scholarly journals Sinomenine hydrochloride injection for knee osteoarthritis

Author(s):  
Zeling Huang ◽  
◽  
Xiao Mao ◽  
Junming Chen ◽  
Junjun He ◽  
...  

Review question / Objective: At present, many clinical studies have been reported on the treatment of KOA by injecting sinomenine hydrochloride into the knee cavity. However, no systematic evaluation has been published on this issue, and it is not clear whether sinomenine hydrochloride injection is effective and safe in the treatment of KOA.Therefore, it is important to conduct systematic evaluation to obtain relatively convincing conclusions as to whether sinomenine hydrochloride injection can be a good choice as a complementary and alternative drug (CAM) for KOA. Condition being studied: The RCTs are eligible, whether or not the blind method is specifically described. There are no restrictions on languages. Moreover, systemic evaluation, review literature and the full article cannot be obtained will be excluded.

2015 ◽  
Vol 45 (4) ◽  
pp. 524-541
Author(s):  
Emma Derbyshire ◽  
Carrie Ruxton

Purpose – This review aims to evaluate and review literature published in the area of rising concerns that red meat consumption may be associated with risk of type 2 diabetes mellitus (T2DM), although there have been discrepancies between study findings, and put the findings into context. Design/methodology/approach – Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature review was undertaken to locate and summarise relevant studies which included epidemiological and clinical studies published between 2004 and 2014. Findings – A total of 23 studies were found, with 21 epidemiological and two clinical studies meeting the criteria. Overall, the totality of the evidence indicates that while processed meat consumption appears to be associated with T2DM risk, the effect is much weaker for red meat, with some associations attenuated after controlling for body weight parameters. Where studies have considered high intakes in relation to T2DM risk, meat intake has tended to exceed 600 g per week. Therefore, keeping red meat intakes within recommended guidelines of no more than 500 g per week, while opting for lean cuts or trimming fat, would seem to be an evidence-based response. Research limitations/implications – The majority of studies conducted to date have been observational cohorts which cannot determine cause and effect. Most of these used food frequency questionnaires which are known to be subject to misclassification errors (Brown, 2006). Clearly, more randomised controlled trials are needed to establish whether red meat consumption impacts on markers of glucose control. Until then, conclusions can only be viewed as speculative. Originality/value – This paper provides an up-to-date systematic review of the literature, looking at inter-relationships between red meat consumption and T2DM risk.


2009 ◽  
Vol 37 (8) ◽  
pp. 1636-1644 ◽  
Author(s):  
Eric J. Strauss ◽  
Jennifer A. Hart ◽  
Mark D. Miller ◽  
Roy D. Altman ◽  
Jeffrey E. Rosen

Intra-articular hyaluronic acid viscosupplementation is gaining popularity as a treatment option in the nonoperative management of patients with osteoarthritis. Recent clinical studies have demonstrated that the anti-inflammatory, anabolic, and chondroprotective actions of hyaluronic acid reduce pain and improve patient function. With evidence mounting in support of the efficacy of this treatment modality for patients with osteoarthritis, its potential use in additional patient populations and for other pathologies affecting the knee is being investigated. The current article reviews the use of intra-articular hyaluronic acid viscosupplementation in the management of knee osteoarthritis and presents the potential for expanding its indications for other joints and alternative patient subpopulations. Additionally, future directions for the use of hyaluronic acid and areas of active research are discussed.


2020 ◽  
Author(s):  
Hafiz Muhammad Asim Raza ◽  
Grazina Krutulyte ◽  
Inesa Rimdeikiene ◽  
Raimondas Savickas

Abstract Objectives To identify literature reporting on thermal mineral water and mud therapy effectiveness on pain, stiffness and knee function in patients with knee osteoarthritis. Design Systematic evidence scan of MEDLINE and PubMed was performed to identify the randomized controlled trial studies published from 2004 to December 2018. Study selection Papers reporting the effect of balneotherapy and mud therapy for treating knee OA, a duration of ≥2 weeks and in which Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were used as an outcome measure. Data extraction Not RCT, Studies not in English. Results A quantitative meta-analysis of ten studies (831 patients) was performed. Five clinical studies (407 patients) measured effectiveness of balneotherapy and there was significant difference between the groups in WOMAC pain score, WOMAC stiffness score and WOMAC function score, with the differences in favour of balneotherapy. Six clinical studies (500 patients) measured effectiveness of mud therapy and there was significant difference between the groups in WOMAC pain score, WOMAC stiffness score and WOMAC function score, with the differences in favour of mud therapy. Conclusion This meta-analysis indicates that balneotherapy and mud therapy were clinically effective in relieving pain, stiffness, and improving function, as assessed by WOMAC score.


2020 ◽  
Vol 11 (3) ◽  
pp. 4418-4423
Author(s):  
Blessy Mariyam Babu

Drug Repurposing is finding new use of an already existing drug. It offers affordable, cheap and faster treatment. Drug repurposing has an additional advantage over new drug development because it lowers drug development costs as toxicity and other measures, including clinical trials, have already gone through them. However, there are few barriers which need to overcome like legal and economic barriers. Alternative drug development strategies are now being explored, such as the repurposing of existing drugs used to treat other diseases. This can save a considerable amount of time and money since the pharmacokinetics, pharmacodynamics and safety profiles of these drugs are already established, effectively enabling pre-clinical studies to be bypassed. Awareness and encouragement can promote the flourishing of drug repurposing, which holds a great future in the modern medical sector. Improvements in health care and nutrition have caused impressive improvements in life expectancy worldwide. Repurposing is an accelerated drug development path since existing drugs have clinical and pharmacokinetic evidence. New approaches to drug discovery, such as the re-use of patented medicines that are used to cure other diseases, are under debate. This can save significant time and money because these drugs' pharmacokinetics, pharmacodynamics, and safety profiles are already known, potentially enabling pre-clinical studies to override.


2021 ◽  
Vol 19 (4) ◽  
Author(s):  
R.V. Senyutovych ◽  
О.І. Ivashchuk ◽  
V.Yu. Bodyaka ◽  
Yu.Ya. Chuprоvska ◽  
I.O. Malyshevsky ◽  
...  

Data of experimental and clinical studies concerning fibrin adhesives’ use for theprotection of anastomoses of the gastrointestinal tract are submitted in the article.Definite data have not been obtained.Objective. The purpose of this study was to review literature on the protection ofanastomoses of the digestive system by fibrin adhesives. The study was conductedaccording to the Internet data.Conclusion. The given data testify that anastomoses strengthening with fibrin adhesivescan be effective in bariatric surgery. The majority investigations, preferably on rats,are an experimental research. It is premature to give recommendations concerningapplication of fibrin adhesives to strengthen other types of anastomoses. Fibrin adhesives’investigations in strengthening gastrointestinal tract anastomoses represent a perspectivedirection of up-to-date surgery. Significant achievements should to be expected.


2016 ◽  
Vol 2 (4) ◽  
pp. 1-4
Author(s):  
H Azzouzi ◽  
FE Abourazzak ◽  
F Lazrak ◽  
N Kadi ◽  
M. Berraho ◽  
...  

2005 ◽  
Vol 14 (5) ◽  
pp. 364-368 ◽  
Author(s):  
Natalie Bridges ◽  
Adrian A. Jarquin-Valdivia

• Objective To review the literature on use of the Trendelenburg position as a position for resuscitation of patients who are hypotensive.• Methods PubMed online, cited bibliographies, critical care textbooks, and Advanced Cardiac Life Support guidelines were searched for information on the position used for resuscitation. Because of the heterogeneity of the data, only pertinent articles and chapters were summarized.• Results Eight peer-reviewed publications on the position used for resuscitation were found. Pertinent information from 2 critical care textbooks and from the Advanced Cardiac Life Support guidelines was included in the review. Literature on the position was scarce, lacked strength, and seemed to be guided by “expert opinion.”• Conclusion The general “slant” of the available data seems to indicate that the Trendelenburg position is probably not a good position for resuscitation of patients who are hypotensive. Further clinical studies are needed to determine the optimal position for resuscitation.


Sign in / Sign up

Export Citation Format

Share Document