A sonochemical approach to the direct surface functionalization of superparamagnetic iron oxide nanoparticles with (3-aminopropyl)triethoxysilane

We report a sonochemical method of functionalizing superparamagnetic iron oxide nanoparticles (SPION) with (3-aminopropyl)triethoxysilane (APTES). Mechanical stirring, localized hot spots and other unique conditions generated by an acoustic cavitation (sonochemical) process were found to induce a rapid silanization reaction between SPION and APTES. FTIR, XPS and XRD measurements were used to demonstrate the grafting of APTES on SPION. Compared to what was reported in literature, the results showed that the silanization reaction time was greatly minimized. More importantly, the product displayed superparamagnetic behaviour at room temperature with a more than 20% higher saturation magnetization.

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Investigation of Combination Effect Between 6 MV X Ray Radiation and Polyglycerol Coated Superparamagnetic Iron Oxide Nanoparticles on U87-MG Cancer Cells

Journal of Biomedical Physics and Engineering ◽

10.31661/jbpe.v0i0.929 ◽

2018 ◽

Cited By ~ 3

Author(s):

S Jafari ◽

M Cheki ◽

M B Tavakoli ◽

A Zarrabi ◽

K Ghazikhanlu Sani ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

X Rays ◽

Dose Verification ◽

Superparamagnetic Behaviour ◽

Mean Size ◽

Novel Strategy

Background: Radiosensitization using nanoparticles is proposed as a novel strategy for treatment of different cancers. Superparamagnetic iron oxide nanoparticles (SPIONs) have been reported to enhance effects of radiotherapy in several researches. The objective of this research is to investigate the radiosensitization properties of polyglycerol coated SPIONs (PG-SPIONs) on U87-MG cancer cells.Material and Methods: Polyglycerol coated SPIONs were synthesized by thermal decomposition method and characterized by FTIR, TEM and VSM analysis. Cellular uptake of nanoparticles by cells was examined via AAS. Cytotoxicity and radiosensitization of nanoparticles in combination with radiation were evaluated by MTT and colony assay, respectively.Results: Mean size of nanoparticles was 17.9±2.85 nm. FTIR verified SPIONs coating by Polyglycerol and VSM showed that they have superparamagnetic behaviour. Viability significantly (P < 0.001) decreased at concentrations above 100µg/ml for SPIONs but not for PG-SPIONs (P > 0.05). Dose verification results by TLD for doses of 2 and 4 Gy were 2±0/19 and 4±0/12 Gy respectively. The combination index for all situations was less than 1 and the effect is antagonism.Conclusion: However, PG-SPIONs combination with 6 MV X rays reduced survival of U87-MG cells compared to radiation alone but the effect is antagonism.

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One minute synthesis of amino-silane functionalized superparamagnetic iron oxide nanoparticles by sonochemical method

Ultrasonics Sonochemistry ◽

10.1016/j.ultsonch.2017.08.040 ◽

2018 ◽

Vol 40 ◽

pp. 837-840 ◽

Cited By ~ 19

Author(s):

Bashiru K. Sodipo ◽

Azlan Abdul Aziz

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Sonochemical Method ◽

Amino Silane

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Optimization of sonochemical method of functionalizing Amino-Silane on superparamagnetic iron oxide nanoparticles using Central Composite Design

Ultrasonics Sonochemistry ◽

10.1016/j.ultsonch.2019.104856 ◽

2020 ◽

Vol 64 ◽

pp. 104856 ◽

Cited By ~ 1

Author(s):

Bashiru Kayode Sodipo ◽

Azlan Abdul Aziz

Keyword(s):

Iron Oxide ◽

Central Composite Design ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Sonochemical Method ◽

Amino Silane ◽

Central Composite

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TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

Journal of Drug Discovery and Therapeutics ◽

10.32553/jddt.v6i10.444 ◽

2018 ◽

Vol 6 (10) ◽

Author(s):

Hosam Zaghloul ◽

Doaa A. Shahin ◽

Ibrahim El- Dosoky ◽

Mahmoud E. El-awady ◽

Fardous F. El-Senduny ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Cellular Uptake ◽

Superparamagnetic Iron Oxide ◽

Cyclin B1 ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Mcf7 Cells ◽

M Phase ◽

The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

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Novel Superparamagnetic Iron Oxide Nanoparticles for a Multifunctional Nanomedicine Platform

10.1557/proc-1140-hh05-11 ◽

2008 ◽

Cited By ~ 1

Author(s):

Oleh Taratula ◽

Ronak Savla ◽

Ipsit Pandya ◽

Andrew Wang ◽

Tamara Minko ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles

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Evaluation of Surface-modified Superparamagnetic Iron Oxide Nanoparticles to Optimize Bacterial Immobilization for Bio-separation with the Least Inhibitory Effect on Microorganism Activity

Nanoscience &Nanotechnology-Asia ◽

10.2174/2210681208666181015120346 ◽

2020 ◽

Vol 10 (2) ◽

pp. 166-174

Author(s):

Mehdi Khoshneviszadeh ◽

Sarah Zargarnezhad ◽

Younes Ghasemi ◽

Ahmad Gholami

Keyword(s):

Iron Oxide ◽

Amino Acid ◽

Magnetic Nanoparticles ◽

Iron Oxide Nanoparticles ◽

Surface Coating ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Surface Charges ◽

Surface Modified

Background: Magnetic cell immobilization has been introduced as a novel, facile and highly efficient approach for cell separation. A stable attachment between bacterial cell wall with superparamagnetic iron oxide nanoparticles (SPIONs) would enable the microorganisms to be affected by an outer magnetic field. At high concentrations, SPIONs produce reactive oxygen species in cytoplasm, which induce apoptosis or necrosis in microorganisms. Choosing a proper surface coating could cover the defects and increase the efficiency. Methods: In this study, asparagine, APTES, lipo-amino acid and PEG surface modified SPIONs was synthesized by co-precipitation method and characterized by FTIR, TEM, VSM, XRD, DLS techniques. Then, their protective effects against four Gram-positive and Gram-negative bacterial strains including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were examined through microdilution broth and compared to naked SPION. Results: The evaluation of characterization results showed that functionalization of magnetic nanoparticles could change their MS value, size and surface charges. Also, the microbial analysis revealed that lipo-amino acid coated magnetic nanoparticles has the least adverse effect on microbial strain among tested SPIONs. Conclusion: This study showed lipo-amino acid could be considered as the most protective and even promotive surface coating, which is explained by its optimizing effect on cell penetration and negligible reductive effects on magnetic properties of SPIONs. lipo-amino acid coated magnetic nanoparticles could be used in microbial biotechnology and industrial microbiology.

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Targeted extracellular vesicle delivery systems employing superparamagnetic iron oxide nanoparticles

Acta Biomaterialia ◽

10.1016/j.actbio.2021.07.027 ◽

2021 ◽

Author(s):

Zewei Zhuo ◽

Jinghua Wang ◽

Yujun Luo ◽

Ruijie Zeng ◽

Chen Zhang ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Extracellular Vesicle ◽

Delivery Systems ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles

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Phosphotungstic acid impregnated niobium coated superparamagnetic iron oxide nanoparticles as recyclable catalyst for selective isomerization of terpenes

RSC Advances ◽

10.1039/d1ra00012h ◽

2021 ◽

Vol 11 (23) ◽

pp. 14203-14212

Author(s):

Luccas Lossano Name ◽

Sergio Hiroshi Toma ◽

Helton Pereira Nogueira ◽

Luis Humberto Avanzi ◽

Rafael dos Santos Pereira ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Conversion Efficiency ◽

Phosphotungstic Acid ◽

Superparamagnetic Iron Oxide ◽

Recyclable Catalyst ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Magnetically Recyclable Catalyst

Conversion efficiency as high as 80–100% and 50% selectivity for camphene and limonene was achieved with low production of polymeric byproducts (18–28%), using a new magnetically recyclable catalyst – SPION-Nb30@HPW.

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