The Effect of Smoking on the Lipid Profile of Inhabitant Smokers of Hasilpur, District Bahawalpur, Pakistan

Background: Health problem are culturally associated with smoking in developing countries. Many hazardous chemicals are taken up by direct or passive smoking causing lipid peroxidation resulting in oxidative stress. Objectives: To estimate the occurrence of smoking and its effects on the lipid profile in populations of Hasilpur, Pakistan. Methodology: The current study was conducted from April - August 2014. Out of 247 apparently healthy subjects of both genders (male=220; female=27), 134 were smokers and 113 were non-smokers. In order to analyze lipid profile, blood samples were collected in early morning hours from the selected members who were asked to fast all night. By using Chem-100 chemistry analyzer, cholesterol, triglyceride, HDL, LDL and VLDL were analyzed. Results: The overall prevalence of smokers was 54.25%. The results showed 60.9% prevalence in males and 0% in females. The mean value of serum triglyceride in control, light smokers and heavy smokers was 147.4±11.7mg/dl, 190.8±41.4 and 205.3±29.7mg/dl, respectively. The results of cholesterol in control, light smokers and heavy smokers were 147.38±7.99mg/dl, 136.8 ±12. 8mg/dl and 173.44±8.63mg/dl, respectively. There was a considerable distinction in the mean level of serum triglyceride and cholesterol between the control group, light smokers and heavy smoker groups (P<00.5). The mean value of HDL of control, light smokers and heavy smokers was 30.93±1.30mg/dl, 31.10±2.45 and 34.58±1.55mg/dl, respectively. The mean values of LDL and VLDL of control, light smokers and heavy smokers were 110.46±3.63mg/dl, 106.00±4.52mg/dl, 117.19±3.48mg/dl and 33.54±3.11mg/dl, 49±9.02mg/dl, 41.06±5.34mg/dl, respectively. There was significant difference in the mean level of HDL, LDL and VLDL between the control group, light smokers and heavy smoker groups (P<0.05). Conclusion: This study concluded that smoking is the reasons of variation in the lipid profile. Elevated period of smoking and the number of smoked cigarettes/day reason the alteration in serum lipid levels and is probably related with increased danger for coronary artery disease.

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CD59 Deficient Granulocytes in High Risk Groups of Myelodysplastic Syndromes (MDS).

Blood ◽

10.1182/blood.v104.11.4717.4717 ◽

2004 ◽

Vol 104 (11) ◽

pp. 4717-4717

Author(s):

Georgia Kaiafa ◽

Vasiliki Tsavdaridou ◽

Athanasios Papadopoulos ◽

Christos Savopoulos ◽

Apostolos Hatzitolios ◽

...

Keyword(s):

Normal Subjects ◽

Risk Groups ◽

Mean Value ◽

Control Group ◽

Refractory Anaemia ◽

Mean Values ◽

Significant Difference ◽

The Mean ◽

Group B ◽

Pnh Clone

Abstract Background: Blood cells are deficient in membrane-bound glycosyl-phosphatidylinositol (GPI)-anchored proteins in paroxysmal nocturnal hemoglobinuria (PNH) because of an acquired disorder of the pluripotent stem cell. CD55 and CD59 antigens are the most common GPI-anchored proteins that are used for the diagnosis of the presence of PNH clone. The association of MDS with PNH is rather controversial. There are few published individual cases of PNH arrived from a previous MDS or MDS following PNH. Aim: Recent studies have demonstrated the existence of PNH clone in some MDS patients. These studies were performed mostly on erythrocytes and to the best of our knowledge they are only 4. Granulocytes appear to be more sensitive markers of PNH clone existence than erythrocytes and therefore we investigate the expression of PNH clone on granulocytes of patients with MDS. Material-Methods: A total number of 95 patients 25–80 yrs old with MDS {A:19 with refractory anaemia (RA), B:9 with refractory anaemia with ring sideroblasts (RARS), C:17 with refractory anaemia with excess blasts (RAEB), D: 12 with refractory anaemia with excess blasts in transformation (RAEB-t) and E: 19 with chronic myelomonocytic leukemia (CMLL)} and 19 healthy donors were included in our study. The presence of GPI-anchored proteins (CD55, CD59)-deficient granulocytes was examined by flow cytometry. For the detection of the PNH clone the commercial kit by Beckman Coulter (cellquant CD55/CD59) was used. Statistical analysis was made by ANOVA, while Robust test was performed because there was no homogeneity of variances by ANOVA. Results: Table 1 shows the percentages of CD55 and CD59 deficient granulocytes in the 5 groups of pts with MDS comparing with the control group. a) Although the mean values of CD55 deficient granulocytes in the groups RAEB, RAEB-t and CMLL were higher enough than those of the normal subjects, there were no statistically significant differences (p>0.10) in the comparison of the mean values of CD55 deficient granulocytes between each group of patients with the control group. b) On the contrary there was a very statistically significant difference in the comparison of the mean value of CD59 deficient granulocytes between the three last groups (C, D and E) of pts with the control group (p< 0.086, p< 0.001 and p<0.001 respectively). The percentages of CD55 and CD59 deficient granulocytes in the 5 groups of patients with MDS and in the control group CD55 CD55 CD59 CD59 Groups N Mean Value Std deviation Mean Value Std deviation A (RA) 19 2.89 2.79 2.91 2.85 B (RARS) 9 1.05 1.14 3.89 3.63 C (RAEB) 17 4.78 4.76 11.75 6.06 D (RAEB-t) 12 4.23 2.85 23.76 8.53 E (CMLL) 19 6.01 4.97 38.26 16.18 Control 19 3.67 2.89 3.67 2.89 Total 95 4.00 3.87 14.44 16.39 Conclusions: There are relatively large CD59 negative subpopulations (mean values 11.75–38.26%) of granulocytes in the last three groups (RAEB, RAEB-t, CMLL) of MDS patients. On the contrary the two low risk forms (RA, RARS) revealed no such populations. Non-expression of CD59 antigen on granulocytes is a more sensitive marker than that of CD55 antigen for the presence of a possible PNH clone in MDS patients.

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Carbocysteine in the Management of Stable COPD: Are Its Antioxidant and Anti-Inflammatory Properties Clinically Relevant?

South East European Journal of Immunology ◽

10.3889/seejim.2017.20011 ◽

2017 ◽

Vol 2017 ◽

pp. 1 ◽

Cited By ~ 1

Author(s):

Jordan Minov ◽

Jovanka Karadzinska-Bislimovska ◽

Tatjana Petrova ◽

Kristin Vasilevska ◽

Saso Stoleski ◽

...

Keyword(s):

Real Life ◽

Mean Value ◽

Control Group ◽

Chronic Obstructive ◽

Initial Visit ◽

Mean Values ◽

Regular Treatment ◽

Positive Effects ◽

Significant Difference ◽

The Mean

BACKGROUND: The recent epidemiological and experimental evidence suggest possible antioxidant effect of carbocysteine in patients with chronic obstructive pulmonary disease (COPD).AIM: To assess efficacy and tolerability of carbocysteine in the management of stable COPD.METHODS: We performed an observational, non-randomized, open study (a real life study) including 87 patients with stable COPD (group B and D by combined COPD assessment) divided in two groups, examined group (EG) and control group (CG). All participants were treated with the regular treatment of the stable disease, but in the participants of the EG carbocysteine 1,500 mg daily was added to their regular treatment during the period of two months. The study protocol included completion of the COPD Assessment Test (CAT) and spirometric measurements at initial visit and at the end of the mentioned period.RESULTS: We found significantly lower mean value of the overall CAT score in the EG at the end of the study as compared to its mean value registered at initial visit (26.9 vs. 24.3; P = 0.007). In regard to certain CAT items, we found significantly lower values of the mean scores related to cough phlegm and sleep disturbances as compared to their mean scores at initial visit. In addition, the mean values of the overall CAT scores at initial visit and at the end of the study in controls were similar. In EG we found significantly higher mean value of the MEF 25-75 at the end of the study as compared to its mean value registered at initial visit (59.3% vs. 67.2%; P = 0.003). There was no significant difference in the mean values of other spirometric parameters at the end of the study as compared to their mean values at initial visit. In controls we registered similar values of all measured spirometric parameters at the end of the study as compared to their values registered at initial visit. Mild gastrointestinal manifestations were registered in 13.3% of the participants of the EG during the examined period.CONCLUSION: Our findings indicate positive effects of carbocysteine regarding the symptoms and lung function, as well as its good tolerability in the patients with stable COPD.

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Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study

Journal of Clinical Medicine ◽

10.3390/jcm7090232 ◽

2018 ◽

Vol 7 (9) ◽

pp. 232 ◽

Cited By ~ 1

Author(s):

Radmila Karan ◽

Suzana Cvjeticanin ◽

Natasa Kovacevic-Kostic ◽

Dejan Nikolic ◽

Milos Velinovic ◽

...

Keyword(s):

Control Sample ◽

Mean Value ◽

Blood Type ◽

Control Group ◽

Mean Values ◽

Individual Variations ◽

Significant Difference ◽

Abo Blood Type ◽

The Mean ◽

Artery Disease

Background: The aim of our study was to evaluate the degree of genetic homozygosity in the group of patients with coronary artery disease (CAD), as well as to evaluate morphogenetic variability in CAD patients regarding the presence of investigated risk factors (RF) compared to a control sample of individuals. Additionally, we aimed to evaluate the distribution of ABO blood type frequencies between tested samples of individuals. Methods: This study analyzed individual phenotype and morphogenetic variability of 17 homozygously-recessive characteristics (HRC), by using HRC test in a sample of 148 individuals in CAD patients group and 156 individuals in the control group. The following RF were analyzed: hypertension, diabetes mellitus, hyperlipidemia, and smoking. Results: The mean value of HRC in CAD patients is significantly higher, while variability decreases compared to the control sample (CAD patients: 4.24 ± 1.59, control sample: 3.75 ± 1.69; VCAD-patients = 37.50%, VC = 45.07%). There is a significant difference in individual variations of 17 HRC between control sample and CAD patients (χ2 = 169.144; p < 0.01), which points out to different variability for tested genes. Mean values of HRC significantly differed in CAD patients in regard to the number of RF present. A blood type (OR = 1.75) is significant predictor for CAD, while O blood type (OR = 0.43) was significantly associated with controls. Conclusion: There is a higher degree of recessive homozygosity in CAD patients versus individuals in the control sample, and the presence of significant variations in the degree of recessive homozygosity as the number of tested RF increases.

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A new simpler approach to measure the strength of toe plantar flexion requiring no mechanical restraint with a light-weight device

Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine ◽

10.1177/09544119211002932 ◽

2021 ◽

pp. 095441192110029

Author(s):

Yuko Komuro ◽

Yuji Ohta

Keyword(s):

Plantar Flexion ◽

Mean Value ◽

Simple Approach ◽

Light Weight ◽

New Approach ◽

Mean Values ◽

Mechanical Restraint ◽

Significant Difference ◽

Ankle Joints ◽

The Mean

Conventionally, the strength of toe plantar flexion (STPF) is measured in a seated position, in which not only the target toe joints but also the knee and particularly ankle joints, are usually restrained. We have developed an approach for the measurement of STPF which does not involve restraint and considers the interactions of adjacent joints of the lower extremities. This study aimed to evaluate this new approach and comparing with the seated approach. A thin, light-weight, rigid plate was attached to the sole of the foot in order to immobilize the toe area. Participants were 13 healthy young women (mean age: 24 ± 4 years). For measurement of STPF with the new approach, participants were instructed to stand, raise the device-wearing leg slightly, plantar flex the ankle, and push the sensor sheet with the toes to exert STPF. The sensor sheet of the F-scan II system was inserted between the foot sole and the plate. For measurement with the seated approach, participants were instructed to sit and push the sensor with the toes. They were required to maintain the hip, knee, and ankle joints at 90°. The mean values of maximum STPF of the 13 participants obtained with each approach were compared. There was no significant difference in mean value of maximum STPF when the two approaches were compared (new: 59 ± 23 N, seated: 47 ± 33 N). The coefficient of variation of maximum STPF was smaller for data obtained with the new approach (new: 39%, seated: 70%). Our simple approach enables measurement of STPF without the need for the restraints that are required for the conventional seated approach. These results suggest that the new approach is a valid method for measurement of STPF.

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Assessment of the Tissue Response to Modification of the Surface of Dental Implants with Carboxyethylphosphonic Acid and Basic Fibroblastic Growth Factor Immobilization (Fgf-2): An Experimental Study on Minipigs

Biology ◽

10.3390/biology10050358 ◽

2021 ◽

Vol 10 (5) ◽

pp. 358

Author(s):

Javier Aragoneses ◽

Ana Suárez ◽

Nansi López-Valverde ◽

Francisco Martínez-Martínez ◽

Juan Manuel Aragoneses

Keyword(s):

Surface Treatment ◽

Test Group ◽

Mean Value ◽

Control Group ◽

P Value ◽

Implant Surface ◽

Bone Contact ◽

Bone Implant ◽

Significant Difference ◽

The Mean

The aim of this study was to evaluate the effect of implant surface treatment with carboxyethylphosphonic acid and fibroblast growth factor 2 on the bone–implant interface during the osseointegration period in vivo using an animal model. The present research was carried out in six minipigs, in whose left tibia implants were inserted as follows: eight implants with a standard surface treatment, for the control group, and eight implants with a surface treatment of carboxyethylphosphonic acid and immobilization of FGF-2, for the test group. At 4 weeks after the insertion of the implants, the animals were sacrificed for the histomorphometric analysis of the samples. The means of the results for the implant–bone contact variable (BIC) were 46.39 ± 17.49% for the test group and 34.00 ± 9.92% for the control group; the difference was not statistically significant. For the corrected implant–bone contact variable (BICc), the mean value of the test group was 60.48 ± 18.11%, and that for the control group, 43.08 ± 10.77%; the difference was statistically significant (p-value = 0.035). The new bone formation (BV/TV) showed average results of 27.28 ± 3.88% for the test group and 26.63 ± 7.90% for the control group, meaning that the differences were not statistically significant (p-value = 0.839). Regarding the bone density at the interthread level (BAI/TA), the mean value of the test group was 32.27 ± 6.70%, and that of the control group was 32.91 ± 7.76%, with a p-value of 0.863, while for the peri-implant density (BAP/TA), the mean value of the test group was 44.96 ± 7.55%, and that for the control group was 44.80 ± 8.68%, without a significant difference between the groups. The current research only found a significant difference for the bone–implant contact at the cortical level; therefore, it could be considered that FGF-2 acts on the mineralization of bone tissue. The application of carboxyethylphosphonic acid on the surface of implants can be considered a promising alternative as a biomimetic coating for the immobilization of FGF-2. Despite no differences in the new bone formation around the implants or in the interthread or peri-implant bone density being detected, the biofunctionalization of the implant surface with FGF-2 accelerates the mineralization of the bone–implant interface at the cortical level, thereby reducing the osseointegration period.

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The Effect of Gongronema Latifolum (Utazi) on Some Haematological Parameters of Rabbit

10.37191/mapsci-jccr-1(2)-014 ◽

2020 ◽

Author(s):

Obeagu Emmanuel Ifeanyi

Keyword(s):

Mean Value ◽

Control Group ◽

Mean Values ◽

Platelet Counts ◽

Group A ◽

The Mean ◽

Group B ◽

Differential White Blood Cell ◽

Group D ◽

Gongronema Latifolium

The hematological features of Gongronema latifolium, aqueous leaves extract was evaluated using standard methods. After 10 days of consecutive infusions into 9 experimental animals (rabbits). The rabbits were monitored and the following parameters determined; hemoglobin (HB), PCV, Platelet, WBC, Differential White Blood Cell. The Rabbits were grouped into 4, one consisting of control (group A), group B was fed with 0.5 mg/kg, group C with 1.0 mg/kg, and Group D with 1.5mg/kg of the aqueous extract of Gongronemalatifolium. The mean values obtained for hemoglobin estimation for the control group is 5.9 ± 4.1 g/dl, 9.1 ± 2.9 g/dl for group B 10.2 ± 1.8 g/dl for group C and 12.8 ± 0.1 g/dl for group D with no significant increase on the PCV estimation, the mean value for the control (group A) is 17.7 ± 12.3%, 27.3 ± 8.7% for group B, group C (30.6 ± 5.4%) and D (28.4 ± 0.3) show increase that statistically significant (p > 0.01). the platelet counts of group C (600 ± 0 x 109/L) and D(600 ± 0 x 109/L) show significant increase (p > 0.01) when compared with the control (600 ± 00). But the platelet value of group B (550 ± 50 x 109/L) shows no difference. No significant changes were observed in the White Blood Counts of the test groups B (3.5 ± 0.5 x 109/L), C (1.9 + 2.1 x 109/L) and D(3.6 ± 0.4) when compared with the control group (2.9 ± 1.9). The values obtained from the differential White Blood Counts (Neutrophils, Lymphocytes, Eosinophils and Monocytes) were not significant. Therefore, Gongronemalatifolium, when properly taken as a nutritional diet, causes beneficial changes on hemoglobin, packed cell volumes and platelet counts of consumers.

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EFFECT OF BRAIN EXERCISE AND BENSON RELAXATION THERAPY ON DEPRESSION LEVEL IN THE ELDERLY IN THE ELDERLY SOCIAL SERVICE UNIT

Belitung Nursing Journal ◽

10.33546/bnj.361 ◽

2018 ◽

Vol 4 (2) ◽

pp. 211-218

Author(s):

Wulansari Wulansari ◽

Ani Margawati ◽

Rita Hadi W

Keyword(s):

Social Service ◽

The Elderly ◽

Mean Value ◽

Control Group ◽

Relaxation Therapy ◽

Service Unit ◽

Significant Difference ◽

Depression Level ◽

The Mean ◽

And Control

Background: Depression is one of the most common psychosocial problems in the elderly. The incidence of depression in the elderly is greater in the elderly living in the social service unit than the elderly in the community. Management of depression in the elderly should be more emphasized on interventions that focus on the individual needs of the biopsychosocial and spiritual aspects. Brain gym therapy and Benson relaxation are considered appropriate in decreasing depression.Objective: This study was to determine the effect of brain exercise and Benson relaxation on the level of depression in elderly in the elderly social service unit.Methods: This was a quasy experimental study with pretest posttest control group design. Fifty-six elderly included in this study, which 28 assigned in the experiment and control group. The depression level was assessed using Geriatric Depression Scale (GDS). Wilcoxon and Mann-Whitney test were used for data analyses.Results: The study showed that the mean GDS score in the experiment group before the intervention was 7.21, while the mean value of GDS in the control group was 6.64. The mean value of GDS in the experiment group after the intervention was 5.04 and the mean in control group was 6.18. There was a significant difference of GDS score between experiment and control group with p-value of 0.021 (<0.05).Conclusion: There was a significant effect of brain gymnastics and Benson relaxation therapy in reducing depression in elderly. brain gymnastic therapy and benson relaxation can be one of independent nursing interventions as an effort to improve care for elderly groups.

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Impact of Two Remineralizing Agents on White Spot Lesions

10.21203/rs.3.rs-45862/v1 ◽

2020 ◽

Author(s):

Ebaa Ibrahim Alagha

Keyword(s):

Mean Value ◽

White Spot ◽

Control Group ◽

Main Concern ◽

White Spot Lesions ◽

Mean Values ◽

Restorative Treatment ◽

Significant Difference ◽

Group B ◽

The Impact

Abstract Aim of the study: This study evaluated the impact of two remineralizing agents containing casein phosphopeptideamorphous calcium phosphate (CPPACP), and Tricalcium phosphate (TCP) on white spot lesions. Materials and Methods: A total of ninety freshly extracted upper premolars were divided in three equal groups (30 each). Group A: Control group. Group B: Varnish containing CPP–ACP. Group C: Varnish containing TCP. The teeth were subjected to Diagnodent test after inducing white spot lesions to assess any surface changes present on the teeth. The readings were repeated post demineralization and post-remineralization. Results: Statistically significant difference was present in the mean values between the tested groups. CPP-ACP group recorded higher mean value at demineralization when compared to TCP group. Statistically significant difference (p < 0.0001) was present between the baseline and the demineralization values. CPP-ACP group presented higher remineralization results when compared to TCP group. T-test proved a significant difference between the tested groups. Conclusion: CPP-ACP containing varnish had higher remineralizing effect when compared to TCP containing varnish. Clinical Significance: Recently, the focus of restorative dentistry has been directed toward a conservative approach. Prevention and non-restorative treatment of initial enamel caries is the main concern. Remineralization procedures are the most preferred way of regeneration of lost tooth structure.

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The Impact of Strengthening Exercise on Dynamic Balance in Patients with Knee Osteoarthritis

10.53350/pjmhs2115103429 ◽

2021 ◽

Vol 15 (10) ◽

pp. 3429-3431

Author(s):

Shenbaga Subramanian Sundaram ◽

Makesh Babu Subramanian ◽

Riziq Allah Mustafa Gaowgeh ◽

Mikhled Falah Maayah ◽

Ziyad Neamatallah ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Dynamic Balance ◽

Mean Value ◽

Control Group ◽

P Value ◽

Strengthening Exercise ◽

Significant Difference ◽

The Mean ◽

The Impact ◽

Experimental Group

Background: Knee osteoarthritis is characterised clinically by usage-related pain and/or functional limitation. OA that is associated with physical dysfunction and decline in health-related quality of life caused the main disability worldwide and is expected to increase due to aging and obesity rates and further load on the population and health system. The strengthening exercises that normally used is knee flexion and extensions, isometric quadriceps exercise, isometric hamstring exercise, and sit to stand to improve the balance. Objectives: is to find out the impact of Strengthening exercise on Balance in patients with knee Osteoarthritis Study Design: Quasi experimental study Methods: Fifty-six (n=56) of knee OA patients were involved in this study by judgemental sampling design. Researcher will first demonstrate and explain the Y-balance tools testing procedure based on Plisky and colleagues study. Participants are given to practice six trials before the formal testing, stated that SEBT have a significant learning effect and found that the reaching distances reached the longest distance after six trials and then will be constant. Results: Independent t-test shows significant difference in only anterior direction. In the experimental group the mean value is 69.83 with a SD of 11.62 while in the control group the mean value is 63.51 with a SD of 11.36; p-value of .045 and t-value of 2.056. In postero-lateral directions result shows there is no significant difference, experimental group the mean value is 91.10 with a SD of 9.74 while in control group mean value is 90.88 with SD value of 12.68; p-value of .947 and t-value of .067. Result of postero-medial shows no significant difference too, in experimental group the mean value of 95.16 with SD of 10.92 while in control group the mean value is 93.40 with SD of 8.20; p=value of .501 and t-value of .678. Conclusion: This study has proven strengthening exercise using YBT improved only anterior direction of YBT but no significant difference in postero-lateral and postero-medial direction. Key Words: Knee Osteoarthritis, Strengthening exercise, Dynamic Balance, Star excursion test

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Effect of Long Term Use of Carbamazepine on Lipid Profile in Adult Epileptic Patients

Bangladesh Journal of Neuroscience ◽

10.3329/bjn.v30i1.57362 ◽

2014 ◽

Vol 30 (1) ◽

pp. 27-34

Author(s):

Md Khairul Kabir Patwary ◽

Shakila Sultana ◽

- Md Salahuddin ◽

Abu Jafor Md Salahuddin ◽

Mohammed Sayeed Hassan ◽

...

Keyword(s):

Lipid Profile ◽

Focal Epilepsy ◽

Serum Triglyceride ◽

Control Group ◽

Case Group ◽

Healthy Population ◽

Female Patients ◽

Epileptic Patients ◽

The Mean

Objective: To evaluate the effect of long term use of carbamazepine on lipid profile in adult epileptic patients Methodology: The study was conducted in the Department of Neurology at BSMMU, Dhaka over a period of 2 years from January 2010 to December 2011. Adult epileptic patients taking carbamazepine as anticonvulsant and attending the Epilepsy Clinic and Neurology OPD of BSMMU, Dhaka were the study population. A total of 107 cases and 107 controls were included in the study. Data were collected by interview of the patients, clinical examination and laboratory investigations using the research instrument Result: The mean age of case and control groups were almost identical (23.3 ± 6.8 vs. 23.8 ± 6.4 years, p = 0.972). The proportion of male and female patients was similar in both the study groups. Of the 107 cases, more than 70% had generalized epilepsy and the rest (29%) focal epilepsy. Of the 107 cases, 8% had family history of epilepsy. The prevalence of raised triglycerides and raised LDL were observed to be significantly higher in the case group than those in the control group (35.5% vs. 23.4%, p = 0.049 and 15% vs. 0.9%, p < 0.001 respectively). The prevalence of low HDL was also significantly higher in the former group than that in the latter group (43.9% vs. 18.7%, p < 0.001). The mean serum triglyceride and LDL were higher and mean HDL was lower in the case group than those in the control group. Over half (51.4%) of the case group exhibited dyslipidemia compared to the control group (27.1%). The risk of developing dyslipidemia in epileptic patients receiving carbamazepine for longer duration was nearly three-fold (95% of CI = 1.6 – 5.0) higher than that in the control group (p < 0.001). There is positive correlation between duration of carbamazepine treatment and lipid profile. Serum total cholesterol and triglycerides bear linear relationship with duration of treatment with carbamazepine (r = 0.201, p = 0.038 and r = 0.223, p = 0.021 respectively). The association of dyslipidemia with sex in epileptic patients receiving carbamazepine for more than 2 years. The proportion of dyslipdemia was considerably higher in the female patients than their male counterparts, although the difference was not statistically significant (55.3% vs. 41.9%, p < 0.211). Conclusion: A conclusion can be made from the above mentioned result that long-term use of carbamazepine in epileptic patients may cause dyslipidemia and the risk of having dyslipidemia in such patients is 3 times greater than the normal healthy population. Bangladesh Journal of Neuroscience 2014; Vol. 30 (1): 27-34

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