scholarly journals Effects of magnesium valproate adjuvant therapy on patients with dementia: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Chen qi Zhang ◽  
◽  
kexin Zheng ◽  
Lingqi Sun ◽  
Hongbin Sun
Keyword(s):  
Systematic Review ◽  
Adjuvant Therapy ◽  
Diagnostic Criteria ◽  
Adjuvant Treatment ◽  
Information Sources ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Review Question

Review question / Objective: To evaluate the efficacy of magnesium valproate(VPM) in the adjuvant treatment of patients with dementia(PwD). Participant or population: Adults with dementia (as diagnosed by a clinician, or using any recognized diagnostic criteria) will be included. Information sources: MEDLINE via PubMed, Cochrane Library, EBSCO, Embase, China National Knowledge(CNKI) and Wan fang databases.

scholarly journals Comparative Effectiveness of Adjuvant Treatment for Resected Hepatocellular Carcinoma: A Systematic Review and Network Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Ying Liu ◽  
Yuzhu Wang ◽  
Xinkun Guo ◽  
Yifeng He ◽  
Jian Zhou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Adjuvant Therapy ◽  
Adjuvant Treatment ◽  
Survival Benefit ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Hepatic Artery Infusion ◽  
Hepatic Artery Infusion Chemotherapy ◽  
Curative Hepatectomy

BackgroundIt is controversial whether adjuvant treatment could be recommended for hepatocellular carcinoma (HCC) after curative hepatectomy. Thus, we performed a network meta-analysis (NMA) to assess adjuvant treatment’s benefit and determine the optimal adjuvant regimen.MethodsWe systematically searched PubMed, Embase, and Cochrane Library for randomized controlled trials comparing adjuvant therapy versus no active treatment after curative hepatectomy among patients with HCC. Pooled data on recurrence and overall survival (OS) were analyzed within pairwise meta-analysis and NMA.ResultsTwenty-three eligible trials (3,940 patients) reporting eight treatments were included. The direct meta-analysis showed that adjuvant therapy prevented the recurrence (OR = 0.65; 95% CI: 0.55, 0.77; P = 0.177; I2 = 21.7%) and contributed to OS (HR = 0.63; 95% CI: 0.54, 0.73; P = 0.087; I2 = 31.1%) in comparison to the observation. In the NMA, internal radiotherapy (IRT; OR = 0.55; 95% CI: 0.39, 0.77; SUCRA = 87.7%) followed by hepatic artery infusion chemotherapy (HAIC; OR = 0.6; 95% CI: 0.36, 0.97; SUCRA = 77.8%), and HAIC (HR = 0.44; 95% CI: 0.21, 0.87; SUCRA = 82.6%) followed by IRT (HR 0.54; 95% CI:0.36, 0.81; SUCRA = 69.7%) were ranked superior to other treatments in terms of preventing recurrence and providing survival benefit, respectively.ConclusionsThe addition of adjuvant therapy lowers the risk of recurrence and provide survival benefit after surgical resection for HCC. HAIC and IRT are likely to be the two most effective adjuvant regimens.Systematic Review Registrationhttps://inplasy.com/inplasy-2020-11-0039/.

scholarly journals A Bayesian Network Meta-analysis of the Effect of Acute Exercise on Executive Function in Middle-aged and Senior People

2021 ◽  
Author(s):  
Peng WANG ◽  
◽  
Zhidong CAI ◽  
Qingying ZHAO ◽  
Wanting JIANG ◽  
...  
Keyword(s):  
Executive Function ◽  
Bayesian Network ◽  
Information Sources ◽  
Acute Exercise ◽  
Web Of Science ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Middle Aged ◽  
Intervention Effect ◽  
Review Question

Review question / Objective: Objective: To compare the intervention effect of multiple acute movement formulas on the executive function in middle-aged and senior people and to provide references for the discussion of the plans for precise movements. P: middle-aged and senior people elderly people; I: acute exercise; C: reading or sitting; O: Executive Function; S: RCT/crossover. Information sources: Randomized searches were carried out in Chinese databases such as CNKI, Wanfang Database, VTTMS, SinoMed and foreign databases such as PubMed, EMBASE, Cochrane Library, Web of Science. The retrieval period is from the beginning of each database to August 2021, supplemented with manual searches for gray literature and references traced back to previous systematic reviews.

scholarly journals Music therapy for sleep quality in cancer patients with insomnia：A protocol for systematic review and meta-analysis

2021 ◽  
Author(s):  
Chenbing Sun ◽  
◽  
Zhe Wang ◽  
Yuening Dai
Keyword(s):  
Systematic Review ◽  
Music Therapy ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Biomedical Literature ◽  
Cochrane Library ◽  
China National Knowledge Infrastructure ◽  
Review Question ◽  
The Cochrane Library

Review question / Objective: The aim of this systematic review is to compare music therapy in terms of efficacy in cancer patients with insomnia disorders to better inform clinical practice. Condition being studied: The effectiveness of music therapy for cancer- associate insomnia is the main interest of this systematic review. Information sources: MEDLINE (PubMed, Ovid) The Cochrane Library, Web of Science, Embase and Electronic retrieval of Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CHKD-CNKI), VIP database, Wanfang Database will be searched from inception time to date. In addition, the included literature will be reviewed and relevant literature will be supplemented.

scholarly journals Adjuvant Therapy of High-Risk (Stages IIC–IV) Malignant Melanoma in the Post Interferon-Alpha Era: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 ◽  
Author(s):  
Konstantinos Christofyllakis ◽  
Claudia Pföhler ◽  
Moritz Bewarder ◽  
Cornelia S. L. Müller ◽  
Lorenz Thurner ◽  
...  
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Malignant Melanoma ◽  
Adjuvant Therapy ◽  
Adjuvant Treatment ◽  
Braf Mutation ◽  
Meta Analysis ◽  
Stage Iiia ◽  
Free Survival ◽  
Braf Mutant

IntroductionMultiple agents are approved in the adjuvant setting of completely resected high-risk (stages IIC–IV) malignant melanoma. Subgroups may benefit differently depending on the agent used. We performed a systematic review and meta-analysis to evaluate the efficiency and tolerability of available options in the post interferon era across following subgroups: patient age, stage, ulceration status, lymph node involvement, BRAF status.MethodsThe PubMed and Cochrane Library databases were searched without restriction in year of publication in June and September 2020. Data were extracted according to the PRISMA Guidelines from two authors independently and were pooled according to the random-effects model. The predefined primary outcome was recurrence-free survival (RFS). Post-data extraction it was noted that one trial (BRIM8) reported disease-free survival which was defined in the exact same way as RFS.ResultsFive prospective randomized placebo-controlled trials were included in the meta-analysis. The drug regimens included ipilimumab, pembrolizumab, nivolumab, nivolumab/ipilimumab, vemurafenib, and dabrafenib/trametinib. Adjuvant treatment was associated with a higher RFS than placebo (HR 0.57; 95% CI= 0.45–0.71). Nivolumab/ipilimumab in stage IV malignant melanoma was associated with the highest RFS benefit (HR 0.23; 97.5% CI= 0.12–0.45), followed by dabrafenib/trametinib in stage III BRAF-mutant melanoma (HR 0.49; 95% CI= 0.40–0.59). The presence of a BRAF mutation was associated with higher RFS rates (HR 0.30; 95% CI= 0.11–0.78) compared to the wildtype group (HR 0.60; 95% CI= 0.44–0.81). Patient age did not influence outcomes (≥65: HR 0.50; 95% CI= 0.36–0.70, <65: HR 0.58; 95% CI= 0.46–0.75). Immune checkpoint inhibitor monotherapy was associated with lower RFS in non-ulcerated melanoma. Patients with stage IIIA benefited equally from adjuvant treatment as those with stage IIIB/C. Nivolumab/ipilimumab and ipilimumab monotherapy were associated with higher toxicity.ConclusionAdjuvant therapy should not be withheld on account of advanced age or stage IIIA alone. The presence of a BRAF mutation is prognostically favorable in terms of RFS. BRAF/MEK inhibitors should be preferred in the adjuvant treatment of BRAF-mutant non-ulcerated melanoma.

scholarly journals Effect of electric stimulation on patients with facial paralysis: A systematic review and Meta-analysis of randomized controlled trials

2022 ◽  
Author(s):  
Jiangna Zhao ◽  
◽  
Yun An ◽  
Huixin Yan ◽  
Tao Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Facial Paralysis ◽  
Electric Stimulation ◽  
Meta Analysis ◽  
Clinical Effectiveness ◽  
Cochrane Library ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Review Question ◽  
The Cochrane Library

Review question / Objective: To investigate the effectiveness of electric stimulation on patients with facial paralysis through a systematic review and meta-analysis. Condition being studied: P: facial paralysis; I: electric stimulation; C: clinical routine treatment; O: total clinical effectiveness, House-Brackmann scale (HBN) and Portmann scale; S:RCT. Information sources: PubMed; the Cochrane Library; Embase; SinoMed; WanFang Data; Vip; China National Knowledge Infrastructure databases.

scholarly journals Bisphosphonates in the adjuvant setting of breast cancer therapy: Effect on survival—A systematic review and meta-analysis.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 548-548 ◽  
Author(s):  
Liath Vidal ◽  
Irit Ben-Aharon ◽  
Shulamith Rizel ◽  
Rinat Yerushalmi ◽  
Aaron Sulkes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Adjuvant Therapy ◽  
Large Scale ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Control Group ◽  
Adjuvant Setting ◽  
Therapy Effect ◽  
Meta Regression

548 Background: The role of bisphosphonates (BP) in the adjuvant setting in breast cancer has been evaluated in several studies, yielding inconsistent evidence. We performed a systematic review and meta-analysis of all randomized controlled trials (RCTs) that evaluate the effects of BP treatment on survival in patients with early breast cancer in the adjuvant setting. Methods: RCTs that compared BP therapy in addition to the standard adjuvant therapy (cytotoxic or hormonal) with standard adjuvant therapy only were identified by searching the Cochrane Library, LILACS, MEDLINE databases and conference proceedings (12.2011). Hazard ratios (HRs) of overall survival (OS), disease-free survival (DFS) and relative risks of adverse events were estimated and pooled. All statistical tests were two-sided. Results: Thirteen trials met the inclusion criteria., among which are the two recently published abstracts of large scale RCTs (NSABP-B34, GAIN) evaluating a total of 15,762 patients. Ten trials reported the OS outcome. Meta-analysis revealed no statistically significant benefit for BP (HR 0.89, 95% CI = 0.79 to 1.01). Nine trials reported the DFS outcome. Meta-analysis revealed no statistically significant better DFS for the intervention (HR 0.95 (0.80-1.11)). Six trials reported DFS stratified upon menopausal status. Postmenopausal patients who were treated with BP therapy had statistically significant better DFS than the control group (HR 0.81(0.69-0.95)). In meta-regression, chemotherapy was negatively associated with HR of OS (coefficient, -0.23; standard error, 0.144). BP therapy resulted in less fractures in the intervention arm, but higher incidence of osteonecrosis of the jaw and pyrexia. Conclusions: Our meta-analysis indicates a positive effect for adjuvant BP on survival outcomes only in postmenopausal patients with breast cancer. Meta-regression appraised the effect of confounders such as chemotherapy, showed a negative association between chemotherapy use and the effect of bisphosphonates on survival. Further large scale RCTs are warranted to unravel the specific subgroups and adjuvant treatments that would benefit from the addition of BP in the adjuvant setting.

scholarly journals Is there a window of opportunity for flexibility development in youth? A systematic review with meta-analysis

2021 ◽  
Author(s):  
Olyvia Donti ◽  
Andreas Konrad ◽  
Ioli Panidi ◽  
Petros Dinas ◽  
Gregory Bogdanis
Keyword(s):  
Systematic Review ◽  
Information Sources ◽  
Team Member ◽  
Meta Analysis ◽  
Window Of Opportunity ◽  
Team Members ◽  
Full List ◽  
Final Version ◽  
Review Team ◽  
Review Question

Review question / Objective: To examine if there is a difference in the effect of stretching training on flexibility during childhood (6-11 years of age) and adolescence (12-18 years of age). Condition being studied: We are going to examine whether there is a greater response to stretching training (i.e. ‘window of opportunity’) during childhood, compared with adolescence. Information sources: Two review team members will independently screen the titles and abstracts of the retrieved publications to select the eligible publications. One review team member will act as a referee in case of disagreement between the review team members. We will also ensure that any retracted publications are identified and excluded from the selection outcome. Furthermore, we will locate the full texts that will not be immediately accessible, via emails to the lead authors and/journals of publication. A full list of the excluded publications will be provided in the final version of the systematic review.

scholarly journals Extended Investigation on the connection of TP73 G4C14-A4T14 Polymorphism with different Cancer Types – An Updated Meta-analysis with 56 Case-control Studies

2022 ◽  
Author(s):  
Sarah Jafrin ◽  
◽  
Md. Abdul Aziz ◽  
Mohammad Safiqul Islam
Keyword(s):  
Information Sources ◽  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Review Question ◽  
Cancer Types ◽  
Risk Of Cancer

Review question / Objective: TP73 G4C14-A4T14 variant has been suspected of elevating the risk of cancer for many years. The available evidence was unsatisfactory and could not provide a reliable conclusion. Therefore, we performed this meta-analysis to re-evaluate the previous findings and illustrate the actual role of TP73 G4C14-A4T14 variant on cancer development. Condition being studied: The association of the G4C14-A4T14 variant with cancer risk was studied. Information sources: PubMed, Google Scholar, EMBASE, Cochrane Library, and Web of Science, CNKI.

scholarly journals Response rate and diagnostic accuracy of PET/CT during and after neo-adjuvant therapies in oesophageal adenocarcinoma: protocol for a systematic review

2020 ◽  
Author(s):  
Jacqueline Jeffries ◽  
Bernadette Coles ◽  
Kevin Bradley ◽  
Alex Holborow ◽  
Elizabeth Smyth ◽  
...  
Keyword(s):  
Systematic Review ◽  
Diagnostic Accuracy ◽  
Surgical Resection ◽  
Adjuvant Treatment ◽  
Response Rate ◽  
Meta Analysis ◽  
Response Rates ◽  
Oesophageal Adenocarcinoma ◽  
Cochrane Library ◽  
Pet Ct

Abstract Background Oesophageal cancer is increasing in incidence and has a poor prognosis. Patients with potentially curable disease have a staging positron emission tomography (PET) examination combined with a computed tomography (CT) to assess loco-regional and distant disease. Although a small proportion of patients are suitable for attempted surgical resection, the majority will receive neo-adjuvant therapy (chemotherapy with or without radiotherapy) before their operation. The current regimen prescribes all patients to complete the neo-adjuvant treatment prior to surgery, but some patients will not experience a beneficial response. A repeat PET/CT after one cycle of neo-adjuvant treatment may identify early response or non-response and could alter subsequent management. The purpose of this systematic review and meta-analysis is to estimate the early and completion response rate defined by fluorodeoxyglucose (FDG)-PET, its diagnostic accuracy and explore associated factors. Methods Primary studies reporting response rates and diagnostic accuracy of PET/CT will be identified from MEDLINE, Embase, Cochrane Library, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Scopus, Web of Science, International Clinical Trials Registry Platform (ICTRP) Search Portal and ClinicalTrials.gov databases. Peer-reviewed studies published from 2005 onwards will be included. Data will be extracted from selected studies and a meta-analysis using a random effects model will be attempted. Pooled early and completion response rates, and diagnostic accuracy (sensitivity and specificity), will be calculated from available data. Heterogeneity between studies, risk of bias and methodological quality will be assessed. Discussion This systematic review and meta-analysis will identify and synthesise evidence to determine early and completion response rates to neo-adjuvant treatment and the corresponding diagnostic accuracy of PET/CT. This strategy has the potential to identify patients that will not respond to the treatment and to offer this group an alternative pre-operative treatment or proceed directly to operation, thereby avoiding a delay in surgical resection and optimising patient outcomes.

scholarly journals The efficacy of kinesio taping in the treatment of ankle sprain: Systematic review and meta-analysis

2021 ◽  
Author(s):  
Haoan Zhu ◽  
◽  
Wenbin Li ◽  
Yitong Lin ◽  
Hao Wu
Keyword(s):  
Systematic Review ◽  
Physical Therapy ◽  
Ankle Sprain ◽  
Information Sources ◽  
Web Of Science ◽  
Meta Analysis ◽  
Ankle Sprains ◽  
Kinesio Tape ◽  
Relieve Pain ◽  
Review Question

Review question / Objective: The purpose of this systematic review is to accurately evaluate the efficacy of kinesio tape for ankle sprains. Condition being studied: Ankle sprain may cause a series of problems, such as pain, swelling, and various dysfunctions. As a physical therapy method that has attracted much attention in recent years, kinesio tape has been proven to relieve pain, reduce swelling and promote functional recovery for some diseases. In this way, we can provide a reference for clinical physical therapy. Information sources: PubMed, Cochrane, Scopus, Web of Science, Embase, CNKI, Wanfang Data, Technological periodical database, SinoMed.

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