Evaluation of Musculoskeletal Hydatid Cyst Cases in Terms of Clinical Manifestations, Method of Dealing, Treatment, and Recurrence

Hydatid disease is one of the most common parasitic diseases caused by Echinococcus granulosus worm. In this disease, involvement of all organs is likely. However, primary hydatid cysts of muscle tissue are so rare that occasionally in differential diagnosis, cystic masses are not placed in endemic areas. Timely and accurate diagnosis is crucial to prevent unnecessary biopsy. In this case-series study conducted in hospitals of Semnan and Tehran, Iran, from 2009 to 2014, 15 patients with musculoskeletal problems due to hydatid cyst were evaluated. In each case, information about the patient’s clinical manifestations, including initial complaint, cyst location, treatment method, location of involvement organ, duration, dose of drug used and diagnostic method was evaluated. According to results of the present study, the prevalence of musculoskeletal system involvement was 7.21%. The most common site of involvement was spine and paravertebral muscles (7 cases) and the most common symptom was compressive symptoms on the spinal canal. Magnetic resonance imaging was the most commonly used diagnostic method and only in 1 case a wrong pre-operative diagnosis was made. Eleven patients reported a history of recurrence at the site of previous surgery (3 cases of hip involvement and 6 cases of spine involvement). There were 5 cases of recurrence following recent treatment, 2 of which were hip involvement and 2 cases of spine involvement. Furthermore, most patients (12 cases) underwent cyst resection surgery. The results of this study showed that although hydatid cystic skeletal muscle is rare, due to the possibility of repeated recurrence, especially in cases of spine and bone involvement, endemic areas should be considered in the differential diagnosis of each cystic mass of muscle and bone.

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NEAR FATAL AMITRAZ: A NOT SO UNCOMMON POISONING

10.36106/gjra/5601517 ◽

2021 ◽

pp. 42-43

Author(s):

Rohan J Desai ◽

Prasad Ugargol

Keyword(s):

Mechanical Ventilation ◽

Respiratory Failure ◽

Clinical Features ◽

Case Series ◽

Agricultural Product ◽

Common Symptom ◽

Retrospective Case ◽

Case Series Study ◽

Cns Depression ◽

Series Study

Background: Amitraz is a pharmaceutical, veterinary, and agricultural product which is used worldwide to control ectoparasites in animals. Its widespread use has led to increased cases of poisoning in rural parts of India. Aim: To study the clinical features, complications, laboratory abnormalities and outcome of the patients with acute amitraz intoxication. Methodology: The study is a retrospective case series study conducted in HSK hospital between the period of Feb 2019 and May 2020. Results: A total of 11 patients were analysed and results revealed CNS depression and vomiting in 8 of those patients with 1 patient with respiratory failure requiring mechanical ventilation. Conclusion: Amitraz poisoning appears to be severe with CNS depression being the most common symptom. But most patients stabilise and recover quickly. Patients should be monitored for respiratory failure as it is a dreadful complication. Treatment is symptomatic as no antidote is available.

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ROLE OF PIROXICAM IN CONTROLLING FEVER IN COVID 19 - AN OBSERVATIONAL CASE SERIES STUDY

10.36106/ijar/5200917 ◽

2021 ◽

pp. 24-25

Author(s):

Kumar Vineet ◽

Vibhu Jain ◽

Adiveeth Deb ◽

Amit Yadav

Keyword(s):

Severe Disease ◽

Case Series ◽

Treatment Method ◽

Blood Oxygen ◽

Limited Data ◽

Disease Category ◽

Blood Oxygen Saturation ◽

Symptomatic Management ◽

Case Series Study ◽

Time Basis

INTRODUCTION- COVID 19 pandemic is creating havoc in medical infrastructure. Further misery is created by the fact that there is no proven treatment of COVID 19 infection. Most of the drugs given currently in COVID 19 is for symptomatic management of infection. Updated protocols released on time to time basis have drugs which are based more on clinical observations rather than experimental ones. These drugs consists mainly repositioned drugs already approved by FDA for other disease treatment. METHOD- In our study, we have used Piroxicam polyhedral crystals sublingually for control of fever in COVID 19 pneumonia which was not controlled by Paracetamol and steroids combination. It was advised in patients progressing to severe disease category or developing pneumonia. RESULT- Our case series with limited data shows that cases have responded well to Piroxicam in control of fever. They became normothermic after single dose of drug. Further, patients' blood oxygen levels have also improved with therapy; however, with limited data, a cause-effect relationship could not be determined. CONCLUSION- At present, Piroxicam can be advised in COVID 19 infection under medical supervision for control of persistent high fever. In future, randomised studies are needed to further consolidate above claim that Piroxicam is helpful in controlling fever as well as improving blood oxygen saturation of cases

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Neonatal seizures: clinical manifestations and etiology

Paediatrica Indonesiana ◽

10.14238/pi46.6.2006.266-70 ◽

2016 ◽

Vol 46 (6) ◽

pp. 266

Author(s):

Daisy Widiastuti ◽

Irawan Mangunatmadja ◽

Taralan Tambunan ◽

Rulina Suradi

Keyword(s):

Metabolic Disorders ◽

Clinical Manifestations ◽

Case Series ◽

Term Infant ◽

Common Type ◽

Neonatal Seizures ◽

Metabolic Disturbances ◽

Case Series Study ◽

Common Etiology ◽

Series Study

Background Neonatal seizures or fits are signs of central ner-vous system (CNS) diseases, metabolic disorders, or other dis-eases disrupting the CNS. Neonatal seizures are poorly classi-fied, under-recognized and often difficult to treat. It is important torecognize the type of neonatal seizures that might be the only signof a CNS disorder.Objective To recognize the type and etiology of neonatal sei-zures in several hospitals in Jakarta.Methods This was an observational case series study on full-termand preterm infants who had seizures during hospitalization in CiptoMangunkusumo, Harapan Kita, and Fatmawati Hospitals betweenJanuary-June 2005. Neonatal seizures were defined as seizuresoccurring in the first 28 days of life of a term infant or 44 completedweeks of the infant’s conception age of preterm infant.Results There were 40 neonates who born within the study periodand had seizures. Girls were outnumbered boys. Most neonateswere full-term with birth weight of more than 2500 grams. Analy-ses were done on 38 neonates with epileptic and non-epilepticseizures, while the other two who had mixed clinical manifestationwere not included. Most seizures occurred in the first 3 days of life(23/38). The most common type was focal clonic (12/14) followedby general tonic (11/24) and motor automatism or subtle (10/24).The most common etiology was hypoxic ischemic encephalopa-thy (HIE) (19/38) followed by metabolic disturbances, mainly hy-pocalcaemia (11/38).Conclusion Common types of seizures in neonates were focalclonic, general tonic, and motor automatism (subtle). The mostcommon etiology was HIE followed by metabolic disturbances,mainly hypocalcaemia

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Absent right superior caval vein in situs solitus

Cardiology in the Young ◽

10.1017/s1047951115000268 ◽

2015 ◽

Vol 26 (2) ◽

pp. 334-339 ◽

Cited By ~ 1

Author(s):

Rebekka Lytzen ◽

Karin Sundberg ◽

Niels Vejlstrup

Keyword(s):

Incidental Finding ◽

Clinical Manifestations ◽

Case Series ◽

Retrospective Case ◽

Caval Vein ◽

Cardinal Vein ◽

Benign Condition ◽

Superior Caval Vein ◽

Case Series Study ◽

The Right

AbstractIntroductionIn up to 0.07% of the general population, the right anterior cardinal vein obliterates and the left remains open, creating an absent right superior caval vein and a persistent left superior caval vein. Absent right superior caval vein is associated with additional congenital heart disease in about half the patients. We wished to study the consequences of absent right superior caval vein as an incidental finding on prenatal ultrasonic malformation screening.Material and methodsThis is a retrospective case series study of all foetuses diagnosed with absent right superior caval vein at the national referral hospital, Rigshospitalet, Denmark, from 2009 to 2012.ResultsIn total, five cases of absent right superior caval vein were reviewed. No significant associated cardiac, extra-cardiac, or genetic anomalies were found. Postnatal echocardiographies confirmed the diagnosis and there were no postnatal complications. All children were found to have healthy hearts at follow-up.ConclusionsIn all cases, the findings proved to be a benign condition with no clinical manifestations or complications. Although isolated absent right superior caval vein does not seem to affect the outcome, associated anomalies may be serious. Absent right superior caval vein should, therefore, prompt a search for additional malformations. Furthermore, the diagnosis of an isolated absent right superior caval vein is important, because knowledge of the anomaly can prevent future problems when invasive procedures are necessary.

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Clinical manifestations of diffuse large B‑cell lymphoma in the skin and subcutaneous tissue a case series study

Advances in Dermatology and Allergology ◽

10.5114/ada.2020.100494 ◽

2020 ◽

Vol 37 (5) ◽

pp. 812-816

Author(s):

Katarzyna Dulik ◽

Grażyna Kamińska-Winciorek ◽

Ryszard Swoboda ◽

Anna Kwiatkowska-Pamula ◽

Sebastian Giebel

Keyword(s):

B Cell ◽

Cell Lymphoma ◽

Subcutaneous Tissue ◽

Clinical Manifestations ◽

Case Series ◽

B Cell Lymphoma ◽

Large B Cell Lymphoma ◽

Case Series Study ◽

Series Study ◽

Large B Cell

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A Case Report of Bullous Emphysema in an Adolescent: Congenital Malformation or Outcome of Bronchopulmonary Dysplasia?

Journal of Rare Diseases and Orphan Drugs ◽

10.36013/jrdod.v2i.36 ◽

2020 ◽

Vol 2 ◽

pp. 2-6

Author(s):

Svitlana Ilchenko ◽

Anastasiia Fialkovska ◽

Oleksii Makoveychuk

Keyword(s):

Differential Diagnosis ◽

Clinical Case ◽

Diagnostic Method ◽

Correct Diagnosis ◽

Clinical Manifestations ◽

Detailed Examination ◽

Pathological Process ◽

Pulmonary Diseases ◽

Chronic Obstructive ◽

Chronic Obstructive Pulmonary Diseases

Pulmonary emphysema belongs to the group of chronic obstructive pulmonary diseases, and inpediatric pulmonology is one of the complex diagnoses that require a careful differential diagnosis. Thearticle describes the possible causes of the formation and clinical manifestations of pulmonaryemphysema in children. We present a clinical case of bullous emphysema in a teenager. This case showsthat a detailed examination using such a modern diagnostic method as high-resolution computedtomography played a crucial role in establishing the patient's correct diagnosis. However, establishing thenature of this pathological process in the child was very difficult. Perhaps an earlier diagnosis couldprevent severe irreversible changes in a teenager's lungs would avoid developing the diffusebronchopulmonary process.

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Experience in the Approach to Insulinoma: A Case Series

Internal Medicine And Medical Investigation Journal ◽

10.24200/imminv.v2i4.175 ◽

2018 ◽

Vol 3 (4) ◽

Author(s):

Ángela María Victoria ◽

Karen Daniela Cándelo ◽

Pedro Tomás Argüello ◽

Karen Milena Fériz ◽

Luz Ángela Casas ◽

...

Keyword(s):

Clinical Manifestations ◽

Case Series ◽

Signs And Symptoms ◽

Serum Levels ◽

Lesion Size ◽

Current Data ◽

Common Symptom ◽

C Peptide ◽

Low Incidence ◽

Clinical And Pathological Features

Introduction: Insulinomas are rare pancreatic neuroendocrine tumors derived from beta cells responsible for insulin secretion. These tumors are typically manifested by hypoglycemia signs and symptoms, which might be non-specific leading to a delay in the diagnosis. The present study describes the experience in the approach of patients with insulinoma at Fundación Valle del Lili, Cali, Colombia.Case Presentation: A retrospective search of patients with the diagnosis of insulinoma within the database of the pathology service was performed between March 2002 and February 2017. Parameters such as the lesion size and localization, the immunohistochemistry findings, the serum levels of glucose, the insulin and C-peptide levels, the presence of metastasis, and the development of diabetes after surgery were evaluated. A total of nine patients with a diagnosis of insulinoma were enrolled in the study. The cohort comprised of seven men and two women, aged 30–50 years. Whipple triad was present in seven patients. The most common symptom was hypoglycemia-related syncope. All patients underwent surgical resection of the tumor with subsequent resolution of the symptoms. Only one patient was diagnosed with diabetes in the postoperative period.Conclusion: In the last 15 years, only nine cases of insulinoma were detected at the Fundación Valle del Lili, which is consistent with the low incidence of the disease. A higher frequency of the disease is noted in men, unlike that in the literature. However, other clinical and pathological features from large studies are in agreement with the current data. Nevertheless, continual experience in the management and identification of these cases is essential as common clinical manifestations may not be observed.

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Prolonged Fever and Exaggerated Hypercoagulopathy in Malaria Vivax Relapse and COVID-19 Co-infection: A Case Report

10.21203/rs.3.rs-907840/v1 ◽

2021 ◽

Author(s):

Tri Pudy Asmarawati ◽

Okla Sekar Martani ◽

Bramantono Bramantono ◽

Muhammad Vitanata Arifianto

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Malaria Infection ◽

Treatment Guidelines ◽

Clinical Manifestations ◽

Malaria Prevalence ◽

Nasopharyngeal Swab ◽

Delayed Treatment ◽

History Of ◽

Endemic Areas

Abstract BackgroundCoronavirus disease 2019 (COVID-19) often causes atypical clinical manifestations similar to other infectious diseases. In malaria-endemic areas, the pandemic situation will very likely result in co-infection of COVID-19 and Malaria, although reports to date are still few. Meanwhile, in areas with low malaria prevalence, this disease will be challenging to diagnose because the symptoms closely resemble COVID-19.Case presentationA 23-year-old male patient presented to hospital with fever, anosmia, headache, and nausea since one week before. He was diagnosed with COVID-19 and treated for approximately ten days then discharged to continue self-quarantine at home. Two weeks later, he came back to the hospital with fever that was raised intermittently every two days, and was marked by a chilling-fever-sweating cycle. We conducted a laboratory test for malaria and nasopharyngeal swab for SARS CoV-2 PCR which confirmed both of the diagnosis. The laboratory examination showed markedly elevated D-dimer. He was treated with Dihydroartemisinin-Piperaquine (DHP) 4 tablets per day for three days and Primaquine 2 tablets per day for 14 days according to Indonesian national anti-malarial treatment guidelines. After six days of treatment, the patient had no complaints, and the results of laboratory tests had improved. This report describes the key points in considering the differential diagnosis and prompt treatment of malaria infection during the pandemic of COVID-19 in an endemic country to prevent the worse clinical outcomes. COVID-19 and malaria may also cause hypercoagulable state, so a co-infection of those diseases may impact on the prognosis of the disease.ConclusionThis case report shows that considering the possibility of a co-infection in COVID-19 patient who presents with fever can prevent delayed treatment that can worsen the disease outcome. Paying more attention to a history of travel to malaria-endemic areas, a history of previous malaria infection, and exploring anamnesis regarding the fever patterns in patients are important points in making a differential diagnosis of malaria infection during the COVID-19 pandemic.

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Proxies for COVID-19 Diagnosis for Adults in Resource Limited Settings: A Case Series Study in Zambia.

10.21203/rs.3.rs-150178/v1 ◽

2021 ◽

Author(s):

Katongo H Mutengo ◽

John S Kachimba ◽

Francis Mupeta

Keyword(s):

Healthcare Costs ◽

Clinical Manifestations ◽

Case Series ◽

Respiratory Disorder ◽

The Novel ◽

Resource Limited Settings ◽

Resource Limited ◽

Case Series Study ◽

Novel Coronavirus ◽

Series Study

Abstract The novel coronavirus disease of 2019 (COVID-19); caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has presented a unique range of clinical manifestations. Thought to be primarily a respiratory disorder during its early outbreak in China in early December of 2019, it has now emerged from various scientific studies that the clinical manifestation of COVID-19 is indeed protean. This paper is aimed at exploring various proxies that can be used to increase the index of suspicion for COVID-19 in resource-limited settings like Zambia by reviewing four cases that presented to our health facilities. We hope this will help reduce healthcare costs through instituting early and more targeted treatment approaches.

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COVID-19 in Neonates, A Case Series Study From Tertiary Neonatal Centers in Iran

Archives of Pediatric Infectious Diseases ◽

10.5812/pedinfect.110603 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Sedigheh Rafiei Tabatabaei ◽

Minoo Fallahi ◽

Abbas Boskabadi ◽

Naeeme Taslimi Taleghani ◽

Fatemeh Pajouhandeh ◽

...

Keyword(s):

Respiratory Symptoms ◽

Neonatal Intensive Care ◽

Heart Surgery ◽

Open Heart Surgery ◽

Clinical Manifestations ◽

Case Series ◽

Reactive Protein ◽

Radiologic Findings ◽

Case Series Study ◽

Novel Coronavirus

Introduction: The Novel coronavirus, sars-cov-2, is responsible for the recent pandemic. Although it mostly affects adults, children of all ages, including neonates, can become ill with Covid-19, as well. The real prevalence rate of coronavirus disease 2019 (COVID-19) in children is unknown. However, the severity of symptoms in children and neonates is less than in adults. Regarding the new presentation of this disease, the current study has reported a case series of COVID-19 in neonates. Case Presentation: In this article, 10 neonates with COVID- 19 admitted to our neonatal intensive care units are reported. All reported neonates had general suspicious symptoms of COVID- 19 with positive results for SARS-CoV-2 assessed by polymerase chain reaction (PCR) from the nasopharynx area or nose of the patients. All neonates, except for two of them, were term neonates. One case had open-heart surgery for congenital heart disease (transposition of the great arteries (TGA)). The patients aged 22 days on admission. The most frequent symptom was fever. Severe respiratory symptoms were reported in two cases. Also, abnormal radiologic findings in the chest x-ray were detected in two cases. Regarding the lack of significant respiratory symptoms in most of the patients, the lung computed tomography (CT) scan was taken just from one neonate. Leukopenia (WBC < 5000/mm3) was detected in one case, with no lymphopenia in all neonates. The positive C-reactive protein test was not found in all cases. No patient was treated by special anti-viral agents for COVID-19, and usual antibiotic treatment for neonatal sepsis was administered for all cases. All patients, except for one, survived with no significant sequela of the disease. Conclusions: This study demonstrated that clinical manifestations, as well as laboratory and radiologic findings of COVID-19, are milder in neonates than in the older ages. Hence, it can be argued that the prognosis of COVID-19 in the neonatal period is generally good.

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