scholarly journals Effect of Castration on Bone Healing in Male Rabbit Model; Clinical, Histopathological and Radiological Study

2021 ◽  
Keyword(s):  
Bone Healing ◽  
Rabbit Model ◽  
Radiological Study ◽  
Male Rabbit

scholarly journals Influence of the Thermal Treatment to Address a Better Osseointegration of Ti6Al4V Dental Implants: Histological and Histomorphometrical Study in a Rabbit Model

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Antonio Scarano ◽  
Ezio Crocetta ◽  
Alessandro Quaranta ◽  
Felice Lorusso
Keyword(s):  
Thermal Treatment ◽  
Dental Implants ◽  
Bone Healing ◽  
Rabbit Model ◽  
Titanium Implants ◽  
Control Group ◽  
Left Femur ◽  
Bone Response ◽  
First Choice ◽  
Significant Difference

Background. Pure titanium continues to be the first choice for dental implants and represents the gold standard for their biocompatibility and physical and mechanical characteristics, while the titanium alloy (Ti6Al4V) has good mechanical properties. The surface structure of the titanium oxide layer formation on the surface influences and improves the bone response around dental implants. Purpose. The purpose of this study is to evaluate the influence of a thermal treatment of Ti6Al4V implant surfaces and the bone healing response in a rabbit model. Methods. Altogether sixteen implants with same design were inserted into the distal femoral metaphysis. A screw (13 mm long, 4 mm in diameter) was inserted in an implant bed. Each rabbit received two implants, one in the left femur and one in the right femur. The samples were histologically and histomorphometrically evaluated at 8 weeks. Results. A statistically significant difference (p = 0.000034) was present histologically in the percentages of bone-implant contact (BIC) between the test group (BIC = 69.25±4.49%.) and control group (BIC = 56.25 ± 4.8%) by one-way analysis of variance (ANOVA). Significance was set at p ≤ 0.05. Conclusions. The outcome of the present study indicates a novel approach to improving bone healing around titanium implants.

scholarly journals Study of nano-hydroxyapatite/zirconia stabilized with yttria in bone healing: histopathological study in rabbit model

2014 ◽  
Vol 1 ◽  
pp. 40-47 ◽  
Author(s):  
Gholamreza Abedi ◽  
Amirali Jahanshahi ◽  
Mohamad Hosein Fathi ◽  
Iraj Sohrabi Haghdost ◽  
Abas Veshkini
Keyword(s):  
Bone Healing ◽  
Rabbit Model ◽  
Histopathological Study

scholarly journals Enhanced Tendon-to-Bone Healing of Chronic Rotator Cuff Tears by Bone Marrow Aspirate Concentrate in a Rabbit Model

2018 ◽  
Vol 10 (1) ◽  
pp. 99 ◽  
Author(s):  
Xiao Ning Liu ◽  
Cheol-Jung Yang ◽  
Ji Eui Kim ◽  
Zhen Wu Du ◽  
Ming Ren ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Rotator Cuff ◽  
Bone Healing ◽  
Bone Marrow Aspirate ◽  
Rabbit Model ◽  
Rotator Cuff Tears ◽  
Bone Marrow Aspirate Concentrate

Effects of Allogenic Dermal Fibroblasts on Rotator Cuff Healing in a Rabbit Model of Chronic Tear

2018 ◽  
Vol 46 (8) ◽  
pp. 1901-1908 ◽  
Author(s):  
Jieun Kwon ◽  
Yun Hee Kim ◽  
Sung-Min Rhee ◽  
Tae In Kim ◽  
Jimin Lee ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Laboratory Study ◽  
Bone Healing ◽  
Rabbit Model ◽  
Dermal Fibroblasts ◽  
The Other ◽  
Histological Evaluation ◽  
Load To Failure ◽  
Group A ◽  
Group B

Background: The failure of rotator cuffs to heal after repair is an unresolved surgical issue. There have been substantial efforts, including the use of biological supplements, to enhance tendon healing. Dermal fibroblasts are a good candidate for tendon tissue engineering because they are similar to the tenocytes used for collagen synthesis. In addition, they are easily accessible because autologous dermal fibroblasts can be obtained from individual skin without major skin defects and allogenic dermal fibroblasts (ADFs) have already been commercialized in the field of skin engineering. Purpose: To determine the effects of dermal fibroblasts on tendon-to-bone healing in a rabbit model of a chronic rotator cuff tear. Study Design: Controlled laboratory study. Methods: A total of 33 rabbits were randomly allocated into 3 groups (n = 11 each). Supraspinatus tendons were detached and left for 6 weeks to establish a chronic rotator tear model. Torn tendons were repaired in a transosseous manner with the injection of 5 × 106 ADFs with fibrin in group A, fibrin only in group B, and saline only in group C. At 12 weeks after repair, the mechanical test and histological evaluation were performed. Results: Seven rabbits died before the evaluation (1 in group A, 2 in group B, 4 in group C). In the final evaluation, the mean ± SD load to failure was 48.1 ± 13.3 N/kg for group A, 34.5 ± 8.9 N/kg for group B, and 31.1 ± 8.3 N/kg for group C, and group A showed significantly higher load-to-failure values than the other groups ( P = .011). The midsubstance tear rate, which presented stronger tendon-to-bone healing than insertional tear, was 50.0% in group A, 22.2% in group B, 28.6% in group C, but the differences were not statistically significant ( P = .413). In the histological evaluation, group A showed greater collagen fiber continuity and better orientation than the other groups. Conclusion: This controlled laboratory study verified, on the basis of biomechanics and histology, the potential for the use of ADFs in rotator cuff healing. The current results suggest a new biological supplement to increase the rate of rotator cuff healing. Clinical Relevance: The most important finding of this study was the potential for a new biological supplement to enhance rotator cuff healing—a continuing challenge.

scholarly journals Effects of concurrent use of royal jelly with hydroxyapatite on bone healing in rabbit model: radiological and histopathological evaluation

Heliyon ◽  
2020 ◽  
Vol 6 (7) ◽  
pp. e04547
Author(s):  
Amin Bigham-Sadegh ◽  
Haleh Sadat Torkestani ◽  
Siavash Sharifi ◽  
Sadegh Shirian
Keyword(s):  
Bone Healing ◽  
Royal Jelly ◽  
Rabbit Model ◽  
Concurrent Use ◽  
Histopathological Evaluation

scholarly journals Enhancement of Rotator Cuff Tendon-bone Healing with Graphene Oxide/PRP Composite Scaffold in a Rabbit Model: A Histological and Biomechanical Study

2020 ◽  
Author(s):  
Bo Qin ◽  
Dingsu Bao ◽  
Shengqiang Zeng ◽  
Kai Deng ◽  
Gang Liu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Rotator Cuff ◽  
Bone Healing ◽  
Surgical Repair ◽  
Composite Scaffold ◽  
Rabbit Model ◽  
Control Groups ◽  
Significant Difference ◽  
Load To Failure ◽  
And Control

Abstract Background: Application of platelet-rich plasma (PRP) can improve tendon-bone healing (TBH) after rotator cuff surgical repair. Graphene Oxide (GO) is a steady, controlled, and sustained carrier. The purpose of this study is to determine whether GO/PRP Composite Scaffold enhances the TBH after RC surgical repair in a rabbit model.Methods: A full-thickness tear of the supraspinatus tendon was created and repaired in 36 adult male New Zealand rabbits. They were divided into three groups: Control group, PRP group, and GO/PRP Composite Scaffold group (GO group). The effect of GO/PRP Composite Scaffold on TBH was assessed using histological and biomechanical evaluations at 8 and 12 weeks postoperatively.Results: Histological analysis showed that greater continuity, better orientation, and more density of collagen fiber were detected in the GO group than PRP and Control groups at 8 and 12 weeks, respectively. Results of biomechanical evaluations showed that the load to failure and stiffness of the GO group were statistically higher than those of PRP and Control groups at both 8 and 12 weeks (P<0.05). Compared with 8 weeks in the GO group, there was no significant difference in load to failure at 12 weeks (P>0.05), while the stiffness at 12 weeks was higher than that at 8 weeks (P<0.05). Conclusions: These results demonstrated that GO/PRP Composite Scaffold enhanced the TBH following rotator cuff surgical repair in a rabbit model. The GO may be an effective carrier for PRP into repair sites.

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