Antimicrobial Activity of 2-((2-(hydroxyimino)-1- phenylpropylidene) Hydrazono)-1, 2- diphenylethanone (HMPPH) and its Derivative

2020 ◽  
Vol 5 (7) ◽  
pp. 1056-1060
Author(s):  
M.J. Lele ◽  
Dr.R.G. Deshmukh
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Schiff Base ◽  
Elemental Analysis ◽  
Magnetic Moment ◽  
Electronic Spectra ◽  
Spectroscopic Investigation ◽  
Molecular Formula ◽  
Preliminary Screening ◽  
First Time

A new series of Cu(II), Pt(II) and Pd(II) complexes were prepared with ligand 2-((2- (hydroxyimino)-1-phenylpropylidene) Hydrazono)-1, 2- diphenylethanone (HMPPH) corresponding to molecular formula (C23H18N3O2) has been synthesized and reported for the first time. The Schiff base and its metal complexes were characterized on the basis of various spectroscopic investigation like IR, NMR, UVVISIBLE spectroscopy, elemental analysis etc. While the geometry of the complexes was confirmed by electronic spectra, magnetic moment measurements. A preliminary screening of these compounds for biological activity against various microorganisms has indicated that they are microbial active against some microorganisms.

Synthesis of Some New Poly cyclic Heterocyclic Compounds of Anticipated Biological Activity

2020 ◽  
Vol 17 ◽  
Author(s):  
Taghreed A. Alsufyani ◽  
Hosam A. Saad ◽  
Asmaa A. A. Al-otaibi
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Heterocyclic Compounds ◽  
Biologically Active ◽  
Supplementary Information ◽  
Diffusion Method ◽  
First Time ◽  
Agar Well Diffusion Method

: Novel polyheterocyclic nitrogen systems such as 2-amino-1H-pyrazolo[5',1':3,4][1,2,4]-triazino[5,6-b]indole-3-carbonitrile 2, which has been synthesized for the first time in the present work, is considered as starting material for the synthesis of more novel polyheterocyclic systems with five fused rings and sometime eight fused rings via heterocyclization with α,β-bifunctional reagents under different conditions. The formed structures of the products were established from their correct elemental analysis and spectral data. Some of the compounds were evaluated for their antimicrobial activity using the Agar Well Diffusion method. Compounds 2, 4, 5, 6, 8 were found to be biologically active (Supplementary information).

scholarly journals Synthesis, Characterization, and Antimicrobial Activity Studies of New Schiff Base Tetradentate Ligands and Their Manganese (II) Complexes

2020 ◽  
pp. 35-46
Author(s):  
Elham Abdalrahem Bin Selim ◽  
Mohammed Hadi Al–Douh ◽  
Dahab Salim Al–Nohey ◽  
Wedad Mohammed Al–Haik ◽  
Khalid Saeed Sonbol
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Biological Activity ◽  
Schiff Base ◽  
General Formula ◽  
Mass Spectroscopy ◽  
Elemental Analysis ◽  
Proteus Mirabilis ◽  
Condensation Reactions ◽  
Tetradentate Ligands

Two Schiff base tetradentate ligands 4 and 5 were synthesized by condensation reactions of 4-hydroxy-3-methoxy-5-((2-nitrophenyl)diazenyl) benzaldehyde 1 with 1,2-diaminoethane 2 and 1,2-diaminobenzene 3, respectively. Treatment of synthesized ligands with the manganese (II) chloride MnCl2 6 gave two complexes 7 and 8 of general formula ML. The synthesized ligands and their complexes were characterized by FTIR, UV-Vis, Mass spectroscopy, and elemental analysis. The biological activity of the synthesized compounds were tested. It was found that ligand 5 and the complexes 7 and 8 possess antibacterial activity against the gram –ve Proteus mirabilis.

scholarly journals Syntheses, Characterization, Crystal Structures and Antimicrobial Activity of Schiff Base Copper(II) Complexes Derived from 2-Bromo-6-((2-(isopropylamino) ethylimino)methyl)phenol

2021 ◽  
Vol 68 (4) ◽  
pp. 1008-1015
Author(s):  
Yong Yuan ◽  
Xi-Kun Lu ◽  
Gao-Qi Zhou ◽  
Xiao-Yang Qiu
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Single Crystal ◽  
Elemental Analysis ◽  
Structure Determination ◽  
Antimicrobial Activities ◽  
X Ray ◽  
Zwitterionic Form ◽  
Square Planar ◽  
Vis Spectroscopy

Three new copper(II) complexes, [Cu(LH)2]Br2 (1), [Cu(LH)2]NCS2 (2), and [Cu(LH)2](NO3)2 (3), where LH is the zwitterionic form of 2-bromo-6-((2-(isopropylamino)ethylimino)methyl)phenol (HL), were synthesized and characterized by elemental analysis, IR and UV-vis spectroscopy. The structures of the complexes were further confirmed by single crystal X-ray structure determination. All compounds are mononuclear copper(II) complexes. The Cu atoms in the complexes are coordinated by two imino N and two phenolate O atoms from two LH ligands, forming square planar coordination. The compounds were assayed for their antimicrobial activities.

scholarly journals Characterization and biological evaluation of some novel pyrazolo[3',4':4,5]thieno[2,3-d]pyrimidin-8-ones synthesized via the Gewald reaction

2008 ◽  
Vol 73 (7) ◽  
pp. 683-690 ◽  
Author(s):  
Dipti Dodiya ◽  
Amit Trivedi ◽  
Samir Jarsania ◽  
Shailesh Vaghasia ◽  
Viresh Shah
Keyword(s):  
Antimicrobial Activity ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Spectroscopic Investigation ◽  
Aromatic Aldehydes ◽  
Biological Evaluation ◽  
Bacterial Strains ◽  
Gewald Reaction ◽  
Compound Ii

The synthesis of substituted pyrazolo[3',4':4,5]thieno[2,3-d]pyrimidin-8-ones (IIIa-j) from 5-amino-3-methyl-1H-thieno[3,2-c]pyrazole-6-carbonitrile (II) is described. The key compound II was synthesized from (5-methyl- -2,4-dihydro-3H-pyrazol-3-ylidene)malononitrile I via the Gewald reaction. The synthesis of the title compounds IIIa-j was accomplished by condensation of II with different aromatic aldehydes. The newly synthesized heterocyles were characterized by elemental analysis, IR, 1H-NMR, 13C-NMR and mass spectroscopic investigation. All the newly synthesized compounds were evaluated for antimicrobial activity against a variety of bacterial strains. .

Biological Activity Studies on a Copper(II) Complex with Taurine Schiff Base

2014 ◽  
Vol 912-914 ◽  
pp. 57-60
Author(s):  
Mei Li ◽  
Guo Ping Yang ◽  
Hong Liang
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Ir Spectra ◽  
Hepg2 Cell ◽  
Cell Lines ◽  
Elemental Analysis ◽  
Ic50 Values ◽  
New Material ◽  
G2 Phase ◽  
Hepg2 Cell Lines

A new material of copper(II) complex (complex 1) with taurine Schiff base has been synthesized and characterized by elemental analysis, ESI-MS and IR spectra. 1 was tested against HepG2 cell lines with IC50 values of 12.89 μM. With the concentrations of 1 increasing, the population of apoptosis was 1.28% for 0 μM, 24.4% for 10 μM and 47.9% for 20μM, and the population of G2 phase was 19.2% for 0 μM, 34.4% for 10 μM and 42.9% for 20μM, respectively. 1 showed significant cytotoxic activity against HepG2 cell lines.

scholarly journals Spectral, Magnetic and Biological Studie on Some Bivalent 3d Metal Complexes of Hydrazine Derived Schiff-Base Ligands

1997 ◽  
Vol 4 (2) ◽  
pp. 65-68 ◽  
Author(s):  
Zahid H. Chohan ◽  
Syed K. A. Sherazi
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Magnetic Moment ◽  
Bacterial Species ◽  
Biological Properties ◽  
Molar Conductance ◽  
Schiff Base Ligands ◽  
H Nmr ◽  
3D Metal Complexes

Metal(II) complexes of hydrazine derived Schiff-base ligands of the type M(L)2Cl2 where M = Co, Cu, Ni and Zn and L = L1 and L2 have been prepared and characterised by molar conductance, magnetic moment, elemental analysis and electronic, IR, H-NMR and C13 spectral data.The different modes of chelation of the ligands and their comparative biological properties against different bacterial species are reported.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of 3-[(2-Hydroxy-quinolin-3-ylmethylene)-amino]-2-phenyl-3H-quinazolin-4-one and its Metal(II) Complexes

2008 ◽  
Vol 5 (1) ◽  
pp. 155-162 ◽  
Author(s):  
K. Siddappa ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Elemental Analysis ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML2 and M′L [where M=Cu(II), Co(II), and Ni(II) and M′= Zn(II), Cd(II) and Hg(II)]. L = 3-[(2-hydroxy-quinolin-3-ylmethylene)-amino]-2-phenyl-3H-quinazolin-4-one, (HQMAPQ) Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HQMAPQ acts as doubly monodentate bridge for metal(II) ions and form mononuclear complexes. The complexes Ni(II), Co(II) and Cu(II) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal(II) complexes were screened for their antimicrobial activity.

Synthesis, Characterisation and Antimicrobial Activity of Manganese(II), nickel(II), cobalt(II), Copper(II) and Zinc(II) Complexes of a Binucleating Tetradentate Ligand

2002 ◽  
Vol 2002 (11) ◽  
pp. 529-531 ◽  
Author(s):  
Abdou Saad El-Tabl
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Schiff Base Ligand ◽  
Magnetic Moment ◽  
Thermal Analyses ◽  
Antimicrobial Activities ◽  
Esr Spectra ◽  
Tetradentate Ligand ◽  
Tetradentate Schiff Base ◽  
Elemental Analyses

The binucleating, tetradentate Schiff base ligand (H2L) has been synthesised by condensation of bis-(4-aminophenyl)-methane with salicyladehyde. The resulting metal(II) complexes [metal = Mn||, Ni||, Co||, Cu|| and Zn||] have been characterised by elemental analyses, molar conductances, magnetic moment, IR, UV-vis spectra, thermal analyses (DTA and TGA) and ESR spectra. Antimicrobial activities of the ligand and its metal(II) complexes have been tested against different microorganisms. The electrochemical data of complexes (2), (9) and (10) are discussed.

scholarly journals Synthesis, Spectral Characterization and Pharmacological Significance of Cr(III) and Mn(II) Complexes with Schiff Base and Thiocyanate Ion as Ligands

2019 ◽  
Vol 11 (05) ◽  
Author(s):  
R. Govindharaju ◽  
P. Durairaj ◽  
T. Maruthavanan ◽  
M. Marlin Risana ◽  
T. Ramachandramoorthy
Keyword(s):  
Schiff Base ◽  
Free Radical ◽  
Ir Spectra ◽  
Metal Complexes ◽  
Magnetic Moment ◽  
Electronic Spectra ◽  
Metal Ion ◽  
Diffusion Method ◽  
Thiocyanate Ion ◽  
Ft Ir

Cr(III) and Mn(II) metal complexes of Schiff base ligand derived from phenylacetylurea condensed with salicylaldehyde (SBPS) and thiocyanate(SCN-) ion were synthesized by using microwave irradiation. Microwave assisted synthesis gives high yield of the complexes within a very short time. The molecular formulae and the geometry of the complexes have been deduced from elemental analysis, metal estimation, electrical conductance, magnetic moment, electronic spectra, FT- IR, Far IR spectra, cyclic voltammetry, thermal analysis and powder-XRD techniques. The molar conductance values indicate that the complexes are non-electrolyte (1:0) type. FT-IR spectra show that Schiff base and thiocyanate ion are coordinated to the metal ion in a monodentate manner. The electronic spectra and the magnetic moment indicate the geometry of the complexes is found to be octahedral. The antimicrobial activities of ligands and their Cr(III) and Mn(II) complexes were studied against the microorganisms, viz., E. coli, Klebsiella Pneumonia, P. aeruginosa, S. aureus, Bacillus cereus, Aspergillus flavus, Aspergillus niger, Aspergillus oryzae, Aspergillus sojae and Candida albicans by agar well diffusion method. The complexes show moderate activity against the bacteria and enhanced activity against the fungi as compared to free SBPS ligand. The free radical scavenging activity of the complexes and the ligands has been determined by measuring their interaction with the stable free radical, DPPH. The complexes have larger antioxidant activity as compared to the ligand. DNA-binding properties have been studied by fluorescence-emissions method. The results suggest that the complexes strongly bind to DNA because of metal complexes are well-known to speed up the drug action and the ability of a therapeutic agent which can frequently be enhanced upon coordination with a metal ion.

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