Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus

2002 ◽  
Author(s):  
H. Ben-Hur ◽  
G. Kossoy ◽  
N. Kossoy ◽  
I. Zusman
Keyword(s):  
Bone Marrow ◽  
Immune System ◽  
Molecular Mass ◽  
Mammary Tumor ◽  
Tumor Associated Antigens ◽  
Tumor Bearing

Effects of tamoxifen and soluble tumor-associated antigens on ovarian structure in mammary tumor-bearing rats

2005 ◽  
Author(s):  
George Kossoy ◽  
Herzl Ben-Hur ◽  
Asher Elhayany ◽  
David Schneider ◽  
Nadja Kossoy ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Tumor Associated Antigens ◽  
Tumor Bearing ◽  
Ovarian Structure

scholarly journals Secondary haemophagocytic lymphohistiocytosis in COVID-19: correlation of the autopsy findings of bone marrow haemophagocytosis with HScore

2021 ◽  
pp. jclinpath-2020-207337
Author(s):  
Claudia Núñez-Torrón ◽  
Ana Ferrer-Gómez ◽  
Esther Moreno Moreno ◽  
Belen Pérez-Mies ◽  
Jesús Villarrubia ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Immune Response ◽  
Immune System ◽  
Multiorgan Failure ◽  
Histological Findings ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Bone Marrow Tissue ◽  
Autopsy Findings ◽  
Specific Finding ◽  
Clinical Records

BackgroundSecondary haemophagocytic lymphohistiocytosis (sHLH) is characterised by a hyper activation of immune system that leads to multiorgan failure. It is suggested that excessive immune response in patients with COVID-19 could mimic this syndrome. Some COVID-19 autopsy studies have revealed the presence of haemophagocytosis images in bone marrow, raising the possibility, along with HScore parameters, of sHLH.AimOur objective is to ascertain the existence of sHLH in some patients with severe COVID-19.MethodsWe report the autopsy histological findings of 16 patients with COVID-19, focusing on the presence of haemophagocytosis in bone marrow, obtained from rib squeeze and integrating these findings with HScore parameters. CD68 immunohistochemical stains were used to highlight histiocytes and haemophagocytic cells. Clinical evolution and laboratory parameters of patients were collected from electronic clinical records.ResultsEleven patients (68.7%) displayed moderate histiocytic hyperplasia with haemophagocytosis (HHH) in bone marrow, three patients (18.7%) displayed severe HHH and the remainder were mild. All HScore parameters were collected in 10 patients (62.5%). Among the patients in which all parameters were evaluable, eight patients (80%) had an HScore >169. sHLH was not clinically suspected in any case.ConclusionsOur results support the recommendation of some authors to use the HScore in patients with severe COVID-19 in order to identify those who could benefit from immunosuppressive therapies. The presence of haemophagocytosis in bone marrow tissue, despite not being a specific finding, has proved to be a very useful tool in our study to identify these patients.

scholarly journals Clinical observations of bone marrow transfusion for promoting bone marrow reconstruction after chemotherapy for AIDS-related lymphoma

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yixuan Liu ◽  
Suhong Xie ◽  
Lei Li ◽  
Yanhui Si ◽  
Weiwei Zhang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Immune System ◽  
T Lymphocytes ◽  
Peripheral Blood ◽  
Autologous Bone Marrow ◽  
Control Group ◽  
Peripheral Vein ◽  
Significant Difference ◽  
Autologous Bone ◽  
Aids Related Lymphoma

Abstract Background This study investigates the effect of autologous bone marrow transfusion (BMT) on the reconstruction of both bone marrow and the immune system in patients with AIDS-related lymphoma (ARL). Methods A total of 32 patients with ARL participated in this study. Among them, 16 participants were treated with conventional surgery and chemotherapy (control group) and the remaining 16 patients were treated with chemotherapy followed by autologous bone marrow transfusion via a mesenteric vein (8 patients, ABM-MVI group) or a peripheral vein (8 patients, ABM-PI group). Subsequently, peripheral blood and lymphocyte data subsets were detected and documented in all patients. Results Before chemotherapy, no significant difference in indicators was observed between three groups of ARL patients. Unexpectedly, 2 weeks after the end of 6 courses of chemotherapy, the ABM-MVI group, and the ABM-PI group yielded an increased level of CD8+T lymphocytes, white blood cells (WBC), and platelet (PLT) in peripheral blood in comparison to the control group. Notably, the number of CD4+T lymphocytes in the ABM-PI group was significantly higher than that in the other two groups. Additionally, no significant difference in haemoglobin levels was observed before and after chemotherapy in both the ABM-MVI and ABM-PI groups, while haemoglobin levels in the control group decreased significantly following chemotherapy. Conclusions Autologous bone marrow transfusion after chemotherapy can promote the reconstruction of both bone marrow and the immune system. There was no significant difference in bone marrow recovery and reconstruction between the mesenteric vein transfusion group and the peripheral vein transfusion group.

IMMUNE SYSTEM OF POIKILOTHERMIC AQUATIC ORGANISMS

2021 ◽  
pp. 71-91
Author(s):  
G.I. PRONINA ◽  
◽  
A.A. IVANOV ◽  
A.G. MANNAPOV ◽  
O.V. SANAYA
Keyword(s):  
Bone Marrow ◽  
Immune System ◽  
Lymphoid Tissue ◽  
Cellular Response ◽  
Aquatic Organisms ◽  
Immune Defense ◽  
Cationic Protein ◽  
Complement Components ◽  
Red Bone Marrow

The paper shows features of the immune system of poikilothermic aquatic organisms of different taxonomic groups: crustaceans, fish, and amphibians. Defense mechanisms of crustaceans are presented by largely innate non-specific factors: external covers (including the exoskeleton), mucus, physical and chemical barriers lysozyme in the hemolymph, propanolamine system, and phagocytosis. The authors identified 4 types of cells (hemocytes) found in the circulating fluid of crayfish, depending on the morphological and functional properties: agranulocytes, progranulin,granulocytes, and transparent cells. Each type performs different functions in the process of immune defense. In fish, there is no red bone marrow and lymph nodes, the main organs of hematopoiesis include thymus, spleen, liver, lymphoid tissue of the brain and the trunk of the kidneys,accumulation of lymphoid tissue of the cranial box, intestine, and pericardium. Humoral components of the immune response of fish are represented by immunoglobulins, system complement components, lysozyme, C-reactive protein, interferon, lysine, hemolysin, hemagglutinin. Only IgM-like antibodies represent immunoglobulins in fish. The central organ of the amphibian immune system is the red bone marrow, but its role in the immune defense of amphibians has not been sufficiently studied. Peripheral organs of the immune system include kidneys, thymus, spleen, lymphomyeloid organs. Depending on the characteristics of the immune system of poikilothermic hydrobionts of different types, the authors offer methods for assessing their humoralimmunity (by determining phenoloxidase) and cellular response (by phagocytosis). Cellular immunity, and phagocytic activity, in particular, can be evaluated using cytochemical methods taking into account oxygenindependent factors – the content of enzymatic lysosomal cationic protein in phagocytes – and oxygendependent ones – NBT-test with nitrosonium tetrazolium that records cytotoxic oxygen radicals generated during the respiratory explosion of cell stimulation in vitro.

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