Early diagnosis of malignant melanoma: Proposal of a working formulation for the management of cutaneous pigmented lesions from the Melanoma Cooperative Group

2003 ◽  
Author(s):  
Paolo Ascierto ◽  
Giuseppe Palmieri ◽  
Gerardo Botti ◽  
Rocco Satriano ◽  
Ignazio Stanganelli ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Early Diagnosis ◽  
Cooperative Group ◽  
Pigmented Lesions ◽  
Working Formulation

scholarly journals A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal Wall

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Tomoko Noguchi ◽  
Nami Ota ◽  
Yasushi Mabuchi ◽  
Shigetaka Yagi ◽  
Sawako Minami ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Uterine Cervix ◽  
Pap Smear ◽  
Lung Metastases ◽  
Female Genital Tract ◽  
Figo Stage ◽  
Vaginal Wall ◽  
Pelvic Lymphadenectomy ◽  
Pigmented Lesions ◽  
Node Metastases

Malignant melanoma (MM) in the female genital tract accounts for less than 2% of all melanomas, and the vast majority associated occur in the vulva and vagina. Primary MM of the uterine cervix is extremely rare and its prognosis is very poor. We report a case of primary MM of the cervix with dissemination throughout the vaginal wall. A 66-year-old woman presented with postmenopausal bleeding. Gynecologic examination demonstrated a 2 cm polypoid blackish-pigmented tumor on the cervix with multiple small blackish-pigmented lesions throughout the vaginal wall. Cervical Pap smear cytology showed malignant melanoma. MRI and PET/CT did not detect any distant or lymph node metastases. She underwent radical hysterectomy, pelvic lymphadenectomy, and total vaginectomy. The pathological diagnosis was FIGO stage IIIA primary cervical MM. She received adjuvant chemotherapy with 6 courses of dacarbazine, but 6 months later, multiple lung metastases were detected. Despite 4 courses of anti-PD-1 antibody (nivolumab) treatment, she died of the disease 13 months after surgery.

Metastatic anorectal malignant melanoma causing ileocaecal junction obstruction due to contiguous spread

2021 ◽  
Vol 14 (4) ◽  
pp. e240621
Author(s):  
Swanit Hemant Deshpande ◽  
Vishal Narkhede ◽  
Sai Krishna Eswaravaka ◽  
Jayashri Sanjay Pandya
Keyword(s):  
Malignant Melanoma ◽  
Early Diagnosis ◽  
Anal Canal ◽  
Loop Ileostomy ◽  
Multiple Metastases ◽  
Diverting Loop Ileostomy ◽  
Ileocaecal Junction ◽  
Contiguous Spread ◽  
Significant Mortality

Malignant melanoma of the anal canal is a rare and aggressive tumour associated with significant mortality. Early diagnosis and early curative surgical resection have shown to offer a survival advantage. We present a case of 53-year-old woman, who was accidentally diagnosed to have a localised lesion of malignant melanoma of the anal canal on histopathology report of the specimen of haemorrhoidectomy done for thrombosed external haemorrhoids. She refused any form of treatment and did not return for follow-up. Two years after the initial diagnosis, she presented with intestinal obstruction. The malignant melanoma had become advanced with multiple metastases to the lungs, the liver, the peritoneum and the spine. The patient underwent a diverting loop ileostomy. At the time of surgery, it was found that the primary malignant melanoma of anal canal had contiguously involved the entire large intestine up to the ileocaecal junction and hence transverse colostomy could not be done.

scholarly journals Metastatic Malignant Melanoma of Parotid Gland with a Regressed Primary Tumor

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
M. Mustafa Kılıçkaya ◽  
Giray Aynali ◽  
Ali Murat Ceyhan ◽  
Metin Çiriş
Keyword(s):  
Malignant Melanoma ◽  
Parotid Gland ◽  
Head And Neck ◽  
Primary Tumor ◽  
Primary Melanoma ◽  
Metastatic Malignant Melanoma ◽  
Malignant Melanomas ◽  
Pigmented Lesions

Malignant melanoma of the parotid gland is often metastatic and mainly originates from malignant melanomas in the head and neck. Nevertheless, some malignant melanomas may metastasize and subsequently regress. Therefore, it may not be possible to observe a metastatic malignant melanoma and its primary melanoma simultaneously. The investigation of a patient’s old photographs may help in the detection of preexisting and regressed pigmented lesions in the facial and neck regions.

scholarly journals Multiple Pigmented Bowen’s Disease: A Diagnostic and Therapeutic Dilemma

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Pratik Gahalaut ◽  
Madhur Kant Rastogi ◽  
Nitin Mishra ◽  
Sandhya Chauhan
Keyword(s):  
Malignant Melanoma ◽  
The Body ◽  
Therapeutic Trial ◽  
Extensive Literature ◽  
Literature Research ◽  
Therapeutic Challenge ◽  
Precancerous Condition ◽  
Pigmented Lesions ◽  
Type V ◽  
Indian Male

Bowens' disease (BD) is a precancerous condition of skin and/or mucosa with a predilection towards sun-exposed areas. Extensive literature research failed to reveal any case of multiple pigmented BD in type V Fitzpatrick skin. Multiple BD is a therapeutic challenge with a tendency to recur. Here we present an otherwise healthy Indian male having multiple pigmented lesions of BD on sun-protected sites of the body mimicking malignant melanoma. These lesions were refractory to treatment with different modalities. This paper is an attempt to review the available literature regarding the pigmented variant of multiple BD. Rationale for a therapeutic trial of UVB therapy for multiple arsenic induced BD is also discussed.

Epiluminescence microscopy as a useful approach in the early diagnosis of cutaneous malignant melanoma

1998 ◽  
Vol 8 (6) ◽  
pp. 529-538 ◽  
Author(s):  
P. A. Ascierto ◽  
R. A. Satriano ◽  
G. Palmieri ◽  
R. Parasole ◽  
L. Bosco ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Early Diagnosis ◽  
Cutaneous Malignant Melanoma

Does the initial biopsy type affect clinically important outcomes in malignant melanoma? A meta-analysis.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e21041-e21041
Author(s):  
Fatima Fayyaz ◽  
Richard A Shellenberger
Keyword(s):  
Malignant Melanoma ◽  
Early Detection ◽  
Risk Ratio ◽  
Meta Analysis ◽  
Excisional Biopsy ◽  
Skin Lesions ◽  
Pigmented Lesions ◽  
Significant Rate ◽  
All Cause Mortality ◽  
Specific Mortality

e21041 Background: Malignant melanoma continues to have an increasing incidence worldwide without a decline in mortality, despite advances in treatment and early detection which have led to improved mortality outcomes for most malignancies. Early detection is particularly favorable for melanoma localized to the site of disease, which confers a five year survival rate of 98.4 %. Guidelines from the American Academy of Dermatology (AAD) give three acceptable options for the initial management of pigmented lesions suspicious for melanoma: elliptical excision, wide punch excision and a deep shave or saucerization. Methods: We performed a systematic review and meta-analysis to better define the evidence for differences between punch incisional and excisional biopsy with regard to clinically important outcomes in the evaluation of skin lesions suspicious for melanoma. These were melanoma specific mortality, all-cause mortality, Breslow tumor thickness, and melanoma recurrence. The comparison groups were punch incisional and excisional biopsy; there was insufficient data to include shave biopsies. Results: The result of pooling the studies that track melanoma specific mortality finds that there is a higher, but non-significant rate of death among those in the punch incisional group. The pooled risk ratio is 1.21, p = 0.153. The results of pooling the all-cause mortality studies also finds a higher, but non-significant, rate of death among the punch incisional group, RR = 1.03, p = 0.390. Pooling the two studies that examine Breslow thickness found that values in the punch incisional group are significantly lower, with a standardized mean difference of -0.17, p = 0.006. Finally, the pooled risk ratio for recurrence was not significant, RR = 1.161, p = 0.198. Conclusions: Until further data is available, there is no evidence to suggest a preferred diagnostic procedure in the initial evaluation of pigmented lesions suspected of cutaneous melanoma related to clinically important outcomes. To our knowledge, this is the first meta-analysis done on this important question regarding melanoma epidemiology and public health.

Sign in / Sign up

Export Citation Format

Share Document