scholarly journals Studies Related to Naturally Occurring Acetylene Compounds. XI. Further Investigation on the Composition of Essential Oils from the Genus Erigeron.

1953 ◽  
Vol 7 ◽  
pp. 1375-1387 ◽  
Author(s):  
Gjertrud Moen Tronvold ◽  
Magne Nestvold ◽  
Dagny Holme ◽  
Jörgine Stene Sörensen ◽  
Nils Andreas Sörensen
Keyword(s):  
Essential Oils ◽  
Naturally Occurring ◽  
Acetylene Compounds

scholarly journals Studies Related to Naturally Occurring Acetylene Compounds. XXIV. 2-Phenyl-5(alpha-propynyl)-thiophene from the essential oils of Coreopsis grandiflora, Hogg ex Sweet.

1958 ◽  
Vol 12 ◽  
pp. 771-776 ◽  
Author(s):  
Jörgine Stene Sörensen ◽  
Nils Andreas Sörensen ◽  
Einar Stenhagen ◽  
Lars Gunnar Sillén ◽  
B. Zaar ◽  
...  
Keyword(s):  
Essential Oils ◽  
Naturally Occurring ◽  
Acetylene Compounds

scholarly journals Studies Related to Naturally Occurring Acetylene Compounds. XVIII. The Synthesis of Some Phenylacetylenes Related to Compositae Compounds.

1954 ◽  
Vol 8 ◽  
pp. 1757-1762 ◽  
Author(s):  
Torger Bruun ◽  
Lars Skatteböl ◽  
Nils Andreas Sörensen ◽  
Nils Andreas Sörensen
Keyword(s):  
Naturally Occurring ◽  
Acetylene Compounds

scholarly journals Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study

2020 ◽  
Vol 71 (6) ◽  
pp. 267-273 ◽  
Author(s):  
Branislava D. Kocic ◽  
Dobrila M. Stankovic Dordevic ◽  
Marija V. Dimitrijevic ◽  
Marija S. Markovic ◽  
Dragoljub L. Miladinovic
Keyword(s):  
Helicobacter Pylori ◽  
Antibacterial Activity ◽  
Natural Products ◽  
Chemical Composition ◽  
Essential Oils ◽  
Principal Component ◽  
Synergistic Activity ◽  
Agglomerative Hierarchical Clustering ◽  
Naturally Occurring ◽  
H Pylori

The susceptibility of Helicobacter pylori to three essential oils (EOs), 12 naturally occurring monoterpene hydrocarbons, oxygenated and phenolic monoterpenes and three reference antibiotics were studied. Classification and comparison of essential oils and monoterpenes on the basis of their chemical composition and antibacterial activity were made by the utilization of principal component analyses (PCA) and agglomerative hierarchical clustering (AHC). The most abundant compound in the Thymus glabrescens Willd. and Thymus pulegioides L. EOs is geraniol (33.8% and 52.5%), while the main constituent in Satureja kitaibelii Wierzb. ex Heuff. EO is limonene (16,1%). The compound that was the most active against H. pylori was carvacrol. EOs of T. glabrescens and S. kitaibelii exhibit higher antibacterial ability in comparison with all monoterpenes, except carvacrol, probably based on the concept of synergistic activity of essential oil components. PCA separated essential oils based on chemical composition and explain 96.5% of the total variance in the first two principal components. Essential oils, phenolic monoterpenes and two antibiotics were classified in the same sub-cluster within AHC analyses. EOs of T. glabrescens and S. kitaibelii can be used to treat infections caused by H. pylori, as a potentially effective, cheap and safe natural products. Further research of antibacterial activity of selected monoterpenes, essential oils and standard antibiotic combinations, as well as clinical study are required.

Quantitative Removal of Pyrrolizidine Alkaloids from Essential Oils by the Hydrodistillation Step in Their Manufacturing Process

Planta Medica ◽  
2021 ◽  
Author(s):  
David S. Giera ◽  
Michael Preisitsch ◽  
Hugues Brevard ◽  
Jörn Nemetz
Keyword(s):  
Essential Oils ◽  
Manufacturing Process ◽  
Pyrrolizidine Alkaloids ◽  
Pyrrolizidine Alkaloid ◽  
Medicinal Products ◽  
Herbal Medicinal Products ◽  
Naturally Occurring ◽  
Herbal Medicinal ◽  
Set Up ◽  
Theoretical Considerations

AbstractPyrrolizidine alkaloids are naturally occurring toxins produced by certain weeds that can, if accidentally co-harvested, contaminate plant-based food, feed, and herbal medicinal products. Focusing on herbal medicinal products, the presence of pyrrolizidine alkaloids is restricted by regulatory prescribed thresholds to assure patient safety. Among the multitude of different herbal active substances utilized in herbal medicinal products, the class of pharmaceutically effective essential oils is considered to exhibit a negligible contribution to pyrrolizidine alkaloid contamination. Within the present investigation, this hypothesis should be scientifically scrutinized. For this purpose, an experimental set-up was chosen that reproduces the typical manufacturing step of hydrodistillation. Essential oils of eucalyptus and lemon were selected exemplarily and spiked with 3 representative pyrrolizidine alkaloids (retrorsine, retrorsine-N-oxide, and lycopsamine), whereupon hydrodistillation was performed. Analysis of the resulting distillates by LC-MS/MS proved that artificially added pyrrolizidine alkaloids were removed completely. Moreover, quantitative pyrrolizidine alkaloid recovery in the aqueous phases was observed. Hence, it was experimentally confirmed that herbal medicinal products employing hydrodistilled essential oils of pharmaceutical quality are intrinsically free of pyrrolizidine alkaloids due to the particularities of their manufacturing process. Furthermore, it can be concluded from theoretical considerations that essential oils produced by cold pressing have a negligible risk of carrying pyrrolizidine alkaloid contamination. Our findings provide a strong indication that the requirement for analytical pyrrolizidine alkaloid testing of essential oils for pharmaceutical use should be fundamentally reconsidered.

scholarly journals Synthesis and Olfactory Characteristics of Hydroxyether Derivatives of Methyl Eugenol

2020 ◽  
Vol 24 (9) ◽  
pp. 1503-1507
Author(s):  
S.O. Okopi ◽  
L.M. Affiku
Keyword(s):  
Double Bond ◽  
Essential Oils ◽  
Plant Species ◽  
Chemical Transformation ◽  
Structural Modification ◽  
Methyl Eugenol ◽  
Naturally Occurring ◽  
Relationship Of ◽  
Derivatives Of ◽  
Functional Alteration

Methyl eugenol is a naturally occurring substance found in the essential oils of several plant species. It is a cheap and abundant material with a rather limited interest as perfuming ingredient. This research investigated the structure-odour relationship of methyl eugenol and its derivatives, focusing on the chemical transformation of the double bond to hydroxyether derivatives in a controlled manner. Two derivatives 2-(4-ethyl- 3-methoxybenzyl)oxirane (68.8% yield) and 1-(3,4-dimethoxyphenyl)-3-ethoxypropan-2-ol (63.58% yield), were synthesized from methyl eugenol. This research found that the odour characteristic of 2-(4-ethyl-3-methoxybenzyl)oxirane[floral, fresh, slight lime and sweet]compounds, is clearly different from the odours of the 1-(3,4-dimethoxyphenyl)-3-ethoxypropan-2-ol [Glue-like, pungent, and Caramel-like]. It is evident from our observations that double bond substitution and functional alteration of the methyl eugenol modifies the perceived odour of methyl eugenol  derivative. Thus, structural modification overall led to an increase in odour potency. Keywords: Fragrance, Methly-Eugenol, Ether, Olfactory characteristic, Epoxidation.

Studies related to naturally occurring acetylene compounds. XXXV. Investigation of Erigeron spp. from the Australian mountains and Tasmania

1969 ◽  
Vol 22 (4) ◽  
pp. 751 ◽  
Author(s):  
JS Sorensen ◽  
NA Sorensen
Keyword(s):  
Carboxylic Acids ◽  
Northern Hemisphere ◽  
Methyl Esters ◽  
Naturally Occurring ◽  
Acetylene Compounds ◽  
Acetylenic Compounds

Two Australian members of the genus Erigeron L. (Compositae, tribe Astereae) have been investigated with particular regard to their content of acetylenic compounds. E. conyzoides F. Muell. contained the methyl esters (I) and (II) of acetylenic carboxylic acids and their corresponding lactones (III) and (IV) and in this resemble the numerous Erigeron spp. of the northern hemisphere investigated earlier. Of the collective species E. pappochroma Labill. three Tasmanian and two Snowy Mountain collections were investigated. None of them contained the acetylenic compounds characteristic of typical Erigeron. Three of these collections contained some simple acetylenic alcohols, (V)-(IX); some of these are characteristic compounds of other genera of the tribus Astereae. In two collections acetylenic compounds were seemingly absent; but dill apiol (XI) was found in appreciable amounts.

scholarly journals Studies related to Naturally Occurring Acetylene Compounds. XXXIII. A Preliminary Investigation of Coreopsis gigantea (Kell.) H. M. Hall.

1966 ◽  
Vol 20 ◽  
pp. 992-1002 ◽  
Author(s):  
Jørgine Stene Sørensen ◽  
Nils Andreas Sørensen ◽  
Bodil Jerslev ◽  
E. Kulonen ◽  
J. Brunvoll ◽  
...  
Keyword(s):  
Preliminary Investigation ◽  
Naturally Occurring ◽  
Coreopsis Gigantea ◽  
Acetylene Compounds

High Resolution Infrared Spectra of Some Naturally Occurring Sesquiterpene Hydrocarbons. II. Second Series

1970 ◽  
Vol 53 (5) ◽  
pp. 949-963 ◽  
Author(s):  
John A Wenninger ◽  
Ronald L Yates
Keyword(s):  
High Resolution ◽  
Ir Spectra ◽  
Essential Oils ◽  
Infrared Spectra ◽  
Capillary Column ◽  
Naturally Occurring ◽  
Sesquiterpene Hydrocarbons

Abstract An additional 24 high resolution IR spectra of naturally occurring sesquiterpene hydrocarbons are presented. Compounds were isolated from essential oils and purified by GLC techniques. The purity of each compound was checked by capillary column GLC. Infrared spectra of the following compounds are included: aromadendrene, allo-aromadendrene, cis-α-bergamotene, trans-β-bergamotene, cisa-α-bisabolene, trans-α-bisabolene, “α2-bisabolene“, cis-γ-bisabolene, β-cadinene, β1-cadinene, α-calacorene, chamazulene, β-chamigrene, “cubenene“, α-himachalene, β-himachalene, longicyclene, longifolene, α-muurolene, γ-muurolene, γ-patchoulene, epi-β-santalene, selina-4,ll-diene, and ylangene.

High Resolution Infrared Spectra of Some Naturally Occurring Sesquiterpene Hydrocarbons

1967 ◽  
Vol 50 (6) ◽  
pp. 1313-1335 ◽  
Author(s):  
John A Wenninger ◽  
Ronald L Yates ◽  
Meyer Dolinsky
Keyword(s):  
High Resolution ◽  
Essential Oils ◽  
Infrared Spectra ◽  
Internal Standard ◽  
Chromatographic Retention ◽  
Chromatographic Techniques ◽  
Naturally Occurring ◽  
Sesquiterpene Hydrocarbons

Abstract High resolution infrared spectra in the region from 4000 to 300 cm- 1 are presented for 36 sesquiterpene hydrocarbons. The compounds were isolated from commercial essential oils and purified by gas chromatographic techniques. The gas chromatographic retention times relative to isodurene as an internal standard and the five strongest infrared hands in the 1250— 300 cm- 1 region are also tabulated

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