scholarly journals Food intake and body weight regulation in diabetes (db/db) and obese (ob/ob) mice

1978 ◽  
Vol 6 (2) ◽  
pp. 187-190 ◽  
Author(s):  
Israel Ramirez ◽  
Richard L. Sprott
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Weight Regulation ◽  
Body Weight Regulation

scholarly journals Effects of intracerebroventricular injection of fatty acids on food intake and body weight regulation

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Douglas Gene Mashek ◽  
Darin Robert Schwinkendorf
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Food Intake ◽  
Intracerebroventricular Injection ◽  
Weight Regulation ◽  
Body Weight Regulation

Brown adipose tissue thermogenesis in testosterone-treated rats

1992 ◽  
Vol 126 (5) ◽  
pp. 434-437 ◽  
Author(s):  
María Abelenda ◽  
Maria Paz Nava ◽  
Alberto Fernández ◽  
María Luisa Puerta
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Food Intake ◽  
Brown Adipose Tissue ◽  
Male Rats ◽  
Weight Regulation ◽  
Body Weight Regulation ◽  
Sexual Hormones ◽  
Brown Adipose ◽  
Brown Adipose Tissue Thermogenesis

The participation of sexual hormones in body weight regulation is partly accomplished by altering food intake. Nonetheless, female sexual hormones also alter brown adipose tissue thermogenesis in females. This study was aimed to find out if male hormones could alter brown adipose tissue thermogenesis in male rats. Testosterone was administered by means of Silastic capsules in adult male rats acclimated either at 28°C (thermoneutrality) or at 6°C (cold), treatment lasting 15 days. Food intake and body weight gain were reduced by hormonal treatment. However, brown adipose tissue mass, protein content, mitochondrial mass and GDP-binding were unchanged at both environmental temperatures. Accordingly, testosterone participation in body weight regulation is thought to be carried out without altering brown adipose tissue thermogenesis. A reduction in the weight of the sex accessory glands was also observed after cold acclimation.

Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats

2001 ◽  
Vol 281 (2) ◽  
pp. R444-R451 ◽  
Author(s):  
Joyce J. Hwa ◽  
Lorraine Ghibaudi ◽  
Jun Gao ◽  
Eric M. Parker
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Receptor Agonist ◽  
Melanocortin Receptor ◽  
Zucker Rats ◽  
Light Cycle ◽  
Weight Regulation ◽  
Central Administration ◽  
Body Weight Regulation ◽  
Obese Zucker Rats

Melanocortins play a critical role in appetite and body weight regulation, because manipulations of this pathway can lead to the development of obesity in several animal models. The purpose of this study was to use a melanocortin receptor agonist and antagonist to evaluate the involvement of melanocortins in feeding, energy metabolism, and body weight regulation in lean and obese Zucker rats. Central administration of a melanocortin receptor antagonist (SHU9119) elevated food intake and body weight of lean Zucker rats but had little effect in obese Zucker rats. In contrast, the melanocortin receptor agonist MTII reduced food intake in both lean and obese rats but was more potent in the obese Zucker rats. These data indicate the existence of functional melanocortin receptors in both lean and obese Zucker rats but suggest that obese Zucker rats have reduced endogenous melanocortin tone. In addition to its effects on food intake, MTII infusion elevated oxygen consumption and decreased respiratory quotient dose dependently during the light cycle. Our data suggest that a melanocortin receptor agonist can induce weight loss by increasing energy expenditure and promoting body fat utilization in addition to its inhibitory effects on food intake in both obese and lean Zucker rats.

Neuropeptides, food intake and body weight regulation: a hypothalamic focus

Peptides ◽  
2002 ◽  
Vol 23 (12) ◽  
pp. 2283-2306 ◽  
Author(s):  
J.J.G. Hillebrand ◽  
D. de Wied ◽  
R.A.H. Adan
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Weight Regulation ◽  
Body Weight Regulation

The effects of high-intensity sweeteners (saccharin and acesulfame potassium) on food intake and body weight regulation in rats.

Appetite ◽  
2007 ◽  
Vol 49 (1) ◽  
pp. 325 ◽  
Author(s):  
S.L. Roy ◽  
T.L. Davidson ◽  
S.E. Swithers
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
High Intensity ◽  
Weight Regulation ◽  
Body Weight Regulation

scholarly journals Role of GABA Release From Leptin Receptor-Expressing Neurons in Body Weight Regulation

Endocrinology ◽  
2012 ◽  
Vol 153 (5) ◽  
pp. 2223-2233 ◽  
Author(s):  
Yuanzhong Xu ◽  
William G. O'Brien ◽  
Cheng-Chi Lee ◽  
Martin G. Myers ◽  
Qingchun Tong
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Leptin Receptor ◽  
Gaba Release ◽  
Neuron Activity ◽  
Chow Diet ◽  
Weight Regulation ◽  
Body Weight Regulation ◽  
The Brain

It is well established that leptin regulates energy balance largely through isoform B leptin receptor-expressing neurons (LepR neurons) in the brain and that leptin activates one subset of LepR neurons (leptin-excited neurons) while inhibiting the other (leptin-inhibited neurons). However, the neurotransmitters released from LepR neurons that mediate leptin action in the brain are not well understood. Previous results demonstrate that leptin mainly acts on γ-aminobutyric acid (GABA)ergic neurons to reduce body weight, and that leptin activates proopiomelanocortin neuron activity by reducing GABA release onto these neurons, suggesting a body weight-promoting role for GABA released from leptin-inhibited neurons. To directly examine the role of GABA release from LepR neurons in body weight regulation, mice with disruption of GABA release specifically from LepR neurons were generated by deletion of vesicular GABA transporter in LepR neurons. Interestingly, these mice developed mild obesity on chow diet and were sensitive to diet-induced obesity, which were associated with higher food intake and lower energy expenditure. Moreover, these mice showed blunted responses in both food intake and body weight to acute leptin administration. These results demonstrate that GABA plays an important role in mediating leptin action. In combination with the previous studies that leptin reduces GABA release onto proopiomelanocortin neurons through leptin-inhibited neurons and that disruption of GABA release from agouti gene-related protein neurons, one subset of LepR-inhibited neurons, leads to a lean phenotype, our results suggest that, under our experimental conditions, GABA release from leptin-excited neuron dominates over leptin-inhibited ones.

Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man

2004 ◽  
Vol 83 (1) ◽  
pp. 55-64 ◽  
Author(s):  
M HALLSCHMID ◽  
C BENEDICT ◽  
J BORN ◽  
H FEHM ◽  
W KERN
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Intranasal Administration ◽  
Weight Regulation ◽  
Body Weight Regulation

scholarly journals Toll-like receptor 4 mediates fat, sugar, and umami taste preference and food intake and body weight regulation

Obesity ◽  
2017 ◽  
Vol 25 (7) ◽  
pp. 1237-1245 ◽  
Author(s):  
Simonetta Camandola ◽  
Mark P. Mattson
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Taste Preference ◽  
Weight Regulation ◽  
Body Weight Regulation ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Umami Taste
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