated pregnancy zone protein levels were also found in two children with growth hormone resistance (Laron type dwarfism). In one patient with placental growth hormone deficiency, pregnancy zone protein serum levels during pregnancy were within the normal range. These results suggest that the serum pregnancy zone protein levels are down-regulated by growth hormone.

AUFTRETEN VON KASTRATIONSZELLEN IM HYPOPHYSENVORDERLAPPEN MÄNNLICHER RATTEN NACH BEHANDLUNG MIT EINEM ANTIANDROGEN

1966 ◽  
Vol 53 (1) ◽  
pp. 53-60 ◽  
Author(s):  
F. Neumann
Keyword(s):  
Pituitary Gland ◽  
Inhibitory Effect ◽  
Anterior Lobe ◽  
Male Rats ◽  
Hormone Deficiency ◽  
Pars Intermedia ◽  
Sexual Hormone ◽  
Releasing Factors

ABSTRACT Following the administration of an androgen-antagonist (1,2α-methylene-6-chloro-pregna-4,6-diene-17α-ol-3,20-dione = cyproterone) to male rats, changes are observed in the anterior lobe of the pituitary gland comparable to those which develop following removal of the gonads. The appearance of so called castration cells is very striking, particularly in the periphery, and in the area adjacent to the pars intermedia. The findings suggest that the androgen-antagonism of cyproterone also manifests itself in those receptors of the sex centre, which regulate the amount of gonadotrophin production and secretion in relation to the production of testosterone. Since endogenous testosterone can no longer exert its inhibitory effect on the sex centre, the sex centre, as in a state of sexual hormone deficiency, reacts by secreting releasing factors for gonadotrophins. Thus those cell elements in the anterior lobe of the pituitary gland are stimulated and this leads to the production of gonadotrophin.

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