scholarly journals Serum Asprosin Levels in Women with Polycystic Ovary Syndrome in Duhok City, Kurdistan Region of Iraq

2021 ◽  
Vol 2 (02) ◽  
pp. 36-41
Author(s):  
Mohammed Ameen ◽  
Dhia Sulaiman ◽  
Khalida
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Hepatic Glucose Production ◽  
Density Lipoprotein ◽  
Current Data ◽  
Kurdistan Region ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Healthy Women

Asprosin is a novel peptide hormone produced and secreted by white adipose tissues. Asprosin associated with insulin resistance and promotes hepatic glucose production. Previous studies showed that serum asprosin was raised in the general population with polycystic ovary syndrome (PCOS). However, there were studies supporting the opposite. Also, there were studies that showed the highest levels of asprosin was due to insulin resistance, as well as in type 2 diabetes patients. PCOS is one of the metabolic disorders related to insulin resistance. Therefore, the current study aims to evaluate the levels of asprosin in the blood serum of women with PCOS compared to the healthy women who resident in Duhok in the Kurdistan Region of Iraq. A cross-sectional study was conducted from 20th of June, 2020 to 11th of January, 2021 at Obstetrics and Gynecology Hospital and Mazi medical clinics. Serum asprosin level was determined in 75 women with PCOS (18-44 years) and 96 healthy women. SPSS software was utilized for analyzing the study data. The (means ± SD) of demographic parameters (body mass index (BMI) and waist circumference (WC)) in women with PCOS were significantly highest in comparison to healthy women. The biochemical parameters (serum asprosin, fasting blood sugar (FBS), fasting insulin (FI), total cholesterol (TC), and triglyceride (TG)) in women with PCOS also were remarkably higher compared to healthy women with the exception of high-density lipoprotein- cholesterol (HDL-C). The current data show that serum asprosin variance significantly between WC, BMI, FBS, FI, TC, TG and HDL-C. The study confirms that serum asprosin in women with PCOS was higher than in the healthy women. In addition in women with PCOS it was found that serum asprosin was positively correlated with BMI, WC, FBS, FI, HOMA-IR, TC and TG (P<0.05). Except, HDL-C was negatively correlated with serum asprosin (P<0.01).

scholarly journals Serum Fetuin-A levels were increased and associated with insulin resistance in  women with polycystic ovary syndrome

2019 ◽  
Author(s):  
Sha Liu ◽  
Wenjing Hu ◽  
Yirui He ◽  
Ling Li ◽  
Hua Liu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Multivariate Regression Analysis ◽  
Cross Sectional Study ◽  
Roc Curve Analysis ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Fetuin A ◽  
Healthy Women

Abstract Background: Insulin resistance (IR) is a common characteristic in women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, in PCOS women, previous reports on changes in circulating Fetuin-A concentrations were inconsistent. Methods: A cross-sectional study was conducted, including 122 PCOS women and 85 healthy women. Circulating Fetuin-A levels were determined using an ELISA kit. Results: We found that circulating Fetuin-A concentration ranged from 196.6 to 418.2 µg/L for most normal women (95 %). Women with PCOS have higher circulating Fetuin-A levels than healthy women (437.9 ± 119.2 vs. 313.8 ± 60.4 μg/L; p <0.01). Serum Fetuin-A concentrations correlated positively with WHR, LDL-C, FIns, HOMA-IR, TEST and DHEA-S. Multivariate regression analysis showed that WHR, HOMA-IR and TEST were independent influencing factors of serum Fetuin-A. Binary logistic regression reaveled that serum Fetuin-A was associated with the .occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 µg/L. Conclusion: Blood Fetuin-A may be a useful biomarker for screening women with PCOS and IR.

scholarly journals Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Tommy Kyaw Tun ◽  
Anne McGowan ◽  
Niamh Phelan ◽  
Neuman Correia ◽  
Gerard Boran ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Apolipoprotein B ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Premenopausal Women ◽  
Postprandial Glucose ◽  
Ovary Syndrome ◽  
Mixed Meal

Postprandial dyslipidaemia may be a plausible mechanism by which polycystic ovary syndrome (PCOS) increases cardiovascular risk. We sought to investigate whether the postprandial glucose and insulin and lipid and lipoprotein responses, including that of apolipoprotein B-48 (apoB-48) containing chylomicrons, to a mixed meal are different in obese PCOS women when compared to obese control subjects and whether differences, if any, are related to obesity, insulin resistance (IR), hyperandrogenaemia, or PCOS status. 26 women with PCOS (age30.4±1.2years (mean ± SEM), body mass index (BMI)36.8±1.5 kg/m2) and 26 non-PCOS subjects (age34.1±0.9years, BMI31.5±1.0 kg/m2) were studied before and up to 8 hours following a standard mixed meal. AUC-triglyceride (AUC-TG) was higher and AUC-high-density lipoprotein (AUC-HDL) lower in PCOS women. These differences were not apparent when BMI was accounted for. Insulin sensitivity (SI), AUC-apoB-48, and AUC-apolipoprotein B (AUC-apoB) were found to be independent predictors of AUC-TG, accounting for 55% of the variance. Only AUC-insulin remained significantly elevated following adjustment for BMI. Obesity related IR explains postprandial hypertriglyceridaemia and hyperinsulinaemic responses. Management of obesity in premenopausal women with PCOS is likely to reduce their cardiovascular risk burden.

scholarly journals Endotrophin as a novel marker in PCOS and its relation with other adipokines and metabolic parameters: a pilot study

2021 ◽  
Vol 12 ◽  
pp. 204201882110496
Author(s):  
Gurhan Guney ◽  
Mine Islimye Taskin ◽  
Ozgur Baykan ◽  
Ertan Adali ◽  
Selin Gul Tezcan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Resistance Index ◽  
Total Testosterone ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Ovary Syndrome ◽  
Significant Difference

Background: Polycystic ovary syndrome is known to be the most common hormonal disorder in women of reproductive age. Current evidence shows that regulatory proteins secreted from the adipose tissue called adipokines may have a role in polycystic ovary syndrome. We planned to investigate the role of endotrophin that has never been researched in polycystic ovary syndrome before and its correlation with other metabolic parameters and adipokines such as adiponectin and ghrelin in patients with polycystic ovary syndrome. Methods: Forty-three women ( n: 43) with polycystic ovary syndrome and 43 ( n: 43) women as a control group were enrolled in this cross-sectional study. Serum levels of endotrophin, adiponectin, and ghrelin levels were measured with the enzyme-linked immunosorbent assay method. High-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol levels, luteinizing hormone/follicle-stimulating hormone ratio, total testosterone, and triglyceride levels were measured. Homeostasis model assessment for insulin resistance index, body mass index, Ferriman Gallwey Score, and waist-to-hip ratio were also evaluated. Results: Total testosterone, homeostasis model assessment for insulin resistance, C-reactive protein, luteinizing hormone/follicle-stimulating hormone ratio, and triglyceride levels were higher in patients with polycystic ovary syndrome ( p < 0.01). No difference was detected between the groups in terms of body mass index, Ferriman Gallwey Score, waist-to-hip ratio, total cholesterol, low-density lipoprotein, and high-density lipoprotein levels ( p > 0.05). We did not observe any significant difference in adiponectin and ghrelin levels between the groups ( p > 0.05). Patients with polycystic ovary syndrome had significantly higher endotrophin levels ( p < 0.01). According to our regression analyses [area under the curve: 0.973 (0.935–1.000), 95% confidence interval, 95.2% sensitivity, and 100% specificity], it was shown that endotrophin greater than 92 ng/ml and homeostasis model assessment for insulin resistance greater than 2.5 might be good predictors for polycystic ovary syndrome diagnosis. Conclusion: We demonstrated that endotrophin level is higher in patients with polycystic ovary syndrome and may have predicted polycystic ovary syndrome with increased homeostasis model assessment for insulin resistance index. There was no significant difference in adiponectin and ghrelin levels in the polycystic ovary syndrome group. Endotrophin may have a role in polycystic ovary syndrome etiology rather than other adipokines.

scholarly journals Thyroid-stimulating Hormone and Insulin Resistance: Their Association with Polycystic Ovary Syndrome without Overt Hypothyroidism

2017 ◽  
Vol 39 (05) ◽  
pp. 224-228 ◽  
Author(s):  
Cristina Benetti-Pinto ◽  
Vanessa Piccolo ◽  
Daniela Yela ◽  
Heraldo Garmes
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Thyroid Stimulating Hormone ◽  
Metabolic Parameters ◽  
Overt Hypothyroidism ◽  
Model Assessment ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Stimulating Hormone

Objective This study analyzed the effectiveness of the thyroid-stimulating hormone (TSH) as a predictor of insulin resistance (IR) and its association with the clinical and metabolic parameters of women with polycystic ovary syndrome (PCOS) without overt hypothyroidism. Study Design A cross-sectional study was performed. Women with PCOS and without overt hypothyroidism (n = 168) were included. Methods Receiver operating characteristic (ROC) curve was used to determine the cut-off point for TSH that would maximize sensitivity and specificity for a diagnosis of IR using homeostatic model assessment of insulin resistance (HOMA-IR) ≥ 2.71. Clinical and metabolic parameters were compared as a function of the TSH cut-off limit and the presence of IR. Results Thyroid-stimulating hormone ≥ 2.77 mIU/L was associated with a diagnosis of IR, with sensitivity of 47.9% and specificity of 65.3%. There were no differences in clinical, hormonal or metabolic parameters between TSH < 2.77 and TSH of 2.77 – 10 mIU/L. Conclusion In women with PCOS without overt hypothyroidism, TSH ≥ 2.77 mIU/L is associated with IR; however, with poor sensibility, showing TSH to be a poor predictor of IR in this population. No clinical or metabolic alterations were found that would justify a change in clinical management. Thus, the IR should be investigated in all women with PCOS irrespective of TSH level.

scholarly journals Alarin: A Novel Circulating Peptide Hormone Linked to Luteinizing Hormone and Hiperandrogenismin Polycystic Ovary Syndrome

2018 ◽  
Vol 1 (1) ◽  
pp. 72-81
Author(s):  
Mehmet CALAN ◽  
Merve Bicer ◽  
Murat Alan ◽  
Pinar Alarslan ◽  
Asli Guler ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Luteinizing Hormone ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Peptide Hormone ◽  
Normal Weight ◽  
Metabolic Parameters ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Circulating Levels

Alarin is a newly identified peptide hormone. It is implicated that alarinplays roles in regulation of energy metabolism and hypothalamo-pituitary-gonadal axis. Polycystic Ovary Syndrome (PCOS) is a common reproductive and metabolic disease in women during reproductive ages. Over-secretion of Luteinizing Hormone (LH) causes hyperandrogenism in women with PCOS. The purpose of the study was to determine the comparison of alarin levels in women with or without PCOS as well as to investigate the relationship between alarin and LH. Eighty-four women with PCOS and 84 age- and BMI- matched controls were recruited in this cross-sectional study. Circulating alarin levels were assessed via ELISA method. The hormonal and metabolic parameters of the recruited subjects were also determined. The circulating levels of alarin in PCOS subjects were higher than controls (6.11 ± 1.91 vs. 3.93 ± 1.60 ng/ml, P <0.001). Alarin showed a positive correlation with insulin resistance marker, BMI, LH and androgens. Moreover, alarin levels were elevated in women with PCOS having insulin resistance compared to those PCOS women without insulin resistance. In both control and PCOS groups, overweight subjects showed an elevation in circulating levels of alarin with respect to normal weight subjects. In the present study, Alarin level with the highest tertile dosage comparing to alarin level with the lowest tertile dosage could highly increase the probability of PCOS risk prevalence in women. Elevated alarin levels in women with PCOS were associated with not only LH and metabolic parameters but also high probability of having PCOS risk independently.

scholarly journals Anti-Müllerian Hormone Accelerates Pathological Process of Insulin Resistance in Polycystic Ovary Syndrome Patients

2021 ◽  
Vol 53 (08) ◽  
pp. 504-511
Author(s):  
Xiang-Juan Li ◽  
Hui Wang ◽  
Dan-Yang Lu ◽  
Tian-Tian Yu ◽  
Kamran Ullah ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Pathological Process ◽  
Model Assessment ◽  
High Concentration ◽  
Ovary Syndrome

AbstractInsulin resistance (IR) is one of the most common features of polycystic ovary syndrome (PCOS), which is related to obesity. Whether increased anti-Müllerian hormone (AMH) levels in PCOS are involved in the pathogenesis of insulin resistance remains unclear. We investigated serum levels of leptin and AMH along with basic clinical and metabolic parameters in 114 PCOS patients and 181 non-PCOS women. PCOS patients presented higher fasting blood glucose, insulin concentrations and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) in addition to body mass index (BMI), lipids profiles and hormone levels. HOMA-IR showed a positive correlation with BMI, AMH, leptin, and low-density lipoprotein-cholesterol (LDL-c) levels. Interestingly, AMH is strongly positively correlated with HOMA-IR and insulin concentrations for 1st and 2nd hours of glucose treatment after fasting. Among PCOS women with BMI≥25 kg/m2, high AMH level group showed an increased HOMA-IR when compared to normal AMH level. However, among PCOS women with normal BMI, women with high AMH presented an elevated fasting insulin levels but not HOMA-IR when compared to normal AMH group. In vitro treatment of isolated islet cells with high concentration of leptin (200 ng/ml) or high leptin plus high concentration of AMH (1 ng/ml) significantly enhanced insulin secretion. Importantly, co-treatment of AMH plus leptin upregulates the expression of pro-apoptotic proteins, such as Bax, caspase-3, and caspase-8 after incubating with a high level of glucose. These results suggest that AMH may involve in the pathological process of pancreatic β-cells in obese PCOS women.

scholarly journals A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME

2021 ◽  
Vol 71 (5) ◽  
pp. 1746-50
Author(s):  
Amena Arif ◽  
Palvasha Waheed ◽  
Robina Anees ◽  
Amir Rashid ◽  
Saleem Ahmed Khan
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Comparative Study ◽  
Polycystic Ovary ◽  
Serum Insulin ◽  
Insulin Level ◽  
Normal Weight ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Control Subjects

Objective: To assess the relationship between obesity and insulin resistance in polycystic ovary syndrome affected women. Study Design: Cross sectional comparative study. Place and Duration of Study: Multidisciplinary Lab-I of Department of Biochemistry, Army Medical College, Rawalpindi, in collaboration with Pakistan Naval Ship Hafeez Hospital, Islamabad from Feb 2018 to Jan 2019. Methodology: One hundred and five selected females (puberty till 25 years of age) were divided into three groups of 35 each. Blood samples were collected an overnight fast (from 8-11 AM). Serum level of insulin was measured and insulin resistance was calculated based on HOMA-IR. Results: HOMA-IR concentrations correlated directly with Basal Metabolic Index, fasting plasma glucose and serum insulin levels. Mean serum insulin level was also elevated in patients with polycystic ovary syndrome (normal weight & overweight) as compared to control subjects (7.4 ± 1.2 mIU/L & 9.1 ± 0.8 mIU/L vs 6.3 ± 1.1 mIU/L; p as 0.003). The insulin resistance was slightly higher in patients with polycystic ovary syndrome as compared to the control subjects (1.4 ± 0.3 & 1.7 ± 0.2 vs. 1.1 ± 0.3; p<0.001). Conclusion: HOMA-IR levels are positively associated with BMI, the intensity of peripheral insulin resistance in polycystic ovary syndrome-affected females, indicating that normal weight, and overweight patients with polycystic ovary syndrome have tendency towards insulin resistance.

scholarly journals Prevalence and Clinical Predictors of Insulin Resistance in Reproductive-Aged Thai Women with Polycystic Ovary Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Thanyarat Wongwananuruk ◽  
Manee Rattanachaiyanont ◽  
Suchada Indhavivadhana ◽  
Pichai Leerasiri ◽  
Kitirat Techatraisak ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Multiple Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Diabetic Mellitus ◽  
Clinical Predictors ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Thai Women

Objectives. To determine the prevalence of insulin resistance (IR) and its predictors in reproductive-aged Thai women with polycystic ovary syndrome (PCOS).Methods. A cross-sectional study was conducted from May 2007 to January 2009. Participants were 250 Thai women with PCOS. Information regarding medical history and physical examination and results of 75 gram OGTT were recorded.Results. The overall prevalence of IR was 20.0%, comprising the prevalence of impaired fasting glucose, impaired glucose tolerance, and diabetic mellitus of 3.2%, 13.6%, and 5.6%, respectively. Multiple logistic regression analysis showed that the independent predictors for IR were age of ≥30 years old, waist circumference (WC) of ≥80 cm, presence of acanthosis nigricans (AN), and dyslipidemia with odds ratios (95% confidence interval) of 2.14 (1.01–4.52), 3.53 (1.28–9.75), 2.63 (1.17–5.88), and 3.07 (1.16–8.11), respectively.Conclusion. The overall prevalence of IR in reproductive-aged Thai women with PCOS is 20.0%. Age ≥30 years old, WC ≥80 cm, the presence of AN, and dyslipidemia are the significant clinical predictors.

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