scholarly journals Features of pain syndrome in patients with bone metastasis

2021 ◽  
Vol 67 (4) ◽  
pp. 569-578
Author(s):  
Evgenii Khmelevskii ◽  
Natalia Bychkova
Keyword(s):  
Pain Relief ◽  
Bone Metastases ◽  
Clinical Symptoms ◽  
Pain Syndrome ◽  
Lesion Length ◽  
High Dose ◽  
Metastatic Bone Pain ◽  
Modern Classification ◽  
The Relationship

Purpose. The purpose of the current study was the search for evaluation criterion for the radiosensitivity of bone metastases of various origins. Materials and methods. The first part of the study presents a modern classification of pain, method of its evaluation, mechanisms and features of metastatic bone pain. The radiobiological patterns of pain relief in low-dose anti-inflammatory radiation therapy were also considered. The analysis of these features testifies in favor of the antitumor mechanism of pain relief in high-dose irradiation. To identify the relationship between pain and other clinical symptoms, 810 cases of bone metastases of various localization and morphology were analyzed. Results. The severity of pain directly correlates with gender, lesion length and little affected by the presence of pathological fracture. The intensity of pain does not depend on the primary tumor and bone metastases localization and does not correlate with the presence of neurological deficit. Conclusion. Completeness and persistence of the analgesic effect may reflect the real radiosensitivity of bone metastases, but taking into account the patient's gender and lesion length in the irradiated area.

Possible Hepatotoxicity Associated With Daptomycin

2016 ◽  
Vol 29 (3) ◽  
pp. 253-256 ◽  
Author(s):  
Yoonsun Mo ◽  
Fletcher Nehring ◽  
Andrew H. Jung ◽  
Seth T. Housman
Keyword(s):  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Pain Syndrome ◽  
Liver Function Tests ◽  
Future Research ◽  
High Dose ◽  
History Of ◽  
The Relationship

Purpose To report a case of isolated daptomycin-induced acute liver injury without elevations in creatine kinase (CK) levels or kidney dysfunction. Summary A 49-year-old female with a history of pancreatitis, lupus, diabetes, congestive heart failure, hypertension, and chronic pain syndrome presented to the emergency department with alteration in mental status and acute liver failure. The patient had been treated with daptomycin for methicillin-resistant Staphylococcus aureus (MRSA) endocarditis for 3 weeks. After ruling out other possible etiologies, daptomycin was suspected as a cause of acute liver failure. Her liver failure resolved gradually following withdrawal of daptomycin. Conclusion Although hepatic abnormalities caused by daptomycin are rare, a handful of cases with daptomycin-induced liver injury have been reported in the literature. Of note, in most cases, patients on daptomycin therapy developed liver damage with elevations in CK levels. Our case report suggests possible severe liver injury associated with high-dose and long-term daptomycin treatment in the absence of rhabdomyolysis. Future research is warranted to further investigate the relationship between daptomycin use and liver injury, yet it is reasonable to monitor liver function tests at baseline and weekly thereafter along with CK levels, especially in patients requiring long-term daptomycin therapy.

scholarly journals Basic principles of treatment of epilepsy in children

1997 ◽  
Vol XXIX (1-2) ◽  
pp. 95-97
Author(s):  
L. S. Petrukhin ◽  
K. Y. Mukhin ◽  
М. I. Medvedev
Keyword(s):  
Clinical Symptoms ◽  
Pediatric Population ◽  
Diagnosis And Treatment ◽  
Basic Principles ◽  
Pediatric Neurology ◽  
Treatment Of Epilepsy ◽  
Epileptic Syndromes ◽  
Modern Classification ◽  
Principles Of Treatment

Currently, epilepsy is one of the most pressing problems in pediatric neurology. The incidence of epilepsy in the pediatric population ranges from 0.5 to 0.75%. The problem of epilepsy is a problem of accurate syndromological diagnosis and treatment. The modern classification of epilepsy, epileptic syndromes and similar disorders distinguishes about 40 different forms of epilepsy, differing in clinical symptoms, principles of therapy, prognosis.

scholarly journals RETINOIDS IN DERMATOLOGY:FUNCTIONAL ACTIVITY AND PROSPECTS OF SYNTHETIC ANALOGUES

2020 ◽  
Vol 13 (5) ◽  
pp. 32-41
Author(s):  
V. B. KOVTUN ◽  
Keyword(s):  
Nuclear Receptors ◽  
Human Body ◽  
Functional Activity ◽  
Chemical Structure ◽  
Practical Application ◽  
Synthetic Analogues ◽  
Dermatological Diseases ◽  
Modern Classification ◽  
The Relationship

The aim of the work was to analyze and summarize information on the functional activity of known retinoids, as well as to determine the directions of their modification and prospects for the use of their synthetic analogues in dermatology. The literature on retinoids metabolism stages in the human body, the mechanisms of their action and the properties that determine their use in various medical fields was considered and analyzed. Information on dermatological diseases treatment with natural retinoids and their synthetic analogues was summarized. The modern classification of retinoids based on the peculiarities of their chemical structure and functional activity is given, the relationship between these characteristics and the direction of use of such drugs in dermatology and cosmetology is shown. Prospects for the practical application of synthetic retinoids represented mainly by polyaromatic compounds are due to their higher stability and efficiency, as well as reduced irritant effect due to selectivity for nuclear receptors.

scholarly journals Internal hernia as one of the causes of abdominal pain

2019 ◽  
Vol 10 (2) ◽  
pp. 27-35
Author(s):  
V. M. Kitaev ◽  
E. G. Koshelev ◽  
O. V. Sokolova ◽  
G. Yu. Belyaev ◽  
A. A. Egorov ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Abdominal Pain ◽  
Abdominal Cavity ◽  
Pain Syndrome ◽  
Internal Hernias ◽  
Diagnostic Difficulties ◽  
Modern Classification ◽  
Acute Small Bowel Obstruction ◽  
Ct Data

Abdominal pain is often observed in clinical practice, causing diagnostic difficulties for doctors of different specialties. Internal hernias are a surgical pathology and may be the cause for the development of acute small bowel obstruction and the occurrence of pain. A modern classification of internal hernias is presented and their topographic-anatomical description is given. The analysis of the results of computed tomography (CT) scan of the abdominal cavity in 20 patients with an unidentified cause of abdominal pain was performed. According to the CT data, three patients had internal hernias that caused the development of pain syndrome. A pathological displacement of intestinal loops with partial disruption of intestinal permeability and curvature of the mesentery without critical disturbance of blood supply was demonstrated in 4 patients with abdominal pain. The findings suggest that CT may be the method of choice when examining patients with an unknown cause of abdominal pain syndrome.

K-MEANS CLUSTERING ALGORITHM BASED CLASSIFICATION OF SOIL FERTILITY IN NORTH WEST NIGERIA

2020 ◽  
Vol 4 (2) ◽  
pp. 780-787
Author(s):  
Ibrahim Hassan Hayatu ◽  
Abdullahi Mohammed ◽  
Barroon Ahmad Isma’eel ◽  
Sahabi Yusuf Ali
Keyword(s):  
Soil Fertility ◽  
Crop Yield ◽  
Clustering Algorithm ◽  
Soil Samples ◽  
North West ◽  
R Programming ◽  
Available Information ◽  
Northwest Region ◽  
The Relationship

Soil fertility determines a plant's development process that guarantees food sufficiency and the security of lives and properties through bumper harvests. The fertility of soil varies according to regions, thereby determining the type of crops to be planted. However, there is no repository or any source of information about the fertility of the soil in any region in Nigeria especially the Northwest of the country. The only available information is soil samples with their attributes which gives little or no information to the average farmer. This has affected crop yield in all the regions, more particularly the Northwest region, thus resulting in lower food production.  Therefore, this study is aimed at classifying soil data based on their fertility in the Northwest region of Nigeria using R programming. Data were obtained from the department of soil science from Ahmadu Bello University, Zaria. The data contain 400 soil samples containing 13 attributes. The relationship between soil attributes was observed based on the data. K-means clustering algorithm was employed in analyzing soil fertility clusters. Four clusters were identified with cluster 1 having the highest fertility, followed by 2 and the fertility decreases with an increasing number of clusters. The identification of the most fertile clusters will guide farmers on where best to concentrate on when planting their crops in order to improve productivity and crop yield.

DONG SON BRONZE DRUM - THE WORK OF THE LAC VIET PEOPLE

2018 ◽  
Author(s):  
Nguyen Van Hao
Keyword(s):  
Classification Criteria ◽  
Way Of Life ◽  
Tribal Identity ◽  
The Relationship

Bronze drums are widely distributed, broader than the range of a nation. Therefore, the identification of each kind of drum is a basic subject, should be concerned. In determining the tribal identity of the drum, the classification of drum is the key stage, the relationship between the objective of the classification and classification criteria is the relation as shape and shadow, if there is no right criteria then the result of division will be difficult to reach the desired goal. Likewise, the criterion of the pattern on the bronze drum brought to the affirmation is the Dong Son bronze drum of the Lac Viet people. And the parallel is the affirmation of the culture, way of life, residence of the nation created the drum.

Sign in / Sign up

Export Citation Format

Share Document