IN VITRO GNAO1-ENCEPHALOPATHY MODEL DEVELOPMENT USING RECOMBINANT ADENO-ASSOCIATED VIRUSES
2020 ◽
pp. 99-100
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Our study presents the verification of recombinant adeno-associated viruses on primary neuronal culture for GNAO1-encephalopathy modeling. We demonstrated neuronal expression of transgenic mutant and wild-type forms of the GNAO1. Downregulation by two-fold of the endogenous GNAO1 in neurons was achieved using RNA interference approach.
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2006 ◽
Vol 17
(8)
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pp. 3705-3716
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1999 ◽
Vol 73
(12)
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pp. 10551-10555
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2020 ◽
Vol 117
(32)
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pp. 19245-19253
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2009 ◽
Vol 54
(1)
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pp. 103-108
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1993 ◽
Vol 268
(13)
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pp. 9629-9635
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