scholarly journals Methylenetetrahydrofolate reductase C677T gene polymorphism and essential hypertension: A meta-analysis of 10,415 subjects

2014 ◽  
Vol 2 (5) ◽  
pp. 699-708 ◽  
Author(s):  
KE-MING YANG ◽  
JIAN JIA ◽  
LI-NA MAO ◽  
CHEN MEN ◽  
KANG-TING TANG ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Gene Polymorphism ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis

scholarly journals Association Between MTHFR Polymorphisms and the Risk of Essential Hypertension: An Updated Meta-analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Hao Meng ◽  
Shaoyan Huang ◽  
Yali Yang ◽  
Xiaofeng He ◽  
Liping Fei ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Essential Hypertension ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
Cochrane Library ◽  
Mthfr Polymorphisms ◽  
Southeast Asians ◽  
Increased Risk ◽  
Meta Analyses

Background: Since the 1990s, there have been a lot of research on single-nucleotide polymorphism (SNP) and different diseases, including many studies on 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphism and essential hypertension (EH). Nevertheless, their conclusions were controversial. So far, six previous meta-analyses discussed the internal relationship between the MTHFR polymorphism and EH, respectively. However, they did not evaluate the credibility of the positive associations. To build on previous meta-analyses, we updated the literature by including previously included papers as well as nine new articles, improved the inclusion criteria by also considering the quality of the papers, and applied new statistical techniques to assess the observed associations. Objectives: This study aims to explore the degree of risk correlation between two MTHFR polymorphisms and EH. Methods: PubMed, EMBASE, the Cochrane Library, CNKI, and Wan Fang electronic databases were searched to identify relevant studies. We evaluated the relation between the MTHFR C677T (rs1801133) and A1298C (rs1801131) polymorphisms and EH by calculating the odds ratios (OR) as well as 95% confidence intervals (CI). Here we used subgroup analysis, sensitivity analysis, cumulative meta-analysis, assessment of publication bias, meta-regression meta, False-positive report probability (FPRP), Bayesian false discovery probability (BFDP), and Venice criterion. Results: Overall, harboring the variant of MTHFR C677T was associated with an increased risk of EH in the overall populations, East Asians, Southeast Asians, South Asians, Caucasians/Europeans, and Africans. After the sensitivity analysis, positive results were found only in the overall population (TT vs. CC: OR = 1.14, 95% CI: 1.00–1.30, Ph = 0.032, I2 = 39.8%; TT + TC vs. CC: OR = 1.15, 95% CI: 1.01–1.29, Ph = 0.040, I2 = 38.1%; T vs. C: OR = 1.14, 95% CI: 1.04–1.25, Ph = 0.005, I2 = 50.2%) and Asian population (TC vs. CC: OR = 1.14, 95% CI: 1.01–1.28, Ph = 0.265, I2 = 16.8%; TT + TC vs. CC: OR = 1.17, 95% CI: 1.04–1.30, Ph = 0.105, I2 = 32.9%; T vs. C: OR = 1.10, 95% CI: 1.02–1.19, Ph = 0.018, I2 = 48.6%). However, after further statistical assessment by FPRP, BFDP, and Venice criteria, the positive associations reported here could be deemed to be false-positives and present only weak evidence for a causal relationship. In addition, when we performed pooled analysis and sensitivity analysis on MTHFR A1298C; all the results were negative. Conclusion: The positive relationships between MTHFR C677T and A1298C polymorphisms with the susceptibility to present with hypertension were not robust enough to withstand statistical interrogation by FPRP, BFDP, and Venice criteria. Therefore, these SNPs are probably not important in EH etiology.

scholarly journals Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis

2007 ◽  
Vol 52 (11) ◽  
pp. 881-890 ◽  
Author(s):  
Elias Zintzaras ◽  
Katrin Uhlig ◽  
George N. Koukoulis ◽  
Afroditi A. Papathanasiou ◽  
Ioannis Stefanidis
Keyword(s):  
Risk Factor ◽  
Diabetic Nephropathy ◽  
Gene Polymorphism ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Reductase Gene ◽  
Methylenetetrahydrofolate Reductase Gene Polymorphism ◽  
Methylenetetrahydrofolate Reductase Gene

Association between 5,10-Methylenetetrahydrofolate Reductase C677T Gene Polymorphism and Risk of Ischemic Stroke: A Meta-analysis

2016 ◽  
Vol 25 (3) ◽  
pp. 679-687 ◽  
Author(s):  
Yanli Song ◽  
Bohong Li ◽  
Chunjuan Wang ◽  
Penglian Wang ◽  
Xiang Gao ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Gene Polymorphism ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis

Association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension: A systematic review and meta-analysis

Metabolism ◽  
2014 ◽  
Vol 63 (12) ◽  
pp. 1503-1511 ◽  
Author(s):  
Yi-Le Wu ◽  
Cai-Yun Hu ◽  
Shan-Shan Lu ◽  
Feng-Feng Gong ◽  
Fang Feng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Essential Hypertension ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Mthfr C677t
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