scholarly journals THREE CASE SERIES INVOLVING PROGRESIVE MOTOR DEFICIT

2016 ◽  
Vol 15 (4) ◽  
pp. 183-186
Author(s):  
Bogdan Pana ◽  
◽  
Alina Anghel ◽  
Iuliana Nicola-Antoniu ◽  
Ioan Buraga ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Muscular Dystrophy ◽  
Muscle Wasting ◽  
Case Series ◽  
Motor Deficit ◽  
Muscular Dystrophies ◽  
The Third ◽  
First Case ◽  
Family Medical History ◽  
Pelvic Muscles

The muscular dystrophies are a group of inherited, non-inflammatory disorders, consisting of progressive muscle wasting, without peripheral or central nerve involvement. We present a series of three cases involving progressive motor deficit and their different evolutions. The first case is about a 57 year old female patient, without a significant family medical history, presenting for progressive motor deficit involving the shoulder and pelvic muscles, started at the age of 20 year old, when she was diagnosed with a sporadic form of limb-girdle muscular dystrophy. The second case is about a 27 year old male, diagnosed with muscular dystrophy at the age of 15. The third case is about a 43 year old male admitted for frequent falls and weakness of the limbs, mainly distal, started 10 years ago. He was diagnosed with myotonic dystrophy. Although there is still no treatment for muscular dystrophies, the pathology is under investigation in clinical trials.

scholarly journals Lymphangioma Circumscriptum of the Vulva- A Case Series

2021 ◽  
Author(s):  
Rashmi S Mahajan ◽  
Yogesh S Marfatia ◽  
Atmakalyani R Shah ◽  
Kishan R Ninama
Keyword(s):  
Late Onset ◽  
Case Series ◽  
Suspected Case ◽  
Age Group ◽  
The Third ◽  
First Case ◽  
History Of ◽  
Subcutaneous Tissues ◽  
Uncommon Condition ◽  
Lymphangioma Circumscriptum

Vulval dermatoses pose a diagnostic and therapeutic challenge for the dermatologists. Lymphangioma Circumscriptum (LC) is a form of lymphangioma affecting the skin and subcutaneous tissues that is characterised by benign dilation of lymphatic channels. This uncommon condition is known to occur over the chest, mouth, axilla, tongue, and rarely in the vulva. In this series, authors present three cases of LC of vulva in women between the age group of 45 to 60 years with late-onset fluid-filled lesions over the vulva. The first case had history of hysterectomy prior to onset of lesions, the second case had a spontaneous onset of lesions while the third was a suspected case of pelvic tuberculosis with secondary lymphangioma.

scholarly journals Chronic blepharitis like picture in patients with Discoid lupus erythematosis – Case series

2018 ◽  
Vol 9 (2) ◽  
pp. 175-179
Author(s):  
K. Jisha ◽  
P.S. Rajesh ◽  
George Kurien ◽  
Gargi Sathish ◽  
N. Vijayamma
Keyword(s):  
Case Series ◽  
Skin Lesions ◽  
Lower Eyelid ◽  
Common Condition ◽  
The Third ◽  
First Case ◽  
Department Of Ophthalmology ◽  
Autoimmune Condition ◽  
Eyelid Lesions ◽  
Chronic Blepharitis

Background: Blepharitis is a very common condition encountered in ophthalmology outpatient care department. Dermatological diseases like seborrheic keratopathy and rosacea have been frequently discussed as being associated with blepharitis. However Discoid lupus erythematosis [DLE], an autoimmune condition has only rarely been reported to involve the eyelids mimicking blepharitis. DLE affecting the eyelids can produce significant morbidity with lid deformities, trichiasis and symblepharon if left untreated.Objective: To report three consecutive cases of DLE with eyelid lesions mimicking blepharitis. They presented to the department of ophthalmology at our institute from April 2014 to March 2016. The first case presented with involvement of lower eyelid in one eye. She was having multiple skin lesions which on biopsy confirmed the diagnosis of DLE. The second case was a diagnosed case of DLE who received treatment 4 years back and came with relapse of the disease affecting the eyelid. The third case was a recently biopsy confirmed case of DLE with multiple skin lesions along with bilateral eyelid involvement. Two of them had madarosis and one case had destruction of the outer lid margin at presentation. All three cases responded well to treatment with Hydrxychloroquin.Conclusion: The discoid lesions of DLE affecting the eyelids can mimic the appearance of chronic blepharitis. Ophthalmologists should be aware that DLE is a possibility while dealing with an atypical case of chronic blepharitis. Early diagnosis and treatment can prevent deformities of eyelid.

scholarly journals Metabolic Disturbance in Patients with Muscular Dystrophy and Reflection of Altered Enzyme Activity in Dystrophic Muscle: One Critical View

2020 ◽  
Vol 1 (8) ◽  
pp. 393-403
Author(s):  
Niraj Kumar Srivastava ◽  
Somnath Mukherjee ◽  
Vijay Nath Mishra
Keyword(s):  
Muscular Dystrophy ◽  
Muscle Wasting ◽  
Tca Cycle ◽  
Becker Muscular Dystrophy ◽  
Metabolic Disturbance ◽  
Muscular Dystrophies ◽  
Acid Oxidation ◽  
Dystrophic Muscle ◽  
Variable Distribution ◽  
Activity Of Enzymes

Muscular dystrophies are inherited myogenic diseases and considered by progressive muscle wasting and weakness with variable distribution and severity. The essential characteristics of muscular dystrophies are selective involvement, significant wasting and weakness of muscles. The most common and frequent types of muscular dystrophies are Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy (BMD), Facioscapulohumeral Dystrophy (FSHD) and Limb Girdle Muscular Dystrophy (LGMD). Metabolic disturbance is observed in muscular dystrophy patients (DMD, BMD, FSHD and LGMD-2B). Alteration in the level of metabolites (BCAA, Glu/ Gln, Ace, alanine, glucose, histidine, propionate, tyrosine and fumarate) in dystrophic muscle reflects the alteration in the activity of enzymes. Collectively, these observations propose that there is alteration in the rate of glycolysis, TCA cycle, fatty acid oxidation, gluconeogenesis pathway and protein metabolism (catabolism & anabolism) in the muscular dystrophy patients. Metabolic disturbance, further provide the explanation about the pathophysiology of muscular dystrophy.

scholarly journals From Diagnosis to Treatment of Muscular Dystrophy: Psychology Meets Medicine

2015 ◽  
Vol 8 (1) ◽  
pp. 85
Author(s):  
Elna Herawati Che Ismail ◽  
Nooraini Othman
Keyword(s):  
Muscular Dystrophy ◽  
Skeletal Muscles ◽  
Muscle Wasting ◽  
Epidemiological Data ◽  
Muscular Dystrophies ◽  
Psychological Approach ◽  
Organ Systems ◽  
Different Types ◽  
Genetic Science ◽  
Degenerative Disorder

<p>This paper will briefly discuss the condition of muscular dystrophy disease in Malaysia and will explore the potential of psychological approach in managing the muscular dystrophy patients in Malaysia. Muscular dystrophy is a hereditary and progressive degenerative disorder affecting skeletal muscles, and also often other organ systems. This term includes many conditions associated to the muscle wasting and weakness where all are still genetic but having different types due to different genes and differ in severity. It is estimated there are around 43 newborns are affected by muscular dystrophy each year in Malaysia. The real burden of muscular dystrophy in Malaysia is difficult to estimate, since the epidemiological data for each of muscular dystrophies and even for muscular dystrophies in collective are not available. There are not many researches focusing on muscular dystrophy in Malaysia. The few available researches related to muscular dystrophy in Malaysia are mostly revolving around the medical and genetic science aspects of it, not in the psychology and social sides of the disease.</p>

scholarly journals Case series of iatrogenic coronary stent avulsion: a rare complication with varied management strategies

2021 ◽  
Vol 5 (5) ◽  
Author(s):  
Majd B Protty ◽  
Elinor H M O’Neill ◽  
Tim Kinnaird ◽  
Sean Gallagher
Keyword(s):  
Rare Complication ◽  
Management Strategies ◽  
Case Series ◽  
Coronary Stent ◽  
Management Options ◽  
Aortic Sinus ◽  
Coronary Syndrome ◽  
The Third ◽  
First Case ◽  
The Wire

Abstract Background Coronary stent avulsion is a rare, infrequently reported complication of percutaneous coronary intervention (PCI) with no consensus on management options. Case summary This case series presents three descriptions of iatrogenic coronary stent avulsions, and three different bailout management strategies. All patients presented with acute coronary syndrome and required PCI. In the first case, a freshly implanted stent was entrapped in a coronary guidewire and avulsed upon withdrawal of the wire into the aortic sinus. In the second case, a staged procedure to implant a new stent was complicated by stent dislodgement and entanglement with a recently implanted stent leading to avulsion of both stents into the aortic sinus and resultant dissection to the coronary arteries. In the third case, following a successful stent implantation, the tip of the coronary guidewire was bound to the proximal edge of the stent resulting in avulsion of the newly implanted stent into the ascending aorta upon retraction of the wire at the end of the procedure. The first two patients were managed percutaneously, and the third surgically. All patients have had acceptable technical and clinical outcomes. Discussion In the absence of a consensus on best bailout management strategy, we discuss the mechanisms of and the potential management options for this rare, but serious, complication.

scholarly journals Modalities to Treat Penile Glans Amputation: Case Series

1970 ◽  
Vol 1 (4) ◽  
Author(s):  
Chaula L. Sukasah ◽  
Parintosa Atmodiwirjo ◽  
Nur Anindhawati
Keyword(s):  
Case Series ◽  
Full Thickness Skin Graft ◽  
Muslim Population ◽  
Advantages And Disadvantages ◽  
The Third ◽  
First Case ◽  
Thickness Skin ◽  
The Family ◽  
Common Operation ◽  
Choice Of Technique

Background: In Indonesia, a country with Muslim population as a majority, circumcision is the most common operation performed in males. However, since circumcisions are also commonly performed by inexperienced individuals and during communal circumcision event, we frequently come across complications. One of the most severe complications is amputation of the penile glans. There are several techniques that can be used to treat this complication. In this paper we present some which have been used in our division and the result. Patient and Methods: We report three cases of traumatic penile glans amputation as a complication of circumcision that has been admitted to Cipto Mangunkusumo Hospital during January 2011 – January 2012. In first case we performed full thickness skin graft, in the second one we performed groin flap, and scrotal flap to reconstruct the third case. We evaluate the result for several months. Results: The three techniques showed no complication, good result in function and also aesthetically acceptable for patient and the family. Choice of technique that has been used to repair the amputated penis depended on the patient condition, and surgeon’s choice.Summary: The three techniques each has advantages and disadvantages, but all of them are acceptable, functionally and aesthetically.

scholarly journals Managing the challenging cases of pemphigus vulgaris with modified pulse therapy: case series

2019 ◽  
Vol 5 (2) ◽  
pp. 434
Author(s):  
Saraswathy P. ◽  
Jayanthi N. S. ◽  
Venkatesh Y.
Keyword(s):  
Therapeutic Response ◽  
Case Series ◽  
Pemphigus Vulgaris ◽  
Pulse Therapy ◽  
Patient Needs ◽  
Skin Infections ◽  
The Third ◽  
Cyclophosphamide Pulse Therapy ◽  
First Case ◽  
Cyclophosphamide Pulse

<p class="abstract">In pemphigus vulgaris, pulse therapy is a promising modality to achieve better therapeutic response and to minimize the side effects of daily steroids. Here we report 5 different challenging situations where we successfully managed with modification of pulse therapy. Our first case had multiple comorbidities with persistent skin infections managed with dexamethasone and cyclophosphamide pulse (DCP) and interval pulse. The second case was unmarried hypertensive male with poor DLQI managed with Azathioprine pulse therapy. The third case was uncontrolled diabetic patient with pulmonary tuberculosis managed with rituximab. The fourth case was diabetic and hypertensive was managed with one day dexamethasone cyclophosphamide pulse therapy (DCP). The fifth case was not completed family with cushingoid features managed with dexamethasone azathioprine pulse therapy (DAP). Pulse therapy is effective in controlling disease activity in pemphigus. But it can be modified in some situations according to the patient needs.</p>

scholarly journals Complicated enteric fever: a case series

2020 ◽  
Vol 7 (7) ◽  
pp. 1179
Author(s):  
Vijay Kumar Shrivas ◽  
Manoj Kumar Rai ◽  
Sandhya Chandel
Keyword(s):  
Respiratory Failure ◽  
Enteric Fever ◽  
Indian Subcontinent ◽  
Case Series ◽  
Severe Thrombocytopenia ◽  
The Third ◽  
First Case ◽  
The World ◽  
Taking Care

Enteric fever is endemic in Indian subcontinent. Authors are presenting 3 rare cases of complicated enteric fever. The first case is a case of enteric fever which was complicated by ARDS leading to respiratory failure. The second case is a case of enteric fever which was complicated by severe thrombocytopenia and the third case is a case of enteric fever which was complicated by severe encephalopathy. In this study authors have discussed and compared the similar cases found in India and other parts of the world. The physicians who are taking care of the patients of enteric fever should be aware of the above complications.

Ayurvedic management of Ducchen’s Muscular Dystrophy - A Case report

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Jayaraj R. ◽  
Veena G. Rao ◽  
Jyothi Nagalikar
Keyword(s):  
Muscular Dystrophy ◽  
Cardiac Dysfunction ◽  
Muscle Wasting ◽  
Progressive Disease ◽  
Genetic Disorder ◽  
Dystrophin Gene ◽  
Wasting Disease ◽  
Number Of Patients ◽  
Choice Of Treatment ◽  
Muscle Wasting Disease

Ducchen’s muscular dystrophy is most common X-linked recessive disorder affecting 30 in 100,000 live male births. The primary cause of this disease is mutations in Dystrophin gene which is essential for the structural and functional integrity of muscle. It is a progressive muscle wasting disease in which patients frequently develop contractures and lose the ability to walk between 6 and 12 years of age. With progressive disease most patients succumb to death from respiratory failure and cardiac dysfunction in their twenties. As this is a genetic disorder we can consider it as Adibala Pravritta Vyadhi. As Mamsa Kshaya is seen at some muscles and Mamsa Vriddhi at other this is an Avarana Vata Vyadhi. In both Upsthambha and Nirupasthmbha Vatavyadhi, Basthi is considered as prime choice of treatment. A Variety of Ksheerabasti in the form of Kalabasti is studied in this condition by taking subjective and objective parameters. As this has given better improvement with no adverse effects in the patient, it can be tried in large number of patients.

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