scholarly journals Effects of vitamin C supplementation on acute phase Chagas disease in experimentally infected mice with Trypanosoma cruzi QM1 strain

2012 ◽  
Vol 54 (6) ◽  
pp. 319-323 ◽  
Author(s):  
Ricardo Guimarães Marim ◽  
Alex Silva de Gusmão ◽  
Roberto Esteves Pires Castanho ◽  
Rafael Deminice ◽  
Altino Luiz Silva Therezo ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin C ◽  
Chagas Disease ◽  
Acute Phase ◽  
Immune Reaction ◽  
Parasite Clearance ◽  
Vitamin C Supplementation ◽  
Affected Tissue ◽  
Tissue Changes ◽  
High Doses

The tissue changes that occur in Chagas disease are related to the degree of oxidative stress and antioxidant capacity of affected tissue. Studies with vitamin C supplementation did not develop oxidative damage caused by Chagas disease in the host, but other studies cite the use of peroxiredoxins ascorbate - dependent on T. cruzi to offer protection against immune reaction. Based on these propositions, thirty "Swiss" mice were infected with T. cruzi QM1 strain and treated with two different vitamin C doses in order to study the parasitemia evolution, histopathological changes and lipid peroxidation biomarkers during the acute phase of Chagas disease. The results showed that the parasite clearance was greater in animals fed with vitamin C overdose. There were no significant differences regarding the biomarkers of lipid peroxidation and inflammatory process or the increase of myocardium in animals treated with the recommended dosage. The largest amount of parasite growth towards the end of the acute phase suggests the benefit of high doses of vitamin C for trypomastigotes. The supplementation doesn't influence the production of free radicals or the number of amastigote nests in the acute phase of Chagas disease.

scholarly journals EFFECTS OF VITAMIN C SUPPLEMENTATION ON THE CHRONIC PHASE OF CHAGAS DISEASE

2015 ◽  
Vol 57 (3) ◽  
pp. 245-250 ◽  
Author(s):  
Ricardo Guimarães MARIM ◽  
Alex Silva de GUSMÃO ◽  
Roberto Esteves Pires CASTANHO ◽  
Rafael DEMINICE ◽  
Altino Luiz Silva THEREZO ◽  
...  
Keyword(s):  
Vitamin C ◽  
Chagas Disease ◽  
Chronic Phase ◽  
Thiobarbituric Acid ◽  
Dose Equivalent ◽  
Thiobarbituric Acid Reactive Substances ◽  
Vitamin C Supplementation ◽  
Histopathologic Analysis ◽  
Different Doses ◽  
Oxidative Insult

Introduction: In order to examine the effectiveness of vitamin C (ascorbic acid) in combating the oxidative insult caused by Trypanosoma cruzi during the development of the chronic phase of Chagas disease, Swiss mice were infected intraperitoneally with 5.0 × 104 trypomastigotes of T. cruzi QM1strain. Methods: Mice were given supplements of two different doses of vitamin C for 180 days. Levels of lipid oxidation (as indicated by thiobarbituric acid reactive substances-TBARS), total peroxide, vitamin C, and reduced glutathione were measured in the plasma, TBARS, total peroxide and vitamin C were measured in the myocardium and histopathologic analysis was undertaken in heart, colon and skeletal muscle. Results: Animals that received a dose equivalent to 500 mg of vitamin C daily showed increased production of ROS in plasma and myocardium and a greater degree of inflammation and necrosis in skeletal muscles than those that received a lower dose or no vitamin C whatsoever. Conclusion: Although some research has shown the antioxidant effect of vitamin C, the results showed that animals subject to a 500 mg dose of vitamin C showed greater tissue damage in the chronic phase of Chagas disease, probably due to the paradoxical actions of the substance, which in this pathology, will have acted as a pro-oxidant or pro-inflammatory.

scholarly journals Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Ljiljana M. Popovic ◽  
Nebojsa R. Mitic ◽  
Dijana Miric ◽  
Boban Bisevac ◽  
Mirjana Miric ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Vitamin C ◽  
Inflammatory Response ◽  
Acute Exercise ◽  
Exercise Group ◽  
Vitamin Supplementation ◽  
Regular Exercise ◽  
Biological Macromolecules ◽  
Vitamin C Supplementation

Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting from exercise induces activation of inflammatory cells followed by the increased activity of myeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aim of this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showed that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group.

scholarly journals Effect of Vitamin C Supplementation on Lipid Peroxidation and Lactate Levels in Individuals Performing Exhaustion Exercise

2017 ◽  
Vol 5 (2) ◽  
pp. 21-27 ◽  
Author(s):  
Süleyman Patlar ◽  
Abdulkerim Kasim Baltaci ◽  
Rasim Mogulkoc ◽  
Mehmet Gunay ◽  
◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin C ◽  
Vitamin C Supplementation ◽  
Lactate Levels

Lipid peroxidation in hemodialysis patients: Effect of vitamin C supplementation

2008 ◽  
Vol 41 (6) ◽  
pp. 381-386 ◽  
Author(s):  
Gianna Ferretti ◽  
Tiziana Bacchetti ◽  
Simona Masciangelo ◽  
Giosafatte Pallotta
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin C ◽  
Hemodialysis Patients ◽  
Vitamin C Supplementation

scholarly journals Vitamin C Intervention for Critical COVID-19: A Pragmatic Review of the Current Level of Evidence

Life ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1166
Author(s):  
Patrick Holford ◽  
Anitra C. Carr ◽  
Masuma Zawari ◽  
Marcela P. Vizcaychipi
Keyword(s):  
Vitamin C ◽  
Respiratory Infections ◽  
Current Level ◽  
Vitamin Supplementation ◽  
Level Of Evidence ◽  
Vitamin C Supplementation ◽  
Retrospective Cohort Studies ◽  
High Doses ◽  
Intravenous Vitamin ◽  
Randomised Controlled

Severe respiratory infections are characterized by elevated inflammation and generation of reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as vitamin C and a higher requirement for the vitamin. Administration of intravenous vitamin C to patients with pneumonia and sepsis appears to decrease the severity of the disease and potentially improve survival rate. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes pneumonia, sepsis and acute respiratory distress syndrome (ARDS) in severe cases, and is referred to as coronavirus disease 2019 (COVID-19). Patients with COVID-19 infection also appear to have depleted vitamin C status and require additional supplementation of vitamin C during the acute phase of the disease. To date there have been 12 vitamin C and COVID-19 trials published, including five randomised controlled trials (RCTs) and seven retrospective cohort studies. The current level of evidence from the RCTs suggests that intravenous vitamin C intervention may improve oxygenation parameters, reduce inflammatory markers, decrease days in hospital and reduce mortality, particularly in the more severely ill patients. High doses of oral vitamin C supplementation may also improve the rate of recovery in less severe cases. No adverse events have been reported in published vitamin C clinical trials in COVID-19 patients. Upcoming findings from larger RCTs will provide additional evidence on vitamin supplementation in COVID-19 patients.

Sign in / Sign up

Export Citation Format

Share Document