scholarly journals Diagnosing a rare case of lymphocytic infiltration of the pituitary gland without the invasive procedure of pituitary biopsy

2021 ◽  
Vol 20 (3) ◽  
pp. 387-391
Author(s):  
Hamad Haider Khan ◽  
◽  
Hameed Ullah ◽  
Siraj Ulhaq Khan ◽  
Huo Guo ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Rare Case ◽  
Clinical Laboratory ◽  
Invasive Procedure ◽  
Rare Condition ◽  
Lymphocytic Infiltration ◽  
Laboratory Evaluation ◽  
Inflammatory Disorder ◽  
Case Presentation ◽  
Cellular Population

Background. Lymphocytic infiltration of the pituitary is an unusual inflammatory disorder of the pituitary and indicated to be autoimmune in origin. Presentations depend on the site of involvement and degree of destruction of the cellular population of the pituitary and may range from an asymptomatic state to pan-hypopituitarism with or without mass effects. In the present study, we represent a rare case of lymphocytic infiltration of the pituitary gland who was diagnosed with such condition and the subsequent management. Case presentation. A 22-year-old male who was admitted with symptoms of increased thirst and excessive fatigue. Following a thorough physical, clinical, laboratory, biochemistry, and imaging examinations a timely diagnosis of lymphocytic infiltration of the pituitary was made without using the invasive procedure of pituitary biopsy. In light of the diagnosis prompt management with the mainstay of glucocorticoid was started along with replenishing the other deficient hormones. In this study we describe a rare case of lymphocytic infiltration of the pituitary discussing in terms of epidemiology, sign and symptoms, laboratory evaluation, imaging studies, histopathology, management, and the usual outcome. Conclusion. Lymphocytic infiltration of the pituitary gland can be diagnosed with the clinical presentation along with lab evaluation and imaging but without pituitary biopsy, which could help in an early and accurate diagnosis which is the basis for better management of the rare condition.

scholarly journals A Rare Case of HHV-8 Associated Hemophagocytic Lymphohistiocytosis in a Stable HIV Patient

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Nonso Osakwe ◽  
Diane Johnson ◽  
Natalie Klein ◽  
Dalia Abdel Azim
Keyword(s):  
Hemophagocytic Lymphohistiocytosis ◽  
Rare Case ◽  
Viral Infections ◽  
Rare Condition ◽  
Lymph Node Biopsy ◽  
Castleman Disease ◽  
Human Herpes Virus 8 ◽  
Case Presentation ◽  
Multicentric Castleman Disease ◽  
History Of

Background. Hemophagocytic lymphohistiocytosis (HLH) is a rare condition associated with viral infections including HIV. Cases have been reported mainly in advanced HIV/AIDS. This is a rare case that reports HLH associated with human herpes virus-8 (HHV-8) associated multicentric Castleman disease in a stable HIV patient. Case Presentation. A 70-year-old Asian male patient with history of stable HIV on medications with CD 4 cell count above 200 presented with cough and fever and was initially treated for pneumonia as an outpatient. Persisting symptoms prompted presentation to the hospital. The patient was found to have anemia which persisted despite repeated transfusion of packed red cells. A bone marrow biopsy to investigate anemia revealed hemophagocytosis. A CT scan revealed multiple enlarged lymph nodes and hepatosplenomegaly. An excisional lymph node biopsy revealed HHV-8 associated multicentric Castleman disease. The patient deteriorated despite initiation of treatment. Conclusion. HLH can occur at any stage of HIV, rapid diagnosis to identify possible underlying reactive infectious etiology and prompt initiation of treatment is crucial to survival.

scholarly journals Recurrent endobronchial fibro-epithelial polyposis in a 73-year-old woman

2021 ◽  
Vol 7 (2) ◽  
pp. e14-e14
Author(s):  
Ramin Sami ◽  
Mina Nickpour ◽  
Noushin Afshar Moghaddam
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Rare Case ◽  
Benign Tumor ◽  
Main Bronchus ◽  
Rare Condition ◽  
Genitourinary Tract ◽  
Fibroepithelial Polyp ◽  
Interventional Bronchoscopy ◽  
Case Presentation

Introduction: Fibroepithelial polyp (FEP) is a benign tumor that is presented frequently in some of the organs like oral cavity, skin, colon and genitourinary tract, but in airway is rare. Case Presentation: We present a rare case in this paper, with recurrent bronchial FEP that was near completely obstructed right main bronchus that we managed her successfully with interventional bronchoscopy. In this case report we describe this rare condition. Conclusion: Airway FEP is uncommon benign tumor that may obstruct airways and rarely may be recurrent like our case.

scholarly journals A rare case presentation of acute myo-pericarditis in a patient with lupus flare

2021 ◽  
Vol 11 (1) ◽  
pp. 21-22
Author(s):  
Luis Caraballo
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Rare Case ◽  
Inflammatory Disorder ◽  
Systemic Lupus ◽  
First Line ◽  
Case Presentation ◽  
First Line Therapy ◽  
Life Threatening ◽  
Autoimmune Etiology

Systemic lupus erythematosus (SLE) is a chronic, multisystem, inflammatory disorder of autoimmune etiology of unknown cause. Cardiac involvement during systemic lupus erythematosus (SLE) may include the pericardium, myocardium, valvular disease, including Libman-Sacks endocarditis, and coronary arteries. Myocarditis is a severe unusual feature most common in African-American that can be asymptomatic with a prevalence of 8-25% in patients with systemic lupus erythematosus. Acute myo-pericarditis with subsequent heart failure is a life threatening complication of SLE that needs to get recognized early to prevent mortality to the patient. Steroids is the first line therapy in patients with acute myopericarditis. Here we present a rare case of SLE flare presenting as Acute myopericarditis.

scholarly journals Idiopathic pneumomediastinum – case report and review of the literature

2019 ◽  
Vol 17 (3) ◽  
pp. 269-272
Author(s):  
Iv. Novakov
Keyword(s):  
Subcutaneous Emphysema ◽  
Rare Case ◽  
Clinical Presentation ◽  
Pathological Condition ◽  
Rare Condition ◽  
Good Prognosis ◽  
Review Of The Literature ◽  
Precipitating Factors ◽  
Case Presentation ◽  
Spontaneous Pneumomediastinum

Idiopathic pneumomediastinum is a form of spontaneous pneumomediastinum without predisposing factors and precipitating factors. The purpose of this publication is to present a rare case of this pathological condition. Case presentation: A 21year-old female with spontaneous pneumomediastinum was revealed. Medical history, physical examination, imaging and interventional diagnosis couldn’t determine any predisposing and precipitating factors for pneumomediatinum: case of idiopathic pneumomediastinum with unusual widespread subcutaneous emphysema. Conclusion In conclusion, this publication refers to one relatively rare condition in the thoracic pathology – idiopathic pneumomediastinum. Being a case of idiopathic pneumomediastinum, there was an unusual clinical presentation of widespread subcutaneous emphysema. Despite widespread subcutaneous emphysema, the presenting case confirms the good prognosis of idiopathic pneumomediastinum.

Congenital Agenesis of Both Vertebro-Basilar Artery-A Rare Case Report

2021 ◽  
Vol 11 (Number 2) ◽  
pp. 68-71
Author(s):  
Tahmina Siddika ◽  
Ashraful Hasib ◽  
Avijith Bhattacharjee ◽  
Naziur Rahman ◽  
M H Khan Pavel ◽  
...  
Keyword(s):  
Case Report ◽  
Intraventricular Hemorrhage ◽  
Rare Case ◽  
Rare Condition ◽  
Cerebral Angiogram ◽  
Case Presentation ◽  
Rare Case Report ◽  
Basilar Arteries ◽  
Congenital Agenesis ◽  
The Brain

Vertebral and basilar arteries are the major blood suppliers of the brain. They supply nearly one-third of the brain. Congenital absence of these arteries is a rare condition. Usually, this condition presents with stroke like presentation. This is a case presentation of a 40-year-old lady who was diagnosed as congenital agenesis of vertebra-basilar arteries. This lady was presented with intraventricular hemorrhage. Subsequently the diagnosis was made by cerebral angiogram.

scholarly journals A Rare Case of Partial Peripheral Thyroid Hormone Resistance Due to a Point Mutation in the Membrane Integrin Α(V)Β(3) and Concomitant Hashimoto`s Thyroiditis

2019 ◽  
Vol 7 (12) ◽  
pp. 1991-1997
Author(s):  
Martina Savovska ◽  
Sinisa Stojanoski ◽  
Nevena Manevska
Keyword(s):  
Thyroid Hormones ◽  
Pituitary Gland ◽  
Point Mutation ◽  
Rare Case ◽  
Mapk Pathway ◽  
Peripheral Resistance ◽  
Rare Condition ◽  
Peripheral Tissues ◽  
Resistance To Thyroid Hormones ◽  
Peripheral Cells

BACKGROUND: Peripheral resistance to thyroid hormones is a type of unresponsiveness of the peripheral cells or tissues to FT3 and/or FT4. Generalised resistance to thyroid hormones affects the pituitary gland and most of the peripheral tissues. Selective pituitary resistance or central resistance to thyroid hormones include unresponsiveness of the pituitary gland, but the peripheral tissues are responsive. Selective peripheral resistance involves peripheral tissue or cellular resistance to thyroid hormones, but the pituitary gland is responsive.CASE PRESENTATION: We present a rare case of a female patient with partial peripheral resistance to thyroid hormones due to a point mutation coding for the beta subunit of the integrin molecule α(V)β(3) and concomitant Hashimoto`s thyroiditis. Clinically, the patient`s symptoms were in favour of hypothyroidism, and the laboratory results were in favour of the secondary hyperthyroid state. PCR protein amplification detected a point mutation coding for the membrane receptor, which mediates a signal via the MAPK pathway when bonded with thyroid hormones.CONCLUSION: Peripheral resistance to thyroid hormones is a very rare condition and can often be misdiagnosed due to the broad spectrum of clinically similar differential diagnostic entities. Molecular analysis is required to confirm the exact underlying cause for the impaired peripheral sensitivity to thyroid hormones syndrome.

scholarly journals Declarations: management of a pulmonary arteriovenous fistulae by uniportal video‐assisted thoracoscopic surgery: a case report

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
R. Li ◽  
Y. Zhou ◽  
S. Kang ◽  
F. Kong ◽  
L. Guan ◽  
...  
Keyword(s):  
Computerized Tomography ◽  
Rare Case ◽  
Thoracoscopic Surgery ◽  
Rare Condition ◽  
Preoperative Assessment ◽  
Ct Reconstruction ◽  
Case Presentation ◽  
Lower Lobectomy ◽  
Video Assisted ◽  
Video Assisted Thoracoscopic Surgery

Abstract Background A pulmonary arteriovenous fistula (PAVF) is a rare condition that is associated with pulmonary arteriovenous malformation (PAVM). Few reports have described managing PAVMs using uniportal video-assisted thoracoscopic surgery (VATS). Case presentation A 13-year-old child with PAVF in the left inferior pulmonary artery was treated by uniportal VATS with left lower lobectomy. After surgery, hemoptysis did not recur and there were no postoperative complications. Six months after the operation, postoperative review of computerized tomography showed no recrudescence of PAVF. Conclusions PAVF is a rare case that should be diagnosed and treated early. 3D- computerized tomography (CT) reconstruction is useful for diagnosis and preoperative assessment. The case shows that PAVF can be managed with uniportal VATS.

scholarly journals Is KCNH1 mutation related to coronary artery ectasia

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Mohammad Rafi Noori ◽  
Bo Zhang ◽  
Lifei Pan
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Rare Case ◽  
Rare Condition ◽  
Coronary Artery Ectasia ◽  
Case Presentation ◽  
Gated Channel ◽  
Uncommon Condition ◽  
Artery Disease

Abstract Background Coronary artery ectasia (CAE) is an uncommon finding in patients undergoing coronary angiography and acute myocardial infarction is an extremely uncommon condition in the presence of coronary artery ectasia. To date, 50 gene variants associated with coronary artery disease have been identified, but none appear to be related to coronary artery ectasia. Case presentation This is a rare case of Coronary artery ectasia which is considered to be related to Gene variations in potassium voltage-gated channel subfamily H member 1, KCNH1 (encoding a protein designated ether à go-go, EAG1 or KV10.1). Conclusion Occurrence of Acute myocardial infarction in patient with coronary artery ectasia after diarrhea is a very rare condition and involvement of KCNH1 gene mutation which is described in this case report.

Study of Toll-like Receptor 3 Gene Polymorphism as a Novel Risk Factor for HCV-related Hepatocellular Carcinoma in Egypt

2020 ◽  
Vol 20 (5) ◽  
pp. 382-389 ◽  
Author(s):  
Shimaa EL-Sharawy ◽  
Osama El- Sayed Negm ◽  
Sherief Abd-Elsalam ◽  
Hesham Ahmed EL-Sorogy ◽  
Mona Ahmed Helmy Shehata
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Gene Polymorphism ◽  
Clinical Laboratory ◽  
Treatment Options ◽  
Laboratory Evaluation ◽  
Toll Like Receptor ◽  
Focal Lesions ◽  
Tlr3 Gene ◽  
Cirrhotic Patients

Background & Aims: Hepatocellular carcinoma (HCC) is a highly aggressive cancer with few treatment options. Toll-like receptor 3 (TLR3) plays a key role in innate immunity and may affect the development of cancers. This study aimed to investigate the association between TLR3 gene polymorphism and HCV-related hepatocellular carcinoma in Egypt. Methods: This work was conducted on 70 individuals; fifty HCV cirrhotic patients were included in two groups; with HCC (30 patients) and without HCC (20 patients) compared with a group of 20 apparently healthy controls. All of the studied individuals underwent clinical-laboratory evaluation. TLR3 gene single-nucleotide polymorphism (SNP) (+1234C/T) was tested by polymerase chain reaction- restriction fragment length polymorphism. Results: This study reported that the prevalence of TLR3 +1234TT genotype was significantly increased in cirrhotic patients with HCC than without HCC, while it was not detected at all among the controls. When analyzing the TLR3 SNP +1234C/T with different clinical parameters in HCC patients, there was a significant association between+1234C/T SNP; namely TT genotype and each of the hepatic focal lesions᾽ number, size and the patients᾽ higher Okuda and BCLC stages. No association could be detected between TLR3 SNP and the age, sex, Child-Pugh grades, MELD score or AFP of the studied HCC cases. Conclusion: TLR3 gene SN P +1234C/T could be a novel risk factor for the HCV-related HCC among the Egyptian population.

Sign in / Sign up

Export Citation Format

Share Document