scholarly journals A Bayesian Network Meta-analysis of the Effect of Acute Exercise on Executive Function in Middle-aged and Senior People

2021 ◽  
Author(s):  
Peng WANG ◽  
◽  
Zhidong CAI ◽  
Qingying ZHAO ◽  
Wanting JIANG ◽  
...  
Keyword(s):  
Executive Function ◽  
Bayesian Network ◽  
Information Sources ◽  
Acute Exercise ◽  
Web Of Science ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Middle Aged ◽  
Intervention Effect ◽  
Review Question

Review question / Objective: Objective: To compare the intervention effect of multiple acute movement formulas on the executive function in middle-aged and senior people and to provide references for the discussion of the plans for precise movements. P: middle-aged and senior people elderly people; I: acute exercise; C: reading or sitting; O: Executive Function; S: RCT/crossover. Information sources: Randomized searches were carried out in Chinese databases such as CNKI, Wanfang Database, VTTMS, SinoMed and foreign databases such as PubMed, EMBASE, Cochrane Library, Web of Science. The retrieval period is from the beginning of each database to August 2021, supplemented with manual searches for gray literature and references traced back to previous systematic reviews.

scholarly journals Extended Investigation on the connection of TP73 G4C14-A4T14 Polymorphism with different Cancer Types – An Updated Meta-analysis with 56 Case-control Studies

2022 ◽  
Author(s):  
Sarah Jafrin ◽  
◽  
Md. Abdul Aziz ◽  
Mohammad Safiqul Islam
Keyword(s):  
Information Sources ◽  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Review Question ◽  
Cancer Types ◽  
Risk Of Cancer

Review question / Objective: TP73 G4C14-A4T14 variant has been suspected of elevating the risk of cancer for many years. The available evidence was unsatisfactory and could not provide a reliable conclusion. Therefore, we performed this meta-analysis to re-evaluate the previous findings and illustrate the actual role of TP73 G4C14-A4T14 variant on cancer development. Condition being studied: The association of the G4C14-A4T14 variant with cancer risk was studied. Information sources: PubMed, Google Scholar, EMBASE, Cochrane Library, and Web of Science, CNKI.

scholarly journals Adults diagnosed with vestibular schwannomas and treated with stereotactic radiosurgery: a scoping review protocol

2021 ◽  
Author(s):  
Ibrahim Almufarrij ◽  
◽  
Cathal Hannan ◽  
Simon Lloyd ◽  
Kevin J Munro
Keyword(s):  
Stereotactic Radiosurgery ◽  
Outcome Measures ◽  
Scoping Review ◽  
Information Sources ◽  
Web Of Science ◽  
Cochrane Library ◽  
Primary Research ◽  
Review Protocol ◽  
Review Question ◽  
Study Designs

Review question / Objective: This review aims to catalogue and collate information on outcome measures, study designs, and dose-related changes in hearing following stereotactic radiosurgery for adults diagnosed with sporadic Vestibular Schwannoma. Study designs to be included: Any peer-reviewed primary research publications will be eligible for inclusion. Information sources: Electronic databases. The following databases will be systematically searched to identify relevant studies: PubMed, PsycINFO, EMBASE, EMCare, Web of Science and Cochrane Library.

scholarly journals Effects of magnesium valproate adjuvant therapy on patients with dementia: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Chen qi Zhang ◽  
◽  
kexin Zheng ◽  
Lingqi Sun ◽  
Hongbin Sun
Keyword(s):  
Systematic Review ◽  
Adjuvant Therapy ◽  
Diagnostic Criteria ◽  
Adjuvant Treatment ◽  
Information Sources ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Review Question

Review question / Objective: To evaluate the efficacy of magnesium valproate(VPM) in the adjuvant treatment of patients with dementia(PwD). Participant or population: Adults with dementia (as diagnosed by a clinician, or using any recognized diagnostic criteria) will be included. Information sources: MEDLINE via PubMed, Cochrane Library, EBSCO, Embase, China National Knowledge(CNKI) and Wan fang databases.

scholarly journals Incidences of Adverse Reactions in BNT162b2: A Meta-analysis

2022 ◽  
Author(s):  
Yi Dong ◽  
◽  
LiJia Liu ◽  
Jianing Liu ◽  
Tianqi Liao ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Web Of Science ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Previous History ◽  
Healthy Adults ◽  
Cochrane Library ◽  
Total Incidence ◽  
Review Question ◽  
The Cochrane Library

Review question / Objective: This study searched PubMed, Cochrane Library, Web of Science, Embase Electronics, and other databases to collect healthy adults aged 16 and older, subjects with no previous history of COVID-19 infection, A randomized controlled trial of Pfizer's vaccine BNT162b2 versus placebo. Using RevMan5.4 software, meta-analysis was conducted to compare the effects of injection of BNT162b2 and placebo on the incidence of adverse reactions in healthy adults over 16 years of age. Main indexes include total incidence of adverse reactions, the incidence of local adverse reactions at the injection site (including red hot accessories), the incidence of systemic adverse reactions, including fever, headache, rash, urticaria, joint pain, muscle pain, gastrointestinal tract reaction, fatigue, cough, etc.), death rate, so as to provide a reference for clinical practice. Information sources: The following electronic databases will be searched from January 2020 to November 2021: PubMed, the Cochrane Library, Web of Science, Embase Electronics. In addition, reference lists of the included studies were manually searched to identify additional relevant studies.

scholarly journals The efficacy of kinesio taping in the treatment of ankle sprain: Systematic review and meta-analysis

2021 ◽  
Author(s):  
Haoan Zhu ◽  
◽  
Wenbin Li ◽  
Yitong Lin ◽  
Hao Wu
Keyword(s):  
Systematic Review ◽  
Physical Therapy ◽  
Ankle Sprain ◽  
Information Sources ◽  
Web Of Science ◽  
Meta Analysis ◽  
Ankle Sprains ◽  
Kinesio Tape ◽  
Relieve Pain ◽  
Review Question

Review question / Objective: The purpose of this systematic review is to accurately evaluate the efficacy of kinesio tape for ankle sprains. Condition being studied: Ankle sprain may cause a series of problems, such as pain, swelling, and various dysfunctions. As a physical therapy method that has attracted much attention in recent years, kinesio tape has been proven to relieve pain, reduce swelling and promote functional recovery for some diseases. In this way, we can provide a reference for clinical physical therapy. Information sources: PubMed, Cochrane, Scopus, Web of Science, Embase, CNKI, Wanfang Data, Technological periodical database, SinoMed.

Polymorphisms and premature ovarian insufficiency and failure: A comprehensive meta-analysis update, subgroup, ranking, and network analysis

2022 ◽  
Author(s):  
Ling Wu ◽  
◽  
Tao Zhang ◽  
Yao Wang ◽  
Xiao Ke Wu ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Network Analysis ◽  
Clinical Outcomes ◽  
Early Identification ◽  
Information Sources ◽  
Web Of Science ◽  
Meta Analysis ◽  
Early Screening ◽  
Ovarian Insufficiency ◽  
Review Question

Review question / Objective: Early identification of women potentially who develop POI and POF is essential for early screening and treatment to improve clinical outcomes. We aim to conduct a comprehensive meta-analysis update, subgroup, ranking and network analysis for all available genetic polymorphism and associated with the POI and POF risk. Information sources: Six electronic databases will be included such as PubMed, Web of Science, Embase, MEDLINE, WANFANG DATA, CNKI. Will contact with authors by emails when necessary.

scholarly journals Brain-Derived Exosomal Proteins as Effective Biomarkers for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 980
Author(s):  
Ka-Young Kim ◽  
Ki-Young Shin ◽  
Keun-A. Chang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Web Of Science ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Blood Biomarkers ◽  
Cell Lineages ◽  
The Central Nervous System ◽  
New Biomarkers ◽  
T Tau

Alzheimer’s disease (AD), a progressive neurodegenerative disease, affects approximately 50 million people worldwide, which warrants the search for reliable new biomarkers for early diagnosis of AD. Brain-derived exosomal (BDE) proteins, which are extracellular nanovesicles released by all cell lineages of the central nervous system, have been focused as biomarkers for diagnosis, screening, prognosis prediction, and monitoring in AD. This review focused on the possibility of BDE proteins as AD biomarkers. The articles published prior to 26 January 2021 were searched in PubMed, EMBASE, Web of Science, and Cochrane Library to identify all relevant studies that reported exosome biomarkers in blood samples of patients with AD. From 342 articles, 20 studies were selected for analysis. We conducted a meta-analysis of six BDE proteins and found that levels of amyloid-β42 (standardized mean difference (SMD) = 1.534, 95% confidence interval [CI]: 0.595–2.474), total-tau (SMD = 1.224, 95% CI: 0.534–1.915), tau phosphorylated at threonine 181 (SMD = 4.038, 95% CI: 2.312-5.764), and tau phosphorylated at serine 396 (SMD = 2.511, 95% CI: 0.795–4.227) were significantly different in patients with AD compared to those in control. Whereas, those of p-tyrosine-insulin receptor substrate-1 and heat shock protein 70 did not show significant differences. This review suggested that Aβ42, t-tau, p-T181-tau, and p-S396-tau could be effective in diagnosing AD as blood biomarkers, despite the limitation in the meta-analysis based on the availability of data. Therefore, certain BDE proteins could be used as effective biomarkers for AD.

scholarly journals The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wenchao Zhang ◽  
Xiaolei Ren ◽  
Lin Qi ◽  
Chenghao Zhang ◽  
Chao Tu ◽  
...  
Keyword(s):  
Web Of Science ◽  
Meta Analysis ◽  
Positive Outcome ◽  
Clinical Applications ◽  
Clinicopathological Features ◽  
Cochrane Library ◽  
Human Osteosarcoma ◽  
Non Coding Rna ◽  
The Cochrane Library ◽  
Long Non Coding Rna

Abstract Background In recent years, emerging studies have demonstrated critical functions and potential clinical applications of long non-coding RNA (lncRNA) in osteosarcoma. To further validate the prognostic value of multiple lncRNAs, we have conducted this updated meta-analysis. Methods Literature retrieval was conducted by searching PubMed, Web of Science and the Cochrane Library (last update by October 2, 2019). A meta-analysis was performed to explore association between lncRNAs expression and overall survival (OS) of osteosarcoma patients. Relationships between lncRNAs expression and other clinicopathological features were also analyzed respectively. Results Overall, 4351 patients from 62 studies were included in this meta-analysis and 25 lncRNAs were identified. Pooled analyses showed that high expression of 14 lncRNAs connoted worse OS, while two lncRNAs were associated with positive outcome. Further, analysis toward osteosarcoma clinicopathologic features demonstrated that overexpression of TUG1 and XIST indicated poor clinical parameters of patients. Conclusions This meta-analysis has elucidated the prognostic potential of 16 lncRNAs in human osteosarcoma. Evidently, desperate expression and functional targets of these lncRNAs offer new approaches for prognosis and therapy of osteosarcoma.

scholarly journals Polyethylene glycol versus lactulose in the treatment of hepatic encephalopathy: a systematic review and meta-analysis

2021 ◽  
Vol 8 (1) ◽  
pp. e000648
Author(s):  
Gilles Jadd Hoilat ◽  
Mohamad Fekredeen Ayas ◽  
Judie Noemie Hoilat ◽  
Ahmed Abu-Zaid ◽  
Ceren Durer ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Hepatic Encephalopathy ◽  
Web Of Science ◽  
Meta Analysis ◽  
Standard Of Care ◽  
Brain Dysfunction ◽  
Cochrane Library ◽  
Continuous Data ◽  
Inverse Variance ◽  
Scoring Algorithm

BackgroundHepatic encephalopathy (HE) is defined as brain dysfunction that occurs because of acute liver failure or liver cirrhosis and is associated with significant morbidity and mortality. Lactulose is the standard of care till this date; however, polyethylene glycol (PEG) has gained the attention of multiple investigators.MethodsWe screened five databases namely PubMed, Scopus, Web of Science, Cochrane Library and Embase from inception to 10 February 2021. Dichotomous and continuous data were analysed using the Mantel-Haenszel and inverse variance methods, respectively, which yielded a meta-analysis comparing PEG versus lactulose in the treatment of HE.ResultsFour trials with 229 patients were included. Compared with lactulose, the pooled effect size demonstrated a significantly lower average HE Scoring Algorithm (HESA) Score at 24 hours (Mean difference (MD)=−0.68, 95% CI (−1.05 to –0.31), p<0.001), a higher proportion of patients with reduction of HESA Score by ≥1 grade at 24 hours (risk ratio (RR)=1.40, 95% CI (1.17 to 1.67), p<0.001), a higher proportion of patients with a HESA Score of grade 0 at 24 hours (RR=4.33, 95% CI (2.27 to 8.28), p<0.0010) and a shorter time to resolution of HE group (MD=−1.45, 95% CI (−1.72 to –1.18), p<0.001) in favour of patients treated with PEG.ConclusionPEG leads to a higher drop in the HESA Score and thus leads to a faster resolution of HE compared with lactulose.

What Types of Exercise Are More Effective in Reducing Obesity and Blood Pressure for Middle-Aged Women? A Systematic Review With Meta-Analysis

2021 ◽  
pp. 109980042110154
Author(s):  
Seong-Hi Park ◽  
Chul-Gyu Kim
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Waist Circumference ◽  
Meta Analysis ◽  
Physical Activities ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Middle Aged

Background: A systematic review was performed to identify the types of physical activities effective as interventions in preventing metabolic syndrome in middle-aged women. Methods: Electronic databases (MEDLINE, EMBASE, the Cochrane Library, and CINAHL) served as the data sources. Cochrane’s Risk of Bias 2 was applied to assess the risk of bias of the randomized controlled trials. Meta-analyses were performed on selected studies using Review Manager 5.3. Thirty-one trials enrolling 2,202 participants were included. Results: Compared to controls, the effects of physical activity were indicated by pooled mean differences, which were −0.57 kg for body weight, −0.43 kg/m2 for body mass index, −1.63 cm for waist circumference, −4.89 mmHg for systolic blood pressure (BP), and −2.71 mmHg for diastolic BP. The effects were greater on the measurements of waist circumference and BP than on body weight and BMI. The types of physical activities were further analyzed according to sub-groups. Only aerobic exercise did not affect body weight and resistance exercise did not significantly change any results. Contrarily, combined exercises significantly reduced measurements of waist circumference and BP. Conclusion: This review can provide valuable information for research and implementation of measures to prevent metabolic syndrome in middle-aged women.

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