scholarly journals Optimization of planning radionuclide diagnostic tests in osteoscintigraphy

2021 ◽  
Vol 2 (1) ◽  
pp. 6-13
Author(s):  
N. A. Maksimova ◽  
V. G. Karpun ◽  
M. A. Arzamastseva ◽  
M. G. Ilchenko ◽  
O. S. Shlyk
Keyword(s):  
Diagnostic Tests ◽  
Diagnostic Procedures ◽  
Mathematical Methods ◽  
High Quality ◽  
Generator System ◽  
Radionuclide Studies ◽  
Generator Operation ◽  
Gamma Cameras ◽  
Factors Influencing ◽  
Day Of The Week

Purpose of the study. Determining maximum possible number of high-quality radionuclide studies by days of the generator operation.Materials and methods. We studied the factors influencing the capacity of radionuclide diagnostic tests in osteoscintigraphy (OSG) by days of service life of a 99mTc generator GT-4K. The OSG capacity, the required resource of 99mTc and its efficiency in OSG were calculated. The optimal days for the generator delivery were determined.The Pirfotech 99mTc radiopharmaceutical (RFP) prepared with the generator was used for OSG.Scanning, data collection and processing of results were carried out on gamma-cameras of the systems Signature Series, Symbia T16 Siemens, and syngo M1 Applications VB10 Siemens.Parameters of the radioactivity of 99mTc were processed by mathematical methods using the Excel program.Results. We revealed specific factors influencing the OSG capacity: 1) three-hour accumulation of RFP after its administration to the patient; 2) generator activity by days of its operation; 3) the day of the week of the generator delivery. We calculated quantitative indicators of the maximum possible OSG capacity during the generator operation (maximum number of OSG procedures by days of operation, total capacity, preferred day of the week for the generator delivery).Conclusion. The most significant factors in optimal OSG planning by days of the generator operation are the generator specifications, quantity and frequency of generator supply, provision of gamma-cameras.The described technique for scheduling diagnostic procedures can be useful for the efficient use of the generator system which ensures the maximum amount of high-quality RFP from the generator eluate and contributes to the objectification of the cancer process in order to choose the treatment tactics.

Analysis Of Factors Influencing Acupuncture Clinical Effects: A Systematic Review

2021 ◽  
Author(s):  
Yali Liu ◽  
Honglin Jiang ◽  
Xiaotong Li ◽  
Xingyue Yang
Keyword(s):  
Systematic Review ◽  
Individual Difference ◽  
Current Status ◽  
Clinical Effects ◽  
High Quality ◽  
Psychological States ◽  
Factors Influencing ◽  
High Quality Evidence ◽  
Stimulus Parameters ◽  
Quality Evidence

Background: Acupuncture therapy has been widely applied all around the world. But there still lacks high-quality evidence to evaluate its clinical effects, safety and cost-effectiveness, which seriously restricts its further promotion and development. Acupuncture, as an operational intervention, is more complex than drug therapy. Factors involved in the acupuncture operation process, such as individual and interventional factors, may affect clinical effects. Purpose:s Through this systematic review, we attempt to analyze the current status of studies about the key factors influencing clinical effects, so as to provide evidence for the design of acupuncture studies. Methods: A literature research was conducted in six databases until May, 2020. Studies were screened and assessed by two authors independently. Data extraction was made after screening. We extracted the basic information of these studies, including publishing years and countries, population and factors influencing clinical effects.Results: Through the initial search in these six database, 6404 records were retrieved. After duplication and screening, a total of 355 studies were finally included in the qualitative analysis. About 88.5% of these studies were conducted in China with increasing number in the past decades, covering neurological disorders, orthopedic disorders, obstetrical and gynecological diseases, digestive diseases and so on; 239 studies focused on stimulus parameters which may influence effects, accounting for 67.3%, and 128, 44, 39, 32, 15, 11 studies discussed acupoints, patients’ pathological states, individual difference, psychological states, deqi, and other factors separately. Conclusion: There are more and more studies focusing on factors influencing acupuncture clinical effects, including stimulus parameters, acupoints, individual difference, patient pathological and psychological states. Based on this systematic review, several ignored factors should be considered for future researches, and more scientifically and objectively high quality evidence should also be proved.

Factors influencing fledgling production in little penguins (Eudyptula minor)

2004 ◽  
Vol 31 (3) ◽  
pp. 339 ◽  
Author(s):  
C. Knight ◽  
T. Rogers
Keyword(s):  
Breeding Season ◽  
Egg Laying ◽  
Breeding Biology ◽  
Single Variable ◽  
Nesting Habitat ◽  
High Quality ◽  
Factors Influencing ◽  
Little Penguin ◽  
Significant Model

An eight-year study was conducted on the breeding biology of the little penguin population at Lion Island. Forwards-selection Poisson regressions were used to determine whether variables such as year, date of lay, years since banding of each parent (indicator of age) and habitat influenced the fledgling numbers and average fledgling weight for adult pairs. 'Date of lay' provided the most significant model of fledgling numbers, while 'habitat' and 'year' as single-variable models also significantly influenced fledgling numbers. 'Date of lay' provided the most significant model of average fledgling weight. Future monitoring of the Lion Island colony therefore should focus on monitoring egg laying at the start of the breeding season, and maintaining high-quality nesting habitat.

Abnormal vaginal bleeding in women with venous thromboembolism treated with apixaban or warfarin

2017 ◽  
Vol 117 (04) ◽  
pp. 809-815 ◽  
Author(s):  
Suzanne Bleker ◽  
Barbara Hutten ◽  
Anne Timmermans ◽  
Harry Büller ◽  
Saskia Middeldorp ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Diagnostic Tests ◽  
Vaginal Bleeding ◽  
Clinical Presentation ◽  
Diagnostic Procedures ◽  
Absolute Number ◽  
Bleeding Events ◽  
Warfarin Group ◽  
Bleeding Episodes ◽  
Abnormal Vaginal Bleeding

SummaryAbnormal vaginal bleeding can complicate direct oral anticoagulant (DOAC) treatment. We aimed to investigate the characteristics of abnormal vaginal bleeding in patients with venous thromboembolism (VTE) receiving apixaban or enoxaparin/warfarin. Data were derived from the AMPLIFY trial. We compared the incidence of abnormal vaginal bleeding between patients in both treatment arms and collected information on clinical presentation, diagnostic procedures, management and outcomes. In the AMPLIFY trial, 1122 women were treated with apixaban and 1106 received enoxaparin/warfarin. A clinically relevant non-major (CRNM) vaginal bleeding occurred in 28 (2.5 %) apixaban and 24 (2.1 %) enoxaparin/warfarin recipients (odds ratio [OR] 1.2, 95 % confidence interval [CI] 0.7–2.0). Of all CRNM bleeds, 28 of 62 (45 %) and 24 of 120 (20 %) were of vaginal origin in the apixaban and enoxaparin/warfarin group, respectively (OR 3.4; 95 % CI 1.8–6.7). Premenopausal vaginal bleeds on apixaban were characterised by more prolonged bleeding (OR 2.3; 95 %CI 0.5–11). In both pre- and postmenopausal vaginal bleeds, diagnostic tests were performed in six (21 %) and in seven (29 %) apixaban and enoxaparin/ warfarin treated patients, respectively. Medical treatment was deemed not necessary in 16 (57 %) apixaban and 16 (67 %) enoxaparin/warfarin recipients. The severity of clinical presentation and course of the bleeds was mild in 75 % of the cases in both groups. In conclusion, although the absolute number of vaginal bleeding events is comparable between apixaban and enoxaparin/warfarin recipients, the relative occurrence of vaginal bleeds is higher in apixaban-treated women. The characteristics and severity of bleeding episodes were comparable in both treatment arms.

Diagnostic information as a commodity

1995 ◽  
Vol 41 (5) ◽  
pp. 781-784 ◽  
Author(s):  
H A Johnson
Keyword(s):  
Diagnostic Tests ◽  
Multiple Testing ◽  
Cost Effective ◽  
Diagnostic Procedures ◽  
Diagnostic Information ◽  
Unit Price ◽  
Screening Tests ◽  
The Cost ◽  
Effective Conditions ◽  
Test Result

Abstract In estimating the cost-effectiveness of diagnostic procedures, it is helpful to treat diagnostic information as a commodity with a unit price. The amount of useful information provided by a test result can be measured in binary units (bits), and the unit price of the information produced by the test result can be expressed in dollars per bit in much the same way that the price of gold is given in dollars per ounce. This allows comparison of the unit prices of various diagnostic tests, examination of the effect of multiple testing, and calculation of the most cost-effective conditions for screening tests.

scholarly journals Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

Processes ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 1539
Author(s):  
Paco Pino ◽  
Joeri Kint ◽  
Divor Kiseljak ◽  
Valentina Agnolon ◽  
Giampietro Corradin ◽  
...  
Keyword(s):  
Diagnostic Tests ◽  
Neutralizing Antibodies ◽  
Good Manufacturing Practice ◽  
Spike Protein ◽  
High Quality ◽  
Virus Surface ◽  
Corona Virus ◽  
Global Demand ◽  
Diagnostic Sensitivity And Specificity ◽  
Spike Proteins

The spike protein of the pandemic human corona virus is essential for its entry into human cells. In fact, most neutralizing antibodies against Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) are directed against the Virus-surface exposed spike protein, making it the antigen of choice for use in vaccines and diagnostic tests. In the current pandemic context, global demand for spike proteins has rapidly increased and could exceed hundreds of grams to kilograms annually. Coronavirus spikes are large heavily glycosylated homo-trimeric complexes, with inherent instability. The poor manufacturability now threatens the availability of these proteins for vaccines and diagnostic tests. Here, we outline scalable, Good Manufacturing Practice (GMP) compliant, and chemically defined processes for the production of two cell-secreted stabilized forms of the trimeric spike proteins (Wuhan and D614G variant). The processes are chemically defined and based on clonal suspension-CHO cell populations and on protein purification via a two-step scalable downstream process. The trimeric conformation was confirmed using electron microscopy and HPLC analysis. Binding to susceptible cells was shown using a virus-inhibition assay. The diagnostic sensitivity and specificity for detection of serum SARS-CoV-2-specific-immunoglobulin molecules was found to exceed that of spike fragments (Spike subunit-1, S1 and Receptor Binding Domain, RBD). The process described here will enable production of sufficient high-quality trimeric spike protein to meet the global demand for SARS-CoV-2 diagnostic tests and potentially vaccines.

Patients Need not be Concerned When Their IVF Retrievals and Transfers Fall on A Weekend: Success Rates Are Not Negatively Affected By the Day of the Week At A High Quality Center

2012 ◽  
Vol 97 (3) ◽  
pp. S8-S9
Author(s):  
Jason Barritt ◽  
Gerardo Vela ◽  
Sofia Akber ◽  
Piraye Yurttas Beim ◽  
Joseph Lee ◽  
...  
Keyword(s):  
Success Rates ◽  
High Quality ◽  
Day Of The Week

Screening by Culture for the Detection of Gonorrhoea in Women

1979 ◽  
Vol 24 (4) ◽  
pp. 302-306 ◽  
Author(s):  
H. Young ◽  
A. B. Harris ◽  
D. Urquhart ◽  
D. H. H. Robertson
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Diagnostic Tests ◽  
Diagnostic Procedures ◽  
Culture Positive

The number of gonoccal infections detected by each of three sets of diagnostic cultures from the urethra, cervix, rectum and occasionally the throat, were Calculated for 1976 when Thayer Martin (TM) medium was used and for 1977 when Modified New York City (MNYC) medium was used. In [1977, 98.7 per cent (451/457) of the total infections diagnosed were confirmed by culture compared with 88.3 per cent (324/367) of infections diagnosed in 1976 (P<0.001). The first set of diagnostic tests detected 97.6 per cent (440/451) of culture-positive infections in 1977 compared with only 88.9 per cent (228/324) in 1976 (P<0.001). The efficiency of screening with a single endocervical culture was also calculated. This procedure would have detected 90.2 per cent (407/451) of culture-positive infections in 1977 when MNYC medium was used compared with only 78.1 per cent (253/324) in 1976 when TM medium was used (P<0.001). It is suggested that the statistically significant improvement in the culture results for 1977 resulted from the introduction of MNYC medium since all other diagnostic procedures were identical to those in 1976. Other advantages associated with the use of MNYC medium are discussed.

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