scholarly journals The Role of Ursodeoxycholic Acid and Phenobarbital in a Child with Cholestasis: A Longitudinal Study

2021 ◽  
Vol 9 (C) ◽  
pp. 254-257
Author(s):  
Harapan Parlindungan Ringoringo
Keyword(s):  
Ursodeoxycholic Acid ◽  
Growth And Development ◽  
Liver Function Tests ◽  
Abdominal Ultrasonography ◽  
Laboratory Results ◽  
Long Term Observation ◽  
Timely Treatment ◽  
Conjugated Bilirubin

BACKGROUND: Cholestasis is a condition that starts in the 1st months of life and progresses with direct (conjugated) bilirubin increase and jaundice as a result of impaired bile production or excretion. Its incidence is known as 1 in 2500 live births. This study shows the effectiveness of ursodeoxycholic acid (UDCA) and phenobarbital in infant cholestasis treatment. CASE REPORT: A 28-days-old boy came with a complaint of yellow eyes. At the age of 3 days, the patient looked yellow, had a fever and difficulty drinking, received phototherapy. After 2 weeks of treatment with neonatal sepsis, the patient was discharged in a stable. The skin appears yellow. The laboratory results show anemia, elevated conjugated bilirubin, and signs of infection; the abdominal ultrasonography shows that the liver and gallbladder were normal. The diagnosis is cholestasis due to sepsis. After 3 months of treatment with UDCA and phenobarbital, jaundiced disappeared, and liver function tests were normal. When the patient is 2 ½ years old, the growth and development suit his age. CONCLUSION: Early diagnosis and timely treatment of UDCA and phenobarbital play a role in cholestasis improvement. On long-term observation, the child’s growth and development are suitable according to his age and average laboratory results.

IMMUNOLOGIC AND BIOCHEMICAL STUDIES IN INFANTS AND CHILDREN WITH SPECIAL REFERENCE TO RHEUMATIC FEVER

PEDIATRICS ◽  
1948 ◽  
Vol 2 (3) ◽  
pp. 239-241
Author(s):  
MAY G. WILSON
Keyword(s):  
Rheumatic Fever ◽  
Epidemiologic Studies ◽  
Direct Result ◽  
Endogenous Factors ◽  
Number Of Children ◽  
Exogenous Agents ◽  
Exogenous Factors ◽  
Long Term Observation

CERTAIN individuals are more susceptible than others to many conditions. In recent years it has become clear that in rheumatic fever, susceptibility of the host is an important factor in the pathogenesis of the disease. It was concluded from genetic and epidemiologic studies that susceptibility to rheumatic fever is on a genetic and age basis. Although the susceptible child cannot be identified at the present time, the number of children expected to be susceptible in a group of families of known genotype may be determined on the basis of recessive inheritance. It may, therefore, be postulated that distributed among a group of families of known hereditary background are children who are susceptible and insusceptible to the acquisition of rheumatic fever. As a direct result of long term observation of rheumatic families over a period of 30 years, a second generation of children of known hereditary background is available to us for exploratory studies. This group includes children from families in which one or both parents are rheumatic, or in which neither parent is rheumatic. In this group there are normal (insusceptible), susceptible and rheumatic children. The nature of the hereditable factors which may be responsible for susceptibility is obscure. Recent advances in biochemical genetics have provocative implications in rheumatic fever. Of particular interest are the observations which demonstrate that such biochemical reactions as enzyme and protein specificities are gene determined. As a working hypothesis it seemed reasonable to postulate that in a susceptible child, abnormal physiologic, chemical, immunologic or hormonal responses might be found. Differences might then be observed in certain reactions between the normal group and a group containing a high proportion of genetically susceptible children. This approach does not conflict with the concept that exogenous factors, irrespective of their nature, may also be operative. If the nature of the endogenous factors were known, the role of possible exogenous agents would be clarified.

scholarly journals Promoting the creation of Innovation Ecosystems: the case of the University of Porto

2018 ◽  
Vol 6 (3) ◽  
pp. 8 ◽  
Author(s):  
Carlos Melo Brito
Keyword(s):  
Growth And Development ◽  
Success Factor ◽  
Policy Makers ◽  
Innovation Ecosystems ◽  
The University ◽  
Key Success Factor ◽  
Knowledge Valorisation

Universities are increasingly acting as promoters of innovation, economic growth and regional development, a trend that has attracted the attention of both policy makers and researchers. The objective of this paper is to contribute to a deeper understanding of the role of higher education institutions as dynamic promoters of growth and development. The University of Porto is used as a case study to explore how universities can act as innovation ecosystems leaders and integrators. The main contributions of the paper are threefold. First, the case puts in evidence a key success factor: the talent to transform the knowledge produced by universities into valuable solutions for companies and other organisations. Second, links between universities and industry must assume a long-term and relational nature rather than an intermittent and transactional character. Finally, the success of university-based ecosystems depends on the integration of a diversity of actors, resources and competences. This means that a sustainable strategy of innovation and knowledge valorisation requires an approach that fosters both internal and external networking.

scholarly journals Play as a Factor of Harmonious and Disharmonious Development in Childhood

2021 ◽  
Vol 19 (3) ◽  
pp. 31-41
Author(s):  
S.A. Voskresenskaya ◽  
G.V. Kozlovskaya ◽  
M.V. Ivanov
Keyword(s):  
Autism Spectrum Disorders ◽  
Mental State ◽  
Autism Spectrum ◽  
Proximal Development ◽  
Play Activity ◽  
Spectrum Disorders ◽  
Long Term Observation ◽  
Clinical Conditions

The article discusses the problems of the development of play activity, as a reflection of harmonious and disharmonious mental development, starting from an early age. 4030 preschool children (2720 boys and 1310 girls) were examined. For the long-term observation, 150 people (92 boys and 58 girls) were selected. Methods: clinical-psychopathological, neurological, psychological, using the concept of leading activity, focused on the “zone of proximal development”. The article analyzes the role of toys as material objects used by children of different ages and clinical conditions, in the structure of which disorders of the mental state and play activity were found. The clinical picture of mental disorders was determined by disorders of the neurosis-like, affective level in combination with individual schizotypal stigmas, and behavioral disorders within the autism spectrum disorders. Conclusions are made about the possibility of an adverse effect of certain forms of play and play objects on the mental state and development of schizo- typal disorders and autism spectrum disorders.

scholarly journals THE ROLE OF URSODEOXYCHOLIC ACID IN THE TREATMENT OF CHRONIC VIRAL HEPATITIS

2017 ◽  
pp. 31-35
Author(s):  
R. G. MYAZIN
Keyword(s):  
Viral Hepatitis ◽  
Ursodeoxycholic Acid ◽  
Safety Profile ◽  
Clinical Manifestations ◽  
Chronic Viral Hepatitis ◽  
Good Tolerability ◽  
Effective Prevention ◽  
Term Administration

Along with etiotropic antiviral therapeutic schemes, treatment of chronic viral hepatitis today involves administration of medications that eliminate the clinical manifestations of the disease. In particular, the use of ursodeoxycholic acid (Urdoxa®), with its high safety profile and good tolerability in case of long-term administration, is justified for the effective prevention of cholestasis.

Outcomes of spontaneous regression of retinopathy of prematurity

2021 ◽  
pp. 167-169
Author(s):  
O.M. Zнukova ◽  
◽  
A.V. Tereshchenko ◽  
I.G. Trifanenkova ◽  
M.S. Tereshchenkova ◽  
...  
Keyword(s):  
Retinopathy Of Prematurity ◽  
Spontaneous Regression ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Ophthalmological Examination ◽  
History Of ◽  
Varying Length ◽  
Long Term Observation ◽  
Timely Treatment

Purpose. To analyze postnatal outcomes in children with spontaneous ROP regression. Material and methods. The study included 37 children (74 eyes) with spontaneous ROP regression. Gestational age was ranged from 23 to 32 weeks, body weight - from 493 to 1660 g at birth. Depending on the observation period, the children were divided into 2 age groups: 1 - from 1 month to 4 years old - 31 children (62 eyes), 2 - from 9 to 13 years old - 6 children (12 eyes). The diagnostics included standard ophthalmological examinations and additional methods. Results. In the first group, upon reaching the age of 1-year, complete retinal vascularization was observed in 26 (83%) cases (52 eyes). 5 children (10 eyes) had a narrow retinal avascular zone in the temporal segment. In the second group, in cases of postponed 3-rd stage of ROP, more severe disorders in the peripheral parts of the retina were revealed: compaction of the posterior hyaloid membrane with fixation and zones of traction retinoschisis of varying length. In the first years of life, all patients with ROP had a history of predominantly hyperopic refraction (94%). However, myopic refraction prevailed (82%) in the second group of children reaching school age. Conclusion. Considering the significant variability of the clinical manifestations of the cicatricial stage of ROP with spontaneous regression, long-term observation and a comprehensive ophthalmological examination of this group of patients are necessary for timely treatment. Key words: retinopathy of prematurity, spontaneous regression, cicatricial phase.

Surgical Treatment of Cholesteatoma: The Role of Staging in Closed Operations

1988 ◽  
Vol 97 (6) ◽  
pp. 667-669 ◽  
Author(s):  
Gordon D. L. Smyth
Keyword(s):  
Surgical Treatment ◽  
Combined Approach ◽  
Two Stage ◽  
Left Behind ◽  
Second Stage ◽  
Retraction Pockets ◽  
Long Term Observation ◽  
Two Stages

It has been proposed that closed operations on cholesteatomatous ears should be performed on a two-stage basis in order to detect disease left behind at the first operation and to correct developing retraction pockets. Two groups of patients who had closed operations performed in two stages, 100 combined approach tympanoplasties and 100 mastoid obliterations with tympanoplasty, were observed for 10 years after the second stage. A much greater than expected incidence of eventual cholesteatoma recurrence suggests that even with staging, closed techniques may provide a less than reliable outcome in surgical control of the disease, and long-term observation of ears thus treated is desirable.

scholarly journals Fertility Disorders in Obese Patients – the Role of Thermal Station Therapy

2019 ◽  
Vol 61 (1) ◽  
pp. 39-43
Author(s):  
Irena Ponikowska ◽  
Przemysław Adamczyk ◽  
Arkadiusz Kapliński
Keyword(s):  
Metabolic Diseases ◽  
Visceral Obesity ◽  
Reproductive Age ◽  
The Metabolic Syndrome ◽  
Comprehensive Health ◽  
Fertility Disorders ◽  
Treatment Of Obesity ◽  
Long Term Observation

a, , S TRESZCZENIE Otyłość jest chorobą metaboliczną, która powoduje szereg powikłań z zakresu układu krążenia, układu ruchu, układu oddechowego, wątroby, wywołuje cukrzycę typu 2, dnę moczanową i wiele innych chorób. Choroby metaboliczne wywołane otyłością trzewną wchodzą w zakres zespołu metabolicznego. Poza ginekologami rzadko się mówi i pisze o zaburzeniach płodności wywołanych otyłością. Tymczasem badania wskazują, że leczenie zaburzeń płodności u otyłych powinniśmy prawie zawsze zacząć od leczenia otyłości. Poza tym inne już wdrożone metody wspierania płodności będą bardziej efektywne jeżeli uwzględni się redukcję masy ciała. Otyłość upośledza płodność u kobiet i mężczyzn. Tkanka tłuszczowa produkuje wiele hormonów, które zaburzają cykl miesiączkowy i prawidłową owulację u kobiet. U mężczyzn otyłych obserwuje się zmniejszenie wartości nasienia, zmniejsza się liczba i ruchliwość plemników. Leczenie więc otyłości u osób obojga płci w wieku prokreacyjnym jest niezbędne. Lecznictwo uzdrowiskowe, które zajmuje się chorobami przewlekłymi może do tego problemu włączyć się aktywnie. W czasie tego leczenia nie tylko uzyskuje się redukcję tkanki tłuszczowej, ale przede wszystkim dokonuje się zmian w stylu życia pacjentów w wyniku przeprowadzonej pełnej edukacji zdrowotnej. Stosowane leczenie balneologiczne wpływa na poprawę ukrwienia narządów miednicy małej oraz powoduje obniżenie poziomu stresu i poprawia wydolność fizyczną. W dalszej perspektywie wyniki uzyskane podczas leczenia uzdrowiskowego nie tylko wpływają na poprawę płodności, ale również pozwalają na uniknięcie poronień i uzyskanie lepszej kondycji zdrowotnej przyszłych rodziców. S łowa kluczowe: otyłość, zaburzenia płodności, leczenie uzdrowiskowe S UMMARY Obesity is a metabolic disorder that causes a number of complications within the cardiovascular system, movement system, respiratory system, and the liver. It also triggers type 2 diabetes, gout, and many other diseases. Metabolic diseases caused by visceral obesity are included in the metabolic syndrome definition. Apart from gynecologists, one rarely speaks and writes about fertility disorders caused by obesity. Meanwhile, research studies indicate that treatment of obesity-related fertility disorders should be almost always started from the treatment of obesity. In addition, other already implemented methods of promoting fertility will be more effective if weight reduction is taken into account. Obesity impairs fertility in women and men. The adipose tissue produces many hormones that interfere with the menstrual cycle and normal ovulation in women. In obese men, the value of sperm is reduced, and the number and mobility of spermatozoa are reduced. Therefore, treating obesity in both sexes in the reproductive age is essential. Thermal station treatment that deals with chronic diseases can be actively involved in this problem. During this treatment, not only the reduction of body fat is obtained, but above all changes in the patients’ lifestyle are made as a result of comprehensive health education. The applied balneological treatment improves the blood supply to the pelvic organs, decreases the level of stress and improves physical fitness. In the long-term observation, the results obtained during thermal station treatment not only improve fertility, but also allow to avoid miscarriages and get better healthiness of future parents.

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