The Effects of Vitamin C Supplementation and Yoga on the Improvement of Serum Lipid Peroxidation in Middle-aged Women

The tissue changes that occur in Chagas disease are related to the degree of oxidative stress and antioxidant capacity of affected tissue. Studies with vitamin C supplementation did not develop oxidative damage caused by Chagas disease in the host, but other studies cite the use of peroxiredoxins ascorbate - dependent on T. cruzi to offer protection against immune reaction. Based on these propositions, thirty "Swiss" mice were infected with T. cruzi QM1 strain and treated with two different vitamin C doses in order to study the parasitemia evolution, histopathological changes and lipid peroxidation biomarkers during the acute phase of Chagas disease. The results showed that the parasite clearance was greater in animals fed with vitamin C overdose. There were no significant differences regarding the biomarkers of lipid peroxidation and inflammatory process or the increase of myocardium in animals treated with the recommended dosage. The largest amount of parasite growth towards the end of the acute phase suggests the benefit of high doses of vitamin C for trypomastigotes. The supplementation doesn't influence the production of free radicals or the number of amastigote nests in the acute phase of Chagas disease.

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Effects of vitamin C supplementation on antioxidants and lipid peroxidation markers in elderly subjects with type 2 diabetes

Archives of Gerontology and Geriatrics ◽

10.1016/j.archger.2007.10.005 ◽

2009 ◽

Vol 48 (1) ◽

pp. 67-72 ◽

Cited By ~ 20

Author(s):

Daniel M. Tessier ◽

Abdelouahed Khalil ◽

Lise Trottier ◽

Tamas Fülöp

Keyword(s):

Type 2 Diabetes ◽

Lipid Peroxidation ◽

Vitamin C ◽

Elderly Subjects ◽

Vitamin C Supplementation

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Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise

Oxidative Medicine and Cellular Longevity ◽

10.1155/2015/295497 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 11

Author(s):

Ljiljana M. Popovic ◽

Nebojsa R. Mitic ◽

Dijana Miric ◽

Boban Bisevac ◽

Mirjana Miric ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Vitamin C ◽

Inflammatory Response ◽

Acute Exercise ◽

Exercise Group ◽

Vitamin Supplementation ◽

Regular Exercise ◽

Biological Macromolecules ◽

Vitamin C Supplementation

Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting from exercise induces activation of inflammatory cells followed by the increased activity of myeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aim of this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showed that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group.

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