scholarly journals Systemic Bacterial Infection and Immune Defense Phenotypes in Drosophila Melanogaster

10.3791/52613 ◽  
2015 ◽  
Author(s):  
Sarah Khalil ◽  
Eliana Jacobson ◽  
Moria C. Chambers ◽  
Brian P. Lazzaro
Keyword(s):  
Drosophila Melanogaster ◽  
Bacterial Infection ◽  
Immune Defense ◽  
Systemic Bacterial Infection

Identification, expression and bioactivity of Paramisgurnus dabryanus β-defensin that might be involved in immune defense against bacterial infection

2013 ◽  
Vol 35 (2) ◽  
pp. 399-406 ◽  
Author(s):  
Yeyu Chen ◽  
Heng Zhao ◽  
Xinshang Zhang ◽  
Huiying Luo ◽  
Xianli Xue ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Immune Defense ◽  
Paramisgurnus Dabryanus

Role of copper in defending against bacterial infection

2015 ◽  
Author(s):  
◽  
Erik Ladomersky
Keyword(s):  
Bacterial Infection ◽  
Host Defense ◽  
Immune Defense ◽  
Copper Proteins ◽  
University Of Missouri ◽  
Susceptibility To Infection ◽  
Essential Nutrient ◽  
The University ◽  
The Relationship

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Copper is an essential nutrient. It plays an important role in development, pigmentation, neurological function, and immune defense. Copper deficiency is known to make host's more susceptible to infection. In this work we show that two copper proteins, ATP7A and ceruloplasmin, are important for host defense against bacterial infection. Studies have shown ATP7A is responsible for increasing copper concentrations inside the phagosome. Our study sheds light on the role of Atp7a and copper in adaptive immunity, and provide a biochemical model for understanding the relationship between copper malnutrition and susceptibility to infection. Iron, another essential nutrient, is linked with copper through the actions of copper-dependent proteins which play a role in maintaining normal iron levels in the blood. One of these proteins is ceruloplasmin, a protein that is also upregulated during infection. Our study sheds light onto why this protein is necessary for host defense against Salmonella infection.

scholarly journals The Genetic Basis of Natural Variation in Drosophila melanogaster Immune Defense against Enterococcus faecalis

Genes ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 234 ◽  
Author(s):  
Joanne R Chapman ◽  
Maureen A Dowell ◽  
Rosanna Chan ◽  
Robert L Unckless
Keyword(s):  
Drosophila Melanogaster ◽  
Enterococcus Faecalis ◽  
Natural Variation ◽  
Genetic Basis ◽  
Genome Wide Association Study ◽  
Association Studies ◽  
Immune Defense ◽  
Nucleotide Polymorphisms ◽  
Disease Response ◽  
A Genome

Dissecting the genetic basis of natural variation in disease response in hosts provides insights into the coevolutionary dynamics of host-pathogen interactions. Here, a genome-wide association study of Drosophila melanogaster survival after infection with the Gram-positive entomopathogenic bacterium Enterococcus faecalis is reported. There was considerable variation in defense against E. faecalis infection among inbred lines of the Drosophila Genetics Reference Panel. We identified single nucleotide polymorphisms associated with six genes with a significant (p < 10−08, corresponding to a false discovery rate of 2.4%) association with survival, none of which were canonical immune genes. To validate the role of these genes in immune defense, their expression was knocked-down using RNAi and survival of infected hosts was followed, which confirmed a role for the genes krishah and S6k in immune defense. We further identified a putative role for the Bomanin gene BomBc1 (also known as IM23), in E. faecalis infection response. This study adds to the growing set of association studies for infection in Drosophila melanogaster and suggests that the genetic causes of variation in immune defense differ for different pathogens.

scholarly journals Defining Host Responses during Systemic Bacterial Infection through Construction of a Murine Organ Proteome Atlas

Cell Systems ◽  
2018 ◽  
Vol 6 (5) ◽  
pp. 579-592.e4 ◽  
Author(s):  
John D. Lapek ◽  
Robert H. Mills ◽  
Jacob M. Wozniak ◽  
Anaamika Campeau ◽  
Ronnie H. Fang ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Host Responses ◽  
Systemic Bacterial Infection

Procalcitonin for discrimination between activity of systemic autoimmune disease and systemic bacterial infection

2000 ◽  
Vol 26 (2) ◽  
pp. S199-S201 ◽  
Author(s):  
R. Brunkhorst ◽  
O. K. Eberhardt ◽  
M. Haubitz ◽  
F. M. Brunkhorst
Keyword(s):  
Autoimmune Disease ◽  
Bacterial Infection ◽  
Systemic Autoimmune Disease ◽  
Systemic Bacterial Infection

scholarly journals The genetic architecture of defence as resistance to and tolerance of bacterial infection in Drosophila melanogaster

2017 ◽  
Vol 26 (6) ◽  
pp. 1533-1546 ◽  
Author(s):  
Virginia M. Howick ◽  
Brian P. Lazzaro
Keyword(s):  
Drosophila Melanogaster ◽  
Bacterial Infection ◽  
Genetic Architecture
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