Relationship of Sarcopenia with Microcirculation Measured by Skin Perfusion Pressure in Patients with Type 2 Diabetes

Background: Access-related hand ischemia (ARHI) is a major complication of arteriovenous fistula (AVF). This study aimed to assess the predictive efficacy of skin perfusion pressure (SPP) measurement for ARHI by examining the relationship between SPP and ARHI development and progression after AVF surgery. Methods: Twenty-five patients (16 men and 9 women) who underwent AVF surgery based on the brachial artery between January 2018 and December 2018 were included. The pre- and postoperative SPP values were measured on the day of surgery. ARHI occurrence and severity were measured within 3 days and at 6 months after surgery. Receiver operating characteristic curve analysis was used to evaluate the prediction model of ARHI, and the cutoff points for the calculated coefficients were determined. Results: There was a significant correlation between the occurrence of immediate ARHI and the SPP gradient ( p = 0.024). An SPP gradient value >50 mmHg had sensitivity and specificity values of 53.85% and 91.67%, respectively, in predicting the occurrence of immediate ARHI. A postoperative SPP <48 mmHg was significantly correlated with the occurrence of 6-month ARHI ( p = 0.005), with sensitivity and specificity values of 71.43% and 83.33%, respectively. Conclusion: The SPP gradient and postoperative SPP values may be effective clinical predictors of ARHI occurring immediately and 6 months after surgery, respectively, with high specificity. These findings could allow clinicians to diagnose and begin early interventions to help prevent ischemic tissue damage in hemodialysis patients following AVF surgery.

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Relationship of vasculoendothelial growth factor - A changes and lipid spectrum in patients with comorbide course of arterial hypertension, type 2 diabetes mellitus and subclinical hypothyroidism

Atherosclerosis ◽

10.1016/j.atherosclerosis.2021.06.701 ◽

2021 ◽

Vol 331 ◽

pp. e228-e229

Author(s):

V.V. Zlatkina ◽

V.D. Nemtsova ◽

I.A. Ilchenko

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Growth Factor ◽

Arterial Hypertension ◽

Subclinical Hypothyroidism ◽

Relationship Of ◽

Lipid Spectrum

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FAMILY DIABETES AND MAIN NONCOMMUNICABLE DISEASES: THE DESCRIBED AND POTENTIAL EFFECT OF METFORMIN (remembering Vladimir Dilman)

Успехи геронтологии ◽

10.34922/ae.2020.33.4.013 ◽

2020 ◽

pp. 713-720

Author(s):

Л. М. Берштейн

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Potential Effect ◽

Noncommunicable Diseases ◽

The Family ◽

Whole Number ◽

Long Time ◽

Relationship Of ◽

Antidiabetic Biguanides

Работа посвящена двум медико-биологическим проблемам - семейному диабету (имея в виду наличие случаев сахарного диабета 2-го типа в семье, в том числе в разных поколениях), а также особенностям его связей с основными неинфекционными заболеваниями человека и приурочена к юбилею известнейшего отечественного специалиста (теоретика и врача) в области геронтологии и эндокринологии профессора В. М. Дильмана. Широко признанные труды Владимира Михайловича, основанные на оригинальных идеях и породившие важные практические следствия (включая применение антидиабетических бигуанидов в не использовавшихся до него областях, необходимость устранения метаболической иммунодепрессии, учета изменений с возрастом на уровне гипоталамического порога в различных гомеостатических системах и целого ряда других предложений), как представляется, в течение долгого времени будут питать интеллектуальным материалом и стимулировать к дальнейшему поиску его последователей и специалистов, которым еще предстоит окунуться в область, очерченную В. М. Дильманом и интересовавшую его в течение многих лет. The work discusses the two biomedical problems: family diabetes (bearing in mind the presence of cases of type 2 diabetes mellitus in the family, including its different generations) and the features of relationship of family diabetes with major non-communicable human diseases (NCDs). The paper is timed to the anniversary of the famous - in our country and abroad - expert in the ﬁeld of gerontology and endocrinology, Professor V. M. Dilman. The widely recognized works of V. M. Dilman, based on original ideas and giving rise to important practical consequences (including the use of antidiabetic biguanides in areas not studied before him, the need to eliminate metabolic immunodepression, to take into account the changes with age at the level of the hypothalamic threshold in various homeostatic systems and a whole number of other essential proposals), which for a long time, as it seems, will stimulate the further scientiﬁc search of his followers and specialists, who have yet to get acquainted with the area that attracted Prof. Dilman and interested him for many years.

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Assessment of the relationship of transcription factor 7-like 2 rs4506565 (T/A) variant with type 2 diabetes in Iraqi Arab patients

Meta Gene ◽

10.1016/j.mgene.2021.101008 ◽

2021 ◽

pp. 101008

Author(s):

Abdullah Sami Abdullah ◽

Seenaa Kadhum Ali

Keyword(s):

Type 2 Diabetes ◽

Transcription Factor ◽

Relationship Of ◽

The Relationship

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Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes

Clinical Science ◽

10.1042/cs20180690 ◽

2018 ◽

Vol 132 (23) ◽

pp. 2509-2518 ◽

Cited By ~ 2

Author(s):

Gargi Mahapatra ◽

S. Carrie Smith ◽

Timothy M. Hughes ◽

Benjamin Wagner ◽

Joseph A. Maldjian ◽

...

Keyword(s):

Type 2 Diabetes ◽

White Matter ◽

African Americans ◽

Mitochondrial Function ◽

Brain Morphology ◽

Intracranial Volume ◽

Peripheral Blood Mononuclear ◽

Relationship Of ◽

The Relationship

Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.

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