scholarly journals RETINOIDS IN DERMATOLOGY:FUNCTIONAL ACTIVITY AND PROSPECTS OF SYNTHETIC ANALOGUES

2020 ◽  
Vol 13 (5) ◽  
pp. 32-41
Author(s):  
V. B. KOVTUN ◽  
Keyword(s):  
Nuclear Receptors ◽  
Human Body ◽  
Functional Activity ◽  
Chemical Structure ◽  
Practical Application ◽  
Synthetic Analogues ◽  
Dermatological Diseases ◽  
Modern Classification ◽  
The Relationship

The aim of the work was to analyze and summarize information on the functional activity of known retinoids, as well as to determine the directions of their modification and prospects for the use of their synthetic analogues in dermatology. The literature on retinoids metabolism stages in the human body, the mechanisms of their action and the properties that determine their use in various medical fields was considered and analyzed. Information on dermatological diseases treatment with natural retinoids and their synthetic analogues was summarized. The modern classification of retinoids based on the peculiarities of their chemical structure and functional activity is given, the relationship between these characteristics and the direction of use of such drugs in dermatology and cosmetology is shown. Prospects for the practical application of synthetic retinoids represented mainly by polyaromatic compounds are due to their higher stability and efficiency, as well as reduced irritant effect due to selectivity for nuclear receptors.

Identification of a reticuloendothelial stimulating agent in zymosan

1961 ◽  
Vol 200 (2) ◽  
pp. 297-300 ◽  
Author(s):  
S. J. Riggi ◽  
N. R. Di Luzio
Keyword(s):  
Cell Wall ◽  
Yeast Cell ◽  
Intravenous Injection ◽  
Functional Activity ◽  
Chemical Structure ◽  
Reticuloendothelial System ◽  
Yeast Cell Wall ◽  
Bound Lipids ◽  
Relationship Of ◽  
The Relationship

The functional activity of the reticuloendothelial system (RES), as determined by the intravascular clearance of colloidal carbon, and the degree of induced RE hyperplasia were studied following the intravenous injection of various constituents of zymosan. The readily extractable lipid component from the yeast cell wall was inactive, as was the polysaccharide, mannan. Stimulatory activity was still present in the zymosan residue after removal of free and bound lipids. The administration of glucan derived either from yeast, or its cell wall, resulted in marked RE activation and induced hyperplasia, demonstrating it to be the active RE stimulating agent. The relationship of glucan's chemical structure to its ability to induce RE hyperfunction and hyperplasia is discussed.

scholarly journals Modern Classification of the Properties of Papillary Patterns of Human Hands and Feet for the Solution of Identification and Non-Identification Problems in Forensic Expert Activities

2021 ◽  
Vol 18 (4) ◽  
pp. 445-459
Author(s):  
V. I. Balko
Keyword(s):  
Body Fat ◽  
Human Body ◽  
Identification Problems ◽  
Basic Properties ◽  
Modern Classification ◽  
Definition Of ◽  
Hands And Feet ◽  
First Time ◽  
Papillary Pattern

The relevance and novelty of the topic of the article is connected with the fact that for the first time the improved classification of the properties of human papillary patterns and their displays and the dynamic trend of expanding the legal base of fingerprint registration in the world are considered. The goal is to systematize the properties of human papillary patterns and their representations. General scientific and special methods were used. The analysis of the literature and the author's practice allow us to identify and consider the following properties of papillary patterns and their mappings, which were divided into three groups for cognitive purposes: their own properties, the properties of mappings, and the properties of the fat-rich substance of the human papillary pattern and its trace. For the first time, the properties of the poly-fat substance of the human papillary pattern and its trace are presented, which is important in view of the trend in the development of complex fingerprint examination. For the first time, the first and second groups are conditionally divided into four subgroups: for solving identification, diagnostic, classification and situational problems. For the first time, the third group is further conditionally divided into four subgroups: according to the interaction of the human body fat with the carrier object; according to the isolation of the human body fat trace; according to the dynamics of the preservation and contrast of the display of the fat-free substance of the human papillary pattern. On the other hand, the properties of papillary patterns themselves are divided into basic properties and properties for solving identification and non-identification problems, respectively. The author's definition of the following concepts is presented: "basic properties of human papillary patterns" and "properties of human papillary patterns", "basic properties of human papillary patterns mappings" and "properties of human papillary patterns mappings", "basic properties of human papillary matter" and "properties of human papillary matter", "basic properties of human papillary matter" and" properties of human papillary matter". This provides an opportunity for specialists and teachers to improve their cognitive and practical activities, and for those responsible and competent for the organization of examinations to consider creating a center for comprehensive fingerprint examination.

scholarly journals Features of pain syndrome in patients with bone metastasis

2021 ◽  
Vol 67 (4) ◽  
pp. 569-578
Author(s):  
Evgenii Khmelevskii ◽  
Natalia Bychkova
Keyword(s):  
Pain Relief ◽  
Bone Metastases ◽  
Clinical Symptoms ◽  
Pain Syndrome ◽  
Lesion Length ◽  
High Dose ◽  
Metastatic Bone Pain ◽  
Modern Classification ◽  
The Relationship

Purpose. The purpose of the current study was the search for evaluation criterion for the radiosensitivity of bone metastases of various origins. Materials and methods. The first part of the study presents a modern classification of pain, method of its evaluation, mechanisms and features of metastatic bone pain. The radiobiological patterns of pain relief in low-dose anti-inflammatory radiation therapy were also considered. The analysis of these features testifies in favor of the antitumor mechanism of pain relief in high-dose irradiation. To identify the relationship between pain and other clinical symptoms, 810 cases of bone metastases of various localization and morphology were analyzed. Results. The severity of pain directly correlates with gender, lesion length and little affected by the presence of pathological fracture. The intensity of pain does not depend on the primary tumor and bone metastases localization and does not correlate with the presence of neurological deficit. Conclusion. Completeness and persistence of the analgesic effect may reflect the real radiosensitivity of bone metastases, but taking into account the patient's gender and lesion length in the irradiated area.

scholarly journals Analysis of some problems in classification of seabed bottom characteristics using acoustic backscattering intensity

2020 ◽  
Vol 198 ◽  
pp. 03022
Author(s):  
FENG Jintao ◽  
BAO Jingyang ◽  
JIN Shaohua ◽  
XIAO Fumin ◽  
BIAN Gang
Keyword(s):  
Practical Application ◽  
Acoustic Image ◽  
Acoustic Backscattering ◽  
Seabed Topography ◽  
Sonar System ◽  
The Relationship

The backscattering intensity collected by multi beam sonar system and scanning sonar system can be used to classify seabed bottom characteristics. However, there are many problems that have not been solved in the practical application. This paper attempts to sort out and analyze the problems encountered in the classification process and put forward some solutions. The relationship among acoustic image, seabed topography and sediment is analyzed

K-MEANS CLUSTERING ALGORITHM BASED CLASSIFICATION OF SOIL FERTILITY IN NORTH WEST NIGERIA

2020 ◽  
Vol 4 (2) ◽  
pp. 780-787
Author(s):  
Ibrahim Hassan Hayatu ◽  
Abdullahi Mohammed ◽  
Barroon Ahmad Isma’eel ◽  
Sahabi Yusuf Ali
Keyword(s):  
Soil Fertility ◽  
Crop Yield ◽  
Clustering Algorithm ◽  
Soil Samples ◽  
North West ◽  
R Programming ◽  
Available Information ◽  
Northwest Region ◽  
The Relationship

Soil fertility determines a plant's development process that guarantees food sufficiency and the security of lives and properties through bumper harvests. The fertility of soil varies according to regions, thereby determining the type of crops to be planted. However, there is no repository or any source of information about the fertility of the soil in any region in Nigeria especially the Northwest of the country. The only available information is soil samples with their attributes which gives little or no information to the average farmer. This has affected crop yield in all the regions, more particularly the Northwest region, thus resulting in lower food production.  Therefore, this study is aimed at classifying soil data based on their fertility in the Northwest region of Nigeria using R programming. Data were obtained from the department of soil science from Ahmadu Bello University, Zaria. The data contain 400 soil samples containing 13 attributes. The relationship between soil attributes was observed based on the data. K-means clustering algorithm was employed in analyzing soil fertility clusters. Four clusters were identified with cluster 1 having the highest fertility, followed by 2 and the fertility decreases with an increasing number of clusters. The identification of the most fertile clusters will guide farmers on where best to concentrate on when planting their crops in order to improve productivity and crop yield.

DONG SON BRONZE DRUM - THE WORK OF THE LAC VIET PEOPLE

2018 ◽  
Author(s):  
Nguyen Van Hao
Keyword(s):  
Classification Criteria ◽  
Way Of Life ◽  
Tribal Identity ◽  
The Relationship

Bronze drums are widely distributed, broader than the range of a nation. Therefore, the identification of each kind of drum is a basic subject, should be concerned. In determining the tribal identity of the drum, the classification of drum is the key stage, the relationship between the objective of the classification and classification criteria is the relation as shape and shadow, if there is no right criteria then the result of division will be difficult to reach the desired goal. Likewise, the criterion of the pattern on the bronze drum brought to the affirmation is the Dong Son bronze drum of the Lac Viet people. And the parallel is the affirmation of the culture, way of life, residence of the nation created the drum.

Matrix metalloproteinases: structure, functions and genetic polymorphism

2017 ◽  
pp. 14-23
Author(s):  
А.С. Шадрина ◽  
И.В. Терешкина ◽  
Я.З. Плиева ◽  
Д.Н. Кушлинский ◽  
Д.О. Уткин ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Matrix Metalloproteinases ◽  
Active Center ◽  
Human Body ◽  
Enzymatic Catalysis ◽  
Structure Functions ◽  
Zinc Ion ◽  
Etiological Factors ◽  
Mmp Genes

Матриксные металлопротеиназы (ММП) - ферменты класса гидролаз, осуществляющие ферментативный катализ с помощью связанного в активном центре иона цинка. Функции ММП разнообразны, и нарушение баланса их активности может быть одним из этиологических факторов различных заболеваний. В данном обзоре рассмотрена классификация ММП человека, особенности их структуры и регуляции, а также роль в физиологических и патологических процессах в организме человека. Приведен перечень наиболее изученных на настоящий момент полиморфных вариантов генов MMП, описаны их функциональные эффекты и представлены результаты ассоциативных исследований. Matrix metalloproteinases (MMPs) are enzymes of the hydrolase class that carry out enzymatic catalysis with the help of a zinc ion bound in the active center. MMP functions are diverse, and a disturbance in the balance of their activity may be one of the etiological factors of various diseases. In this review, the classification of human MMP, the features of their structure and regulation, as well as the role in physiological and pathological processes in the human body are considered. A list of the most studied polymorphic versions of MMP genes has been given, their functional effects have been described, and the results of associative studies have been presented.

Correction of Posture Deviations in the Sagittal Plane Using the Pilates Method

2019 ◽  
pp. 3-13
Author(s):  
Alexandru Cîtea ◽  
George-Sebastian Iacob
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Postural Control ◽  
Human Body ◽  
Sagittal Plane ◽  
The Body ◽  
Lower Limbs ◽  
Low Back ◽  
Pilates Method ◽  
The Relationship

Posture is commonly perceived as the relationship between the segments of the human body upright. Certain parts of the body such as the cephalic extremity, neck, torso, upper and lower limbs are involved in the final posture of the body. Musculoskeletal instabilities and reduced postural control lead to the installation of nonstructural posture deviations in all 3 anatomical planes. When we talk about the sagittal plane, it was concluded that there are 4 main types of posture deviation: hyperlordotic posture, kyphotic posture, rectitude and "sway-back" posture.Pilates method has become in the last decade a much more popular formof exercise used in rehabilitation. The Pilates method is frequently prescribed to people with low back pain due to their orientation on the stabilizing muscles of the pelvis. Pilates exercise is thus theorized to help reactivate the muscles and, by doingso, increases lumbar support, reduces pain, and improves body alignment.

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